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Author
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University ORCID Kaken ID publons researchmap
Kanzaki, Norie Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Sakoda, Akihiro Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Shuto, Hina Graduate School of Health Sciences, Okayama University
Yano, Junki Graduate School of Health Sciences, Okayama University
Naoe, Shota Graduate School of Health Sciences, Okayama University
Tanaka, Hiroshi Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Hanamoto, Katsumi Graduate School of Health Sciences, Okayama University Kaken ID publons researchmap
Terato, Hiroaki Advanced Science Research Center, Okayama University
Mitsunobu, Fumihiro Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID publons researchmap
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University Kaken ID publons researchmap
Abstract
Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m(3) for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs.
Keywords
radon
redox state
oxidative stress
antioxidative function
principal component analysis
Published Date
2021-01-27
Publication Title
Journal of Radiation Research
Volume
volume62
Issue
issue3
Publisher
Oxford Univ Press
Start Page
390
End Page
400
ISSN
0449-3060
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© The Author(s) 2021.
File Version
publisher
PubMed ID
NAID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1093/jrr/rraa129
License
http://creativecommons.org/licenses/by/4.0/
Funder Name
JAEA Nuclear Energy S&T and Human Resource Development Project through Concentrating Wisdom
助成番号
JPJA18B18072098
Open Access (Publisher)
OA