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ID 56439
Sort Key
3
Title Alternative
Synthetic studies of ancistrocladinium A and B, antileishmanial compounds isolated from a Congolese Ancistrocladus Species
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Author
Kiyota, Hiromasa Graduate School of Environmental and Life Science, Okayama University
Saito, Akihito Graduate School of Agricultural Science, Tohoku University
Takai, Momoko Graduate School of Agricultural Science, Tohoku University
Kuwahara, Shigefumi Graduate School of Agricultural Science, Tohoku University
Abstract
Synthetic studies of ancistrocladinium A and B, antileishmanial compounds isolated from a Congolese Ancistrocladus sp., are described. Buchwald‒Hartwig coupling reaction between the dihydroisoquinoline and the naphthyl triflate failed. The main framework of ancistrocladinium A was constructed by 1,2‒addition of the amine to the naphthoquinone in the presence of celium trichloride as a catalyst. On the other hand, 1,4‒addition of the amine to the naphthoquinone proceeded without catalyst to form the framework of B. These products will be valuable leads for antileishmanial agents.
Keywords
ancistrocladinium A and B
synthetic studies
leishmania, Ancistrocladus
isoquinoline
Note
原著論文 (Original paper)
Publication Title
Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date
2019-02-01
Volume
volume108
Publisher
岡山大学農学部
Publisher Alternative
The Faculty of Agriculture, Okayama University
Start Page
1
End Page
4
ISSN
2186-7755
Content Type
Departmental Bulletin Paper
OAI-PMH Set
岡山大学
language
日本語
File Version
publisher
Eprints Journal Name
srfa