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ID 57742
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Nakashima, Masahiro Department of Radiological Technology, Graduate School of Health Sciences, Okayama University
Shinya, Takayoshi Department of Pediatric Radiology, Okayama University Hospital
Oto, Takahiro Department of Organ Transplant Center, Okayama University Hospital
Okawa, Tomoyo Department of Organ Transplant Center, Okayama University Hospital
Takeda, Yoshihiro Department of Radiological Technology, Graduate School of Health Sciences, Okayama University Kaken ID
Abstract
OBJECTIVE:
To evaluate the diagnostic value of function volume/morphological volume ratio calculated from ventilation/perfusion single-photon emission computed tomography/computed tomography in distinguishing the lungs with bronchiolitis obliterans syndrome (BOS) from the lungs without this syndrome after lung transplantation and to assess its relationship with spirometry parameters.
MATERIALS AND METHODS:
We retrospectively identified 84 consecutive lung transplant recipients and 13 donors who underwent ventilation/perfusion single-photon emission computed tomography/computed tomography. Differences in the function volume/morphological volume ratio of unilateral lungs were tested for significance between the lungs with and without BOS. Receiver operating characteristics and correlations between function volume/morphological volume ratios of bilateral lungs and forced expiratory volume in 1 s, forced vital capacity, and total lung capacity were analyzed.
RESULTS:
The function volume/morphological volume ratios of ventilation and perfusion images of unilateral lungs were significantly lower in lungs with BOS (each P<0.0001). The area under the curve values of ventilation and perfusion images were 0.97 and 0.99, respectively. Significant correlations were identified between the function volume/morphological volume ratios of ventilation and perfusion images and forced expiratory volume in 1 s (r=0.54, P<0.0001 and r=0.45, P<0.0001, respectively). The function volume/morphological volume ratio of ventilation image had a significantly weak correlation with forced vital capacity.
CONCLUSION:
The function volume/morphological volume ratio enables a semiquantitative assessment of ventilation and perfusion lung functions and is useful for diagnosing BOS after lung transplantation.
Keywords
bronchiolitis obliterans syndrome
forced expiratory volume
function volume
lung transplantation
morphological volume
Note
This is a accepted manuscript of Nakashima, Masahiro et. al. Diagnostic value of ventilation/perfusion single-photon emission computed tomography/computed tomography for bronchiolitis obliterans syndrome in patients after lung transplantation. Nuclear Medicine Communications. (2019) 40(7), 703-710. To see pulished version, see doi: 10.1097/MNM.0000000000001021.
Published Date
2019-07
Publication Title
Nuclear Medicine Communications
Volume
volume40
Issue
issue7
Publisher
Lippincott, Williams & Wilkins
Start Page
703
End Page
710
ISSN
0143-3636
NCID
AA10624879
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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isVersionOf https://doi.org/10.1097/MNM.0000000000001021