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ID 52023
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Author
Kubota, Junichi
Terada, Ryo
Kobashi, Haruhiko
Fujioka, Shin-ichi
Okamoto, Ryoichi
Baba, Shinsuke
Morimoto, Youichi
Ando, Masaharu
Makino, Yasuhiro
Taniguchi, Hideaki
Yasunaka, Tetsuya
Iwasaki, Yoshiaki ORCID Kakenhi
Abstract
Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC patients. The study was a systematic cohort analysis of 308 consecutive patients diagnosed with asymptomatic PBC. We compared prognosis between the elderly (55 years or older at the time of diagnosis) and the young patients (< 55 years). The mortality rate of the patients was also compared with that of an age- and gender-matched general population. The elderly patients showed a higher aspartate aminotransferase-to-platelet ratio, and lower alanine aminotransferase level than the young patients (P < 0.01 and P = 0.03, respectively). The two groups showed similar values for alkaline phosphatase and immunoglobulin M. Death in the young patients was more likely to be due to liver failure (71%), while the elderly were likely to die from other causes before the occurrence of liver failure (88%; P < 0.01), especially from malignancies (35%). The mortality rate of the elderly patients was not different from that of the age- and gender-matched general population (standardized mortality ratio, 1.1; 95% confidence interval, 0.6-1.7), although this rate was significantly higher than that of the young patients (P = 0.044). PBC often presents as more advanced disease in elderly patients than in the young. However, the mortality rate of the elderly patients is not different from that of an age- and gender-matched general population.
Keywords
Primary biliary cirrhosis
Age difference
Mortality rate
Published Date
2009-09
Publication Title
Journal of Gastroenterology
Volume
volume44
Issue
issue9
Start Page
1000
End Page
1006
ISSN
0944-1174
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1007/s00535-009-0090-2
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51954
language
英語
File Version
author
Refereed
True
DOI
Web of Sience KeyUT