JaLCDOI 10.18926/AMO/56650
FullText URL 73_2_147.pdf
Author Hayashi, Masao| Taniguchi, Arata| Kaku, Ryuji| Fujimoto, Shusaku| Isoyama, Satoshi| Manabe, Sei| Yoshida, Tsubasa| Suzuki, Satoshi| Shimizu, Kazuyoshi| Morimatsu, Hiroshi| Momota, Ryusuke|
Abstract Tachycardia is common in intensive care units (ICUs). It is unknown whether tachycardia or prolonged tachycardia affects patient outcomes. We investigated the association between tachycardia and mortality in critically ill patients. This retrospective cohort study’s primary outcome was patient mortality in the ICU and the hospital. We stratified the patients (n=476) by heart rate (HR) as LowHR, MediumHR, and HighHR groups. We also stratified them by their durations of HR >100 (prolonged HR; tachycardia): MildT, ModerateT, and SevereT groups. We determined the six groups’ mortality. The ICU mortality rates of the LowHR, MediumHR, and HighHR groups were 1.0%, 1.5%, and 7.9%, respectively; significantly higher in the HighHR vs. LowHR group. The in-hospital mortality rates of these groups were 1%, 4.5%, and 14.6%, respectively; significantly higher in the HighHR vs. LowHR group. The ICU mortality rates of the MildT, ModerateT, and SevereT groups were 0.9%, 5.6%, and 57.1%, respectively. The mortality of the HRT=0 (i.e., all HR ≤ 100) patients was 0%. The in-hospital mortality rates of the MildT, ModerateT, and SevereT groups were 1.8%, 16.7%, and 85.7%, respectively; that of the HRT=0 patients was 0.5%. Both higher HR and prolonged tachycardia were associated with poor outcomes.
Keywords tachycardia mortality ICU in-hospital
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 147
End Page 153
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015749
JaLCDOI 10.18926/AMO/56649
FullText URL 73_2_135.pdf
Author Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka|
Abstract The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization.
Keywords collagen XVIII basement membrane wound healing re-epithelialization skin
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 135
End Page 146
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015748
JaLCDOI 10.18926/AMO/56648
FullText URL 73_2_127.pdf
Author Iwasaki, Yukari| Miyahara, Kimiko| Miyatake, Nobuyuki| Nakatsuka, Mikiya|
Abstract We aimed to clarify the state of thyroid function in female high school long-distance runners. We evaluated the associations between thyroid function and menstrual condition, bone mineral density (BMD), nutritious status, and body composition. The subjects’ height and weight were measured, along with fat percentage, fat mass, muscle mass, and BMD with dual-energy X-ray absorptiometry. A nutrition and dietary survey measured the subjects’ intake of energy and nutrients based on meals provided at the subjects’ dorm for 3 days in July of 2016 and 2017. Blood parameters including thyroid hormone and estradiol were measured. Most of the subjects (81.3%) were underweight (body mass index <18.5). The thyroid hormone free T3 value was decreased, but TSH was not increased and was similar to that observed in individuals with anorexia nervosa. In our subjects, thyroid hormone was associated with BMD and nutritional intake. To improve the menstruation abnormality of female athletes and to increase their bone density, the athletes’ weight should be managed by proper nutrient intake and the maintenance of their thyroid function.
Keywords thyroid function nutritious status female high school long-distance runners bone mineral density menstrual condition
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 127
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015747
JaLCDOI 10.18926/AMO/56647
FullText URL 73_2_117.pdf
Author Yamasaki, Yukie| Tamiya, Nanako| Yamamoto, Hideki| Miyaishi, Satoru|
Abstract According to the World Health Organization’s World Report, approx. 950,000 children and young people < 18 years old die from an injury each year, and unintentional injury deaths account for a large portion of these cases. Here we used medico-legal documents to epidemiologically analyze the cases of unintentional injury deaths among children < 5 years old in Okayama Prefecture, Japan from 2001 to 2015. Age, sex, manner/cause of death, and various circumstances of the incident were investigated. There were 73 unintentional injury deaths during the study period. Drowning (n=29), suffocation (n=24), and transport accidents (n=13) were the major categories of unintentional injury deaths. Twenty-two cases (30.1%) were autopsied. Differences in the characteristics of the unintentional injury deaths by age were observed. Information which cannot be obtained from Vital Statistics was available from medico-legal documents, and detailed characteristics of unintentional injury deaths among children < 5 years old were elucidated. Investigating medico-legal information is one of the meaningful measures for the prevention of unintentional injury deaths among children in Japan.
