Title Alternative A preoperative SUVmax greater than the ADCmin of the primary tumour : A predictor of disease recurrence and survival in patients with endometrial cancer
FullText URL 126_11.pdf
Author Nakamura, Keiichiro| Joja, Ikuo| Fukushima, Chikako| Haruma, Tomoko| Hayashi, Chiaki| Kusumoto, Tomoyuki| Seki, Noriko| Hongo, Atsushi| Hiramatsu, Yuji|
Keywords endometrial cancer SUVmax PET/CT predictor of poor prognosis
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 11
End Page 15
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.11
JaLCDOI 10.18926/AMO/49044
FullText URL 66_6_475.pdf
Author Hase, Soichiro| Mitsumori, Akihito| Inai, Ryota| Takemoto, Mitsuhiro| Matsubara, Shinichiro| Akamatsu, Nobuo| Fujisawa, Masayoshi| Joja, Ikuo| Sato, Shuhei| Kanazawa, Susumu|
Abstract The purpose of this study is to evaluate the diagnostic usefulness of magnetic resonance imaging (MRI) characteristics of endometrial polyps in order to differentiate them from other endometrial lesions. MRI was retrospectively reviewed in 40 patients with pathologically proven endometrial polyps. Special attention was paid to the sizes, shapes, margins, internal structures, signal intensities, and post-contrast enhancement patterns. A central fibrous core, intratumoral cysts, and hemorrhage were seen in 30 (75%), 22 (55%), and 14 (35%) patients, respectively. The predominant signal intensity of the lesions showed iso-to slightly low signal intensity relative to the endometrium on T2-weighted images in 36 (90%), low signal intensity on diffusion-weighted images in 32 (80%), and strong or moderate enhancement on enhanced T1-weighted images in 28 patients (70%), respectively. In 32 (80%) patients, the endometrial polyps showed global or partial early enhancement. On dynamic study, rapid enhancement with a persistent strong enhancement pattern was seen in 17 (42.5%) and a gradually increasing enhancement pattern was seen in 17 patients (42.5%). These MRI features can be helpful to distinguish the endometrial polyps from various other endometrial lesions.
Keywords endometrial polyp central fibrous core intratumoral cyst magnetic resonance imaging (MRI) uterus
Amo Type Original Article
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 475
End Page 485
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254582
Web of Sience KeyUT 000312966100007
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/49723
JaLCDOI 10.18926/AMO/31630
FullText URL fulltext.pdf
Author Yamamoto, Michinori| Joja, Ikuo| Takemoto, Mitsuhiro| Kuroda, Masahiro| Hiraki, Yoshio|
Abstract We analyzed the influence of various parameters on the results of radiotherapy for T1 glottic cancer by assessing the outcomes of 60 patients with this cancer who received definitive radiotherapy between 1985 and 1994. Seven patients were treated with a cobalt-60 unit, and the other 53 with a linear accelerator (26 patients at 3-MV, 10 at 6-MV, and 17 at 10-MV). Of the 17 patients treated at 10-MV, 4 also received part of their treatment with a cobalt-60 unit. The total radiation dose ranged from 56 Gy to 70 Gy (mean, 61 Gy). The total radiation dose of 51 patients (85%) was 60 Gy. The factors found to influence local control were the strength of the radiation beam energy and whether or not there was gross tumor invasion of the anterior commissure. The local control rate was 71% in the patients treated with a 10-MV linear accelerator, 56% in those treated with a 6-MV linear accelerator and, 97% in those treated with a cobalt-60 unit or a 3-MV linear accelerator (P = 0.0173). The local control rate was 43% in the patients with gross anterior commissure invasion and 88% in those without (P = 0.0075). We conclude that low energy photon beams are more suitable for the treatment of early glottic cancers, especially if the lesion grossly invades the anterior commissure.
