ID | 32840 |
JaLCDOI | |
FullText URL | |
Author |
Abe, Asaki
researchmap
Kawasoe, Chiaki
Sato, Katsunori
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Abstract | Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions. |
Keywords | diabetes mellitus
vascular smooth muscle
norepinephrine
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2003-02
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Volume | volume57
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 45
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End Page | 48
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |