Author MINOWA, Hirotsugu| MUNESAWA, Yoshiomi| SUZUKI, Kazuhiko|
Published Date 2012-10-15
Publication Title 安全工学
Volume volume51
Issue issue5
Content Type Journal Article
Author Yang, Zong Xiao| Suzuki, Kazuhiko| Shimada, Yukiyasu| Sayama, Hayatoshi|
Published Date 1995-3
Publication Title Fuzzy Systems
Volume volume1
Content Type Journal Article
JaLCDOI 10.18926/AMO/32194
FullText URL fulltext.pdf
Author Suzuki, Kazuhiko| Ogata, Masana|
Abstract <p>Effects of Gabexate mesilate (GM) (([ethyl-4-(6-guanidino hexanoyloxy) benzoate] methane sulfonate)), a protease inhibitor, on the activities of catalase in liver, erythrocytes and reticulocytes from acatalasemic mice were examined. Preincubation without GM at 37 degrees C for 160 min lowered the catalase activities of liver, erythrocytes and reticulocytes from acatalasemic mice, to 24%, 40% and 10% of the initial levels, respectively. But, preincubation with GM at 37 degrees C for 160 min delayed the rapid decrease in activities of residual catalases in the liver, erythrocytes and reticulocytes of acatalasemic mice to 65%, 93% and 85% of the initial values, respectively. At 20 degrees C or below, no reduction in catalase activity of reticulocytes from acatalasemic mice occurred with or even without GM. At pH 5.0, the decrease in catalase activity of acatalasemic mice was small both in the presence and the absence of GM. In the alkaline range, the reduction in the enzyme activity of the mutant mice without GM was enhanced with increase in pH values up to 8.5. But the presence of GM during preincubation at pH 7.5, retained the catalase activity of acatalasemic mice, to 64% of the activity at pH 6.5. These data suggest that some factors affected by GM, might be responsible for the low stability and activity of catalase in the acatalasemic mice.</p>
Keywords acatalasemic mouse residual catalase Gabexate mesilate protease inhibitor
Amo Type Article
Published Date 1991-10
Publication Title Acta Medica Okayama
Volume volume45
Issue issue5
Publisher Okayama University Medical School
Start Page 363
End Page 369
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1755340
Web of Sience KeyUT A1991GN53800011
Author Ohkura Akira| Kameyama, Yoshimasa| Sayama, Hayatoshi| Suzuki, Kazuhiko| Fukumoto Shuichi|
Published Date 1991-03-28
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Volume volume25
Issue issue2
Content Type Departmental Bulletin Paper
Author Shimada, Yukiyasu| Suzuki, Kazuhiko| Sayama, Hayatoshi|
Published Date 1992-11-25
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Volume volume27
Issue issue1
Content Type Departmental Bulletin Paper
Author 鈴木 和彦|
Published Date 1991-12-31
Publication Title
Content Type Thesis or Dissertation