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ID 30741
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Author
Goel, Ajay
Matsubara, Nagahide
Tanaka, Noriaki
Abstract
Aberrant promoter methylation, an 'epigenetic' form of genomic instability that leads to transcriptional silencing of tumor suppressor genes, is increasingly being recognized as a crucial component in the evolution of human cancers. With our limited knowledge of the molecular basis and timing of the initiation of altered methylation events in the stepwise progression of cancers, the biggest challenge we currently face is to identify novel biomarkers and technologies for the timely screening of patients carrying such alterations. One such strategy would be to develop tests for the detection of fecal DNA methylation patterns that will improve the sensitivity of noninvasive screening tests for colorectal neoplasia, and moreover, will decrease both mortality and the incremental costs of treating colorectal cancers.
Keywords
fecal DNA
colorectal cancer
methylation
epigenetics
Amo Type
Review
Published Date
2006-10
Publication Title
Acta Medica Okayama
Volume
volume60
Issue
issue5
Publisher
Okayama University Medical School
Start Page
249
End Page
256
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT