start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=489 end-page=506 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Clinicohistological Study of Bleeding Mechanism in Myomata of the Uterus kn-title=子宮筋腫の出血機序に関する臨床的研究並びに内膜血管の組織学的及び形態学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Genital bleeding as a main symptome of myoma of the uterus is not uncommonly encountered by gynecologist. Clinical and histological studies were carried on both entdometria and ovaries of 24 patients with myoma of the uterus. Specific attention was paid to clarify the bleeding mechanism from this diease, using histological and transparently modeled specimens of the blood vessels. The transparent specimens were made as follows. After hysterectomy was done, a pigment solution was injected into the vessels and then, after an adequate dehydration, the specimens were trausferred to methylsalcilate for immersion. The binocular stereomicroscope was used for the present study. Results of the study are summarized in the following. 1) Menstrual abnormality was found in 70,9% of all the cases. 2) The endometrial and ovarian histology has the same cyclic changes as the normal does, and the endometrial secretory phase is compatible with the corpus luteam in the ovary. 3) The majority of cases showed endometrial hyperplasia. 4) In case of submucous myomata, a striking difference of the endometrial thickness and the histologic pictures between the surface endometria above the myomata and the other areas. 5) The blood vessels of myomatous endometria have the same cycle as those of the normal do. Although the intramuscular blood vessels in influenced by the myomata mass, there is no specific morphological changes found in the endometrial blood vessels. 6) In this study, no venous sinus was observed in the endometrium. 7) It would appear that the menstrual abnormality under myoma of the uterus may be caused by the mechanical effect from the myomatous mass upon the endometrial and myometrial vessels. en-copyright= kn-copyright= en-aut-name=SeoTakashi en-aut-sei=Seo en-aut-mei=Takashi kn-aut-name=瀬尾貴 kn-aut-sei=瀬尾 kn-aut-mei=貴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=507 end-page=513 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Transaminase of Brain (I) Transaminase Activities of the Monkey and Human Brain kn-title=脳のトランスアミナーゼ 第1編 タイワンザル脳およびヒト脳におけるトランスアミナーゼ活性について en-subtitle= kn-subtitle= en-abstract=The author measured the transaminase activities of eighteen amino acids with α-keto-glutarate in a Pithecus monkey brain and in two human brains, one obtained from a man died from accident and another from a woman died of senile psychosis due to brain atrophy. 1. In the monkey brain, alanine and valine showed low activities in the cerebral cortex in comparison with other parts but γ-amino-β-hydroxybutyric acid showed a low activity. 2. In normal human brain, lower activities of valine, leucine and three ω-amino acids were showed in the cerebral cortex, which were different from the monkey and lower vertebrates. 3. The markedly atrophic cerebral cortex was more similar to the lower vertebrates than to the normal human brain in high activities of alanine, leucine, valine and γ-amino-β-hydroxybutyric acid. But an increase of activities of histidine, proline and ornithine was not similar to both of normal human and animal brain. These high activities of histidine and praline correspond unlikely to the transamination only. kn-abstract=タイワンザル脳，事故死ヒト脳の大脳皮質，大脳白質および小脳皮質，さらに高度の脳萎縮を伴い老人性痴呆にて死亡したヒト脳の大脳皮質を用い， 11種のα-アミノ酸， 3種のω-アミノ酸， 3種のヂアミノ酸，システイン酸，タウリンについて，組織のトランスアミナーゼ活性を測定した. 1. タイワンザル脳では，大脳皮質においてアラニンとバリンの活性が他部より低く，γ-アミノ酪酸とγ-アミノ-β-オキシ酪酸が高い. 2. 健常人脳では，アスパラギン酸，セリンが大脳皮質に，ヒスチジン，ロイシン，バリンが小脳皮質にて他部より高く，アラニン，フエニールアラニン，システイン酸は大脳白質において低い活性を示した. 3. タイワンザルおよび健常ヒト脳の大脳皮質では，いずれもアスパラギン酸，グリシン，フエニールアラニン，オルニチン，システイン酸の高い活性，およびアラニンの低い活性の点で他の下等動物脳と異なる. 4. 健常ヒト大脳皮質は，バリン，ロイシンおよび3種のω-アミノ酸の低い活性を以つてサルおよび下等動物と異なる. 5. 萎縮したヒト大脳皮質は，アラニン，ロイシン，バリン，γ-アミノ-β-オキシ酪酸の活性が健常ヒト大脳皮質より高く，むしろ下等動物のそれに近い.ヒスチジン，プロリン，オルニチンのグルタミン酸生成の著しい増加は健常ヒト脳および下等動物脳のいずれとも異なるが，ヒスチジンとプロリンはトランスアミナーゼ活性増加のみによるものかどうか疑わしい. en-copyright= kn-copyright= en-aut-name=OnoMasaya en-aut-sei=Ono en-aut-mei=Masaya kn-aut-name=小野昌也 kn-aut-sei=小野 kn-aut-mei=昌也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1-3 article-no= start-page=297 end-page=316 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Treatment of Malignant Tumors With Fibroblasts Inhibiting Agents Basic and Clinical Studies of Chloroquine Derivatives. (1) kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 クロロキン剤の基礎と臨床（第一報） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Followings are the results derived from the treatment of animal and human cancers with a fibroblasts inhibiting agent such as chloroquine, based on the unique idea of ours. 1). In implanted tumors of animals, the effect was noted in Bashford cancer and Brown-Pearce cancer relatively rich in connective tissue in terms of life prolongation, an inhibition of tumor growth and of decrease of liver catalase activity, an improvement of iron metabolism, an enlargement of necrotic area in histology, an inhibition of connective tissue conponents, and a decrease of acid mucopolysaccharides. A tendency for a decrease of amount and cell numbers of ascites was almost the only effect noted in Ehrlich cancer, Yoshida sarcoma, and MH 134 poor in connective tissue. 2). 75 cases of humau cancer were treated with this agent and among these 75 the effect was evaluated in 40 cases with definite histological diagnosis in respects with subjective and objective improvement. It was effective in 28 cases, resulted failure in 11 cases, and gave an obscure result in 1 case. Cases which were treated for more than 2m onths never resulted in therapeutic failure, indicating that the agent was somehow effective for all cases but those in the last stadium. In respect with organs involved, the effect was most prominent in lung cancer and urinary bladder cancer, somewhat less in gastric cancer, and often seen in carcinomatous peritonitis and many other advanced cancers. This effect was noted in a comparatively short period in terms of subjective improvement, regression in size of tumors in a number of cases, a decrease of serum lactic acid dehydrogenase, and improvement of general condition, a tendency for necrosis of tumor and an inhibition of interstitium. 3). The above results indicate that the agent is more effective for tumors rich in connective tissue and that it's secondary effect on tumors through the inhibition of interstitial connective tissue is considered as the operative mechanism of chloroquine against malignant tumors, but it's anti-inflammatory effect and generalized influence on hosts are to be taken into consideration. The agent is indicated in inoperable cases, postoperative relapse, or prior and following an operation. A search for stronger fibroblasts inhibiting agents and an evaluation of combined therapy with so called anti-cancer agents are being made and that with mitomycin C is giving a fairly promising result. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=2 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=3 ORCID= en-aut-name=AsanoKenwo en-aut-sei=Asano en-aut-mei=Kenwo kn-aut-name=浅野健夫 kn-aut-sei=浅野 kn-aut-mei=健夫 aut-affil-num=4 ORCID= en-aut-name=KageyamaHiroshi en-aut-sei=Kageyama en-aut-mei=Hiroshi kn-aut-name=影山浩 kn-aut-sei=影山 kn-aut-mei=浩 aut-affil-num=5 ORCID= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷貢一 kn-aut-sei=渋谷 kn-aut-mei=貢一 aut-affil-num=6 ORCID= en-aut-name=KotaniHidenari en-aut-sei=Kotani en-aut-mei=Hidenari kn-aut-name=小谷秀成 kn-aut-sei=小谷 kn-aut-mei=秀成 aut-affil-num=7 ORCID= en-aut-name=MatsuuraRyozo en-aut-sei=Matsuura en-aut-mei=Ryozo kn-aut-name=松浦良三 kn-aut-sei=松浦 kn-aut-mei=良三 aut-affil-num=8 ORCID= en-aut-name=TsuchidaJunichiro en-aut-sei=Tsuchida en-aut-mei=Junichiro kn-aut-name=土田潤一郎 kn-aut-sei=土田 kn-aut-mei=潤一郎 aut-affil-num=9 ORCID= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=10 ORCID= en-aut-name=HiraokaToshinobu en-aut-sei=Hiraoka en-aut-mei=Toshinobu kn-aut-name=平岡敏延 kn-aut-sei=平岡 kn-aut-mei=敏延 aut-affil-num=11 ORCID= en-aut-name=HimeiHajime en-aut-sei=Himei en-aut-mei=Hajime kn-aut-name=姫井孟 kn-aut-sei=姫井 kn-aut-mei=孟 aut-affil-num=12 ORCID= en-aut-name=MoritaniYoshiaki en-aut-sei=Moritani en-aut-mei=Yoshiaki kn-aut-name=守谷欣明 kn-aut-sei=守谷 kn-aut-mei=欣明 aut-affil-num=13 ORCID= en-aut-name=YamanaMasatoshi en-aut-sei=Yamana en-aut-mei=Masatoshi kn-aut-name=山名正俊 kn-aut-sei=山名 kn-aut-mei=正俊 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=12 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=13 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=14 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=515 end-page=520 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Transaminase of Brain (U) Effects of Psychotropic and Neurotropic Drugs on the Transaminase Activities kn-title=脳のトランスアミナーゼ 第2編 各種向精神・神経薬のダイコクネズミ脳組織トランスアミナーゼ活性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract=Effects of 18 psychotropic and 3 neurotropic drugs were measured by the author on the glutamic-aspartic transaminase (GAT) activities in the rat brain homogenates. 1. Chlorpromazine, chlopromazine sulfoxide, acetylpromazine, levomepromazine, mepazine and perphenazine inhibited GAT, while prochlorperazine showed no effect. Both of diethazine and promethazine did not effect on GAT. 2. Pipradrol and dimethylaminoethanol activated GAT, while methylphenidate showed no effect. 3. Azacyclonol, amobarbital, phenobarbital, methyprylon, glutethimide and primidone were inhibitory in acion on GAT. 4. LSD-25 inhibited to GAT and bemegride did not effect on. 5. In the effect on GAT, similarities of imipramine to the phenothiazine derived depressants, or differences of diethazine and promethazine from other phenothiazine derivatives seemed to be causad due to the resemble or different distance between two nitrogen atoms. kn-abstract=ダイコクネズミ脳homogenateを用い，グルタミン酸-アスパラギン酸トランスアミナーゼ（GAT）活性に及ぼす18種の向精神薬，および3種の向神経薬の影響を測定した. 1. フエノチアジン系向精神薬は， Prochlorperazineを除く他の6種はいずれもGAT阻害を示し，阻害作用はChlorpromazineに最も強かつた. Chlorpromazine S-oxideはChlorpromazineに比してGAT阻害作用は著しく弱い. 2種のフエノチアジン系向神経薬はGAT活性に影響をみなかつた. 2. AzacyclonolはGAT阻害を示し， LSD-25は高濃度で阻害を示したが低濃度では影響を与えなかつた. 3. 中枢刺戟剤4種のうち， PipradrolとDMAEは促進， Methylphenidateは影響なく， Tofranilは阻害を示した. 4. バルビツール酸系睡眠剤AmobarbitalとPhenobarbital，非バルビツール酸系睡眠剤MethyprylonとGlutethimideは，すべて阻害を示した.しかるにバルビツール酸拮抗剤BemegrideはGATに無影響であつた.抗てんかん剤Primidoneは阻害を示した. 5. 実験に用いた中枢抑制剤13種のうち12種が阻害を示した. 6. GATに及ぼす作用において， ImipramineとChlorpromazineの類似， DiethazineやPromethazineとChlorpromazineとの差異を，化学構造における2個のN原子間の距離の一致と相異に対応すると考えた. en-copyright= kn-copyright= en-aut-name=OnoMasaya en-aut-sei=Ono en-aut-mei=Masaya kn-aut-name=小野昌也 kn-aut-sei=小野 kn-aut-mei=昌也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=521 end-page=535 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Liver Biopsy Chapter 1. Correlations between Liver Biopsy Findings and Liver Function Tests in Infectious Hepatitis kn-title=肝生検に関する研究 第1編 流行性肝炎に於ける肝生検所見と肝機能検査成績との関係に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=35 cases of acute viral hapatitis and 60 cases of chronic hepatitis underwent needle liver biopsies, and the studies were made on the correlations between histological findings and liver function tests of these cases, and the following results were obtained. 1. In the preicteric and icteric stages of the acute viral hepatitis cases, cephalin cholesterol flocculation test, serum bilirubin and Azorubin-S excretion test presented closest correlations with histological findings of the liver. 2. In the convelescent stages of acute viral hepatitis, delayed recoveries were observed in Glisson's capsules and peripheral areas of the lobules rather than liver cells. in these cases, 63.3% of cephalin cholesterol flocculation test and Azorbin-S excretion test had mutual relations with histological pictures. 3. In the chronic hepatitis cases there was no evidence of close correlation between liver function tests and histological findings. 4. In the chronic hepatitis cases, in whom pseudolobules were formed histologically, hyperbilirubinemia, various serum colloid liver function tests and pigment excretion tests were all positive. 5. In the hepatitis type II (H. Eppinger) cases, a dissociation was observed between liver function tests and histological findings despite severe icterus and advanced impairment of the liver cells. en-copyright= kn-copyright= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=537 end-page=544 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Liver Biopsy Chapter 2. Studies on Bilifustin like Substance in the Liver and its Entity kn-title=肝生検に関する研究 第2編 肝臓内Bilifuscin様物質の検出とその本態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A cases thought to be a I. N. Dubin & F, B. Johson's constitutional hemolytic icterus, a case with carcinoma of the stomach and a case with posthepatitic syndrome were described in this study. In the latter two cases, brown colored granules in the liver cells were noted. Studying these granules histochemically, in comparison with histochemical features of granules which were considered to bilifuscin or its analogous substance obtained following the administration of blood, verdohemoglobin and biliverdin into the subcutaneous tissues of mouse, these granules were not I. N. Dubin's lipofuscin like pigment but precipitation of bilifuscin in the liver cells stemmed from decomposition of bilirubin as results of abnormal bilirubin metabolism. en-copyright= kn-copyright= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学綿一内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=153 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassette transporter G2 (ABCG2) are known to regulate PpIX accumulation. In addition, serum enhances PpIX export by ABCG2. We investigated here whether and how inhibitors of FECH and ABCG2 and their combination could improve PpIX accumulation and PDT efficacy in an oral cancer cell line in serum-containing medium. ABCG2 inhibitor and the combination of ABCG2 and FECH inhibitors increased PpIX in the presence of fetal bovine serum (FBS) in an oral cancer cell line. Analysis of ABCG2 gene silencing also revealed the involvement of ABCG2 in the regulation of PpIX accumulation. Inhibitors of FECH and ABCG2, and their combination increased the efficiency of ALA-PDT even in the presence of FBS. ALA-PDT-induced cell death was accompanied by apoptotic events and lipid peroxidation. These results suggest that accumulation of PpIX is determined by the activities of ABCG2 and FECH and that treatment with a combination of their inhibitors improves the efficacy of PDT for oral cancer, especially in the presence of serum. en-copyright= kn-copyright= en-aut-name=YamamotoMasanao en-aut-sei=Yamamoto en-aut-mei=Masanao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujitaHirofumi en-aut-sei=Fujita en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KataseNaoki en-aut-sei=Katase en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=InoueKeiji en-aut-sei=Inoue en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NagatsukaHitoshi en-aut-sei=Nagatsuka en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UtsumiKozo en-aut-sei=Utsumi en-aut-mei=Kozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SasakiJunzo en-aut-sei=Sasaki en-aut-mei=Junzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhuchiHideyo en-aut-sei=Ohuchi en-aut-mei=Hideyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Oral Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Urology, Kochi University Medical School affil-num=5 en-affil= kn-affil=Department of Oral Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=5-aminolevulinic acid kn-keyword=5-aminolevulinic acid en-keyword=protoporphyrin IX kn-keyword=protoporphyrin IX en-keyword=oncology kn-keyword=oncology en-keyword=photodynamic therapy kn-keyword=photodynamic therapy en-keyword=apoptosis kn-keyword=apoptosis END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=545 end-page=552 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis Part 1. On the Histological Changes of the Internal Organs of Mouse Following the Oral Administrations of the Various Concentrations of Arsenious Acid kn-title=実験的肝炎の組織学的研究 第1編 種々な濃度の亜砒酸を経口投与した場合の体内諸臓器の組織学的変化に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the histological changes of the internal organs of mouse following the oral administrations of 0.5 cc of arsenious acid in various concentrations, and the following results were obtained. 1. In the cases given 0.5 and 1.0% of arsenious acid orally, marked degenerations of the parenchymal cells ware observed mainly in the kidney and heart. But, vascular damages were present in every organ, especially evident in the liver and spleen; hypertrophy of stelliform cells, destruction, dilatation, hyperemia, swelling and roughness of the vascular walls. 2. In the cases given daily 0.05% arsenious acid orally, increased degenerations of the parenchymal cells in the kidney and heart, comparing with initial stadium, was noted. But, the similar vascular damages were observed in the organs especially in the liver and spleen. Moreover, the lymphatic spaces have been dilated progressively, and some serous exudates was seen in the lymphatic spaces of the liver on the 6 th day. 3. In the cases given daily 0.05% arsenious acid orally. nodules accompanied with diffuse infiltration of round cells were observed on the 6 th day. On the 7 th to 8 th day, there appeared coagulation necrosis in which central areas were almost full of polymorphnucleous leucocytes, stelliform cells and degenerative products from the liver cells. Small necrosis composed of lymphocytes and stelliform cells was seen on the 9 th to 10 th days. 4. As the histological changes of the mouse organs described above, were quite similar to those of the infectious hepatitis cases, this study would offer some suggestions to clarify the contributing factors in the pathology of infectious hepatitis. en-copyright= kn-copyright= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=553 end-page=560 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis Part 2. On the Histological Changes of the Internal Organs of Mouse Given Daily Small Dosis of Arsenious Acid Orally, with Ectromelia virus Infection kn-title=実験的肝炎の組織学的研究 第2編 亜砒酸少量連日投与廿日鼠にEetromelia virusを感染させた場合の体内諸臓器の組織学的変化について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the histological changes of the internal organs of the mice, having daily oral administrations of arsenious acid and simultaneous oral infection of Ectromelia virus and of the mice infected Ectromelia virus 4 days after the beginning of the arsenious acid administration, in compared with those that had daily arsenious acid without the infection, and the following results were obtained. 1. In the cases had the continuous administration of arsenious acid administration, in compared with those that had daily arsenious acid without the infection, and the following results were obtained. In the liver of the same cases, degeneration and necrosis of the liver cells and nuclei were marked, on the other hand, regenerations of the liver cells in association with round cell infiltrations were noted. There were extensive parenchimal impairments in the kideny and heart as well. 2. In the cases with Ectromelia virus infection on the 4 th day after the beginning of the arsenious acid administration, much severe vascular damages, and degenerations and necrosis of the liver parenchyma especially marked in the peripheral areas of the lobules were observed There were more extensive parenchymal imparments in the kidney and heart. 3. The cases with both Ectromelia virus infection and the administration of the arsenic acid presented the pathological findings summed up both of damages but especially marked in the vascular regions. In the cases with viral infection following the arsenious acid intoxication, the vascular damages due to the intoxication gave some influences upon the further pathological changes. 4. The vascular damages caused by the arsenious acid intoxication appeared to be essentially similar to those of Ectromelia virus infections. en-copyright= kn-copyright= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=561 end-page=567 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukocyte Functions in Case of Liver Impairment Part 1. Motility and Phagocytosis of Leukocyte in Experimental Liver Impairment kn-title=肝障碍時に於ける白血球機能に関する研究 第1編 肝炎患者の白血球遊走速度並びに墨粒貪喰能に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing leukocyte motility and leukocyte phagocytosis of Indiaink on the infectious hepatitis cases, and the following results were obtained. 1. In the healthy individuals, the leukocyte motility was ranging over 22.05 to 35.71 μ/min. and 1.88 to 2.22 in the leukocyte phagocytosis of India-ink. 2. In the acute hepatitis cases, the leukocyte motility was depressed initially and was then accelated in the convalescent stadium. Leukocyte phagocytosis of India-ink showed similar tendencies although they were fairly variable in the clinical courses. 3. The both functions of leukocyte showed approximate correlations to the impairments of liver functions. 4. In the acute hepatitis cases, the both functions of leukocyte were depressed in almost parallel with fever and leukocytosis. 5. In the chronic hepatitis cases, the leukocyte motility was within normal range, however, the phagocytosis of India-ink was depressed in some cases. The leukocyte motility showed approximate correlation to the impairments of liver function, on the other hand, the phagocytosis of India-ink did not always showed such correlation. en-copyright= kn-copyright= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=317 end-page=329 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli, Catalase-Activity and Virulence Part T Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli kn-title=INH耐性結核菌の耐性低下ならびにcatalase活性と毒力に関する研究 第1編 INH耐性結核菌の耐性低下に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to bring light to the mechanism of weakening of resistance to INH, the author cultured several generations of a perfect INH-resistant single colony of bacilli, conducted experiments on several generations of mixed population, further cultured generations of bacilli in a poorly fed culture medium and studied the change of population and thoroughly examined the factor in culture medium which has effects on the weakening of resistance. The results of the experiments observed were as follows: 1. No weakening of resistance could be observed in INH 10γ resistant strains obtained by one step, step by step cultured or by direct separation from patient if strains have been cultured in 1% KH(2)PO(4) medium. 2. No weakening of resistance could be observed by testing generations of strains, some of which were obtained by step by step culture and some by means of separation from patient, in a poorly fed culture medium. 3. According to the method of mixed population, the ratio of INH resistant bacilli contained therein decreased as generation of bacilli cultured in a 1% KH(2)PO(4) medium descends. 4. The ratio of INH resistant bacilli in mixed population cultured in a poorly fed medium rapidly decreased as generation descends compared to corresponding generation of bacilli cultured in 1% KH(2)PO(4) medium. However, the difference in viability between INH resistant bacilli and INH receptive bacilli cultured in a poorly fed medium could not be observed clearly. Neither could any mutagenic effect on the INH resistance of bacilli on a poorly fed culture medium be found. 5. Upon finding the rapid weakening of the resistance of INH resistant bacilli cultured in a poorly medium, the author prepared a glycerine lacking medium and also a sodium glutamine lacking medium and conducted experiments on generations of bacilli cultured in such mediums to determine the factors in the medium which cause the weakening. The author found that in the former case (glycerine lacking medium) weakening is delayed whereas in the latter case weakening process is observed promptly. It is presumed that INH resistant bacilli requires glutamic acid far more than INH receptive bacilli and that for that reason the growth of bacilli in a sodium glutamine lacking medium is delayed. en-copyright= kn-copyright= en-aut-name=NakataniAkira en-aut-sei=Nakatani en-aut-mei=Akira kn-aut-name=中谷照 kn-aut-sei=中谷 kn-aut-mei=照 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=569 end-page=579 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukocyte Functions in Case of Liver Impairment Part 2. Leukocyte Motility and Leukocyte Phagocytosis of Indiaink in Experimental Liver Impairment kn-title=肝障碍時に於ける白血球機能に関する研究 第2編 実験的肝障碍時の白血球遊走速度並びに墨粒貪喰能に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing leukocyte motility and leukocyte phagocytosis of India-ink in the two groups of cases, the one of the which had formic acid allyl for only once and the other had daily small dosis, and studying the effect to the motility and phagocytosis of leukocyte of various drugs for infectious hepatitis, and the following results were obtained. 1. Following the administration of formic acid allyl (30 mg/kg), the leukocyte motility was accelated within one hour and thereafter depressed abruptly. On the other hand, the phagocytosis of Indiaink have dicreased after giving formic acid allyl. Both functions of leukocyte depressed markedly in the cases given increased formic acid allyl up to 50 mg/kg. 2. Following the administration of formic acid allyl, no effect to the both functions by giving Cortisone, unclear by DOCA, and an accelation and regaining of the both fnnctions were noted by giving ACTH. Regaining of the motility, not of the phagocytosis, from depressed state and further accelation were observed following the administration of 5% dextrose in water. Ferric chlorophyll preparations had the leukocyte motility regained from depressed state following the administration of formic acid allyl of 30 mg/kg, but no effect was seen after 50 mg/kg of formic acid allyl. There was no effect by ferric chlorophyll. Glucuronic acid showed a transient effect do leukocyte motility, but not to the phagocytosis of India-ink. 3. The both functions of leukocyte have markedly depressed, the maximum at 9th day in the cases who had been having formic acid allyl 10 mg/kg for 4 days. 4. In the above cases a slight improvement to the both functions of leukocyte was seen by giving Cortisone or DOCA, a distinctive improvement, on the other hand, by ACTH. 5% dextrose in water was effective only for leukocyte motility, and ferric chlorophyll demonstrated a slight effect for the both functions and so did glucuronic acid although transient for the phaocytsois. en-copyright= kn-copyright= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=581 end-page=586 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spectrochemical Studies on Bile Pigment. Part 1. Spectrochemical Studies on the Pigments in Urine, Especially on the Bile Pigment kn-title=胆汁色素の分光化学的研究 第1編 尿色素特にその胆汁色素の分光化学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. The absorption spectra of urobilin, bilirubin, uroerythrin, urochrom A and urochrom B were determined after separating them from urine. 2. In the absorption spectra using some solvents, there were other absorption spectra which were specific to the solvents and unspecific to the solutes. The mechanism of these absorption spectra was clarified. 3. Besides urochrom, uroerythrin had the most contributing factor to the color of urine, on the other hand urobilin and bilirubin were displaying very little rolls. en-copyright= kn-copyright= en-aut-name=HizutaTuguo en-aut-sei=Hizuta en-aut-mei=Tuguo kn-aut-name=日伝二雄 kn-aut-sei=日伝 kn-aut-mei=二雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=587 end-page=591 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spectrochemical Studies on Bile Pigment Part 2. Spectrochemical Features of Biliverdin, Bilirubin and of their Decomposition Pigments kn-title=胆汁色素の分光化学的研究 第2編 Biliverdin, Bilirubin及びその分解によつて生ずる各種色素の分光化学的諸性状について en-subtitle= kn-subtitle= en-abstract= kn-abstract=After clarifying the spectrochemical features of biliverdin and bilirubin, absorption spectral analyses of their oxidative decompositions, absorption spectral analyses of their oxidative decompositions, following chromatographic fractions, were performed, and the following results were obtained. 1. As biliverdin was unstable chemically, accessory products were easily formed by washing bilirubin with water. 2. Choletelin, propentdyopent urochron etc, were proved, following the oxidation of biliverdin, 3. A blue colored chemically unstable substance was present after the oxidation of bilirubin, at wihch time the formations of biliverdin, propentdyopent and urochrom were proved in the absorption spectra. en-copyright= kn-copyright= en-aut-name=HizutaTuguo en-aut-sei=Hizuta en-aut-mei=Tuguo kn-aut-name=日伝二雄 kn-aut-sei=日伝 kn-aut-mei=二雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=593 end-page=600 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Serological Reactions in Infectious Hepatitis Part 1. Studies on Auto-Liver-Antibody by Means of Colloidion Agglutination Reaction kn-title=肝炎の血清反応に関する研究 第1編 コロジウム凝集反応による肝自己抗体の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the significance of serological diagnosis of auto-liver-antibody by means of collodion agglutination reaction, and also observing the production of the antibody following a few experimental liver impairments, the following results were obtained. 1. Positive titers of agglutination was determined as 128 times since the majority of the collodion agglutination reactions in the healthy individuals as well as in the cases of extrahepatic diseases, demonstrated below 128 times. 2. The positive titers of agglutination were noted in 73.9% on investigating the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction. 3. Observing the alteration of the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction and complement fixation reaction, it was noted that the collodion agglutination was more sensitive and that there were relatively high positive titers of the antibody in the acute stages (the second and third week) as well as in the chronic stages. 4. In the mutual relations between the quantities of the auto-liver-antibody detected by the agglutination reaction, the various clinical pictures and the laboratory data of infectious hepatitis, the reactive positive titer of agglutination have increased in proportion to serum colloid liver function tests, serum bilirubin (over 1 to 2 mg. %), positive urine urobilinogen reaction, and to hepato-splenomegalia. No evident correlation was noted between the reactive positive titers of agglutinations and the hemograms of infectious hepatitis, but in the group of the positive reaction fairy numbers of the cases with lymphocytosis and monocytosis were seen, compared with the group of negative ones. 5. Detecting the auto-liver-antibody by means of the collodion agglutination reaction have reflected the clinical pictures fairly well and would be a effective means for clarify the pathophysiology of hepatic diseases. 6. For the purpose of the investigation regarding the production of the auto-liver-antibody in case of aseptic liver impairment, experiments were performed such as aseptic squeezing, cauterization and ligation of the common bile duct. In these experiments, a production of the auto-liver-antibody was confirmed, in relatively early stages, by means of the collodion agglutination reaction. en-copyright= kn-copyright= en-aut-name=HinoMasuo en-aut-sei=Hino en-aut-mei=Masuo kn-aut-name=日野益雄 kn-aut-sei=日野 kn-aut-mei=益雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=601 end-page=607 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Serological Reactions in Infectious Hepatitis Part 2. Studies on Hetero-Erythrocyte Agglutination Reaction in Infectious Hepatitis kn-title=肝炎の血清反応に関する研究 第2編 流行性肝炎における異種赤血球凝集反応に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing erythrocyte agglutination reaction mainly in infectious hepatitis and with considerations of the correlation between sheep and rabbit erythrocyte agglutination and of absorption test, the following results were obtained. 1. In infectious hepatitis, the agglutination titer for rabbit erythrocyte agglutination reaction exhibited fairly high value and appeared to be almost paralled with that for sheep erythrocyte agglutination reaction. In this experiment, however, it seemed to be difficult to argue on the presence of Forssman-antibody. 2. The erythrocyte agglutination reaction with trypsin modified sheep erythrocytes showed fairly high titers in infectious hepatitis and even in other diseases compared with the agglutination titers for sheep erythrocyte agglutination reaction (Paul-Bunnell reaction). But, the alteration of these titers were approximately in proportion to those of Paul-Bunnell reaction. 3. In the absorption test of the sheep erythrocyte agglutination reaction in infectious hepatitis, the absorptions for boiled guinea pig kidney, guinea pig liver, bovine and sheep erythrocyte were quite variable and irregular. But, in a fairly number of cases of infectious hepatitis, moderately increased absorptions for guinea pig kidney and bovine erythrocytes were observed. In view of the alteration of the absorptions, during the periods of infections, the difference of the nature of the antibodies in infectious hepatitis and normal sera was predicted. en-copyright= kn-copyright= en-aut-name=HinoMasuo en-aut-sei=Hino en-aut-mei=Masuo kn-aut-name=日野益雄 kn-aut-sei=日野 kn-aut-mei=益雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=331 end-page=339 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli, Catalase-Activity and Virulence Part U Study on Weakening of INH Resistance under the Influence of Sulfa Drugs kn-title=INH耐性結核菌の耐性低下ならびにcatalase活性と毒力に関する研究 第2編 サルフア剤影響下のINH耐性低下に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to make clear the mechanism of how the INH　resistance weakens under the influence of sulfa drugs, the author conducted experiments by using the method of mixed population and also tested the susceptibility of INH resistant bacilli and INH receptive bacilli to sulfa drugs and their gaining of resistance against sulfa drgus. By such experiments, the author obtained the following　results. 1. In the case of studying the clone of a perfect INH resistant strain for generations cultured in a SI-added culture medium, the author observed no weakening of the resistance. 2. Rapid weakening of INH resistance was found in the bacilli cultured in a SI-added medium for generations by use of the method of mixed population.　Assuming that this phenomenon of weakening might be attributable to the difference between the susceptibility of INH resistant bacilli to SI and that of INH receptive bacilli to SI, the author further examined but was unable to find any bacterioseptic action in either bacilli by adding 500γ of SI. As regards bacteriostatic action, no difference was observed in the case of small inoculation of bacilli. In the case of massive inoculation of bacilli difference of some measure appeared. The results of the experiments seem to indicate that, although there is no difference in the susceptibility itself between INH　resistant bacilli and INH receptive bacilli to SI, SI had delicate effects in delaying the growth of INH resistant bacilli. 3. The author studied the bacteriostatic action of long acting sulfa drugs such SD, SIM, SP and SMP and found that the action of SD and SIM was most violent,　about twice as much as that of SI. The bacteriostatic　action of SP was a little milder than that of SD and SIM and that of SMP most mild. As regards the bacteriostatic action of long acting sulfa drugs such as the ones quoted in the above on INH resistant bacilli and INH receptive bacilli, no significant difference could be found. 4. No difference was observed in the process of gaining resistance against SI between INH resistant bacilli and receptive bacilli. The resistance of neither bacilli　increased beyond 125γ. en-copyright= kn-copyright= en-aut-name=NakataniAkira en-aut-sei=Nakatani en-aut-mei=Akira kn-aut-name=中谷照 kn-aut-sei=中谷 kn-aut-mei=照 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=645 end-page=651 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Mechanism of Bile Pigment Formation in vivo Part 1. On the Mechanism of Bile Pigment Formation in the Liver of Rabbit kn-title=生体内胆汁色素生成過程に関する研究 第1編 家兎肝臓内胆汁色素生成機序について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Irrigation experiments were performed on the liver of rabbit determining bilirubin and biliverdin in the bile and irrigating solution, and the following results were obtained. 1. Upon irrigation with hemoglobin added blood, bilirubin was not detected from the irrigating solution, however, the excretion of biliverdin and indirect bilirubin resulted from decomposition of hemoglobin, was observed. It is hard to determin whether these biliverdin and indirect bilirubin really stemmed from hemoglobin or from hemolysis during the irrigation. The reticuloendothelial system in the liver and liver cells played important roles in the formation of biliverdin and indirect bilirubin from hemoglobin. 2. Upon irrigation with verdohemochrome added blood, the verdohemochrome was easily decomposed into biliverdin and bilirubin. They were excreted into the bile, and reticuloendothelial system and liver cells would be involved in these depositions. 3. Upon irrigation with biliverdin added blood, over a half of the biliverdin was excreted into the bile. The excreting biliverdin was found to be two forms, the one was biliverdin without any change and the other was bilirubin deoxidized from biliverdin. In the cases with impairment of reticuloendothelial system and/or of liver cells, the excretions of these pigments were rather accelated. The process of the deoxidization of biliverdin into bilirubin took place not only in reticuloendothelial system but even after the excretion from the liver into the bile ducts. 4. In the mechanism of bile pigment formation, not only the reticuloendothelial system played an important role but the liver cells did. en-copyright= kn-copyright= en-aut-name=AkagiKaoru en-aut-sei=Akagi en-aut-mei=Kaoru kn-aut-name=赤木香 kn-aut-sei=赤木 kn-aut-mei=香 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=341 end-page=353 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli, Catalase-Activity and Virulence Part V Study on Catalase Activity and Virulence of INH Resistant Bacilli kn-title=INH耐性結核菌の耐性低下ならびにcatalase活性と毒力に関する研究 第3編 INH耐性結核菌のcatalase活性と毒力に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to see the relation between the catalase activity and virulence of INH resistant bacilli, the author studied the clone of INH resistant bacilli in vitro, looked into its catalase activity and the change of activity as generation descends and tested the virulence by inoculating guinea pigs with each generation of the bacilli. The results found were as follows: 1. The INH resistance bacilli obtained in one step was found to have a resistance potential of 0.05γ or more and to have lost its catalase activity. At this stage the selectivity of INH resistant bacilli which has a resistance of 0.05γ-10γ and the population composition of each group were similar. Therefore it is believed that the metabolic system of INH resistant bacilli made available by means of selection by use of drugs is different from that of receptive bacilli, and that the loss of catalase activity is attributable to this difference. 2. It was found that the negative catalase activity of INH 10γ resistant strains using the clone can be changed to positive by changing the conditions of the culture medium. Other multiple resistant strains which have the INH resistance are all C (-) and could not be changed to C (+) by changing the conditions of the culture medium. Therefore it is presumed that there is greater difference in the metabolic system between a single resistance strain which resists only INH and multiple resistance strain which resists not only INH. 3. A H(2)O(2) resistance test was given in respect of C (-) INH resistant bacilli and INH resistant bacilli the catalase activity of which had been changed from negative to positive and found that the resistance of both bacilli weakens compared to that of receptive bacilli and also that even the catalase activity of INH resistant bacilli changed from negative to positive is far weaker than that of receptive bacilli. 4. The author tested the virulence of C (-) INH resistant bacilli and INH resistant bacilli the catalase of which changed from negative to positive on guinea pigs, and found that the virulence of both had weakened. The author also tested virulence of each generation of cultured bacilli and found that it had lost its virulence. Juding from the results of the tests, it appears that the weakening of the virulence of INH resistant bacilli is an inherent property of the bacilli itself. However, the results of the H(2)O(2) resistance tests seem to indicate that the relation between the virulence and catalase cannot be completely denied. Further the author inoculated guinea pigs with C (-) INH resistant bacilli and some with C (+) INH resistant bacilli and separated them into two groups, one group killed at 3rd week and the other group killed at 8th week after the inoculation and found many cases of local disorder in the group killed at 3rd week irrespective of the kind of catalase, which led to believe that the disorder of guinea pigs attributable to INH resistant bacilli is reversible. en-copyright= kn-copyright= en-aut-name=NakataniAkira en-aut-sei=Nakatani en-aut-mei=Akira kn-aut-name=中谷照 kn-aut-sei=中谷 kn-aut-mei=照 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=653 end-page=662 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Mechanism of Bile Pigment Formation in Vivo Part 2. Studies on the Bile Pigment in the Bile following the Administration of the Decompositions of Hemeglobin kn-title=生体内胆汁色素生成過程に関する研究 第2編 血色素分解産物負荷による胆汁中胆汁色素の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the formation process of the bile pigment in vivo with reference to the vicisitude of the bile pigment in the bile following the administration of the docompositions of hemoglobin into the portal vein of the rabbit with artificial biliary fistula. And the following results were obtained. 