Title Alternative The 2014 Incentive Award of the Okayama Medical Association in General Medical Science (2014 Yuuki Prize)
FullText URL 127_179.pdf
Author Kitamura, Shinji|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 179
End Page 181
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.179
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.179
NAID 130005116821
Author Kitamura, Shinji| Sakurai, Hiroyuki| Makino, Hirofumi|
Published Date 2015-03
Publication Title Stem cells
Volume volume33
Issue issue3
Content Type Journal Article
Author Kitamura, Shinji|
Published Date 2014-11
Publication Title Okayama University Medical Research Updates
Volume volume3
Content Type Others
Author Tsuji, Kenji| Kitamura, Shinji| Makino, Hirofumi|
Published Date 2014-04-25
Publication Title Biochemical and Biophysical Research Communications
Volume volume447
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/52138
FullText URL 68_1_7.pdf
Author Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi|
Abstract Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration.
Keywords cell biology immunosuppression stem cells
Amo Type Original Article
Published Date 2014-02
Publication Title Acta Medica Okayama
Volume volume68
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24553483
Web of Sience KeyUT 000331592800002
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52247
Author Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi|
Published Date 2013-02-19
Publication Title PLoS ONE
Volume volume8
Issue issue2
Content Type Journal Article
Author Takiue, Keiichi| Sugiyama, Hitoshi| Inoue, Tatsuyuki| Morinaga, Hiroshi| Kikumoto, Yoko| Kitagawa, Masashi| Kitamura, Shinji| Maeshima, Yohei| Wang, Dahong| Masuoka, Noriyoshi| Ogino, Keiki| Makino, Hirofumi|
Published Date 2012-05-25
Publication Title BMC Nephrology
Volume volume13
Issue issue14
Content Type Journal Article
Author Kitamura, Shinji|
Published Date 2007-05-01
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue1
Content Type Journal Article
Author Kitamura, Shinji|
Published Date 2004-03-25
Publication Title
Content Type Thesis or Dissertation