ID | 48706 |
FullText URL | |
Author |
Teraoka, Junichi
Sakoda, Akihiro
Nishiyama, Yuichi
Yamato, Keiko
Monden, Mayuko
Ishimori, Yuu
Nomura, Takaharu
Taguchi, Takehito
Kaken ID
researchmap
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Abstract | We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.
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Keywords | radon inhalation
inflammation
carrageenan
edema
antioxidative function
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Published Date | 2012-04-01
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Publication Title |
Inflammation
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Volume | volume35
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Issue | issue2
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Publisher | Springer Science+Business Media, LLC
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Start Page | 713
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End Page | 722
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ISSN | 0360-3997
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NCID | AA00673765
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Content Type |
Journal Article
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Official Url | http://www.springerlink.com/content/l301166n92348401/
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language |
English
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Copyright Holders | © Springer Science+Business Media, LLC 2011
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File Version | author
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Refereed |
True
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DOI | |
PubMed ID | |
Web of Science KeyUT |