1. Following the administration of saline into the portal vein, production of the bile pigment in the liver was transiently depressed and then increased because of choleretic action of saline. 2. Following the administration of verdohemochrome solution, which was decomposed into biliverdin and, in part, was deoxidized to bilirubin. verdohemochrome was excreted in the healthy cases. The decomposition process was prolonged or less in the cases with blocked reticuloendothelial systems, and little decomposition was observed in the cases with liver impairments. 3. Following the administration of biliverdin solution to the healthy cases, the majority of biliverdin was excreted unchanged but part of it was deoxidized to bilirubin. There was no such evidence in the cases with blocked reticuloendothelial system and was very slight degree in the cases with liver impairment. In consequence, the deoxidation of biliverdin was presumably due to reticuloendothelial system. However, in the cases with blocked reticuloendothelial system or liver impairment, it was supposed that biliverdin was excreted from the liver and easily deoxidized into bilirubin. en-copyright= kn-copyright= en-aut-name=AkagiKaoru en-aut-sei=Akagi en-aut-mei=Kaoru kn-aut-name=赤木香 kn-aut-sei=赤木 kn-aut-mei=香 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=663 end-page=670 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Particular Environmental Influences to a Feu Components of Blood in Mountainous Farm Village Part 1. Serum Protein Fractions in Various Conditions kn-title=農山村の特種環境が血液中二,三の成分に及ぼす影響に関する研究 第1編 各種条件下における血清蛋白像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the influences of particular envireronment in the mountainous farm village of Hokuriku-district to serum protein fractions, and the following results were obtained. 1. In the farming seasons, in contrast to the leisure seasons for farmers, a slight decrease in total serum protein and a relative increase in α1, α2 and β-globulin were noted. 2. In the cases of malnutrition, seen during the farming seasons, a decrease in total serum protein, especially in albumin fraction, and a relative increase in α1, α2 and β-globulin were noted. 3. The changes of the serum proteins during the farming seasons were rather due to poor nutrition and fatigue than seasonable climates. 4. In the cases of pulmonary tuberculosis, increased total protein, decreased albumin and increased α1, α2 and γ-globulin were noted in the severe cases, on the other hand, in the mild or convalescent cases, a slight increase of γ-globulin was observed. 5. In the group of essential hypertension, a decrease in albumin and an increase in α1 and β-globulin were noted only in the severe cases with complications. 6. In the cases of angina pectoris with coronary insufficiency, a slight decrease in albumin and a slight increase in γ-globulin were seen, however, these changes were disappeared in the convalescent stages. In the cases of myocardial infarction, a slight decrease in total serum protein, a marked decrease in albumin and a slight increase in β and especially γ-globulin were observed. 7. In the cases of valvular heart diseases, a decrease in albumin and an increase in γ-globulin in the compensated phase, and in the decompensated phase these tendencies have become evident. 8. In the cases of stomach cancer especially of its terminal stage, a marked decrease in total serum protein, especially in albumin, and a moderate increase in γ, and a relative increase in α1, α2 and β globulin were noted. 9. In the cases of peptic ulcer, gastric and duodenal, a decrease in albumin and an increase in α1, and α2 globulin were observed. 10. In the pregnant females, no changes in serum protein fractions by 5 th month but thereafter a slight increase in α1, α2 and β-globuin and an increase in albumin were noted. These changes were evident especially in the cases of hyperemesis. en-copyright= kn-copyright= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=671 end-page=676 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Particular Environmental Influences to a Few Components of Blood in Mountainous Farm Village Part 2. Alteration of Serum Electrolytes, Especially of Calcium, in Various Conditions kn-title=農山村の特種環境が血液中二，三の成分に及ぼす影響に関する研究 第2編 各種条件下における血液無機物質特にカルシウム量の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the influences of particular environment in the mountainous farm village of Okunoto-district to serum electrolytes, especially to calcium, and the following results were obtained. 1. Serum calcium in the healthy farmers including both sexes demonstrated gradual alteration throughout the year with the minimum peak at May and June. 2. Serum electrolytes of the healthy male and female farmers were determined in both farming and leisure seasons for farmers. In the farming seasons, serum calcium was evidently decreased in both sexes compared with the leisure seasons for farmers, and, contrariwise, potassium was increased, and sodium was almost unchanged or slightly increased during the farming seasons. 3. It was supposed that such decrease in serum calcium during the farming seasons was not due to the influence of ultraviolet ray but to poor calcium intake by their eating habits and to fatigue as a result of the particular condition, the farming seasons. 4. In the control group of the healthy individuals other than farmers, serum calcium demonstrated almost no change throughout the year except for a very slight decrease during the periods of April, May and June. 5. In the school children, a decrease in serum calcium was noted during the winter time when ultraviolet rays were diminished. This indicated the fact that many babies suffering from rickets in this district. Such tendencies were also seen in the pregnant females. 6. A decrease in serum calcium due to diminution of ultraviolet rays were observed not only in the babies but in the school children and pregnant females except for the adults in good health. 7. A marked restoration of serum calcium level was noted 2 months after the administration of vitamin D and ultraviolet rays as a treatment of rickets. en-copyright= kn-copyright= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=165 end-page=170 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=p53 Expression in Pretreatment Specimen Predicts Response to Neoadjuvant Chemotherapy Including Anthracycline and Taxane in Patients with Primary Breast Cancer. en-subtitle= kn-subtitle= en-abstract= kn-abstract=While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC. en-copyright= kn-copyright= en-aut-name=ShienTadahiko en-aut-sei=Shien en-aut-mei=Tadahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KinoshitaTakayuki en-aut-sei=Kinoshita en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SekiKunihiko en-aut-sei=Seki en-aut-mei=Kunihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshidaMiwa en-aut-sei=Yoshida en-aut-mei=Miwa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HojoTakashi en-aut-sei=Hojo en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShimizuChikako en-aut-sei=Shimizu en-aut-mei=Chikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TairaNaruto en-aut-sei=Taira en-aut-mei=Naruto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=DoiharaHiroyoshi en-aut-sei=Doihara en-aut-mei=Hiroyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=Akashi-TanakaSadako en-aut-sei=Akashi-Tanaka en-aut-mei=Sadako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsudaHitoshi en-aut-sei=Tsuda en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujiwaraYasuhiro en-aut-sei=Fujiwara en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital affil-num=2 en-affil= kn-affil=Department of Surgical Oncology, National Cancer Center Hospital affil-num=3 en-affil= kn-affil=Department of Pathology, National Cancer Center Hospital affil-num=4 en-affil= kn-affil=Department of Surgical Oncology, National Cancer Center Hospital affil-num=5 en-affil= kn-affil=Department of Surgical Oncology, National Cancer Center Hospital affil-num=6 en-affil= kn-affil=Department of Medical Oncology, National Cancer Center Hospital affil-num=7 en-affil= kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital affil-num=8 en-affil= kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital affil-num=9 en-affil= kn-affil=Department of Surgical Oncology, National Cancer Center Hospital affil-num=10 en-affil= kn-affil=Department of Pathology, National Cancer Center Hospital affil-num=11 en-affil= kn-affil=Department of Medical Oncology, National Cancer Center Hospital en-keyword=breast cancer kn-keyword=breast cancer en-keyword=neoadjuvant chemotherapy kn-keyword=neoadjuvant chemotherapy en-keyword=predictors kn-keyword=predictors END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=171 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Application of a First Impression Triage in the Japan Railway West Disaster en-subtitle= kn-subtitle= en-abstract= kn-abstract=On April 25, 2005, a Japanese express train derailed into a building, resulting in 107 deaths and 549 injuries. We used “First Impression Triage (FIT)”, our new triage strategy based on general inspection and palpation without counting pulse/respiratory rates, and determined the feasibility of FIT in the chaotic situation of treating a large number of injured people in a brief time period. The subjects included 39 patients who required hospitalization among 113 victims transferred to our hospital. After initial assessment with FIT by an emergency physician, patients were retrospectively reassessed with the preexisting the modified Simple Triage and Rapid Treatment (START) methodology, based on Injury Severity Score, probability of survival, and ICU stay. FIT resulted in shorter waiting time for triage. FIT designations comprised 11 red (immediate), 28 yellow (delayed), while START assigned six to red and 32 to yellow. There were no statistical differences between FIT and START in the accuracy rate calculated by means of probability of survival and ICU stay. Overall validity and reliability of FIT determined by outcome assessment were similar to those of START. FIT would be a simple and accurate technique to quickly triage a large number of patients. en-copyright= kn-copyright= en-aut-name=HashimotoAtsunori en-aut-sei=Hashimoto en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UedaTakahiro en-aut-sei=Ueda en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KuboyamaKazutoshi en-aut-sei=Kuboyama en-aut-mei=Kazutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaTaihei en-aut-sei=Yamada en-aut-mei=Taihei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TerashimaMariko en-aut-sei=Terashima en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyawakiAtsushi en-aut-sei=Miyawaki en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KotaniJoji en-aut-sei=Kotani en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine affil-num=2 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine affil-num=3 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine affil-num=4 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine affil-num=5 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine affil-num=6 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine affil-num=7 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine affil-num=8 en-affil= kn-affil=Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine en-keyword=simple triage and rapid treatment kn-keyword=simple triage and rapid treatment en-keyword=injury severity score kn-keyword=injury severity score en-keyword=probability of survival kn-keyword=probability of survival END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=677 end-page=694 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Nucleic Acid Metabolism in Pulmonary Tuberculosis Part 1. Uric acid Metabolism and the Effects of Vitamin B(12) and Folic Acid kn-title=肺結核症の核酸代謝に関する研究 第1編 肺結核症の尿酸代謝並びにこれに及ぼすビタミンB(12)及び葉酸の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the amount of uric acid excretion into the urine in the healthy and various stages of pulmonary tuberculosis cases and studying the effects of vitamin B(12) and folic acid, and the following results were obtained. 1. An increase in the amount of uric acid excretion into the urine was noted in the cases of moderately and far advanced pulmonary tuberculosis. 2. In the healthy and postoperative cases of pulmonary tuberculosis cases, an increase, both in the concentration and the amount, of uric acid excretion into the urine was noted one hour after the administration of vitamin B(12). A slight decrease or unchanged in the amount of uric acid excretion into the urine was observed, one hour after the administration of folic acid, and an increase of it was seen in the urine after 4 hours. 3. The effects of vitamin B(12) and folic acid were less evident in the far advanced cases of pulmonary tuberculosis and rather marked in the minimal cases. 4. The same effects were observed in the cases who had the breakfast only of rice and soybean soup at the same time with the administration of vitamin B(12) or folic acid. Increased uric acid excretion into the urine was observed in the cases who had breakfast alone. 5. The effects of these vitamines were quite the same in the cases who had breakfast and vitamin B(12) or folic acid at the same time and also in the cases who had PAS-calcium later on. 6. It was supposed that vitamin B(12) and folic acid did not have an effect upon dietary purine bodies metabolism, but promote general metabolism and thus effect upon nucleic acid metabolism. Vitamin B(12) and folic acid have presumably regulated the uric acid metabolism in the cases of far advanced pulmonary tuberculosis. en-copyright= kn-copyright= en-aut-name=OhsumiMichiko en-aut-sei=Ohsumi en-aut-mei=Michiko kn-aut-name=大隅美智子 kn-aut-sei=大隅 kn-aut-mei=美智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=695 end-page=711 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Nucleic Acid Metabolism in Pulmonary Tuberculosis Part 2. Alteration of Urine Ketoenolsubstances and the Effects of Vitamin B(12) and Folic Acid kn-title=肺結核症の核酸代謝に関する研究 第2編 肺結核症の尿ケトエノール物質の消長並びにこれに及ぼすビタミンB(12)及び葉酸の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying urine ketoenolsubstances (KES) and the effects of vitamin B(12) and folic acid in the healthy and pulmonary tuberculosis cases, and the following results were obtained. 1. An increase in the urine KES was noted in the cases of moderately and far advanced pulmonary tuberculosis. 2. In the healthy and postoperative cases, the urine KES were increased from two hours after the administration of vitamin B(12), and from one hour after the administration of folic acid respectively. 3. These effects of vitamin B12 and folic acid were decreased in such order as minimal, moderately advanced and far advanced pulmonary tuberculosis. 4. Following the administration of folic acid, an increased precipitation was noted on the determination of the urine KES. This precipitation would be a source of error and might be a excretion of folic acid itself. 5. The effects of these vitamines were quite the same in the cases who had the breakfast with rice and soybean soup at the same time with the administration of vitamin B(12) or folic acid. 6. The effects of these vitamines were quite the same in the cases who had breakfast and vitamin B(12) or folic acid at the same time and also in the cases who had PAS-calcium later on. However, attention should be paid for the determination of the urine KES because of the precipitation due to PAS-calcium. 7. It was supposed that vitamin B(12) and folic acid did not have an effect upon dietary purine body metabolism, but promote general metabolisms and thus effect upon nucleic acid metabolism. Vitamin B12 and folic acid did not regulate the metabolism of KES which were excreted in the far advanced pulmonary tuberculosis cases. en-copyright= kn-copyright= en-aut-name=OhsumiMichiko en-aut-sei=Ohsumi en-aut-mei=Michiko kn-aut-name=大隅美智子 kn-aut-sei=大隅 kn-aut-mei=美智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=713 end-page=727 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 1. Influences of Splenectomy, Homoioplastic Transplantation of Spleen, and of Spleen Extract on the Erythropoietic Function of the Rabbit Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼす影響に関する実験的研究 第1編 剔脾,脾他家移植及び脾エキスが家兎骨髄造赤血球機能に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to study the influences of the spleen on the erythropoietic function of bone marrow the cell suspension culture of the rabbit bone marrow was conducted, and the following results were obtained. 1. In the bone-marrow tissue culture of splenectomized rabbits conducted from time to time the rate of the increase in the number of erythrocytes is temporarily accelerated having its peak around 4 to 7 days after the operation as compared with the control, while on the contrary, the increase in hemoglobin declines slightly. About three weeks after the operation both values of erythrocytes and hemoglobin return approximately to those in the control group, normal ones without splenectomy. 2. In the bone-marrow tissue culture of the rabbits transplanted with hemoioplastic spleenand conducted from time to time, the rate of the increase in the number of erythrocytes temporarily declines having the minimum around the fifth day after the operation and the rate of the increase in hemo-globin falls slightly around the fifth day but by around the thenth day it shows a slight acceleration, as compared with those of the control, rabbits transplanted with normal kidney. However, after about 30 days both of these values return approximately to those of the control. 3. In the observations of the bone-marrow tissue culture of normal rabbits with addition of Ringer's solutions of normal rabbit spleen extract at various concentrations, the extract at a higher concentration brings about the fall in the increasing rate of erythrocytes and hemoglobin, while on the contrary it brings about a slight acceleration in the increasing rate of both at a lower concentration. 4. From these results it is assumed that the spleen of the normal rabbit with the aid of some body-fluid agent adjusts the erythropoietic function of the bone marrow either suppressingly or acceleratingly, but from the physiological aspect the suppressing action seems to be superior: namely, an abnormal formation of the erythrocyte series is suppressed, while on the other hand the hemoglobin synthesis seems to be accelerated, thus suppressing the incomplete maturation of erythrocytes. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=355 end-page=366 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=T. Effects of Drugs on the Cerebral Blood Flow of the perfused Cat Brain kn-title=T 灌流ネコ脳循環に及ぼす諸種薬物の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of various drugs on the Cerebral Blood Flow (CBF) in the cats were investigated by the brain perfusion methode. The results were as follows. 1. Adrenaline constricted the brain vessels and decreased the C B F. 2. The CBF was decreased by the administration of Noradrenaline. 3. administration of large doses (1 mg) of Adrenaline and Noradrenaline was found to have an action on cerebral vasomotoric center, but this action was not found in small doses of these drugs. 4. Electrocorticogram was activated by the administration of large doses (over 0.1 mg) of Adrenaline and Noradrenaline, and the application of small doses (0.01 mg) of these drugs also had a tendency to activation of Electrocorticogram. 5. Papaverine exerted an augmenting effect on the CBF and dilated the brain vessels. 6. It was observed that Nicotinic Acid showed no change in CBF at small doses, however, with large doses of the drug, a slight increase of CBF occured. And Nicotinic Acid had no action on cerebral vasomotoric center. 7. The CBF was slightly increased by the application of small doses of Imidazoline, but at higher doses of the drug, the rate of increase in CBF showed diminution or no change in CBF was caused. 8. Imidazoline had no action on cerebral vasomotoric center. 9. Phenobarbital dilated the brain vessels and increased the CBF. 10. No significant changes in CBF were ovserved by the administration of Atropine. en-copyright= kn-copyright= en-aut-name=IchiyamaTakuji en-aut-sei=Ichiyama en-aut-mei=Takuji kn-aut-name=市山卓爾 kn-aut-sei=市山 kn-aut-mei=卓爾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=729 end-page=743 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 2. Influences of Spelenectomy, Homoioplastic Transplantation of Spleen, and of Spleen Extract on the Leucopoietic Function of the Rabbit Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼす影響に関する実験的研究 第2編 剔脾脾他家移植及び脾エキスが家兎骨髄白血球系造血に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the influences of spleen on the leucopoietic function of bone marrow the author performed the bone-marrow tissue culture (by cover-slip method) of rabbits, and obtained the following results. 