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ID 31557
JaLCDOI
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Author
Hizuta, Akio
Iwagaki, Hiromi
Makihata, Eiichi
Nishikawa, Koji
Gao, Xian Shu
Nakagawa, Tomio
Togami, Izumi
Kawasaki, Shoji
Orita, Kunzo
Hiraki, Yoshio
Abstract

Between November 1984 and August 1992 we used hyperthermotherapy in six cases of local recurrence of rectal cancer. Hyperthermotherapy was performed on the average 8.7 times (range: 3-18) for each patient for 60 min each. All patients underwent combined radiotherapy and received a mean radiation dose of 42.5 Gy (range: 9-60 Gy). Five patients underwent heating within 1 h after irradiation and one patient simultaneously with the irradiation. Four patients underwent combined chemotherapy and two patients immunotherapy. Before the treatment all patients had painful lesions, but pain decreased posttherapeutically in five patients. Performance status improved in two patients. High carcinoembryonic antigen levels prior to the therapy in four patients decreased in all cases after treatment. Posttherapeutical computed tomograms revealed only minor response or no changes. After the treatment, four patients died of exacerbations of recurrent tumors and one patient of distant metastases. The patient who underwent simultaneous radiohyperthermotherapy is presently alive, in August 1992, 38 months after initiation of the treatment. The 50% survival time after initiation of the treatment was 25 months (range: 10-38 months). Hyperthermotherapy combined with radiotherapy, chemotherapy and/or immunotherapy was useful for the alleviation of pain in patients who developed local recurrence after surgery, and improved survival after recurrences can be expected.

Keywords
rectal cancer
local recurrence
hyperthermia
radiotherapy
chemotherapy
Amo Type
Article
Published Date
1993-08
Publication Title
Acta Medica Okayama
Volume
volume47
Issue
issue4
Publisher
Okayama University Medical School
Start Page
249
End Page
254
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT