Okayama University Medical School Acta Medica Okayama 0386-300X 49 4 1995 Effect of vasopressin V1- and V2-receptor stimulation on blood pressure in DOCA-salt hypertensive rats. 187 194 EN Yukari Mimura Toshio Ogura Takayoshi Yamauchi Fumio Otsuka Tetsuya Oishi Kazushi Harada Masami Hashimoto Zensuke Ota Article 10.18926/AMO/30375 <p>We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investigated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injections of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hypertensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered after injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR decreased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR.</p> No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 111 3-8 1999 病院基盤の訪問看護ステーションの問題点 ―患者67名からの検討― 85 93 EN Yukari Mimura Hirofumi Makino Youko Oka Kimiko Watanabe Hifumi Kanami Kazuhiko Moriwaki Eriko Katayama Hiromichi Fujiwara Takazi Sadakane Yoshiyuki Satou Ippei Hayashi Kamehiro Satou Toshio Ogura We investigated the curent status of home nursing in our instiution, and visiting nurses' station "chime", to clarify current problems and possible improvements in home care service. A large number of the subjects were aged, and had various diseases usually involving cerebrovascular disorder. Patients requiring medical treatment comprised less than half, and it was considered that support was strong in the current home nursing siuation, particulrly. We examined the age status of persons who looked after the patients, and tce burden on women who provided care. Furthemore, problems with the prenent visit nursing syntem were evaluated by an anonymous questionnaire survey of patients and their attendants. Many of the subjects were worried or troubled about what to do about exacerbation or sudden chages of he patients' condition, the health of the caretakers, and the tight schedule of the caretakers'　life. Based on the results of this questionnaire, we would like to improve the cooperation among members the visting nurse staff including doctors, and physiotherapists so that each of them may better play their roles and provide more appropriate nursing based on the wishes and needs of indvidual patients patients and their caretakers rather than those of the uniform service. No potential conflict of interest relevant to this article was reported.

岡山大学大学院教育学研究科 Acta Medica Okayama 1883-2423 140 2009 熱中症予防対策のための湿球黒球温度の簡便な自動測定記録装置 7 11 EN Takehiko Ito Yukari Mimura Hisao Suzuki 熱中症予防対策に使用する目的で,湿球黒球温度を自動的に連続して測定･記録できる簡便な装置を試作した｡この装置を本学グラウンドに設置し,2008年夏季の暑熱環境の測定を行った結果に若干の考察を加えて報告した。 No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 49 1 1995 Enhanced pressor response in spontaneously hypertensive rats induced by stimulation of vasopressin-V1 receptors. 53 59 EN Takayoshi Yamauchi Toshio Ogura Tetsuya Oishi Kazushi Harada Masami Hashimoto Yukari Mimura Naoko Asano Zensuke Ota Jingo Kageyama Article 10.18926/AMO/30419 <p>To elucidate the effect of the arginine vasopressin (AVP) system in vivo, especially V1 and V2 activity, on blood pressure, we measured the acute changes in blood pressure and heart rate after AVP, OPC-21,268 (a V1 receptor antagonist), and OPC-31,260 (a V2 receptor antagonist) were injected intravenously in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at the age of 15 weeks. Compared with the control period, single injection of AVP 5 ng/kg significantly increased systolic blood pressure in WKY rats without a concomitant increase in heart rate, but there was no significant increase in blood pressure in SHR. In contrast, single injection of either OPC-21,268 3 mg/kg or OPC-31,260 3 mg/kg did not affect blood pressure or heart rate in either SHR or WKY rats. Injection of AVP after the administration of OPC-31,260 induced a greater increase in blood pressure in SHR than in WKY rats, whereas injection of AVP after the administration of OPC-21,268 did not induce any clear increase in blood pressure in SHR or WKY rats. These results suggest that SHR have enhanced pressor activity mediated by V1 receptors and that this increase may be due to an increase in their number. In conclusion, enhancement of V1 activity may contribute to the development of high blood pressure in SHR.</p> No potential conflict of interest relevant to this article was reported.

岡山大学大学院教育学研究科 Acta Medica Okayama 1883-2423 147 2011 Clinical Usefulness of TSH Receptor Autoantibody Using Different Assay Systems 135 144 EN Yukari Mimura Toshio Ogura Fumio Otsuka Thyroid stimulating hormone receptor antibody (TRAb) plays an important role in Graves' disease (GD). A second-generation measurement system has been developed and we have gotten a benefit by the system clinically. In this study, we determined 4 kinds of TRAb in 42 GD patients using the current and second-generation measurement systems to investigate the differences between them. The secondgeneration measurement system exhibited higher positive rates and inhibition rates of thyroid stimulating hormone (TSH) binding than those of the current system. Furthermore, 42 patients with GD were classified into 4 groups by GD activity. The actual values of all TRAbs and positive rates exhibited a tendency to increase significantly with GD activity. Of significance, 2 TRAbs in the second-generation measurement system exhibited high positive rates. However, all actual values of patients did not necessarily agree with these tendencies. The values of TRAb-human detecting anti-human TSH receptors at an approximate cut-off value reflected GD activity more accurately than those of TRAb-CT detecting anti-porcine TSH receptor. This suggests the possibility of specific differences between TSH receptors and further studies are required to further examine these effects. No potential conflict of interest relevant to this article was reported.

岡山大学教師教育開発センター Acta Medica Okayama 2186-1323 5 2015 教育実習における附属学校園養護教諭の取組 : 学校保健活動を遂行する教員を養成するために 129 138 EN Mio Kamikawa Hiroe Honda Akie Kitahara Ikumi Furukawa Hiroko Kamimura Takehiko Ito Yoshihisa Sumino Yukari Mimura 10.18926/CTED/53243 　子どもの多様な健康課題に対応して，学校における安全・安心な環境の確保や子どもの心身の健康を守り，は ぐくむことのできる体制構築が求められる今日，教育実習等においては，実習生を学校保健に対する関心・理解 を高め，子どもの健康・安全な学校生活を考慮した教育活動を展開できる教員として育成することが重要となる。 そこで，教育実習等の機会に附属学校園養護教諭が，学校保健活動を遂行できる教員養成を目的とした講義・演 習を実施した。その結果，実習生は学校保健に対する認識を高めることができた。附属学校園養護教諭が教員養 成に積極的に参画することは，学校保健活動を遂行できる教員養成に果たす役割が大きいといえる。 No potential conflict of interest relevant to this article was reported.

岡山大学大学院教育学研究科 Acta Medica Okayama 1883-2423 161 2016 養護教諭に必要とされるフィジカルアセスメント ― 保健室でみられる原因を根拠とした提案 ― 25 33 EN Yukari Mimura Mutsumi Matsueda Atsuko Kasai Tomiko Nakashita Nobuko Sato Ai Yamauvhi Aiko Tsushima Hiroko kamimura 学校において適切な救急処置を行うために，養護教諭には緊急度・重症度の判断が求められている。しかし，養護教諭に必要な救急処置の範囲は明確にされておらず，困難を感じる要因となっている。近年，救急度・重症度の判断のためにフィジカルアセスメントの重要性が認識されているが，これについても必要な項目が明確になっていないのが現状である。そこで，本研究では，養護教諭が保健室で経験する疾患を根拠として，養護教諭に必要なフィジカルアセスメントを明らかにすることを試み，「息苦しい」の訴えに対して必要な項目を示した。 No potential conflict of interest relevant to this article was reported.

岡山大学大学院教育学研究科 Acta Medica Okayama 1883-2423 161 2016 オーストラリアのサウスオーストラリア州における学校保健の現状 43 49 EN Ai Yamauchi Yukari Mimura Kayo Takahashi 本研究では，オーストラリア，サウスオーストラリア州の学校20校を対象に，学校保健の現状について，ならびにスクールナースが配置されていない公立学校と配置されている私立学校の現状について調査分析し，養護専門職が配置される意義について質問紙法と直接面談法により検討した。サウスオーストラリア州の学校保健は教師，事務職員，外部保健機関，保護者などが関与し，連携と同時に役割分担がされていた。また，公立学校の保健従事者と私立学校のスクールナースの分析では，意識や職務内容に違いがあり，スクールナースなどの養護専門職が果たす役割は大きいと考えられた。 No potential conflict of interest relevant to this article was reported.

岡山大学大学院教育学研究科 Acta Medica Okayama 1883-2423 164 2017 小学生における運動器検診の結果と課題 41 47 EN Aiko Tsushima Graduate School of Education, Okayama University Yukari Mimura Graduate School of Education, Okayama University Hiroe Honda Primary School Attached to Faculty of Education, Okayama University Mana Ogihara Faculty of education, Okayama University Wakana Kuwashima Faculty of education, Okayama University Kana NOUMI Faculty of education, Okayama University 　児童生徒の運動に関連した現代的健康課題として，運動不足に伴う肥満などの生活習慣病と運動過多に伴う四肢および脊柱のスポーツ傷害が指摘されている。「運動器の10 年」日本委員会1）は，運動器疾患の罹患率を，６〜７％と報告しており，「過度な運動，スポーツによる運動器疾患・障害を抱える子どももみられる状況」と指摘している。その流れを受けて，学校保健安全法施行規則の一部改正により検診項目に「運動器」が加えられ，平成28 年度より幼稚園から高等学校までの学校において運動器検診が義務化された。この検診を通じて，運動器疾患の早期発見やスポーツ障害を予防することが目指されている。しかし，平成23年の文部科学省の調査によると内科検診で運動器の検診している学校は，3.2 〜 4.7％であり多くの学校で運動器検診は，これまで実施されていない。本研究は，平成27 年度に，義務実施に先行して小学校において運動器検診を行い，実施上の問題点や児童の運動器の現状を明らかにした。 No potential conflict of interest relevant to this article was reported.

Acta Medica Okayama 1997 第１編　In　vitro　macro-and　micro-　　autoradiographic　　localization　of　V１　and　V２　　receptors　in　the　rat　kidney　　using　OPC-’２1’２68　and　OPC-　　31’２60.第2編　Alterations　of　renal　V１　and　V２　receptors　in　spontaneously　hypertensive　rats　and　DOCA-salt　hypertensive　rats　using　computerized　quantification　for　macro-autoradiogram. EN No potential conflict of interest relevant to this article was reported.