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ID 17138
Eprint ID
17138
FullText URL
Thumnail 92_1015.pdf 425 KB
Title Alternative
Alteration of mitochondrial functions by lipid peroxidation and inhibition by biscoclaurine alkaloid
Author
Aono, Kaname
Morimoto, Setsuo
Hashimoto, Keiji
Sato, Katashi
Kimoto, Shin
Ezoe, Hiroshi
Miyake, Masayoshi
Hayashi, Hidehiro
Wakabayashi, Hisao
Tamai, Toyosato
Morino, Yasuo
Shiraishi, Noriyuki
Abstract
During investigation of the changes in mitochondrial function accompanying lipid peroxidation, it was found that a biscoclaurine alkaroid protected their functional changes. The results obtained were as follows: 1) Fe(2+) induces lipid peroxidation of isolated mitochondria, resulting in deterioration of oxidative phosphorylation. 2) This deterioration relates to alteration in ion compartmentation of the mitochondrial membrane and an increase in latent ATPase activity. 3) This deterioration by Fe(2+) in ion compartmentation of mitochondrial membrane is strongly protected by a biscoclaurine alkaloid, cepharanthine. 4) Cepharanthine also inhibits the mitochondrial. lipid peroxidation induced by Fe(2+). 5) The protective effect of cepharanthine against deterioration in mitochondrial functions caused by Fe(2+) depends on its inhibitive action on lipid peroxidation as well as on its membrane stabilizing action. 6) Cepharanthine inhibits the lipid peroxidation of soybean lecithine liposomes by (60)Co-irradiation. 7) The action of cepharanthine described above is common to head to head type of biscoclaurin alkaloids which have diether bonds.
Keywords
Lipid Peroxidation
Cepharanthine (Biscoclaurine Alkaloid)
Mitochondrial Function
Published Date
1980-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume92
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1015
End Page
1024
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/92/9-10/92_9-10_1015/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma