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ID 57797
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Yoshioka, Yohsuke Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yamachika, Eiki Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital
Nakanishi, Makoto Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University Kakenhi publons
Ninomiya, Tadashi Department of Anatomy, Nihon University School of Dentistry
Akashi, Sho Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kondo, Sei Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Moritani, Norifumi Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kakenhi
Kobayashi, Yasuhiro Division of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University
Fujii, Tatsuo Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University Kakenhi
Iida, Seiji Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kakenhi
Abstract
Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.
Published Date
2019-5-29
Publication Title
Scientific Reports
Volume
volume9
Publisher
Nature Publishing Group
Start Page
8041
ISSN
2045-2322
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© The Author(s) 2019
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DOI
Web of Science KeyUT
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isVersionOf https://doi.org/10.1038/s41598-019-44389-8
License
https://creativecommons.org/licenses/by/4.0/
Funder Name
Japan Society for the Promotion of Science
助成番号
JP18K09721
JP18H06309