このエントリーをはてなブックマークに追加
ID 31293
JaLCDOI
FullText URL
Author
Hashimoto, Kozo
Ohno, Norihito
Aoki, Yoshiyuki
Takahara, Jiro
Ofuji, Tadashi
Abstract

The distribution of corticotropin releasing factor (CRF) and arginine vasopressin (AVP) in hypothalamic nuclei were examined in control and estrogen-treated female rats. CRF activity was measured using monolayer cultured rat anterior pituitary cells and AVP by radioimmunoassay. Hypothalamic nuclei were punched out according to the method of Palkovits. The distribution of CRF activity in 5 different hypothalamic nuclei was similar to that of AVP in intact female rats. CRF activity in hypothalamic nuclei, pituitary ACTH content and plasma ACTH levels in estrogen-treated rats were not significantly different from those in control rats. However, significant elevation of AVP content was observed in the supraoptic and paraventricular nuclei of estrogen-treated rats. These results indicate that CRF and AVP are distributed in similar hypothalamic nuclei, but that they are not identical.

Keywords
corticotropin releasing factor (CRF)
arginine vasopressin (AVP)
hypothalamic nucler.
Amo Type
Article
Published Date
1981-02
Publication Title
Acta Medica Okayama
Volume
volume35
Issue
issue1
Publisher
Okayama University Medical School
Start Page
37
End Page
43
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT