JaLCDOI 10.18926/AMO/53024
FullText URL 68_6_349.pdf
Author Yamamoto, Tsuyoshi| Kajikawa, Yutaka| Otani, Satoru| Yamada, Yuki| Takemoto, Syunji| Hirota, Minoru| Ikeda, Masae| Iwagaki, Hiromi| Saito, Shinya| Fujiwara, Toshiyoshi|
Abstract Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have protective roles against inflammatory responses such as hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients and other patients undergoing cardiac surgery to determine whether this treatment would increase plasma EPA levels and to clarify the association between EPA treatment and adiponectin production in hyperlipidemic patients. We also assessed the effect of preoperative EPA administration on postoperative adverse events such as postoperative atrial fibrillation (POAF) and postoperative infection in the cardiac surgery patients. The EPA administration significantly increased the serum EPA concentrations in both patient populations (p<0.001). In the hyperlipidemic patients, the EPA administration significantly increased plasma adiponectin levels (p<0.05), accompanied by a decrease in insulin resistance designated by the HOMA-IR (homeostasis model assessment of insulin resistance) score (p<0.05) and Hs-CRP (high sensitivity C-reactive protein) value (p<0.05). In the cardiac surgery patients, no significant effect of EPA on cardiac adverse events such as POAF was observed. However, our results clearly demonstrated that both the neutrophil-to-lymphocyte ratio and the 2nd-line antibiotic requirement in the EPA group were significantly decreased compared to the untreated control group (p<0.05). We suggest that EPA administration may exert anti-inflammatory effects in patients with hyperlipidemia and in those undergoing cardiac surgery, possibly through an increase in plasma adiponectin levels.
Keywords eicosapentaenoic acid adiponectin hyperlipidemic patients cardiac surgery atrial fibrillation
Amo Type Original Article
Published Date 2014-12
Publication Title Acta Medica Okayama
Volume volume68
Issue issue6
Publisher Okayama University Medical School
Start Page 349
End Page 361
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25519029
Web of Sience KeyUT 000346882200005
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53125
Author Kobayashi, Yuka| Yamada, Misa| Fujii, Hiromi| Ko, Yukiko| Uotani, Izumi| Tamoto, Mariko| Nada, Masako| Murai, Hiroyuki| Kado, Ei| Iwagaki, Hiromi| Tomoda, Jun| Saito, Shinya|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/32683
FullText URL fulltext.pdf
Author Sakagami, Kenichi| Saito, Shinya| Shiozaki, Shigehiro| Takasu, Shinji| Matsuno, Tsuyoshi| Fujiwara, Takuzo| Kusaka, Satoshi| Uda, Masashi| Matsuoka, Junji| Naomoto, Yoshio| Gouchi, Akira| Hamazaki, Keisuke| Tanaka, Shinichiro| Orita, Kunzo|
Abstract <p>A retrospective study was carried out in 110 cadaveric kidney transplant recipients to compare the effects of low doses of cyclosporine (CsA), azathioprine (AZP) and steroids (triple-drug therapy) with those of higher doses of steroids plus AZP (conventional immunosuppression). Graft survival rate in the triple-drug therapy was 77%, 69%, and 69% at 1, 3, and 5 years, respectively. This was significantly better than 48%, 34%, and 29% in conventional immunosuppression. The incidence of acute rejection episodes was significantly lower in the triple-drug therapy than in conventional immunosuppression (25% vs 58%). In conclusion, our study shows that triple-drug therapy using low-dose cyclosporine is the safest of the immunosuppressive regimens and provides a beneficial effect on the long-term survival of cadaveric kidney transplants.</p>
Keywords cadaveric kindney transplantation cyclosporine triple-drug therapy
Amo Type Article
Published Date 1992-02
Publication Title Acta Medica Okayama
Volume volume46
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 56
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1561907
Web of Sience KeyUT A1992HH01700010
JaLCDOI 10.18926/AMO/32678
FullText URL fulltext.pdf
Author Sakagami, Kenichi| Saito, Shinya| Shiozaki, Shigehiro| Fujiwara, Takuzo| Haisa, Minoru| Niguma, Takefumi| Kusaka, Satoshi| Uda, Masashi| Matsuno, Tsuyoshi| Takasu, Shinji| Yerdel, Mehmet Ali| Matsuoka, Junji| Tanaka, Shinichiro| Orita, Kunzo|
