Author 景山 甚郷|
Published Date 1984-12-31
Publication Title
Content Type Thesis or Dissertation
Author Kageyama, Jingo|
Published Date 1996-02-29
Publication Title 岡山大学医療技術短期大学部紀要
Volume volume6
Content Type Departmental Bulletin Paper
Author Hayashi, Yuko| Kageyama, Jingo| Nakanishi, Yoshiko| Ishizaki, Hiroyuki| Morimoto, Michiko| Mori, Keiko| Tsuboi, Keiko|
Published Date 2003-03-20
Publication Title 岡山大学医学部保健学科紀要
Volume volume13
Issue issue2
Content Type Departmental Bulletin Paper
Author Kageyama, Jingo| Ohta, Takeo| Yamada, Ichiro|
Published Date 1999-02-26
Publication Title 岡山大学医療技術短期大学部紀要
Volume volume9
Issue issue2
Content Type Departmental Bulletin Paper
Author Ohta, Niwa| Ikeda, Toshiko| Ohi, Nobuko| Kageyama, Jingo| Kanao, Naomi| Kobayashi, Yu| Hayashi, Yuko|
Published Date 1998-01-31
Publication Title 岡山大学医療技術短期大学部紀要
Volume volume8
Issue issue2
Content Type Departmental Bulletin Paper
Author Ohta, Takeo| Shimoishi, Yasuaki| Kageyama, Jingo| Shibuya, Koichi| Tohge, Hiroko| Endo, Hiroshi|
Published Date 1997-09-10
Publication Title 岡山大学医療技術短期大学部紀要
Volume volume8
Issue issue1
Content Type Departmental Bulletin Paper
Author Ohta, Takeo| Shimoishi, Yasuaki| Kageyama, Jingo| Shibuya, Koichi| Tohge, Hiroko| Endo, Hiroshi|
Published Date 1997-01-31
Publication Title 岡山大学医療技術短期大学部紀要
Volume volume7
Issue issue2
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/AMO/30419
FullText URL fulltext.pdf
Author Yamauchi, Takayoshi| Ogura, Toshio| Oishi, Tetsuya| Harada, Kazushi| Hashimoto, Masami| Mimura, Yukari| Asano, Naoko| Ota, Zensuke| Kageyama, Jingo|
Abstract <p>To elucidate the effect of the arginine vasopressin (AVP) system in vivo, especially V1 and V2 activity, on blood pressure, we measured the acute changes in blood pressure and heart rate after AVP, OPC-21,268 (a V1 receptor antagonist), and OPC-31,260 (a V2 receptor antagonist) were injected intravenously in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at the age of 15 weeks. Compared with the control period, single injection of AVP 5 ng/kg significantly increased systolic blood pressure in WKY rats without a concomitant increase in heart rate, but there was no significant increase in blood pressure in SHR. In contrast, single injection of either OPC-21,268 3 mg/kg or OPC-31,260 3 mg/kg did not affect blood pressure or heart rate in either SHR or WKY rats. Injection of AVP after the administration of OPC-31,260 induced a greater increase in blood pressure in SHR than in WKY rats, whereas injection of AVP after the administration of OPC-21,268 did not induce any clear increase in blood pressure in SHR or WKY rats. These results suggest that SHR have enhanced pressor activity mediated by V1 receptors and that this increase may be due to an increase in their number. In conclusion, enhancement of V1 activity may contribute to the development of high blood pressure in SHR.</p>
Keywords vasopressin V1 and V2 receptor antagonist hypertension pressor response OPC-31260
Amo Type Article
Published Date 1995-02
Publication Title Acta Medica Okayama
Volume volume49
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 59
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7762410
Web of Sience KeyUT A1995QK32500008
JaLCDOI 10.18926/AMO/30454
FullText URL fulltext.pdf
Author Hashimoto, Kozo| Makino, Shinya| Hirasawa, Ryuto| Takao, Toshihiro| Kageyama, Jingo| Ogasa, Takashi| Ota, Zensuke|
Abstract <p>We examined 8 normal subjects and 16 patients with non-functioning pituitary tumors with a combined anterior pituitary test to evaluate the clinical usefulness of the test. Diagnoses included 9 of chromophobe adenoma, 3 of craniopharyngioma, 2 of Rathke's cleft cyst, and 1 each of intrasellar cyst and tuberculum sella meningioma. All subjects received hypothalamic releasing hormones: 1 micrograms/kg corticotropin releasing hormone (CRH), 1 micrograms/kg growth hormone releasing hormone (GRH), 500 micrograms thyrotropin-releasing hormone (TRH), 100 micrograms luteinizing hormone releasing hormone (LH-RH), and a relatively small dose (5 mU/kg) of lysine vasopressin (LVP). In the normal subjects, the addition of LVP potentiated the secretion of adenocorticotropic hormone (ACTH) induced by CRH, but had no significant effect on the secretion of other anterior pituitary hormones. In the combined test with 5 releasing hormones, the plasma ACTH and cortisol responses were not impaired in the majority of the patients before pituitary surgery. Serum thyroid-stimulating hormone (TSH), prolactin (PRL) and follicle-stimulating hormone (FSH) responses were not impaired in 82%, 70% and 67% of the patients, respectively, while the serum LH and GH responses were impaired in 67% and 73% of the patients, respectively. Following pituitary surgery, responses of these hormones to combined testing were similarly impaired in more than 75% of the patients. These results indicate that plasma ACTH, cortisol and serum TSH responses are fairly good before pituitary surgery but are impaired significantly after surgery. No subjects experienced any serious adverse effects related to the testing. These results suggest that combined testing with hypothalamic hormones is a convenient and useful method for evaluating pituitary function.</p>
