ID | 32101 |
JaLCDOI | |
FullText URL | |
Author |
Zhang, Shan
Hagioka, Shingo
Morita, Kiyoshi
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Abstract | To elucidate the mechanism by which hyperbaric oxygen (HBO2) induces electrical discharge, changes in the extracellular concentrations of GABA and glutamate were measured every 5 min using a microdialysis technique in rats during a period of exposure to HBO2 (5 atm abs). Electrical discharge was observed at 28 +/- 4 min after the onset of exposure. Though the extracellular concentrations of glutamate remained unchanged, the extracellular GABA concentrations (pre-exposure level, 0.026 +/- 0.005 microM in dialysate) began to decrease 15 min after the onset of exposure and reached their lowest level (74 +/- 14%, 0.019 +/- 0.004 microM) at the time of appearance of the discharge. There was a close logistic relationship between extracellular GABA concentrations and the discharge incidence, and the extracellular concentrations of GABA causing electrical discharge in 50% of the animals were estimated to be 80% of the pre-exposure level. These results suggest a possible mechanism that HBO2 exposure-induced discharge is caused by the decrease in extracellular concentration of GABA. |
Keywords | glutamic acid
hyperbaric oxygenation
gamma-aminobutyricacid
microdialysis
seizures
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2004-04
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Volume | volume58
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Issue | issue2
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Publisher | Okayama University Medical School
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Start Page | 91
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End Page | 95
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |