| Author | Kinugasa, Hideaki| Nouso, Kazuhiro| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Nakamura, Shin-ichiro| Shiraha, Hidenori| Kuwaki, Kenji| Hagihara, Hiroaki| Ikeda, Fusao| Miyake, Yasuhiro| Takaki, Akinobu| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-04 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume47 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Tanaka, Shigetomi| Shiraha, Hidenori| Nakanishi, Yutaka| Nishina, Shin-Ichi| Matsubara, Minoru| Horiguchi, Shigeru| Takaoka, Nobuyuki| Iwamuro, Masaya| Kataoka, Junro| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-12-01 |
| Publication Title | International Journal of Cancer |
| Volume | volume131 |
| Issue | issue11 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/48568 |
|---|---|
| FullText URL | 66_3_279.pdf |
| Author | Nishimura, Mamoru| Nouso, Kazuhiro| Kariyama, Kazuya| Wakuta, Akiko| Kishida, Masayuki| Wada, Nozomu| Higashi, Toshihiro| Yamamoto, Kazuhide| |
| Abstract | The artificial ascites technique is often used during radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) treatment because it prevents visceral damage and improves visualization by minimizing interference of the lungs and mesentery. This study determined the efficacy and safety of RFA using the artificial ascites technique in HCC patients. We examined 188 HCC patients who were treated by RFA and fulfilled the Milan criteria. Treatment outcomes (complete ablation rate, local recurrence rate, complication rate, liver function including total bilirubin level, alanine aminotransferase level, albumin level, and prothrombin time) were compared among patients divided into 3 groups based on the volume of artificial ascites injected:GroupⅠ (n＝86), no artificial ascites injected;GroupⅡ (n＝35), ＜1,000ml artificial ascites injected;and Group Ⅲ (n＝67), ＞1,000ml artificial ascites injected. No significant difference was observed in complete ablation or local recurrence rates among the 3 groups, or in the extent of liver function damage after RFA. Artificial ascites disappeared within 7 days; additional diuretics were needed only in 5 (all from Group Ⅲ) of 102 patients. No serious complications such as intestinal perforation or intraperitoneal bleeding were observed. Thus, we found that artificial ascites injection during RFA is effective and safe, and can be used to prevent major procedural complications. |
| Keywords | radiofrequency ablation hepatocellular carcinoma artificial ascites |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 284 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729109 |
| Web of Science KeyUT | 000305669700012 |
| Author | Iwamuro, Masaya| Ohya, Shogen| Yoshioka, Masao| Nasu, Tatsuyo| Ogawa, Tsuneyoshi| Ito, Mamoru| Ishiyama, Shuhei| Fujiwara, Akiko| Shiode, Junji| Yamamoto, Kazuhide| Itoshima, Tatsuya| |
|---|---|
| Published Date | 2005-09-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume117 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ohnishi, Atsuyuki| Miyake, Yasuhiro| Matsushita, Hiroshi| Matsumoto, Kazuyuki| Takaki, Akinobu| Yasunaka, Tetsuya| Koike, Kazuko| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012 |
| Publication Title | Digestion |
| Volume | volume86 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Takayama, Hiroki| Miyake, Yasuhiro| Nouso, Kazuhiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume26 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nishimura, Mamoru| Takaki, Akinobu| Tamaki, Naofumi| Maruyama, Takayuki| Onishi, Hideki| Kobayashi, Sayo| Nouso, Kazuhiro| Yasunaka, Tetsuya| Koike, Kazuko| Hagihara, Hiroaki| Kuwaki, Kenji| Nakamura, Shinichiro| Ikeda, Fusao| Iwasaki, Yoshiaki| Tomofuji, Takaaki| Morita, Manabu| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2013-01-30 |
| Publication Title | Hepatology Research |
| Volume | volume43 |
| Issue | issue10 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/31826 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Fujikawa, Tatsuya| Shiraha, Hidenori| Yamamoto, Kazuhide| |
| Abstract | Serum des-gamma-carboxy prothrombin (DCP) is commonly used to detect hepatocellular carcinoma (HCC). This review focuses on the clinical features of DCP-positive HCC and the molecular function of DCP in HCC. DCP-positive HCC demonstrates more aggressive clinicopathological features than DCP-negative HCC. Analysis of the biological effects of DCP revealed that DCP acts as a growth factor in both an autocrine and paracrine manner. DCP stimulates HCC cell proliferation through the Met-Janus kinase 1-signal transducer and activator of transcription 3 signaling pathway, whereas for vascular endothelial cells, it stimulates cell proliferation and migration through the kinase insert domain receptor-phospholipase C-gamma-mitogen-activated protein kinase signaling pathway. |