Keywords anterior pituitary function test pituitary tumors corticotropin releasing hormone growth hormone releasing hormone luteinzing hormone releasing hormone thyrotropin releasing hormone
Amo Type Article
Published Date 1990-06
Publication Title Acta Medica Okayama
Volume volume44
Issue issue3
Publisher Okayama University Medical School
Start Page 141
End Page 147
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2200236
Web of Sience KeyUT A1990DM18300005
JaLCDOI 10.18926/AMO/31290
FullText URL fulltext.pdf
Author Hashimoto, Kozo| Ohno, Norihito| Aoki, Yoshiyuki| Kageyama, Jingo| Takahara, Jiro| Ofuji, Tadashi|
Abstract <p>The distribution of corticotropin releasing factor (CRF) and arginine vasopressin (AVP) in hypothalamic nuclei were examined in control and estrogen-treated female rats. CRF activity was measured using monolayer cultured rat anterior pituitary cells and AVP by radioimmunoassay. Hypothalamic nuclei were punched out according to the method of Palkovits. The distribution of CRF activity in 5 different hypothalamic nuclei was similar to that of AVP in intact female rats. CRF activity in hypothalamic nuclei, pituitary ACTH content and plasma ACTH levels in estrogen-treated rats were not significantly different from those in control rats. However, significant elevation of AVP content was observed in the supraoptic and paraventricular nuclei of estrogen-treated rats. These results indicate that CRF and AVP are distributed in similar hypothalamic nuclei, but that they are not identical.</p>
Keywords corticotropin releasing factor (CRF) arginine vasopressin (AVP) hypothalamic nucler.
Amo Type Article
Published Date 1981-02
Publication Title Acta Medica Okayama
Volume volume35
Issue issue1
Publisher Okayama University Medical School
Start Page 37
End Page 43
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6266205
Web of Sience KeyUT A1981LH76300004
JaLCDOI 10.18926/AMO/31293
FullText URL fulltext.pdf
Author Hashimoto, Kozo| Ohno, Norihito| Aoki, Yoshiyuki| Kageyama, Jingo| Takahara, Jiro| Ofuji, Tadashi|
Abstract <p>The distribution of corticotropin releasing factor (CRF) and arginine vasopressin (AVP) in hypothalamic nuclei were examined in control and estrogen-treated female rats. CRF activity was measured using monolayer cultured rat anterior pituitary cells and AVP by radioimmunoassay. Hypothalamic nuclei were punched out according to the method of Palkovits. The distribution of CRF activity in 5 different hypothalamic nuclei was similar to that of AVP in intact female rats. CRF activity in hypothalamic nuclei, pituitary ACTH content and plasma ACTH levels in estrogen-treated rats were not significantly different from those in control rats. However, significant elevation of AVP content was observed in the supraoptic and paraventricular nuclei of estrogen-treated rats. These results indicate that CRF and AVP are distributed in similar hypothalamic nuclei, but that they are not identical.</p>
Keywords corticotropin releasing factor (CRF) arginine vasopressin (AVP) hypothalamic nucler.
Amo Type Article
Published Date 1981-02
Publication Title Acta Medica Okayama
Volume volume35
Issue issue1
Publisher Okayama University Medical School
Start Page 37
End Page 43
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6266205
Web of Sience KeyUT A1981LH76300004
JaLCDOI 10.18926/AMO/32221
FullText URL fulltext.pdf
Author Suemaru, Shuso| Kageyama, Jingo| Ota, Zenske| Ohnoshi, Taisuke| Sakamoto, Kenji| Kamura, Junta|
Abstract <p>A patient with a diffuse, small cleaved cell, non-Hodgkin's lymphoma associated with marked hypecalcemia was described. Antibody to the adult T-cell leukemia-lymphoma virus was absent. Although bone marrow was infiltrated by lymphoma cells, destructive or lytic bone lesions could not be detected. The serum level of immunoreactive parathyroid hormone C-terminal (PTH-C) was normal. The serum level of 1, 25-dihydroxyvitamin D was lower than normal. This case suggests that other humoral substances produced by lymphoma cells may be responsible for hypercalcemia.&#60;/P&#62;</p>
Keywords hypercalcemia non-Hodgkin7s lymphoma bone resorption parathyroid hormone(PTH) 1 25-dihydroxyvitamin D
Amo Type Article
Published Date 1991-02
Publication Title Acta Medica Okayama
Volume volume45
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 59
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2063696
Web of Sience KeyUT A1991FA75000008