Author | 岡山大学農学部附属農場| |
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Published Date | 1989-03-20 |
Publication Title | 岡山大学農学部農場報告 |
Volume | volume11 |
Content Type | Others |
Author | 岡山大学農学部附属農場| |
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Published Date | 1990-03-20 |
Publication Title | 岡山大学農学部農場報告 |
Volume | volume12 |
Content Type | Others |
Author | 岡山大学農学部附属農場| |
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Published Date | 1992-02-10 |
Publication Title | 岡山大学農学部農場報告 |
Volume | volume13-14 |
Content Type | Others |
Author | 岡山大学農学部附属農場| |
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Published Date | 1995-12-28 |
Publication Title | 岡山大学農学部農場報告 |
Volume | volume18 |
Content Type | Others |
Author | 岡山大学農学部附属農場| |
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Published Date | 1993-03-15 |
Publication Title | 岡山大学農学部農場報告 |
Volume | volume15 |
Content Type | Others |
Author | 緒方 益雄| |
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Published Date | 1929-03-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume41 |
Issue | issue3 |
Content Type | Others |
Author | Takai, Toshiyuki| |
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Published Date | 1995-07 |
Publication Title | 岡山実験動物研究会報 |
Volume | volume12 |
Content Type | Others |
Author | Kagawa, Hiroaki| |
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Published Date | 2001-09 |
Publication Title | 岡山実験動物研究会報 |
Volume | volume18 |
Content Type | Others |
Title Alternative | Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics |
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FullText URL | poalas_033_015_017.pdf |
Author | Takarada, Takeshi| |
Abstract | Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts. |
Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
Published Date | 2017-04 |
Volume | volume33 |
Start Page | 15 |
End Page | 17 |
language | Japanese |
File Version | publisher |
Author | 岡山大学農学部附属農場| |
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Published Date | 1998-03-27 |
Publication Title | 岡山大学農学部農場報告 |
Volume | volume20 |
Content Type | Others |
Author | 岡山大学農学部附属農場| |
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Published Date | 1999-03-27 |
Publication Title | 岡山大学農学部農場報告 |
Volume | volume21 |
Content Type | Others |
Author | Kawara, Osami| |
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Published Date | 1997-07 |
Publication Title | 環境制御 |
Volume | volume19 |
Content Type | Others |
Author | Naito, Ichiro| Okigaki, Toru| |
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Published Date | 1986-04 |
Publication Title | 岡山実験動物研究会報 |
Volume | volume4 |
Content Type | Others |
Author | Ohara, Hiroshi| |
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Published Date | 1993-06 |
Publication Title | 岡山実験動物研究会報 |
Volume | volume10 |
Content Type | Others |
Author | Koide, Tsuyoshi| |
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Published Date | 2006-12 |
Publication Title | 岡山実験動物研究会報 |
Volume | volume23 |
Content Type | Others |
Author | 岡山大学環境管理センター| |
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Published Date | 1988-12-01 |
Publication Title | 岡山大学環境管理センター報 |
Volume | volume10 |
Content Type | Others |
Author | 上原 偉男| |
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Published Date | 1950-05-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume62 |
Issue | issue3 |
Content Type | Others |
FullText URL | oer_051_2-3_139.pdf |
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Publication Title | Okayama Economic Review |
Published Date | 2020-03-19 |
Volume | volume51 |
Issue | issue2-3 |
Start Page | 139 |
End Page | 141 |
ISSN | 2433-4146 |
language | Japanese |
Copyright Holders | Copyright © 2020 岡山大学経済学会 |
File Version | publisher |
Author | 山本 進一| |
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Published Date | 2015-02 |
Publication Title | 環境制御 |
Volume | volume36 |
Content Type | Others |
Author | 吉田 裕一| 西本 登志| 松崎 朝浩| 山崎 敬亮| |
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Publication Title | |
Content Type | Others |