| Keywords | des-gamma-carboxy prothrombin hepatocellular carcinoma signaling pathway cell proliferation angiogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2009-12 |
| Volume | volume63 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 299 |
| End Page | 304 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20035286 |
| Web of Science KeyUT | 000273145900001 |
| JaLCDOI | 10.18926/AMO/49667 |
|---|---|
| FullText URL | 67_2_93.pdf |
| Author | Kita, Masahide| Yokota, Kenji| Okada, Hiroyuki| Take, Susumu| Takenaka, Ryuta| Kawahara, Yoshiro| Oguma, Keiji| Matsushita, Osamu| Yamamoto, Kazuhide| |
| Abstract | Atrophy of the gastric mucosa is a precursor of intestinal-type gastric cancer, and Helicobacter pylori infection causes atrophic gastritis. The aim of this study was to determine whether the genetic diversity of H. pylori virulence genes is associated with the development and progression of gastric atrophy in humans. We isolated and cultured H. pylori strains from patients with gastric ulcer and duodenal ulcer accompanied by atrophic gastritis in background mucosa. H. pylori strains were stored at －80℃ prior to the experiments being carried out. We analyzed iceA, babA, vacA, cagA, and cagE genes by PCR. The cagA gene was analyzed through sequencing of the C-terminal region containing the EPIYA motif, which is related to tyrosine phosphorylation. Severe atrophy was observed in patients with gastric ulcer. The major phenotype of the vacA gene was s1c/m1 (93ｵ). The cagA gene was detected in all strains. The cagE gene was not detected in 2 and 5 strains from the mild cases and severe cases, respectively. The major cagA EPIYA motif, which is amino acids repeat in the C terminus, was the A-B-D type (44 of 58 strains). The virulence genes were not statistically associated with the severity of atrophy in the background gastric mucosa in humans. Not only identification of bacterial virulence factors but also studies of the host response will be necessary to investigate the progression of gastric atrophy and subsequent cancer development in humans. |
| Keywords | Helicobacter pylori virulence genes chronic atrophic gastritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-04 |
| Volume | volume67 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 93 |
| End Page | 98 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23603925 |
| Web of Science KeyUT | 000317801700003 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52508 |
| Author | Takeuchi, Yasuto| Ikeda, Fusao| Moritou, Yuki| Hagihara, Hiroaki| Yasunaka, Tetsuya| Kuwaki, Kenji| Miyake, Yasuhiro| Ohnishi, Hideki| Nakamura, Shinichiro| Shiraha, Hidenori| Takaki, Akinobu| Iwasaki, Yoshiaki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume48 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/31029 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Makino, Yasuhiro| Yamamoto, Kazuhide| Tsuji, Takao| |
| Abstract | The three-dimensional arrangement of ductular structures formed by oval cells in rats fed 2-acetylaminofluorene (2-AAF) was studied by scanning electron microscopy (SEM) of biliary tract casts and light microscopy of sections of liver injected with india ink via the biliary tract. Both resin and india ink were well injected up to bile ductules, and the findings of each method correlated with each other. By the second week after 2-AAF administration, a few oval cells appeared in the periportal areas forming ductular structures which connected with the portal bile ducts. At the 4th week, increased ductular structures occupied two thirds of the lobule and formed networks communicating with each other, and with the portal bile ducts. At the 8th week, such ductular structures were compressed around hyperplastic nodules and appeared like a basket in biliary casts examined by SEM. Although a histochemical study of gamma-glutamyl transpeptidase revealed activity both on the luminal side of the ductular structures and hepatocytes in hyperplastic nodules, no transition was observed between these two cell populations. These results suggest that oval cells have characteristics more similar to those of biliary epithelia than of hepatocytes, and have no relation to the development of hyperplastic nodules. |
| Keywords | oval cells biliary tract casts scanning electron microscopy hyperplastic nodules hepatocarcinogenesis |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1988-06 |
| Volume | volume42 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 143 |
| End Page | 150 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 2899946 |
| Web of Science KeyUT | A1988P034000004 |
| Author | Matsuo, Noriyuki| Shiraha, Hidenori| Fujikawa, Tatsuya| Takaoka, Nobuyuki| Ueda, Naoki| Tanaka, Shigetomi| Nishina, Shinichi| Nakanishi, Yutaka| Uemura, Masayuki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-07-18 |
