Author 岡山大学農学部附属農場|
Published Date 1989-03-20
Publication Title 岡山大学農学部農場報告
Volume volume11
Content Type Others
Author 岡山大学農学部附属農場|
Published Date 1990-03-20
Publication Title 岡山大学農学部農場報告
Volume volume12
Content Type Others
Author 岡山大学農学部附属農場|
Published Date 1992-02-10
Publication Title 岡山大学農学部農場報告
Volume volume13-14
Content Type Others
Author 岡山大学農学部附属農場|
Published Date 1995-12-28
Publication Title 岡山大学農学部農場報告
Volume volume18
Content Type Others
Author 岡山大学農学部附属農場|
Published Date 1993-03-15
Publication Title 岡山大学農学部農場報告
Volume volume15
Content Type Others
Author 緒方 益雄|
Published Date 1929-03-31
Publication Title 岡山医学会雑誌
Volume volume41
Issue issue3
Content Type Others
Author Takai, Toshiyuki|
Published Date 1995-07
Publication Title 岡山実験動物研究会報
Volume volume12
Content Type Others
Author Kagawa, Hiroaki|
Published Date 2001-09
Publication Title 岡山実験動物研究会報
Volume volume18
Content Type Others
Title Alternative Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics
FullText URL poalas_033_015_017.pdf
Author Takarada, Takeshi|
Abstract Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2017-04
Volume volume33
Start Page 15
End Page 17
language Japanese
File Version publisher
Author 岡山大学農学部附属農場|
Published Date 1998-03-27
Publication Title 岡山大学農学部農場報告
Volume volume20
Content Type Others
Author 岡山大学農学部附属農場|
Published Date 1999-03-27
Publication Title 岡山大学農学部農場報告
Volume volume21
Content Type Others
Author Kawara, Osami|
Published Date 1997-07
Publication Title 環境制御
Volume volume19
Content Type Others
Author Naito, Ichiro| Okigaki, Toru|
Published Date 1986-04
Publication Title 岡山実験動物研究会報
Volume volume4
Content Type Others
Author Ohara, Hiroshi|
Published Date 1993-06
Publication Title 岡山実験動物研究会報
Volume volume10
Content Type Others
Author Koide, Tsuyoshi|
Published Date 2006-12
Publication Title 岡山実験動物研究会報
Volume volume23
Content Type Others
Author 岡山大学環境管理センター|
Published Date 1988-12-01
Publication Title 岡山大学環境管理センター報
Volume volume10
Content Type Others
Author 上原 偉男|
Published Date 1950-05-31
Publication Title 岡山医学会雑誌
Volume volume62
Issue issue3
Content Type Others
FullText URL oer_051_2-3_139.pdf
Publication Title Okayama Economic Review
Published Date 2020-03-19
Volume volume51
Issue issue2-3
Start Page 139
End Page 141
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2020 岡山大学経済学会
File Version publisher
Author 山本 進一|
Published Date 2015-02
Publication Title 環境制御
Volume volume36
Content Type Others