1. In the observations on the bone-marrow tissue culture of the splenectomized rabbits conducted from time to time, the relative growth rate, the cell density index and the wandering velocity of pseudoeosinophils all show a transient acceleration with their peak around 4 to 7 days after the operation, while on the contrary the carbon particle phagocytic ability of pseudoeosinophils shows a transient fall. However, all these values return to respective levels of the control, normal rabbits without splenectomy, about 3 weeks after the operstion. 2. In the bone-marrow tissue culture of the rabbits transplanted with homoioplastic spleen conducted from time to time, the relative growth rate, the cell density index and the wandering velocity of pseudoeosinophils all show a transient fall around 5 to 10 days after the operation, but no marked change can be observed in the carbon particle phagocytic ability of pseudoeosinophils. However, all these values resurn approximately to those of the control, rabbits transplanted with normal kidney, about 30 days after the operation. 3. In the bone-marrow tissue culture of normal rabbits with addition of Ringer's solution of normal rabbit spleen extract, the extract at a higer concentration has a suppressing effect on the relative growth rate, the wandering velocity and the carbon particle phagocytic ability of pseudoeosinophils, while the extract at a lower concentration mostly gives a slightly accelerating effect. 4. From these results it seems that the spleen of normal rabbits with aid of some fluid agent adjusts the production of the leucocyte series of the bone marrow either suppressingly or acceleratingly. However, from the physiological aspect the suppressing action seems to be slightly superior and hence the over-production of the granulocyte series of the bone marrow as well as the incomplete maturation of granulocytes seem to be controled. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=745 end-page=755 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 3. Influences of Homoioplastic Transplatation of Spleen and Spleen extract on the Production of Platelet in the Guinea-pig Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼず影響に関する実験的研究 第3編 脾他家移植及び脾エキスが海?骨髄栓球系造血に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of observing the influences of the spleen on the production of the platelet in bone marrow the author performed the bone-marrow tissue culture (cover-slip method) of guinea pigs and observed the function of megakaryocytes, and obtained the follo wing results. 1. In the bone marrow tissue culture of the guinea pigs transplanted with homoioplastic spleen conducted from time to time to the megakaryocyte function, when compared with that of the control group transplanted with normal spleen, shows a marked decline transiently about 3 to 5 days after the operation, but by 20th to 30th day it shows hardly any significant difference from that of the control. 2. In the bone-marrow tissue culture of normal guinea pigs added with Ringer's solution of spleen extract of normal guinea pigs, the extract at a higher concentration brings about a fall in the megakaryocyte function whereas on the contrary at a higher concentration it accelerates the function. 3. From these results it seems that the spleen of normal guinea pigs with the aid of some fluid agent acts on the thrombopoiesis of the bone marrow interchangeably either suppressingly or acceleratingly, but from the physiological aspect the suppressing action seems to be slightly stronger. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=757 end-page=761 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Relation Between Tumor and Hormone Report 5. On the Effect of Sex Hormones on the Growth and Immunity of Tumor kn-title=腫瘍とホルモンに関する実験的研究 第5報 腫瘍免疫並びに増殖に及ぼす性ホルモンの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Formerly, concerning the relation between hormone and heterotransplantation, the author reported that, while teststerone inhibited heterotransplantation, estrogen and testectomy acceralate it. In this experiment, mice of R(3) strain were used. All mice were transplanted of mammary carcinoma from the R(3) strain of female mouse. The conclusions of this experiment are as follows; 1) Testaterone inhibited the homotransplantation and growth of tumor. 2) Estrogen and testectomy acceraiate the homotransplantation and growth of tumor. en-copyright= kn-copyright= en-aut-name=KiyamaTakashi en-aut-sei=Kiyama en-aut-mei=Takashi kn-aut-name=木山敞 kn-aut-sei=木山 kn-aut-mei=敞 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=763 end-page=779 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Disturbance in Blood Clotting Following Massive Transfusion of Preserved Blood Part I. Experimental Investigation on the Mechanism of Disturbed Blood Clotting Following Massive Transfusion of Preserved Blood kn-title=保存血大量輸血に伴う血液凝固障害に関する研究 第1編 血液凝固障害発現の成因に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Influences of operative stress, shock, anoxia and/or liver damage upon the disturbances in blood clotting following massive transfusion of preserved blood were investigated experimentally. None of coagulation factors were so disturbed to invite a hemorrhagic tendency only by one of them. Qualitative and quantitative decrease in platelets and decrease in AHG level were thought to be caused by massive preserved blood transfusion itself. Decreases in prothrombin and labile factor following preserved blood transfusion were much intensive in case of accompanying with operative stress, shock, anoxia or liver damage. It was surmized that the occurrence of fibrinolysis had an imptortant part to cause the decrease in clotting factors. en-copyright= kn-copyright= en-aut-name=ShimizuHiroshi en-aut-sei=Shimizu en-aut-mei=Hiroshi kn-aut-name=志水浩 kn-aut-sei=志水 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=367 end-page=388 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=U. Effects of Chlorpromazine on the Function and　metabolism of the Perfused Cat Brain kn-title=U Chlorpromazineの灌流ネコ脳髄に対する作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cat brain was perfused through the isolated cerebral circulation by the modified Geiger & Magnes' methode, and the effects of Chlorpromazine (CP) on cerebral blood flow (CBF), blood pressure (BP), carbohydrate metabolism and electroencephalogram (EEC) were investigated by the use of the brain perfusion methode. The results were as follows. 1) The CBF was increased by the administration of small doses of CP while no significant changes in CBF were showed with large doses of the drug, and it is suggested that this finding is explainable on the basis of inhibition of the brain metabolism caused by the dosage. 2) BP kept intact or dropped case by case with CP, and it is considered that this difference may be due to individual characteristics of the cats, doses to be applied, degrees of operation etc.. When BP dropped in the case of perfusion, it means a central vasomotoric action. BP dropped to a level on the dosage best suited to individual, morever, its central vasodilatatoric action was more persistent and not to be influenced by the subsequent administration of CP, while the direct effect on dilating the cerebral blood vessels was transient and appeared similarly by the subsequent application of CP. 4) With a small dosage of CP, a tendency toward increase of the oxygen and glucose consumption, and most remarkable increase of the lactic acid liberation were observed. On the other hand, oxygen and glucose consumption, and lactic acid liberation were all diminished by the application of large doses of CP, and particularly, both the oxygen consumption and the lactic acid liberation was markedly diminished. And at the same time, I explained a little opinion about those alterations in metabolism. 5) The changes in EEGs of neocortex, paleocortex and archicortex were observed by the administration of CP. Namely, EEG of neocortex showed slowing of frequency and increase in amplitude with CP, and in hippocampus the regularity of hippocampal regular slow waves was lost and there appeared fast waves, contrarily, amygdala showed no change after the administration of CP and low voltage fast waves from beginning to end. en-copyright= kn-copyright= en-aut-name=IchiyamaTakuji en-aut-sei=Ichiyama en-aut-mei=Takuji kn-aut-name=市山卓爾 kn-aut-sei=市山 kn-aut-mei=卓爾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=781 end-page=796 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Disturbance in Blood Clotting Following Massive Transfusion of Preserved Blood Part U. Clinical and Experimental Studies on the Prophylaxis and Therapy of Impaired Blood Clotting Following Massive Transfusion of Preserved Blood kn-title=保存血大量輸血に伴う血液凝固障害に関する研究 第2編 血液凝固障害発生の予防とその治療について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the impaired blood clotting due to massive blood transfusion prophylaxis is to be the best treatment, for measures after its occurreance are often very difficult.　As prophylactic treatment, continuous drip infusion of a large amount of hydrocortisone, alternated transfusion of fresh and preserved blood, administration of tissue thromboplastin preparation and ACTH were effective. As thrapy for hemorrhagic tendency, massive infusion of hydrocortisone, administration of tissue thromboplastin preparation, transions of fressh blood or platelets were proved to be effective. For decreased clotting factors in case fibrinolysis. intravenous ε-aminocapronic acid and hydrocortisone were efficacious to depress the fibrinolysis. en-copyright= kn-copyright= en-aut-name=ShimizuHiroshi en-aut-sei=Shimizu en-aut-mei=Hiroshi kn-aut-name=志水浩 kn-aut-sei=志水 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=797 end-page=799 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influences of γ-Amino-β-hydroxybutyric Acid (GABOB) On the Mouse Brain Water Content kn-title=脳含水量におよぼすγ-アミノ-β-ハイドロオキシ酪酸の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of GABOB on water content of CF-1 pure strain mouse cerebral cortex having artificaly increased water content in cerebral cortex and non treated one as the control were investigated, and it was clarfied that GABOB has no effect on the water content of the brain in both cases. en-copyright= kn-copyright= en-aut-name=HigashiTohru en-aut-sei=Higashi en-aut-mei=Tohru kn-aut-name=東徹 kn-aut-sei=東 kn-aut-mei=徹 aut-affil-num=1 ORCID= en-aut-name=MoriAkitane en-aut-sei=Mori en-aut-mei=Akitane kn-aut-name=森昭胤 kn-aut-sei=森 kn-aut-mei=昭胤 aut-affil-num=2 ORCID= en-aut-name=YoshikawaTamotsu en-aut-sei=Yoshikawa en-aut-mei=Tamotsu kn-aut-name=吉川全 kn-aut-sei=吉川 kn-aut-mei=全 