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ID 32953
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Author
Maki, Yu
Asaumi, Jun-ichi
Fukui, Kazuhiro
Kawai, Noriko
Tanaka, Noriaki
Matsubara, Nagahide
Kishi, Kanji
Abstract

The DNA repair enzyme, O-6-methylguanine-DNA methyltransferase (MGMT) modulates the effectiveness of alkylating agents. However, the relationship between MGMT and the sensitivities to other agents has not been explored. In the present study, the association between MGMT expression and the cellular sensitivity to the platinum agent, CDDP was examined in four human oral cancer cell tines. CDDP depleted MGMT protein and mRNA levels in all four cell tines. Two cell lines with low MGMT expression were sensitive to an alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine and CDDP, whereas two other cell tines with high MGMT expression were resistant to both agents. Furthermore, the addition of the MGMT inhibitor, O-6-benzylguanine (O-6-BG), invariably enhanced CDDP sensitivity. CDDP depleted MGMT expression, and CDDP sensitivity was enhanced by O-6-BG. These results provide valuable information about the relationship between MGMT expression and CDDP sensitivity in oral cancer chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved.

Keywords
mgmt
cddp
o-6-bg
oral cancer
Note
Digital Object Identifer:10.1016/j.oraloncology.2005.05.011
Published with permission from the copyright holder. This is the institute's copy, as published in Oncology, July 2005, Volume 41, Issue 10, Pages 984-993.
Publisher URL:http://dx.doi.org/10.1016/j.oraloncology.2005.05.011
Direct access to Thomson Web of Science record
Copyright © 2005 Elsevier Ltd All rights reserved. All rights reserved.
Published Date
2005-7
Publication Title
Oral Oncology
Volume
volume41
Issue
issue10
Start Page
984
End Page
993
Content Type
Journal Article
language
英語
Refereed
True
DOI
Web of Sience KeyUT
Submission Path
dentistry_general/8