| Title Alternative | Isothiocyanates as Novel Cancer Chemopreventive Agents and Their Underlying Molecular Mechanisms |
|---|---|
| FullText URL | 095_0087_0091.PDF |
| Author | Nakamura, Yoshimasa| |
| Abstract | A promising group of compounds that have a chemopreventive property are isothiocyanates (ITCs). ITCs have been shown to induce apoptosi in various cancer cell lines and experimental rodents. Multiple signaltransduction pathways as well as apoptosis intermediates have been also posturalted. We recently clarified the moleculae mechanism underlying the relationship between cell cycle arrest ad apoptosis induced by benzyl isothiocyanate(BITC), a major ITC compound isolated from papaya. The exposure of cells to BITC resulted in the inhibition of the G2/M progression that coincided with not only hte up-regulated expression of the G2/M cell cycle arrest-regulating genes but also the apoptosis induction. Conversely, treatment with an excessive concentration of BITC resulted in an abortive apoptotic pathway without DNA ladder formation. This commentary will review the biological impact of cell death induction by BITC as well as other ITCs and the involved signal transduction pathways. |
| Keywords | isothiocyanates cancer chemoprevention apoptosis cell cycle arrest necrosis |
| Publication Title | 岡山大学農学部学術報告 |
| Published Date | 2006-02 |
| Volume | volume95 |
| Issue | issue1 |
| Start Page | 87 |
| End Page | 91 |
| ISSN | 0474-0254 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002311108 |
| Author | Abe, N| Hou, D-X| Munemasa, S| Murata, Y| Nakamura, Y| |
|---|---|
| Published Date | 2014-11-20 |
| Publication Title | Cell Death and Disease |
| Volume | volume5 |
| Content Type | Journal Article |
| FullText URL | Plant_Cell_Physiol_57_8_1779.pdf img.pdf suppl.pdf |
|---|---|
| Author | Yin, Ye| Adachi, Yuji| Nakamura, Yoshimasa| Munemasa, Shintaro| Mori, Izumi C.| Murata, Yoshiyuki| |
| Keywords | ABA ABA receptors Arabidopsis thaliana Guard cells Methyl jasmonate OST1 protein kinase |
| Note | This is an Accepted Manuscript of an article published by Oxford University Press| |
| Published Date | 2016-08-01 |
| Publication Title | Plant and Cell Physiology |
| Volume | volume57 |
| Issue | issue8 |
| Publisher | Japanese Society of Plant Physiologists |
| Start Page | 1779 |
| End Page | 1990 |
| ISSN | 0032-0781 |
| NCID | AA0077511X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 27354421 |
| DOI | 10.1093/pcp/pcw102 |
| Web of Science KeyUT | 000384717100015 |
| Related Url | https://doi.org/10.1093/pcp/pcw102 |
| FullText URL | fcell_2019_00160_p.pdf fcell_2019_00160_a.pdf |
|---|---|
| Author | Satoh, Ayano| Hayashi-Nishino, Mitsuko| Shakuno, Takuto| Masuda, Junko| Koreishi, Mayuko| Murakami, Runa| Nakamura, Yoshimasa| Nakamura, Toshiyuki| Abe-Kanoh, Naomi| Honjo, Yasuko| Malsam, Joerg| Yu, Sidney| ishino, Kunihiko | |
| Keywords | Golgi golgins glycosylation endoplasmic reticulum electron tomography |
| Published Date | 2019-08-27 |
| Publication Title | Frontiers in Cell and Developmental Biology |
| Volume | volume7 |
| Start Page | 160 |
| ISSN | 2296634X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31544102 |
| DOI | 10.3389/fcell.2019.00160 |
| Related Url | isVersionOf https://doi.org/10.3389/fcell.2019.00160 |
| FullText URL | SR9_1_8866.pdf |
|---|---|
| Author | Abe-Kanoh, Naomi| Kunisue, Narumi| Myojin, Takumi| Chino, Ayako| Munemasa, Shintaro| Murata, Yoshiyuki| Satoh, Ayano| Moriya, Hisao| Nakamura, Yoshimasa| |
| Published Date | 2019-6-20 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 8866 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 31222108 |
| DOI | 10.1038/s41598-019-45248-2 |
| Web of Science KeyUT | 000472136900040 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-45248-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ye, Wenxiu| Ando, Eigo| Rhaman, Mohammad Saidur| Tahjib-Ul-Arif, Md| Okuma, Eiji| Nakamura, Yoshimasa| Kinoshita, Toshinori| Murata, Yoshiyuki| |
| Keywords | Allyl isothiocyanate Arabidopsis calcium channel potassium channel proton pump stomatal closure stomatal opening |
| Published Date | 2020-02-27 |
| Publication Title | Journal of Experimental Botany |
| Volume | volume71 |
| Issue | issue10 |
| Publisher | Oxford University Press |
| Start Page | 2922 |
| End Page | 2932 |
| ISSN | 0022-0957 |
| NCID | AA00697526 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020. |
| File Version | publisher |
| PubMed ID | 32103265 |
| DOI | 10.1093/jxb/eraa073 |
| Web of Science KeyUT | 000538790700010 |
| Related Url | isVersionOf https://doi.org/10.1093/jxb/eraa073 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Selvam, Karthik Paneer| Nagahata, Taichi| Kato, Kosuke| Koreishi, Mayuko| Nakamura, Toshiyuki| Nakamura, Yoshimasa| Nishikawa, Takeshi| Satoh, Ayano| Hayashi, Yasuhiko| |
| Keywords | Carbon Nanohorns Cellulose Skin sensitization Composites Bio-compatible |
| Published Date | 2021-10-23 |
| Publication Title | Biomaterials Research |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 18 |
| ISSN | 1226-4601 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 33110624 |
| DOI | 10.1186/s40824-020-00194-3 |
| Web of Science KeyUT | 000672709800001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40824-020-00194-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Liu, Yujia| Myojin, Takumi| Li, Kexin| Kurita, Ayuki| Seto, Masayuki| Motoyama, Ayano| Liu, Xiaoyang| Satoh, Ayano| Munemasa, Shintaro| Murata, Yoshiyuki| Nakamura, Toshiyuki| Nakamura, Yoshimasa| |
| Keywords | 3-hydroxyphenylacetic acid aldehyde dehydrogenase quercetin metabolites aryl hydrocarbon receptor acetaldehyde |
| Published Date | 2022-02-03 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1762 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35163684 |
| DOI | 10.3390/ijms23031762 |
| Web of Science KeyUT | 000756270900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms23031762 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shigehiro, Tsukasa| Ueno, Maho| Kijihira, Mayumi| Takahashi, Ryotaro| Umemura, Chiho| Taha, Eman A.| Kurosaka, Chisaki| Asayama, Megumi| Murakami, Hiroshi| Satoh, Ayano| Nakamura, Yoshimasa| Futami, Junichiro| Masuda, Junko| |
| Keywords | breast cancer cells dendritic cells mesenteric lymph node myeloid-derived suppressor cells |
| Published Date | 2022-09-20 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue19 |
| Publisher | MDPI |
| Start Page | 11035 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36232335 |
| DOI | 10.3390/ijms231911035 |
| Web of Science KeyUT | 000867767200001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms231911035 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Wu, Hongyan| Nakamura, Toshiyuki| Guo, Yingnan| Matsumoto, Riho| Munemasa, Shintaro| Murata, Yoshiyuki| Nakamura, Yoshimasa| |
| Keywords | cycloartenyl ferulate antioxidative effect cytoprotective potential heme oxygenase-1 nuclear factor erythroid 2-related factor 2 |
| Published Date | 2023-01-03 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 822 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 36614263 |
| DOI | 10.3390/ijms24010822 |
| Web of Science KeyUT | 000910246300001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms24010822 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zhao, Maoxiang| Nakamura, Toshiyuki| Nakamura, Yoshimasa| Munemasa, Shintaro| Mori, Izumi C| Murata, Yoshiyuki| |
| Keywords | dihydroxyacetone methylglyoxal growth anthocyanin glyoxalase system |
| Published Date | 2023-08-08 |
| Publication Title | Bioscience, Biotechnology, and Biochemistry |
| Volume | volume87 |
| Issue | issue11 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 1323 |
| End Page | 1331 |
| ISSN | 1347-6947 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37553179 |
| DOI | 10.1093/bbb/zbad109 |
| Web of Science KeyUT | 001188663700005 |
| Related Url | isVersionOf https://doi.org/10.1093/bbb/zbad109 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sato, Haruna| Kato, Kosuke| Koreishi, Mayuko| Nakamura, Yoshimasa| Tsujino, Yoshio| Satoh, Ayano| |
| Published Date | 2024-01-05 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue1 |
| Publisher | Public Library of Science |
| Start Page | e0296408 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Sato et al. |
| File Version | publisher |
| PubMed ID | 38181031 |
| DOI | 10.1371/journal.pone.0296408 |
| Web of Science KeyUT | 001153716700065 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0296408 |
