ID | 32805 |
JaLCDOI | |
FullText URL | |
Author |
Matsuka, Yoko
Suganuma, Narufumi
Imai, Kaori
Taketa, Kazuhisa
Kira, Shohei
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Abstract | We studied the association of gamma-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking. |
Keywords | gamma-glutamyltransferase(GGT)
daily alcohol consumption
good responder and poor responder
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2003-08
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Volume | volume57
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 171
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End Page | 178
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |