start-ver=1.4
cd-journal=joma
no-vol=356
cd-vols=
no-issue=2
article-no=
start-page=598
end-page=607
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110815
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Defective proventriculus specifies the ocellar region in the Drosophila head
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A pair of the Drosophila eye-antennal disc gives rise to four distinct organs (eyes, antennae, maxillary palps, and ocelli) and surrounding head cuticle. Developmental processes of this imaginal disc provide an excellent model system to study the mechanism of regional specification and subsequent organogenesis. The dorsal head capsule (vertex) of adult Drosophila is divided into three morphologically distinct subdomains: ocellar, frons, and orbital. The homeobox gene orthodenticle (otd) is required for head vertex development, and mutations that reduce or abolish ad expression in the vertex primordium lead to ocelliless flies. The homeodomain-containing transcriptional repressor Engrailed (En) is also involved in ocellar specification, and the En expression is completely lost in otd mutants. However, the molecular mechanism of ocellar specification remains elusive. Here, we provide evidence that the homeobox gene defective proventriculus (dye) is a downstream effector of Otd, and also that the repressor activity of Dye is required for en activation through a relief-of-repression mechanism. Furthermore, the Dye activity is involved in repression of the frons identity in an incoherent feedforward loop of Otd and Dye.
en-copyright=
kn-copyright=

en-aut-name=YorimitsuTakeshi
en-aut-sei=Yorimitsu
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KiritooshiNaruto
en-aut-sei=Kiritooshi
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakagoshiHideki
en-aut-sei=Nakagoshi
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=3
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
en-keyword=Drosophila
kn-keyword=Drosophila
en-keyword=Eye
kn-keyword=Eye
en-keyword=Orthodenticle
kn-keyword=Orthodenticle
en-keyword=Hedgehog
kn-keyword=Hedgehog
en-keyword=Engrailed
kn-keyword=Engrailed
en-keyword=Iroquois
kn-keyword=Iroquois
END