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ID 48708
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Author
Nomura, Takaharu
Taguchi, Takehito Kaken ID researchmap
Mori, Shuji
Kira, Shohei
Abstract
The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.
Keywords
Acatalasemic mouse
Catalase
CCl<sub>4</sub>
Hepatotoxicity
Low-dose X-irradiation
Antioxidant substances
Published Date
2004-05-07
Publication Title
Journal of Radiation Research
Volume
volume45
Issue
issue1
Publisher
Journal of Radiation Research Editorial Committee
Start Page
89
End Page
95
ISSN
0449-3060
NCID
AA00705792
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/jrr/45/1/45_1_89/_article
language
English
Copyright Holders
Copyright © 2004 by Journal of Radiation Research Editorial Committee
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Refereed
True
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