Keywords T1 glottic cancers radiotherapy radiation beam energy
Amo Type Article
Published Date 1999-04
Publication Title Acta Medica Okayama
Volume volume53
Issue issue2
Publisher Okayama University Medical School
Start Page 91
End Page 94
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Copyright© 1999 Okayama University Medical School
File Version publisher
Refereed True
Web of Sience KeyUT 000080058700005
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/3496
JaLCDOI 10.18926/AMO/31599
FullText URL fulltext.pdf
Author Kuroda, Masahiro| Tsushima, Tomoyasu| Nasu, Yasutomo| Asaumi, Junichi| Nishikawa, Koji| Gao, Xian Shu| Joja, Ikuo| Takeda, Yoshihiro| Togami, Izumi| Makihata, Eiichi| Kawasaki, Shoji| Ohmori, Hiroyuki| Hiraki, Yoshio|
Abstract <p>We performed a long-term follow-up of 4 patients with penile cancer who underwent hyperthermotherapy from August 1985 until August 1992. Hyperthermia was applied using a frequency of 350 MHz with a waveguide applicator twice a week for 60 min each for an average of 9.5 times (varying from 6 to 13 times). The total heating time that the temperature of urethra could be kept above 42 degrees C, was 166 min on the average (ranging from 0 to 463 min). Two patients classified as stage I according to the Jackson classification and 1 patient classified as stage IV underwent combined radiotherapy and received an average radiation dose of 53 Gy (range, 40-70 Gy). Among these patients 2 underwent combined chemotherapy with bleomycin or peplomycin. Malignant cells disappeared posttherapeutically and in August 1992, after an average of 5 years and 9 months (varying from 4 years 6 months to 6 years 10 months), the patients were free of recurrences. The one patient on stage IV had extensive invasion of the abdominal wall, but still recovered completely. One patient on stage III underwent combined chemotherapy and hyperthermotherapy, but heating had obviously been insufficient. There was a residue of malignant cells after the treatment and we performed a penectomy. Regarding functional preservation of the penis a multidisciplinary therapy incorporating hyperthermotherapy can be expected to increase the curativity. This indicates that it could induce in an advanced case, where an operation would be difficult, complete remission.</p>
Keywords penile cancer hyperthermia radiotherapy chemotherapy
Amo Type Article
Published Date 1993-06
Publication Title Acta Medica Okayama
Volume volume47
Issue issue3
Publisher Okayama University Medical School
Start Page 169
End Page 174
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8379345
Web of Sience KeyUT A1993LL12400005
JaLCDOI 10.18926/AMO/31557
FullText URL fulltext.pdf
Author Kuroda, Masahiro| Hizuta, Akio| Iwagaki, Hiromi| Makihata, Eiichi| Asaumi, Junichi| Nishikawa, Koji| Gao, Xian Shu| Nakagawa, Tomio| Togami, Izumi| Takeda, Yoshihiro| Joja, Ikuo| Kawasaki, Shoji| Orita, Kunzo| Hiraki, Yoshio|
Abstract <p>Between November 1984 and August 1992 we used hyperthermotherapy in six cases of local recurrence of rectal cancer. Hyperthermotherapy was performed on the average 8.7 times (range: 3-18) for each patient for 60 min each. All patients underwent combined radiotherapy and received a mean radiation dose of 42.5 Gy (range: 9-60 Gy). Five patients underwent heating within 1 h after irradiation and one patient simultaneously with the irradiation. Four patients underwent combined chemotherapy and two patients immunotherapy. Before the treatment all patients had painful lesions, but pain decreased posttherapeutically in five patients. Performance status improved in two patients. High carcinoembryonic antigen levels prior to the therapy in four patients decreased in all cases after treatment. Posttherapeutical computed tomograms revealed only minor response or no changes. After the treatment, four patients died of exacerbations of recurrent tumors and one patient of distant metastases. The patient who underwent simultaneous radiohyperthermotherapy is presently alive, in August 1992, 38 months after initiation of the treatment. The 50% survival time after initiation of the treatment was 25 months (range: 10-38 months). Hyperthermotherapy combined with radiotherapy, chemotherapy and/or immunotherapy was useful for the alleviation of pain in patients who developed local recurrence after surgery, and improved survival after recurrences can be expected.</p>
Keywords rectal cancer local recurrence hyperthermia radiotherapy chemotherapy
Amo Type Article
Published Date 1993-08
Publication Title Acta Medica Okayama
