ID | 67179 |
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Kunisada, Toshiyuki
Department of Medical Materials for Musculoskeletal Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Nakata, Eiji
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Fujiwara, Tomohiro
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Hata, Toshiaki
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sato, Kohei
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Katayama, Haruyoshi
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kondo, Ayana
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Ozaki, Toshifumi
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Abstract | Unidirectional porous hydroxyapatite (UDPHAp) was developed as a remarkable scaffold characterized by a distinct structure with unidirectional pores oriented in the horizontal direction and connected through interposes. We evaluated the radiographic changes, clinical outcomes, and complications following UDPHAp implantation for the treatment of bone tumors. Excellent bone formation within and around the implant was observed in all patients treated with intralesional resection and UDPHAp implantation for benign bone tumors. The absorption of UDPHAp and remodeling of the bone marrow space was observed in 45% of the patients at a mean of 17 months postoperatively and was significantly more common in younger patients. Preoperative cortical thinning was completely regenerated in 84% of patients at a mean of 10 months postoperatively. No complications related to the implanted UDPHAp were observed. In a pediatric patient with bone sarcoma, when the defect after fibular resection was filled with UDPHAp implants, radiography showed complete resorption of the implant and clear formation of cortex and marrow in the resected part of the fibula. The patient could walk well without crutches and participate in sports activities. UDPHAp is a useful bone graft substitute for the treatment of benign bone tumors, and the use of this material has a low complication rate. We also review and discuss the potential of UDPHAp as a bone graft substitute in the clinical setting of orthopedic surgery.
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Keywords | hydroxyapatite
bone tumor
orthopedic surgery
unidirectional porous hydroxyapatite
bone graft
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Published Date | 2024-05-15
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Publication Title |
Biomimetics
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Volume | volume9
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Issue | issue5
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Publisher | MDPI
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Start Page | 294
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ISSN | 2313-7673
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2024 by the authors.
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.3390/biomimetics9050294
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License | https://creativecommons.org/licenses/by/4.0/
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Citation | Kunisada, T.; Nakata, E.; Fujiwara, T.; Hata, T.; Sato, K.; Katayama, H.; Kondo, A.; Ozaki, T. Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery. Biomimetics 2024, 9, 294. https://doi.org/10.3390/biomimetics9050294
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Funder Name |
Japan Society for the Promotion of Science
Kuraray Co., Ltd.
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助成番号 | 23K08632
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