Keywords child death unintentional injury prevention medico-legal document
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 117
End Page 125
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015746
JaLCDOI 10.18926/AMO/56646
FullText URL 73_2_109.pdf
Author Abe, Makoto| Iwamuro, Masaya| Kawahara, Yoshiro| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Tsumura, Munechika| Makino, Takuma| Noda, Yohei| Marunaka, Hidenori| Nishizaki, Kazunori| Okada, Hiroyuki|
Abstract The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.
Keywords endoscopic submucosal dissection superficial cancer pharynx endoscopic resection
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 115
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015745
JaLCDOI 10.18926/AMO/56645
FullText URL 73_2_101.pdf
Author Iida, Atsuyoshi| Naito, Hiromichi| Yorifuji, Takashi| Zamami, Yoshito| Yamada, Akane| Koga, Tadashi| Imai, Toru| Sendo, Toshiaki| Nakao, Atsunori| Ichiba, Shingo|
Abstract Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.
Keywords sedatives ECMO polyvinyl chloride pharmacokinetics pharmacodynamics
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 101
End Page 107
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015744
JaLCDOI 10.18926/AMO/56644
FullText URL 73_2_95.pdf
Author Ercan, Sabriye| Başkurt, Ferdi| Başkurt, Zeliha| Çetin, Cem|
Abstract The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62.3% of the study subjects identified themselves as fatigued. The body weight and BMI values of fatigued subjects were found to be higher than those of the non-fatigue group (p<0.05). The reported exercise habits of the fatigue group were found to be significantly lower than their non-fatigued peers (p<0.05). The level of functional mobility (Timed Up and Go Test), static balance (One-Legged Stance Test with Eyes Open) and dynamic balance (Functional Reach Test and the 3-meter Timed Tandem Walk Test) were measured, and statistically significant differences were found between fatigue and non-fatigue groups on all of them (p<0.05). In addition, correlations were found between the sub-parameters of the CIS-T scale and the functional tests at
Keywords fatigue obesity mobility balance woman
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 95
End Page 100
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015743
Title Alternative Why simulation education:The ultimate method of active learning
Author Mandai, Yasuhiro|
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 179
End Page 180
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.179
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.179
NAID 130007542829
Title Alternative Drug interaction(43. Drug interaction in cutaneous T-cell lymphoma)
Author Tanaka, Yuta| Kanzaki, Hirotaka| Morishita, Yosuke| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 175
End Page 178
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.175
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.175
NAID 130007542850
Title Alternative Q26 Q27
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 173
End Page 174
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.173
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.173
NAID 130007542847
Title Alternative General Practitioner
Author Obika, Mikako| Kataoka, Hitomi| Ogawa, Hiroko| Otsuka, Fumio|
Keywords 新専門医制度 総合診療専門医
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 167
End Page 172
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.167
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.167
NAID 130007542846
Title Alternative A survey of nurses’ and physicians’ safety awareness in CT/MRI examinations
Author Watanabe, Manae| Matsuura, Ryutaro| Namba, Shihoko|
Abstract To perform computed tomography (CT)/magnetic resonance imaging (MRI) scans safely and reliably, adherence to a pre-scan checklist is crucial. However, physicians and nurses may differ in their recognition of the usefulness of this checklist. We conducted the present study to investigate possible differences between physicians’ and nurses’ awareness of CT/MRI scan safety in terms of their adherence to the pre-scan checklist. We prepared an independently developed self-administered 23-item questionnaire about attributes of subjects, CT/ MRI scan safety recognition and current situation for CT/MRI examinations. The survey was distributed to 468 participants who combined nurses and physicians at Okayama University Hospitalin Okayama, Japan. We analysis the responses of the 224 participants (117 nurses and 107 physicians)who returned the survey with on missing data (a 65.1% completion rate). The overall safety recognition scores were significantly higher for the nurses than for the physicians (p<0.001). In addition, the physicians did not sufficiently know or implement the guidelines in the CT/MRI scan safety manual used at our hospital. Nurses and physicians demonstrated marked differences in their awareness and knowledge of safety regarding CT/MRI scans. Measures for improving safety recognition should thus be designed for individual healthcare occupations.