Abstract <p>One-hundred-nine HLA-haploidentical living related renal transplants have been retrospectively analysed to compare the effect of donor-specific blood transfusion (DST) and different immunosuppressive regimens on graft survival and acute rejection. The recipients were divided into four groups according to the immunosuppressive therapy. Group 1 (n = 44): conventional therapy with posttransplant azathioprine (AZP) + methylprednisolone (MP). Group 2 (n = 25): pretransplant DST + posttransplant AZP + MP. Group 3 (n = 12): triple-drug therapy with posttransplant AZP + MP + cyclosporine (CS). Group 4 (n = 25): pretransplant DST + posttransplant AZP + MP + CS. The five-year actuarial survival rates for groups 1, 2, 3 and 4 were 48%, 73%, 79%, and 89%, respectively. The graft survival rate in group 3 was significantly (p less than 0.01) better than that in group 1. The transfusion effect was reduced, and appears as a 10% improvement in the graft survival in the cyclosporin era compared with a 25% improvement at pre-cyclosporin era. Furthermore, the incidence of the first rejection episode was decreased in recipients that received DST. The present study revealed that DST, as pretransplant conditioning has a definite impact on rejection-free long-term graft survival in HLA-haploidentical living-related kidney recipients and the most favorable outcome in such patients could be achieved by DST pretreatment in conjunction with posttransplant triple-drug therapy including cyclosporine.</p>
Keywords living-related kindney transplantation donor-specific blood transfusion (DST) cyclosporine
Amo Type Article
Published Date 1992-02
Publication Title Acta Medica Okayama
Volume volume46
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 5
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1561899
Web of Sience KeyUT A1992HH01700001
JaLCDOI 10.18926/AMO/31928
FullText URL fulltext.pdf
Author Sakagami, Kenichi| Miyazaki, Masashi| Matsuoka, Junji| Shiozaki, Shigehiro| Saito, Shinya| Orita, Kunzo|
Abstract <p>An artificial liver support system for plasma exchange and plasma perfusion through BR-601 resin using a membrane separator was applied to 5 patients with postoperative liver failure. Percent absorption of total and direct bilirubin, and of bile acids were 77.1 +/- 6.4, 78.4 +/- 6.1, and 93.4 +/- 3.6%, respectively, when 250 ml of plasma was treated. Percent reductions in total and direct bilirubin, and in bile acids were 24.5 +/- 5.8, 25.5 +/- 5.8 and 30.9 +/- 8.5%, respectively. In contrast, percent reductions in total and direct bilirubin, and in bile acids by plasma exchange were 30.9 +/- 13.3, 34.5 +/- 12.5 and 24.2 +/- 8.5%, respectively. The coma grade was improved in 4 out of 5 cases, but unfortunately the patients did not recover. In conclusion, plasma perfusion through BR-601 resin is expected to play a promising role in artificial liver support systems because of its capacity to absorb bilirubin and bile acids.</p>
Keywords anion exchange resin (BR-601) postoperative liver failure artificial liver support
Amo Type Article
Published Date 1986-10
Publication Title Acta Medica Okayama
Volume volume40
Issue issue5
Publisher Okayama University Medical School
Start Page 249
End Page 255
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3788665
Web of Sience KeyUT A1986E557800003
JaLCDOI 10.18926/AMO/31855
FullText URL fulltext.pdf
Author Nishibori, Masahiro| Takahashi, Hide K.| Katayama, Hiroshi| Mori, Shuji| Saito, Shinya| Iwagaki, Hiromi| Tanaka, Noriaki| Morita, Kiyoshi| Ohtsuka, Aiji|
Abstract Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been used for the treatment of LPS-induced septic shock. In this study, we demonstrated that PMX also specifically bound monocytes from the peripheral blood leukocytes of septic patients by mean of an analysis of bound cells using immunocytochemical and electron microscopic techniques. The specific removal of monocytes from septic patients may produce beneficial effects by reducing the interaction between monocytes and functionally associated cells including vascular endothelial cells.
