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ID 32110
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Author
Shinji, Toshiyuki
Kyaw, Yi Yi
Gokan, Katsunori
Tanaka, Yasuhito
Ochi, Koji
Fujioka, Shin-ichi
Lwin, Aye Aye
Shiratori, Yasushi
Mizokami, Masashi
Khin, Myo
Miyahara, Masayuki
Okada, Shigeru
Koide, Norio
Abstract
The prevalence of hepatitis C virus (HCV) genotypes in Myanmar in comparison with the rest of Southeast Asia is not well known. Serum samples were obtained from 201 HCV antibody-positive volunteer blood donors in and around the Myanmar city of Yangon. Of these, the antibody titers of 101 samples were checked by serial dilution using HCV antibody PA test II and Terasaki microplate as a low-cost method. To compare antibody titers by this method and RNA identification, we also checked HCV-RNA using the Amplicor 2.0 test. Most high-titer groups were positive for HCV-RNA. Of the 201 samples, 110 were successfully polymerase chain reaction (PCR) amplified. Among them, 35 (31.8%) were of genotype 1, 52 (47.3%) were of genotype 3, and 23 (20.9%) were of type 6 variants, and phylogenetic analysis of these type 6 variants revealed that 3 new type 6 subgroups exist in Myanmar. We named the subgroups M6-1, M6-2, and M6-3. M6-1 and M6-2 were relatively close to types 8 and 9, respectively. M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed.
Keywords
hepatitis C virus(HCV)genotype
type 6 variant
Myanmar
Southeast Asia
phylogenetic analysis
Amo Type
Article
Published Date
2004-06
Publication Title
Acta Medica Okayama
Volume
volume58
Issue
issue3
Publisher
Okayama University Medical School
Start Page
135
End Page
142
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT