Title Alternative The 26th Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism
FullText URL 127_161.pdf
Author Abe, Koji|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 161
End Page 162
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.161
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.161
NAID 130005096246
JaLCDOI 10.18926/AMO/32033
FullText URL fulltext.pdf
Author Wang, Jiang Ming| Hayashi, Takeshi| Zhang, Wen Ri| Li, Feng| Iwai, Masanori| Abe, Koji|
Abstract <p>In order to investigate a possible effect of insulin-like growth factor-1 (IGF-1) on ischemic brain injury, IGF-1 was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the middle cerebral artery territory showed that Caspase-3 staining was markedly reduced in the cases with IGF-1 treatment, but 72-kDa heat shock protein staining remained almost unchanged. The present results suggest that treatment with IGF-1 exerts a significant effect on ameliorating brain injury after transient focal brain ischemia. Moreover, this effect is greatly associated with the reduction of Caspase-3 staining, but is only minimally associated with a decreasd stress response at the cellular level.</p>
Keywords caspase-3 cerebra? ischemia 72-KDa heat shock protein
Amo Type Article
Published Date 2001-02
Publication Title Acta Medica Okayama
Volume volume55
Issue issue1
Publisher Okayama University Medical School
Start Page 25
End Page 30
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11246974
Web of Sience KeyUT 000167249900004
Title Alternative Guidelines for the treatment of dementia
FullText URL 126_155.pdf
Author Kurata, Tomoko| Abe, Koji|
Publication Title 岡山医学会雑誌
Published Date 2014-08-01
Volume volume126
Issue issue2
Start Page 155
End Page 157
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.155
NAID 130004685268
FullText URL Autophagy_6_8_1107-1114.pdf
Author Tian, FengFeng| Deguchi, Kentaro| Yamashita, Toru| Ohta, Yasuyuki| Morimoto, Nobutoshi| Shang, Jingwei| Zhang, Xuemei| Liu, Ning| Ikeda, Yoshio| Matsuura, Tohru| Abe, Koji|
Keywords autophagy apoptosis GFP-LC3 Tg mice in vivo imaging tMCAO
Published Date 2010-11-16
Publication Title Autophagy
Volume volume6
Issue issue8
Start Page 1107
End Page 1114
ISSN 1554-8627
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 20930570
DOI 10.4161/auto.6.8.13427
Web of Sience KeyUT 000284258900010
Official Url http://doi.org/10.4161/auto.6.8.13427|
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/49128
FullText URL K0005478_other1.pdf
Author Matsuzono, Kosuke| Ikeda, Yoshio| Liu, Wentao| Kurata, Tomoko| Deguchi, Shoko| Deguchi, Kentaro| Abe, Koji|
Keywords Prion disease Novelgene mutation 2bp deletion in codon 178 stopcodon at codon 195 Sensoryneuropathy HSAN Pan-autonomicfailure Familial case
Note 岡山大学審査学位副論文
Published Date 2013-05
Publication Title European journal of neurology
Volume volume20
Issue issue5
Publisher Wiley
Start Page e67
End Page e69
ISSN 1351-5101
NCID AA11015934
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja
File Version author
PubMed ID 23577609
Web of Sience KeyUT 000317609800003
Related Url https://doi.org/10.1111/ene.12089 http://ousar.lib.okayama-u.ac.jp/55031
JaLCDOI 10.18926/AMO/46846
FullText URL 65_4_219.pdf
Author Yamashita, Toru| Abe, Koji|
Abstract Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to brain edema and HT. In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. We provide an overview of the available scientific reports to improve our understanding of the mechanisms leading to HT, and highlight recent progress in the development of new therapeutic strategies for preventing HT in the post-stroke brain.
Keywords cerebral ischemia hemorrhagic transformation activator free radical matrix metalloproteinase-9
Amo Type Review
Published Date 2011-08
Publication Title Acta Medica Okayama
Volume volume65
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 223
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21860527
Web of Sience KeyUT 000294236700001
JaLCDOI 10.18926/AMO/53521
FullText URL 69_3_145.pdf
Author Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi|
Abstract Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
Keywords ECP reactive oxygen species Akt ERK
Amo Type Original Article
Published Date 2015-06
Publication Title Acta Medica Okayama
Volume volume69
Issue issue3
Publisher Okayama University Medical School
Start Page 145
End Page 153
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26101190
Web of Sience KeyUT 000356903000003
Author Matsuura, Tohru| Abe, Koji|
Published Date 2014-12-01
Publication Title 岡山医学会雑誌
Volume volume126
Issue issue3
Content Type Journal Article
Author Sato, Kota| Morimoto, Nobutoshi| Kurata, Tomoko| Mimoto, Takafumi| Miyazaki, Kazunori| Ikeda, Yoshio| Abe, Koji|
Published Date 2012-09-14
Publication Title Brain Research
Volume volume1473
Content Type Journal Article
Author Kono, Syoichiro| Deguchi, Kentaro| Omote, Yoshio| Yunoki, Taijun| Yamashita, Toru| Kurata, Tomoko| Ikeda, Yoshio| Abe, Koji|
Published Date 2014-01
Publication Title Journal of Neuroscience Research
Volume volume92
Issue issue1
Content Type Journal Article
Author Omote, Yoshio| Deguchi, Kentaro| Tian, FengFeng| Kawai, Hiromi| Kurata, Tomoko| Yamashita, Toru| Ohta, Yasuyuki| Abe, Koji|
Published Date 2012-06
Publication Title Stroke
Volume volume43
Issue issue6
Content Type Journal Article
Author Morimoto, Nobutoshi| Abe, Koji|
Published Date 2014-04-01
Publication Title 岡山医学会雑誌
Volume volume126
Issue issue1
Content Type Journal Article
Author Liu, Ning| Shang, Jingwei| Tian, Fengfeng| Nishi, Hiroyoshi| Abe, Koji|
Published Date 2011-06-23
Publication Title Brain Research
Volume volume1397
Content Type Journal Article
Author Ikeda, Yoshio| Abe, Koji|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Deguchi, Kentaro| Abe, Koji|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Takamiya, M.| Miyamoto, Y.| Yamashita, T.| Deguchi, K.| Ohta, Y.| Abe, K.|
Published Date 2012-09-27
Publication Title Neuroscience
Volume volume221
Content Type Journal Article
Author Kurata, Tomoko| Abe, Koji|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
Author Ikeda, Yoshio| Abe, Koji|
Published Date 2011-12-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue3
Content Type Journal Article
Author Yamashita, Toru| Kamiya, Tatsushi| Deguchi, Kentaro| Inaba, Toshiki| Zhang, Hanzhe| Shang, Jingwei| Miyazaki, Kazunori| Ohtsuka, Aiji| Katayama, Yasuo| Abe, Koji|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
Author 阿部 康二|
Published Date 2001-12-31
Publication Title 岡山医学会雑誌
Volume volume113
Issue issue3
Content Type Journal Article