ID | 48710 |
FullText URL | |
Author |
Mizuguchi, Yuko
Yoshimoto, Masaaki
Taguchi, Takehito
Kaken ID
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Abstract | We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.
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Keywords | Edema
Ischemia-reperfusion injury
Low-dose irradiation
Reactive oxygen species
Antioxidation function
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Published Date | 2007-11-21
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Publication Title |
Journal of Radiation Research
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Volume | volume48
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Issue | issue6
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Publisher | Journal of Radiation Research Editorial Committee
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Start Page | 505
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End Page | 513
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ISSN | 0449-3060
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NCID | AA00705792
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/jrr/48/6/48_6_505/_article
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language |
English
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Copyright Holders | Copyright © 2007 by Journal of Radiation Research Editorial Committee
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File Version | publisher
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Refereed |
True
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DOI | |
PubMed ID | |
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