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ID 32825
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Author
Nakajima, Hirofumi
Shimomura, Hiroyuki
Iwasaki, Yoshiaki ORCID Kakenhi
Ikeda, Fusao
Umeoka, Fumi
Chengyu, Piao
Taniguchi, Hideaki
Ohnishi, Yasuhiro
Takagi, Shin-jiro
Fujioka, Shin-ichi
Shiratori, Yasushi
Abstract

To improve the efficacy of interferon (IFN) treatment for chronic hepatitis C, we have proposed the twice-daily administration of IFN-beta as a promising induction therapy. In this study, we demonstrated differences between the clearance of circulating HCV-RNA and the induction of anti-viral actions during the first 2 weeks of treatment. Nine patients with a high viral load and genotype 1b were randomly assigned to 3 groups: group A received 3MU of IFN-beta twice a day at intervals of 5 and 19 h; group B received 3MU of IFN-beta twice a day at intervals of 10 and 14 h; group C received 6MU of IFN-alpha once a day with ribavirin. The expression of OAS2, PKR, and MxA in peripheral blood mononuclear cells (PBMCs) were quantified by real-time polymerase chain reaction method. The viral clearance showed a bi-phasic pattern, and those in the second phase of groups A and B were significantly steeper than that of group C. The peak level of OAS2 during the first phase was correlated with the first phase decay. The MxA expression tended to be higher in group A and B than in group C. The expression of these 3 proteins tended to decrease at day 6 in group C, but increase in groups A and B. These might make differences in the viral decay during the second phase

Keywords
chronic hepatitis C(CHC)
interferon(IFN)beta
hepatitis C virus(HCV)dynamics
antiviral actions
real time PCR
Amo Type
Article
Published Date
2003-10
Publication Title
Acta Medica Okayama
Volume
volume57
Issue
issue5
Publisher
Okayama University Medical School
Start Page
217
End Page
225
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT