| Author | Maki, Yu| Murakami, Jun| Asaumi, Jun-ichi| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| Kokeguchi, Susumu| Fukui, Kazuhiro| Kawai, Noriko| Yanagi, Yoshinobu| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji| |
|---|---|
| Published Date | 2005-7 |
| Publication Title | Oral Oncology |
| Volume | volume41 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Murakami, Jun| Asaumi, Jun-ichi| Kawai, Noriko| Tsujigiwa, Hidetsugu| Yanagi, Yoshinobu| Nagatsuka, Hitoshi| Inoue, Tetsuyoshi| Kokeguchi, Susumu| Kawasaki, Shoji| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji| |
|---|---|
| Published Date | 2005-07 |
| Publication Title | Cancer Chemotherapy and Pharmacology |
| Volume | volume56 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Murakami, Jun| Asaumi, Jun-ichi| Maki, Yuu| Tsujigiwa, Hidetsugu| Kuroda, Masahiro| Nagai, Noriyuki| Yanagi, Yoshinobu| Inoue, Tetsuyoshi| Kawasaki, Shoji| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji| |
|---|---|
| Published Date | 2004-2 |
| Publication Title | Oral Oncology |
| Volume | volume40 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Yanagi, Yoshinobu| Fujita, Mariko| Hisatomi, Miki| Matsuzaki, Hidenobu| Konouchi, Hironobu| Katase, Naoki| Nagatsuka, Hitoshi| Asaumi, Jun-ichi| |
|---|---|
| Published Date | 201012 |
| Publication Title | Oral Radiology |
| Volume | volume26 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Yamanaka, Reiko| Soga, Yoshihiko| Nawachi, Kumiko| Yanagi, Yoshinobu| Kodama, Naoki| Nakata, Takashi| Miura, Rumi| Hagawa, Misao| Takeuchi, Tetsuo| Yamane, Mieko| Morita, Manabu| Takashiba, Shogo| Asami, Jun-ichi| Minagi, Shogo| Yoshiyama, Masahiro| Shimono, Tsutomu| Kuboki, Takuo| Sasaki, Akira| Morita, Kiyoshi| |
|---|---|
| Published Date | 2009-06 |
| Publication Title | 岡山歯学会雑誌 |
| Volume | volume28 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kawakami, Shigehisa| Kodama, Naoki| Maeda, Naoto| Sakamoto, Shunichi| Oki, Kazuhiro| Yanagi, Yoshinobu| Asaumi, Jun-Ichi| Maeda, Teruta| Minagi, Shogo| |
|---|---|
| Published Date | 2012-01-15 |
| Publication Title | Journal of Neuroscience Methods |
| Volume | volume203 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Hisatomi, Miki| Yanagi, Yoshinobu| Konouchi, Hironobu| Matsuzaki, Hidenobu| Takenobu, Toshihiko| Unetsubo, Teruhisa| Asaumi, Jun-ichi| |
|---|---|
| Published Date | 2011-02 |
| Publication Title | Oral Oncology |
| Volume | volume47 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52009 |
|---|---|
| FullText URL | 67_6_359.pdf |
| Author | Katashima, Kazunori| Kuroda, Masahiro| Ashida, Masakazu| Sasaki, Takanori| Taguchi, Takehito| Matsuzaki, Hidenobu| Murakami, Jun| Yanagi, Yoshinobu| Hisatomi, Miki| Hara, Marina| Kato, Hirokazu| Ohmura, Yuichi| Kobayashi, Tomoki| Kanazawa, Susumu| Harada, Sosuke| Takemoto, Mitsuhiro| Ohno, Seiichiro| Mimura, Seiichi| Asaumi, Junichi| |
| Abstract | It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis. |
| Keywords | ADC apoptosis necrosis hyperthermia cell density |
| Amo Type | Original Article |
| Published Date | 2013-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 367 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356720 |
| Web of Science KeyUT | 000328915700004 |
| Author | Asaumi, Jun-ichi| Yanagi, Yoshinobu| Konouchi, Hironobu| Hisatomi, Miki| Matsuzaki, Hidenobu| Shigehara, Hiroshi| Kishi, Kanji| |
|---|---|
| Published Date | 2004-9 |
| Publication Title | European Journal of Radiology |
| Volume | volume51 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Asaumi, Jun-ichi| Yanagi, Yoshinobu| Konouchi, Hironobu| Hisatomi, Miki| Matsuzaki, Hidenobu| Kishi, Kanji| |
|---|---|
| Published Date | 2004-7 |
| Publication Title | Oral Oncology |
| Volume | volume40 |
| Issue | issue6 |
| Content Type | Journal Article |
| FullText URL | isd-49-27.pdf |
|---|---|
| Author | Bamgbose, Babatunde O.| Okada, Shunsuke| Hisatomi, Miki| Yanagi, Yoshinobu| Takeshita, Yohei| Abdu, Zahrau Saleh| Ekuase, Edugie J.| Asaumi, Jun-ichi| |
| Keywords | Tooth Supernumerary Odontoma Odontogenic Cyst |
| Published Date | 2019-05-25 |
| Publication Title | Imagining Science in Dentistry |
| Volume | volume49 |
| Issue | issue1 |
| Publisher | Korean Academy of Oral and Maxillofacial Radiology |
| Start Page | 27 |
| End Page | 34 |
| ISSN | 22337822 |
| NCID | AA12764256 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by Korean Academy of Oral and Maxillofacial Radiology |
| File Version | publisher |
| PubMed ID | 30941285 |
| DOI | 10.5624/isd.2019.49.1.27 |
| Web of Science KeyUT | 000462925200004 |
| Related Url | isVersionOf https://doi.org/10.5624/isd.2019.49.1.27 |