Volume volume47
Issue issue4
Publisher Okayama University Medical School
Start Page 249
End Page 254
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8213219
Web of Sience KeyUT A1993LV73800005
JaLCDOI 10.18926/AMO/30978
FullText URL fulltext.pdf
Author Matsushita, Toshi| Anami, Daigo| Arioka, Tadashi| Inoue, Seiji| Kariya, Yusuke| Fujimoto, Masako| Ida, Kentaro| Sasai, Nobuya| Kaji, Mitsumasa| Kanazawa, Susumu| Joja, Ikuo|
Abstract <p>With the aim of sequence optimization in susceptibility-weighted imaging (SWI), 2 image acquisition parameters (slice thickness and matrix size) and 2 image processing conditions (number of slices per minimum intensity projection (MIP) and Sliding Window) were investigated using a 1.5-T magnetic resonance imaging (MRI) system. The subjects were 12 healthy volunteers and the target region for scanning was the whole brain. Informed consent was obtained from all subjects. First, susceptibility-weighted images were acquired with various slice thicknesses from 1mm to 5mm and various matrix sizes from 256x256 to 512x512, and the images were assessed in terms of the contrast-to-noise ratio (CNR) and were also visually evaluated by three radiologists. Then, the number of slices per MIP and the usefulness of the Sliding Window were investigated. In the study of the optimal slice thickness and matrix size, the results of visual evaluation suggested that a slice thickness of 3mm and a matrix size of 448x448 are optimal, while the results of evaluation based on CNR were not significant. As regards the image processing conditions, the results suggested that the number of slices per MIP should be set to a minimum value of 2 and that the use of Sliding Window is effective. The present study provides useful reference data for optimizing SWI sequences.</p>
Keywords susceptibility phase contrast-to-noise ratio number of slices per MIP Sliding Window
Amo Type Original Article
Published Date 2008-06
Publication Title Acta Medica Okayama
Volume volume62
Issue issue3
Publisher Okayama University Medical School
Start Page 159
End Page 168
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18596832
Web of Sience KeyUT 000257130300003
JaLCDOI 10.18926/AMO/30776
FullText URL fulltext.pdf
Author Makihata, Eiichi| Kuroda, Masahiro| Kawai, Akira| Ozaki, Toshifumi| Sugihara, Shinsuke| Inoue, Hajime| Joja, Ikuo| Asaumi, Junichi| Kawasaki, Shoji| Hiraki, Yoshio|
Abstract <p>We report the results of phase I/II studies of preoperative multidisciplinary treatment of 14 patients with soft tissue sarcoma using hyperthermia from November 1990 to April 1995. The preoperative treatment was conducted with thermo-radio-chemotherapy in 11 cases of stage III, and with thermo-radiotherapy as well as thermo-chemotherapy in three cases of stages I and II. Hyperthermia was carried out twice a week with totals ranging from 4 to 14 times (average: 8.4 times); each session lasted 60min. Radiotherapy was administered four or five times per week, and the dose was 1.8 2Gy/fraction, with a total of 30-40Gy in a four week period. Chemotherapy was mainly in the form of MAID regimen (2-mercaptoethanesulphonic acid (mesna), adriamycin, ifosfamide and dacarbazine). The tumors were surgically resected in all patients after completing the preoperative treatment. The efficacy rate, as expressed by the percentage of either tumors in which reduction rate was 50% or more, or tumors for which post-treatment contrast enhanced CT image revealed low density volumes occupying 50% or more of the total mass, was 71 % (ten of the 14 tumors). The mean tumor necrosis rate in the resected specimens was 78%. The tumor necrosis rate was significantly high (P &#60; 0.05) in patients whose Time &#8805; 42°C was of long duration. Postoperative complications were observed in six patients; among these, two patients developed wound infection that required surgical treatment as a complication of surgery performed in the early stage following the preoperative treatment. After a mean postoperative follow-up of 27 months, distant metastasis occurred in four patients resulting in three fatalities. The three-year cumulative survival rate was 64.3%. No local recurrence was observed in any patient during the follow-up, thus confirming our hypothesis that preoperative multidisciplinary treatment has an excellent local efficacy. We think that it would be valuable to conduct, at many facilities, phase III studies on the treatment of soft tissue sarcoma by a combination of surgery and preoperative multidisciplinary treatment using hyperthermia, paying close attention to the interval between these two modalities.</p>
Keywords soft tissue tumor hyperthermia radiotherapy chemotherapy
Amo Type Article
Published Date 1997-04
Publication Title Acta Medica Okayama
Volume volume51
Issue issue2
Publisher Okayama University Medical School
Start Page 93
End Page 99
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9142346
Web of Sience KeyUT A1997WX19600006
Author Aono, Kaname| Morimoto, Setsuo| Hashimoto, Keiji| Sato, Katashi| Joja, Ikuo| Kimoto, Shin| Ezoe, Hiroshi| Takeda, Yoshihiro| Miyake, Masayoshi| Hayashi, Hidehiro| Wakabayashi, Hisao| Tamai, Toyosato| Morino, Yasuo| Shiraishi, Noriyuki|
Published Date 1980-10-30
Publication Title 岡山医学会雑誌
Volume volume92
Issue issue9-10
Content Type Journal Article
Author Ehara, Kazuhiko| Joja, Ikuo| Sato, Katashi| Hashimoto, Keiji| Morimoto, Setsuo| Tamai, Toyosato| Morino, Yasuo| Sugita, Katsuhiko| Hiraki, Yoshio| Aono, Kaname| Tanabe, Masatada| Yamamoto, Michio|
Published Date 1979-12-30
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue11-12
Content Type Journal Article
Author Tamai, Toyosato| Tanabe, Masatada| Aono, Kaname| Mizukawa, Kiichiro| Wakabayashi, Hisao| Satoh, Katashi| Morimoto, Setsuo| Ohkawa, Motoomi| Johja, Ikuo| Kojima, Kanji| Kimoto, Shin|
Published Date 1982-12-30
Publication Title 岡山医学会雑誌
Volume volume94
Issue issue11-12
Content Type Journal Article
Author Morino, Yasuo| Morimoto, Setsuo| Sato, Katashi| Hashimoto, Keiji| Joja, Ikuo| Tamai, Toyosato| Aono, Kaname| Tanabe, Masatada| Uchida, Hatsuzo| Shimizu, Nobuyoshi|
Published Date 1979-06-30
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue5-6
Content Type Journal Article
Author Morino, Yasuo| Takeda, Yoshihiro| Morimoto, Setsuo| Miyake, Masayoshi| Hayashi, Hidehiro| Ezoe, Hiroshi| Kimoto, Shin| Joja, Ikuo| Hashimoto, Keiji| Aono, Kaname| Hayashi, Kyoichi| Takaoka, Kazuko| Oshima, Yukiko|
Published Date 1981-08-30
Publication Title 岡山医学会雑誌
Volume volume93
Issue issue7-8
Content Type Journal Article
Author Aono, Kaname| Morino, Yasuo| Tamai, Toyosato| Wakabayashi, Hisao| Morimoto, Setsuo| Hashimoto, Keiji| Sato, Katashi| Joja, Ikuo| Kimoto, Shin| Ezoe, Hiroshi| Takeda, Yoshihiro| Miyake, Masayoshi| Hayashi, Hidehiro|
Published Date 1981-02-28
Publication Title 岡山医学会雑誌
Volume volume93
Issue issue1-2
Content Type Journal Article
Author Hiraki, Yoshio| Morimoto, Setsuo| Satoh, Nobuo| Yamamoto, Yoshio| Shirakami, Toshiaki| Joja, Ikuo| Kimoto, Shin| Hashimoto, Keiji| Aono, Kaname| Nakagiri, Yoshitada| Arakawa, Kenzo|
Published Date 1986-08-30
Publication Title 岡山医学会雑誌
Volume volume98
Issue issue7-8
Content Type Journal Article
Author Togami, Izumi| Hiraki, Yoshio| Kimoto, Shin| Shirakami, Toshiaki| Ueda, Hiroyuki| Satoh, Nobuo| Nakamura, Tetsuya| Yamamoto, Hiromichi| Joja, Ikuo| Hashimoto, Keiji| Morimoto, Setsuo| Aono, Kaname| Takeda, Yoshihiro|
Published Date 1985-10-30
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue9-10
Content Type Journal Article
Author Joja, Ikuo| Hiraki, Yoshio| Ueda, Hiroyuki| Nakamura, Tetsuya| Yamamoto, Yoshio| Kaji, Mitumasa| Togami, Izumi| Niiya, Harutaka| Shirakami, Toshiaki| Hayashi, Hidehiro| Kimoto, Shin| Aono, Kaname| Sugita, Katsuhiko| Ueoka, Hiroshi| Ohnoshi, Taisuke| Kimura, Ikuro|
Published Date 1985-10-30
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue9-10
Content Type Journal Article
Author Hashimoto, Keiji| Kimoto, Shin| Shirakami, Toshiaki| Joja, Ikuo| Hayashi, Hidehiro| Takeda, Yoshihiro| Togami, Izumi| Niiya, Harutaka| Ueda, Hiroyuki| Shimizu, Mitsuharu| Sugita, Katsuhiko| Hiraki, Yoshio| Aono, Kaname| Kaji, Mitsumasa|
Published Date 1986-04-30
Publication Title 岡山医学会雑誌
Volume volume98
Issue issue3-4
Content Type Journal Article
Author Hashimoto, Keiji| Kimoto, Shin| Jouja, Ikuo| Yamamoto, Yoshio| Ueda, Hiroyuki| Kaji, Mitsumasa| Shirakami, Toshiaki| Hiraki, Yoshio| Aono, Kaname| Sugita, Katsuhiko|
Published Date 1985-06-30
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue5-6
Content Type Journal Article
Author Joja, Ikuo|
Published Date 1985-04-30
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue3-4
Content Type Journal Article
Author Kaji, Mitumasa| Joja, Ikuo| Shimizu, Mituharu| Nakamura, Tetsuya| Ueda, Hiroyuki| Yamamoto, Yoshio| Shirakami, Toshiaki| Komoto, Shin| Hashimoto, Keiji| Morimoto, Setsuo| Sugita, Katsuhiko| Hiraki, Yoshio| Aono, Kaname| Utida, Hatsuzou| Teramoto, Shigeru|
Published Date 1986-02-28
Publication Title 岡山医学会雑誌
Volume volume98
Issue issue1-2
Content Type Journal Article