| Publication Title | BMC Cancer |
| Volume | volume9 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/53026 |
|---|---|
| FullText URL | 68_6_369.pdf |
| Author | Iwamuro, Masaya| Miyashima, Yuichi| Yoshioka, Takahiro| Murata, Toshihiro| Miyabe, Yoshio| Kawai, Yoshinari| Urata, Haruo| Shiraha, Hidenori| Okada, Hiroyuki| Yamamoto, Kazuhide| |
| Abstract | A 67-year-old Japanese man underwent enterotomy because of enterolith ileus. Component analysis by infrared spectroscopy revealed that the enterolith was composed of a high concentration of deoxycholic acid. We further analyzed and compared the ultrastructure of the enterolith and a commercially available powdered form of deoxycholic acid by means of scanning electron microscopy and energy dispersive X-ray spectroscopy. Energy dispersive X-ray spectroscopy analysis revealed that the ratios of carbon and oxygen in the enterolith were equal to those in the deoxycholic acid powder. Scanning electron microscopy analysis showed rectangular prism-shaped particles on the surface of the enterolith. This structure was similar to that of the deoxycholic acid powder. The surgically removed enterolith had a twisted and coiled appearance. Possible mechanisms underlying the formation of this unique form are discussed. |
| Keywords | enterolith deoxycholic acid scanning electron microscopy infrared spectroscopy energy dispersive X-ray spectroscopy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-12 |
| Volume | volume68 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 374 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25519031 |
| Web of Science KeyUT | 000346882200007 |
| JaLCDOI | 10.18926/AMO/45269 |
|---|---|
| FullText URL | 65_2_105.pdf |
| Author | Tsuzuki, Takao| Okada, Hiroyuki| Nasu, Junichiro| Takenaka, Ryuta| Inoue, Masafumi| Kawano, Seiji| Kita, Masahide| Hori, Keisuke| Yamamoto, Kazuhide| |
| Abstract | The objectives of this study were to evaluate the accuracy of endoscopic ultrasonography (EUS) in local and regional staging of early gastric cancer, to analyze the factors influencing the accuracy of EUS, and to reveal the usefulness and problems of EUS in pre-treatment staging of gastric cancer. We examined 105 lesions in 104 patients with histologically confirmed gastric cancer and retrospectively evaluated them with EUS. The diagnostic accuracy, sensitivity, and specificity of EUS were determined by comparing the pre-treatment EUS with the postoperative histopathological findings. The overall diagnostic accuracy of EUS for the depth of cancer invasion was 86%. The overall sensitivity and specificity were 60% and 96%, respectively. The accuracy significantly declined in lesions located in the upper-third of the stomach (70%). Type 0-I lesions tended to be over-staged (12&), and the upper-third lesions tended to be under-staged (23%). The accuracy significantly declined in differentiated adenocarcinoma with massive submucosal invasion (56.5%). EUS is useful for evaluating the depth of gastric cancer invasion which determines the feasibility of endoscopic treatment. However, it is noteworthy that the diagnostic accuracy of the invasion depth diminished for lesions in the upper third of the stomach. |
| Keywords | endoscopic ultrasonography early gastric cancer accuracy sensitivity specificity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-04 |
| Volume | volume65 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 105 |
| End Page | 112 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21519368 |
| Web of Science KeyUT | 000289818800006 |
| Author | Asagi, Akinori| Ohta, Koji| Nasu, Junichirou| Tanada, Minoru| Nadano, Seijin| Nishimura, Rieko| Teramoto, Norihiro| Yamamoto, Kazuhide| Inoue, Takeshi| Iguchi, Haruo| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | Pancreas |
| Volume | volume42 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nakarai, Asuka| Kato, Jun| Hiraoka, Sakiko| Kuriyama, Motoaki| Inokuchi, Toshihiro| Takei, Daisuke| Moritou, Yuki| Akita, Mitsuhiro| Takahashi, Sakuma| Harada, Keita| Okada, Hiroyuki| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Tsutsumi, Koichiro| Kawamoto, Hirofumi| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2010-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ogawa, Tsuneyoshi| Kawamoto, Hirofumi| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Fukuda, Tetsuya| Yamada, Gotaro| Ogawa, Hiromichi| Okushin, Hiroaki| Hyodo, Ichinosuke| Nishihara, Takashi| Mizuno, Motowo| Sakamoto, Yuji| Nagashima, Hideo| Yamamoto, Kazuhide| Kobayashi, Toshinari| Yoshida, Tomoro| |
|---|---|
| Published Date | 1984-04-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume96 |
| Issue | issue3-4 |
| Content Type | Journal Article |
| Author | Kawano, Seiji| Okada, Hiroyuki| Kawahara, Yoshiro| Inoue, Masafumi| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
