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ID 34164
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Author
Akiyama, Kozue
Kitagawa, Kouhei
Shibata, Kazuhiko
Suemaru, Katsuya
Araki, Hiroaki
Gomita, Yutaka
Abstract

The use of carbamazepine has been reported to be an effective treatment for severe depression. We have already shown that the antidepressant-like effects of tricyclic antidepressants in the rat forced swim test (FST) are blocked by chronic treatment with adrenocorticotropic hormone (ACTH). In the present study, we examined the effect of the chronic administration of carbamazepine on the FST and the wet-dog shakes induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aiminopropane (DOI), a 5-HT2A receptor agonist, in ACTH-treated rats. Chronic administration of carbamazepine did not affect the duration of immobility in saline-treated and ACTH-treated rats. The reduction of immobility, induced by chronic administration of imipramine, was blocked by treatment with ACTH. When carbamazepine was administered concurrently with imipramine, we observed a significant decrease in immobility in rats treated with ACTH. Chronic ACTH treatment increased the number of the wet-dog shakes induced by DOI. This effect of ACTH was significantly increased by the coadministration of carbamazepine and imipramine. These results suggest that the use of carbamazepine together with tricyclic antidepressants had the effect of reducing immobility time in the FST in a tricyclic antidepressant-treatment-resistant depressive model induced by chronic ACTH treatment.

Keywords
Imipramine
Carbamazepine
ACTH
5-HT2A receptor
Forced swim test
Wet-dog shakes
Treatment–resistant
Note
Published with permission from the copyright holder.
This is a author's copy,as published in Pharmacology Biochemistry and Behavior , 2008, volume 89, issue 3, pp235-240.
Publisher URL: http://dx.doi.org/10.1016/j.pbb.2007.12.015
Direct access to Thomson Web of Science record
Copyright © 2008 Elsevier B. V. All rights reserved.
Published Date
2008-05-20
Publication Title
Pharmacology Biochemistry and Behavior
Volume
volume89
Issue
issue3
Content Type
Journal Article
language
英語
Refereed
True
DOI
Web of Sience KeyUT
Submission Path
pharmacology_general/3