ID | 17138 |
Eprint ID | 17138
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FullText URL | |
Title Alternative | Alteration of mitochondrial functions by lipid peroxidation and inhibition by biscoclaurine alkaloid
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Author |
Aono, Kaname
Morimoto, Setsuo
Hashimoto, Keiji
Sato, Katashi
Joja, Ikuo
publons
researchmap
Kimoto, Shin
Ezoe, Hiroshi
Miyake, Masayoshi
Hayashi, Hidehiro
Wakabayashi, Hisao
Tamai, Toyosato
Morino, Yasuo
Shiraishi, Noriyuki
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Abstract | During investigation of the changes in mitochondrial function accompanying lipid peroxidation, it was found that a biscoclaurine alkaroid protected their functional changes. The results obtained were as follows: 1) Fe(2+) induces lipid peroxidation of isolated mitochondria, resulting in deterioration of oxidative phosphorylation. 2) This deterioration relates to alteration in ion compartmentation of the mitochondrial membrane and an increase in latent ATPase activity. 3) This deterioration by Fe(2+) in ion compartmentation of mitochondrial membrane is strongly protected by a biscoclaurine alkaloid, cepharanthine. 4) Cepharanthine also inhibits the mitochondrial. lipid peroxidation induced by Fe(2+). 5) The protective effect of cepharanthine against deterioration in mitochondrial functions caused by Fe(2+) depends on its inhibitive action on lipid peroxidation as well as on its membrane stabilizing action. 6) Cepharanthine inhibits the lipid peroxidation of soybean lecithine liposomes by (60)Co-irradiation. 7) The action of cepharanthine described above is common to head to head type of biscoclaurin alkaloids which have diether bonds.
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Keywords | Lipid Peroxidation
Cepharanthine (Biscoclaurine Alkaloid)
Mitochondrial Function
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Published Date | 1980-10-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume92
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Issue | issue9-10
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 1015
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End Page | 1024
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/92/9-10/92_9-10_1015/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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