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ID 49111
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Author
Sugiura, Yuko
Yamabe, Kokoro
Tsutani, Soichiro
Ishimaru, Fumihiko
Nishimura, Fusanori
Abstract
The commercial saliva substitute OralbalanceA (R) has been reported to alleviate symptoms of postradiotherapy xerostomia in head and neck cancer patients. OralbalanceA (R) may also be effective for xerostomia in patients undergoing hematopoietic cell transplantation (HCT) with high-dose chemotherapy and total-body irradiation. However, HCT patients are in a severely compromised condition, and saliva substitute must not promote infection. We reported previously that OralbalanceA (R) has antimicrobial effects against microbial species detected during HCT in vitro. This study was performed to determine the in vivo effects of OralbalanceA (R) on oral mucosal total bacterial counts in patients undergoing HCT. A total of 18 neutropenic patients undergoing HCT were enrolled in this study. Before and after 1 week of OralbalanceA (R) use, bacterial samples were obtained from patients by wiping an area of I center dot 1 cm on the buccal mucosa with sterilized cotton swabs. Total bacterial counts of the obtained samples were examined by quantitative polymerase chain reaction amplification of the bacterial 16S ribosomal RNA gene. As controls, bacterial samples were also obtained from ten healthy subjects, and total bacterial counts were examined. No significant increase in bacterial count was observed with use of OralbalanceA (R). None of the patients showed bacterial counts above the range found in healthy controls after using OralbalanceA (R). In neutropenic patients undergoing HCT, OralbalanceA (R) did not increase the total counts of oral mucosal bacteria beyond the range found in healthy controls. Oral care using OralbalanceA (R) may alleviate the symptoms induced by hyposalivation without promoting infection.
Keywords
Hematopoietic cell transplantation
Xerostomia
Saliva substitute
Published Date
2010-03
Publication Title
Supportive Care in Cancer
Volume
volume18
Issue
issue3
Start Page
395
End Page
398
ISSN
0941-4355
Content Type
Journal Article
Official Url
http://dx.doi.org/ 10.1007/s00520-009-0789-x
language
英語
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT