このエントリーをはてなブックマークに追加
ID 57933
FullText URL
Author
Seno, Akimasa Laboratory of Nano-Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University ORCID Kaken ID researchmap
Murakami, Chikae Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University
El‑Aarag, Bishoy Laboratory of Nano-Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Iwasaki, Yoshiaki Health Service Center, Okayama University ORCID Kaken ID researchmap
Ohara, Toshiaki Department of Pathology and Experimental MedicineOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID researchmap
Seno, Masaharu Laboratory of Nano-Biotechnology, Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems ORCID Kaken ID publons researchmap
Abstract
Although cancers are often removed by surgery and treated by chemotherapy and/or radiation therapies, they often reoccur following treatment due to the presence of resistant residual cells such as cancer stem cells (CSCs). CSCs are characterized by their self-renewal, pluripotency, and tumorigenicity properties, and are promising therapeutic targets for the complete therapy of cancers; however, the number of CSCs in cancer tissue is typically too small to investigate fully. We have previously reported that CSCs could be established from induced pluripotent stem cells (iPSCs) using a conditioned medium during cancer cell culture. In the present study, mouse embryonic stem cells (mESCs) were observed to be converted to CSCs (mES-CSCs). This demonstrated that CSC induction does not exclusively occur following gene editing in somatic cells, and that conditioned medium from cancer cells may contain factors that can induce CSCs. Therefore, not only iPSCs but also mESCs, were demonstrated to be able to produce CSCs as one of the potentials of pluripotency of stem cells, suggesting that the conversion to CSCs is not specific to iPSCs. The resultant mES-CSCs would be also useful to generate tissue specific cancers and these naturally occurring cancers can contribute to drug screenings, but also undergo further investigation in order to reveal cancer mechanisms.
Keywords
cancer stem cell
conditioned medium
mouse embryonic stem cells
Published Date
2019-09
Publication Title
Oncology Letters
Volume
volume18
Issue
issue3
Publisher
Spandidos Publications
Start Page
2756
End Page
2762
ISSN
1792-1074
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© Seno et al.
File Version
publisher
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.3892/ol.2019.10614
License
https://creativecommons.org/licenses/by/4.0/
Funder Name
Japan Society for the Promotion of Science
助成番号
25242045
16K07116
26640079