Keywords septic shock polymixin B-immobilized column monocyte adsorptive removal
Amo Type Short Communication
Published Date 2009-02
Publication Title Acta Medica Okayama
Volume volume63
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 69
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Sience KeyUT 000263730300009
JaLCDOI 10.18926/AMO/31581
FullText URL fulltext.pdf
Author Saito, Shinya| Sakagami, Kenichi| Fujiwara, Takuzo| Matsuno, Tsuyoshi| Orita, Kunzo| Hiramatsu, Yuji| Kudo, Takafumi|
Abstract <p>Three cases of successful pregnancies in renal transplant recipients who had undergone transplantation in the Okayama University Medical School Hospital are reported. Two of the women had received an organ from a living relative and one woman received a cadaveric organ graft. These patients, aged 28-37 at the time of the delivery, had received their transplants 2-5 years prior to their conception. The periods of gestation ranged between 35 and 40 weeks. The weight of the babies at birth ranged from 2,380g to 2,500g and the apgar score at 1 min was 8 or 9. None of the infants showed any congenital abnormalities. Lower-segment cesarean section was performed in all of three cases. Serum creatinine levels, an indicator of renal graft function, did not deteriorate during the pregnancy or after delivery. Although further work is needed to solve problems regarding pregnancy in renal transplant recipients, these results encouraged us to meet their hope for a baby.</p>
Keywords pregnancy renal transplantation immunosuppression
Amo Type Article
Published Date 1993-10
Publication Title Acta Medica Okayama
Volume volume47
Issue issue5
Publisher Okayama University Medical School
Start Page 347
End Page 349
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8273458
Web of Sience KeyUT A1993ME47100009
JaLCDOI 10.18926/AMO/31304
FullText URL fulltext.pdf
Author Gotohda, Naoto| Iwagaki, Hiromi| Itano, Satoshi| Horiki, Sadayuki| Fujiwara, Toshiya| Saito, Shinya| Hizuta, Akio| Isozaki, Hiroshi| Takakura, Norihisa| Terada, Norihiko| Tanaka, Noriaki|
Abstract <p>POSSUM, a Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity, is a scoring system which assesses perioperative surgical risks (Copeland GP et al.: Br J Surg, 1991, Vol 78, 356-360). The POSSUM scoring system consists of two categories of assessment to assess the risk of surgery. A 12-factor (age, cardiac status, pulse rate, systolic blood pressure, respiratory status, Glasgow Coma Score, serum concentration of urea, potassium and sodium, hemoglobin concentration, white cell count and findings on electrocardiography) and 4-grade physiological score (PS) were developed. This was combined with a 6-factor (type of surgical procedure, number of procedures, blood loss, peritoneal soiling, presence of malignancy and mode of surgery) and 4-grade operative severity score (OSS). The present paper attempts to validate it retrospectively. Postoperative hospitalization period and duration of antibiotics administration were both significantly correlated with OSS, but not with PS. These results suggest that the POSSUM scoring system is useful for predicting the postoperative clinical course.</p>
Keywords surgical risk Physiological and Operative Severity Source for the enUmeration of Mortality and morbidity
Amo Type Article
Published Date 1998-12
Publication Title Acta Medica Okayama
Volume volume52
Issue issue6
Publisher Okayama University Medical School
Start Page 325
End Page 329
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9876770
Web of Sience KeyUT 000077707300007
JaLCDOI 10.18926/AMO/31132
FullText URL fulltext.pdf
Author Fujiwara, Takuzo| Sakagami, Kenichi| Saito, Shinya| Uda, Masashi| Orita, Kunzo|
Abstract <p>The antidonor immune response was examined in a one haplotype-mismatched renal transplant recipient with an allograft that had been well-functioning for more than 10 years. Although the relative response of the mixed lymphocyte reaction (MLR) was (45.8)% and the MLR responder cells stimulated by donor cells produced measurable amounts of interleukin-2 (IL-2) (11.6 U/ml), the cytotoxic T lymphocytes (CTL) could not be generated against donor cells, even with exogenous IL-2. These results indicate that antidonor CTL precursors were either deleted or inactivated in this recipient.</p>
Keywords renal transplantation long-term stable recipient cytotoxic T lymphocytes
Amo Type Article
Published Date 1994-02
Publication Title Acta Medica Okayama
Volume volume48
Issue issue1
Publisher Okayama University Medical School
Start Page 63
End Page 65
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8191919
Web of Sience KeyUT A1994MY85100011
JaLCDOI 10.18926/AMO/30962
FullText URL fulltext.pdf
Author Otani, Satoru| Kuinose, Masahiko| Murakami, Takashi| Saito, Shinya| Iwagaki, Hiromi| Tanaka, Noriaki| Tanemoto, Kazuo|
Abstract <p>Activation of inflammatory response during cardiopulmonary bypass (CPB) may lead to considerable post-operative mortality. Recently, pentoxifylline (PTX), a methylxanthine derivative, has been reported to be effective in inhibiting proinflammatory cytokine production. This study aimed to determine whether or not PTX prevented CPB-induced systemic inflammatory response syndrome (SIRS) in patients undergoing cardiovascular surgery. Thirty adult patients were randomly separated into 2 experimental groups and 1 control group of 10 patients each. The experimental group received peroral PTX administration (Group 1: 600 mg/day, Group 2: 900 mg/day), while the control group did not. In Group 1 and Group 2, PTX administration was started on preoperative day 5 and continued for 5 days. Serum levels of PTX and IL-6 were measured just before and at 4 h after CPB using HPLC and ELISA, respectively. Respiratory index (RI) before and at 4 h after CPB was calculated, and serum levels of C-reactive protein (CRP) and fibrinogen on postoperative day 1 were also determined. There were no significant differences in age, body weight, sex, surgical procedures, CPB time, haemodynamics or risk factors among the 3 groups. Serum IL-6 level and RI index after CPB in Group 2 were significantly decreased compared with those in Group 1 and the control group. These results, therefore, suggested that preoperative daily administration of 900 mg/day PTX contributed to the attenuation of CPB-induced SIRS and had a beneficial effect on the postoperative course after cardiovascular surgery.</p>
Keywords pentoxifylline CPB IL-6 SIRS respiratory index
Amo Type Original Article
Published Date 2008-04
Publication Title Acta Medica Okayama
Volume volume62
Issue issue2
Publisher Okayama University Medical School
Start Page 69
End Page 74
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18464882
Web of Sience KeyUT 000255297600002
JaLCDOI 10.18926/AMO/30766
FullText URL fulltext.pdf
Author Iwagaki, Hiromi| Hizuta, Akio| Uomoto, Masashi| Takeuchi, Yoshiaki| Saito, Shinya| Tanaka, Noriaki|
Abstract <p>Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-&#947;) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-&#947; induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia.</p>
Keywords cancer cachexia neuro-endocrine-immune interactio serotonin neopterin cortisol
Amo Type Article
Published Date 1997-08
Publication Title Acta Medica Okayama
Volume volume51
Issue issue4
Publisher Okayama University Medical School
Start Page 233
End Page 236
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9284972
Web of Sience KeyUT A1997XU03200008
Author Mori, Keiko| Kanao, Naomi| Nanba, Kayo| Ishikawa, Takako| Saito, Shinya| Naomoto, Yoshio|
Published Date 2003-03-20
Publication Title 岡山大学医学部保健学科紀要
Volume volume13
Issue issue2
Content Type Departmental Bulletin Paper
Author Saito, Shinya| Sakagami, Kenichi| Matsuno, Tsuyoshi| Orita, Kunzo| Akiyama, Takao|
Published Date 1993-02-27
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue1-2
Content Type Journal Article
Author 齋藤 信也|
Published Date 1987-09-30
Publication Title
Content Type Thesis or Dissertation