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ID 62458
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Kataoka, Takahiro Graduate School of Health Sciences, Okayama University ORCID Kaken ID publons researchmap
Shuto, Hina Graduate School of Health Sciences, Okayama University
Naoe, Shota Graduate School of Health Sciences, Okayama University
Yano, Junki Graduate School of Health Sciences, Okayama University
Kanzaki, Norie Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Sakoda, Akihiro Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Tanaka, Hiroshi Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Hanamoto, Katsumi Graduate School of Health Sciences, Okayama University Kaken ID publons researchmap
Mitsunobu, Fumihiro Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID publons researchmap
Terato, Hiroaki Advanced Science Research Center Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University Kaken ID publons researchmap
Abstract
Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m(3) (for one, three, or 10 days). The 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m(3) radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m(3) radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m(3) for three days or 20 kBq/m(3) for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.
Keywords
radon
oxidative DNA damage
Mn-superoxide dismutase (SOD)
8-oxoguanine DNA glycosylase
Published Date
2021-08-09
Publication Title
Journal of Radiation Research
Volume
volume62
Issue
issue5
Publisher
Oxford University Press
Start Page
861
End Page
867
ISSN
0449-3060
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© The Author(s) 2021.
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publisher
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1093/jrr/rrab069
License
http://creativecommons.org/licenses/bync/4.0/
Open Access (Publisher)
OA