Keywords CT/MRI検査(CT/MRI examinations) 安全認識(safety recognition) 職種の差異(difference between occupations) CT/MRI検査マニュアル(CT/MRI examinations manual)
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 161
End Page 166
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.161
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.161
NAID 130007542844
Title Alternative Video capsule endoscopy usage: Intra-hospital consultations before and after the expansion of indications
Author Kawano, Seiji| Iwamuro, Masaya| Inokuchi, Toshihiro| Sugihara, Yuusaku| Harada, Keita| Hiraoka, Sakiko| Okada, Hiroyuki|
Abstract Approximately 10 years have passed since video capsule endoscopy (VCE)was introduced in routine clinical practice in Japan. We started using VCE in January 2009. Here we investigated the contribution of VCE and its level of recognition at our 855-bed hospital. We compared the clinical characteristics of intra-hospital consultation cases with non-consultation cases, and the details of the cases from each of our hospital’s departments. The number of intra-hospital consultations was notably increased by our expansion of the indications for non-obscure gastrointestinal bleeding (OGIB)cases. However, most of our hospital’s departments are sub-departments of internal medicine, in which almost no change in indications has been made. We found that the percentage of OGIB cases was higher among the intra-hospital consultations than non-consultations, and that the OGIB percentages differed markedly among the departments. Especially for OGIB cases, all hospital departments should be better informed regarding the indications for and efficacy of VCE.
Keywords カプセル内視鏡(video capsule endoscopy) 適応拡大(expansion of indication) 院内紹介(intra-hospital consultation)
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 155
End Page 159
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.147
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.147
NAID 130007542857
Title Alternative Feasibility evaluation of a remote monitoring system in the home
Author Kasahara, Shingo|
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 147
End Page 154
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.147
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.147
NAID 130007542853
Title Alternative Research on arginase is interesting
Author Ogino, Keiki|
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 141
End Page 145
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.141
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.141
NAID 130007542858
Title Alternative Basic studies on S100-mediated cancer metastasis based on the development of innovative biologics to aim at its effective prevention
Author Sakaguchi, Masakiyo|
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 135
End Page 139
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.135
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.135
NAID 130007542849
Title Alternative Two Nobel laureates, Alexis Carrel and Peyton Rous, intended to use cells in culture for theirresearch at the beginning of the 20th century
Author Namba, Masayoshi|
Abstract 21世紀になって2017年までに,34件のノーベル生理学・医学賞と化学賞が出ているが,その約半数の研究に培養細胞(動物の細胞,あるいは,イースト)が使われている.すなわち,現代の生命科学の研究には,培養細胞がきわめて大きな役割を果たしているといえる.今回は,今から約100年前,細胞を培養して研究を進めようとした先見性に富んだ 2人のノーベル生理学・医学賞受賞者,Alexis Carrel(以下,本文ではカレルとする)と Peyton Rous(以下,ラウス)の経歴と業績を紹介し,彼等の培養細胞との係りについて述べる.
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 129
End Page 133
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.129
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.129
NAID 130007542837
Title Alternative EB virus-associated T/NK lymphoproliferative disorders in East Asia, and South and Central America: Special reference to hydroa vacciniforme and hypersensitivity to mosquito bites
Author Iwatsuki, Keiji|
Keywords 種痘様水疱症 蚊刺過敏症 慢性活動性EBウイルス感染症 病態 予後
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 123
End Page 128
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.123
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.123
NAID 130007542836
Title Alternative The 2017 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2017 Sunada Prize)
Author Takaya, Yoichi|
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 119
End Page 121
ISSN 0030-1558
Related Url references https://doi.org/10.1016/j.jcin.2017.06.022
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.119
NAID 130007542835
Title Alternative The 2017 Incentive Award of the Okayama Medical Association in Cancer Research (2017 Hayashibara Prize and Yamada Prize)
Author Otani, Yoshihiro|
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 117
End Page 118
ISSN 0030-1558
Related Url references https://doi.org/10.1038/onc.2017.373
language 日本語
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.117
NAID 130007542865