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ID 31590
JaLCDOI
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Author
Segawa, Yoshihiko
Ohnoshi, Taisuke
Hiraki, Shunkichi
Ueoka, Hiroshi
Kamei, Haruhito
Shibayama, Takuo
Miyatake, Kazuyo
Genda, ken-ichi
Matsumura, Tadashi
Kimura, Ikuro
Abstract

In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75% for P-gp-positive initial tumors and 86% for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy.

Keywords
small cell lung cancer
immunohistochemistry
drug resistance
P-glycoprotein
carcinoembryonic antigen
Amo Type
Article
Published Date
1993-06
Publication Title
Acta Medica Okayama
Volume
volume47
Issue
issue3
Publisher
Okayama University Medical School
Start Page
181
End Page
189
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT