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Title Alternative	Pharmacokinetic analysis of drug absorption following nasal application to rats
FullText URL	poalas_033_003_007.pdf
Author	古林呂之\|
Abstract	Since a drug applied to the nose in an in vivo physiologic condition is translocated to the gastrointestinal (GI) tract by mucociliary clearance (MC), the drug undergoes absorption both from the nasal cavity and from the GI tract. The detailed MC of the rat was examined, using inulin as a marker of the applied solution. Inulin disappeared monoexponentially from the nasal cavity, indicating that the MC can be assumed to follow first-order kinetics. In the proposed kinetic model, the fractional absorption of the drug following nasal application is predicted as the sum of fractional absorption from the nasal cavity and fractional absorption from the GI tract, both of which are estimated indirectly from the permeability to the Caco-2 monolayer. This kinetic model is the first estimation system for nasal drug absorption based on drug disposition after nasal application and is useful for the development of nasal dosage forms.
Publication Title	Proceedings of Okayama Association for Laboratory Animal Science
Published Date	2017-04
Volume	volume33
Start Page	3
End Page	7
language	Japanese
File Version	publisher

Title Alternative	Breeding and genetics of mutant strains and domestication of wildlife for laboratory animal science
FullText URL	poalas_033_002.pdf
Author	Oda, Sen-ichi\|
Publication Title	Proceedings of Okayama Association for Laboratory Animal Science
Published Date	2017-04
Volume	volume33
Start Page	2
End Page	2
language	Japanese
File Version	publisher

Title Alternative	Transcription factor Runx3 in the mouse hypothalamo-pituitary-gonadal system
FullText URL	poalas_034_002.pdf
Author	Takahashi, Sumio\|
Abstract	Runx3 is a transcription factor that belongs to the Runx family. Female Runx3 knockout (Runx3−⁄−) mouse was anovulatory and infertile. Ovarian transplantation experiment suggested that lack of ovulation in Runx3−⁄− mice was caused by alteration of gonadotropin secretion in Runx3−⁄− mice. Cyp11a1 mRNA expression was less in Runx3−⁄− mouse ovaries than in wt ones. Hypothalamic Gnrh1 mRNA was increased, and Kiss1 mRNA expression in the anteroventral periventricular nucleus was decreased, but Kisspeptin mRNA in the arcuate nucleus was increased in Runx3-/- mice. Pituitary Fshb mRNA levels were increased in Runx3−⁄− mice. Cholesterol side-chain cleavage enzyme gene (Cyp11a1) expression was decreased in ovaries of Runx3−⁄− mice. These findings suggest that anovulation in Runx3−⁄− mice was partly due to the alterations in hypothalamus-pituitary-ovary system. Runx3 plays a key role in female reproduction through alteration of gonadotropin secretion.
Publication Title	Proceedings of Okayama Association for Laboratory Animal Science
Published Date	2018-04
Volume	volume34
Start Page	2
End Page	4
language	Japanese
File Version	publisher