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=177 end-page=183 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Postural Stability Changes during Large Vertical Diplopia Induced by Prism Wear in Normal Subjects en-subtitle= kn-subtitle= en-abstract= kn-abstract=To test the effect of double vision on postural stability, we measured postural stability by electric stabilometry before prism-wearing and immediately, 15, 30, and 60min after continuous prism-wearing with 6 prism diopters in total (a 3-prism-diopter prism placed with the base up in front of one eye and with the base down in front of the other eye) in 20 normal adult individuals with their eyes open or closed. Changes in stabilometric parameters in the time course of 60min were analyzed statistically by repeated-measure analysis of variance. When subjectsｾ eyes were closed, the total linear length (cm) and the unit-time length (cm/sec) of the sway path were significantly shortened during the 60-minute prism-wearing (p＜0.05). No significant change was noted in any stabilometric parameters obtained with the eyes open during the time course. In conclusion, postural stability did not change with the eyes open in the condition of large vertical diplopia, induced by prism-wearing for 60min, while the stability became better when measured with the eyes closed. A postural control mechanism other than that derived from visual input might be reinforced under abnormal visual input such as non-fusionable diplopia. en-copyright= kn-copyright= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamasakiHanako en-aut-sei=Yamasaki en-aut-mei=Hanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasuharaHirotaka en-aut-sei=Yasuhara en-aut-mei=Hirotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HasebeKayoko en-aut-sei=Hasebe en-aut-mei=Kayoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Ophthalmology, Okayama University Medical School and Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Undergraduate Course for Medicine, Okayama University Medical School affil-num=3 en-affil= kn-affil=Undergraduate Course for Medicine, Okayama University Medical School affil-num=4 en-affil= kn-affil=Department of Medical Technology, Okayama University Hospital en-keyword=body sway kn-keyword=body sway en-keyword=postural stability (postural control) kn-keyword=postural stability (postural control) en-keyword=stabilometry kn-keyword=stabilometry en-keyword=prism kn-keyword=prism en-keyword=vertical diplopia kn-keyword=vertical diplopia END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=185 end-page=190 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of Dysphagia and Trismus Developed after C1-2 Posterior Fusion in Extended Position en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cervical misalignment after upper cervical fusion including the occipital bone may cause trismus or dysphagia, because the occipito-atlanto joint is associated with most of the flex and extended motion of the cervical spine. There are no reports of dysphagia and trismus after C1-2 fusion. The purpose of this paper is to demonstrate the potential risk of dysphagia and trismus even after upper cervical short fusion without the occipital bone. The patient was a 69-year-old man with myelopathy caused by os odontoideum and Klippel-Feil syndrome, who developed dysphagia and trismus immediately after C1-2 fusion and C3-6 laminoplasty. Radiographs and CT revealed that his neck posture was extended, but his symptoms still existed a week after surgery. The fixation angle was hyperextended 12 days after the first surgery. His symptoms disappeared immediately after revision surgery. The fixation in the neck-flexed position is thought to be the main cause of the patient?s post-operative dysphagia and trismus. Dysphagia and trismus may occur even after short upper cervical fusion without the occipital bone or cervical fusion in the neck-extended position. The pre-operative cervical alignment and range of motion of each segment should be thoroughly evaluated. en-copyright= kn-copyright= en-aut-name=MisawaHaruo en-aut-sei=Misawa en-aut-mei=Haruo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugimotoYoshihisa en-aut-sei=Sugimoto en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KoshimuneKouichiro en-aut-sei=Koshimune en-aut-mei=Kouichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Kure Kyosai Hospital affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Orthopaedic Surgery, Kobe Red Cross Hospital affil-num=5 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=dysphagia kn-keyword=dysphagia en-keyword=trismus kn-keyword=trismus en-keyword=os odontoid kn-keyword=os odontoid en-keyword=Klippel-Feil syndrome kn-keyword=Klippel-Feil syndrome en-keyword=atlantoaxial posterior fusion kn-keyword=atlantoaxial posterior fusion END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=801 end-page=810 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epidemiological Observations on Infectious Hepatitis Prevailed in Okayama Prefecture kn-title=岡山県における流行性肝炎の流行に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=6246 infectious hepatitis cases treated at 25 hospitals located in Okayama Prefecture during the last six years, 1952 to 1957, were studied mainly from the epidemiological point of view, and the following results were obtained. 1) Infectious hepatitis has been prevailed all over the prefecture since the initial epidemic in 1951. As the mode of epidemic became protracted, chronic and abortive forms were prone to increase in number. The ratio of total patients to infectious hepatitis cases was 1.27 per cent. 2) Extensive infections among villagers were noted in 73 hamlets, and it was presumed that the epidemic has been prevailed over the whole prefecture taking a hamlet, village or a town as unit. Infections among family were noted in 62 families, however, fnrther detailed study in the epidemic areas might show the higher morbidity. It was not certain whether these infections were entirely family or simultaneous infections. 3) As to seasonal occurence, considerable number of cases had onset of the disease during the period of early summer to early fall. 4) As to age, it has ranged mostly from the second to third decade, rather many in children but not rare in the aged. As to sex, predominant in males in general, but considerable differences were seen among hospitals and times. No definite relationship was noted between the epidemc and sex. 5) Throughout the last six years there have been 38.7 per cent of chronic hepatitis cases. In 41.3 per cent of the whole patients presented jaundice in their clinical courses. The fact that the longer the period of the epidemic the more increase increase in anicteric cases was noted. 6) Two year's follow-up studies after the epidemic, showed 209 of relapsed cases in whom 36.4 per cent were icteric. 7) 110 cases has jaundice, which was thought to be infectious hepatitis, in the past. Some of them were presumably reinfections or superinfections but definite conclusion could not be made. 8) 20 cases of fulminant hepatitis, malignant type of infectious hepatitis, and 6 cases of protracted form were studied. 22 cases of them were fatal. Such severe hepatitis patients were seen mainly in males of the second and third decades. 9) 61 cases (0.98%) developed postnecrotic cirrhosis, and 10 cases of them were fatal. 10) Serum hepatitis was noted in 1.6 per cent of the whole patients seen in Medical Services at 18 hospitals in Okayama Prefecture during the last six years, 1952 to 1957. No definite correlation between the epidemic of infectious hepatitis and outbreak of serum hepatitis was noted. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= en-aut-name=ShimadaYoshihiro en-aut-sei=Shimada en-aut-mei=Yoshihiro kn-aut-name=島田宜浩 kn-aut-sei=島田 kn-aut-mei=宜浩 aut-affil-num=3 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=4 ORCID= en-aut-name=KawaguchiMasamitsu en-aut-sei=Kawaguchi en-aut-mei=Masamitsu kn-aut-name=川口正光 kn-aut-sei=川口 kn-aut-mei=正光 aut-affil-num=5 ORCID= en-aut-name=YamamotoShigeru en-aut-sei=Yamamoto en-aut-mei=Shigeru kn-aut-name=山本繁 kn-aut-sei=山本 kn-aut-mei=繁 aut-affil-num=6 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=7 ORCID= en-aut-name=UjikeMutsuo en-aut-sei=Ujike en-aut-mei=Mutsuo kn-aut-name=氏家睦夫 kn-aut-sei=氏家 kn-aut-mei=睦夫 aut-affil-num=8 ORCID= en-aut-name=KusakaYoshiro en-aut-sei=Kusaka en-aut-mei=Yoshiro kn-aut-name=草加芳郎 kn-aut-sei=草加 kn-aut-mei=芳郎 aut-affil-num=9 ORCID= en-aut-name=MitsudaToshihiro en-aut-sei=Mitsuda en-aut-mei=Toshihiro kn-aut-name=光田利弘 kn-aut-sei=光田 kn-aut-mei=利弘 aut-affil-num=10 ORCID= en-aut-name=KiharaTsuyoshi en-aut-sei=Kihara en-aut-mei=Tsuyoshi kn-aut-name=木原彊 kn-aut-sei=木原 kn-aut-mei=彊 aut-affil-num=11 ORCID= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=12 ORCID= en-aut-name=HaraokaSyoichi en-aut-sei=Haraoka en-aut-mei=Syoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=13 ORCID= en-aut-name=AmiokaTadashi en-aut-sei=Amioka en-aut-mei=Tadashi kn-aut-name=網岡忠 kn-aut-sei=網岡 kn-aut-mei=忠 aut-affil-num=14 ORCID= en-aut-name=IshimitsuTetsusaburo en-aut-sei=Ishimitsu en-aut-mei=Tetsusaburo kn-aut-name=石光鉄三郎 kn-aut-sei=石光 kn-aut-mei=鉄三郎 aut-affil-num=15 ORCID= en-aut-name=KonoHiroya en-aut-sei=Kono en-aut-mei=Hiroya kn-aut-name=河野浩哉 kn-aut-sei=河野 kn-aut-mei=浩哉 aut-affil-num=16 ORCID= en-aut-name=MitsumotoToshiro en-aut-sei=Mitsumoto en-aut-mei=Toshiro kn-aut-name=光本敏郎 kn-aut-sei=光本 kn-aut-mei=敏郎 aut-affil-num=17 ORCID= en-aut-name=AisakaTadakazu en-aut-sei=Aisaka en-aut-mei=Tadakazu kn-aut-name=相坂忠一 kn-aut-sei=相坂 kn-aut-mei=忠一 aut-affil-num=18 ORCID= en-aut-name=KosakaChuihiro en-aut-sei=Kosaka en-aut-mei=Chuihiro kn-aut-name=小坂忠一郎 kn-aut-sei=小坂 kn-aut-mei=忠一郎 aut-affil-num=19 ORCID= en-aut-name=MoritaniYui en-aut-sei=Moritani en-aut-mei=Yui kn-aut-name=森谷有為 kn-aut-sei=森谷 kn-aut-mei=有為 aut-affil-num=20 ORCID= en-aut-name=TabuchiHiroshi en-aut-sei=Tabuchi en-aut-mei=Hiroshi kn-aut-name=田渊博司 kn-aut-sei=田渊 kn-aut-mei=博司 aut-affil-num=21 ORCID= en-aut-name=HashimotoKyoji en-aut-sei=Hashimoto en-aut-mei=Kyoji kn-aut-name=橋本恭治 kn-aut-sei=橋本 kn-aut-mei=恭治 aut-affil-num=22 ORCID= en-aut-name=KimuraKenichi en-aut-sei=Kimura en-aut-mei=Kenichi kn-aut-name=木村健一 kn-aut-sei=木村 kn-aut-mei=健一 aut-affil-num=23 ORCID= en-aut-name=KonoHiroshi en-aut-sei=Kono en-aut-mei=Hiroshi kn-aut-name=河野宏 kn-aut-sei=河野 kn-aut-mei=宏 aut-affil-num=24 ORCID= en-aut-name=TamaoHiroyasu en-aut-sei=Tamao en-aut-mei=Hiroyasu kn-aut-name=玉尾博康 kn-aut-sei=玉尾 kn-aut-mei=博康 aut-affil-num=25 ORCID= en-aut-name=HiguchiYosimitsu en-aut-sei=Higuchi en-aut-mei=Yosimitsu kn-aut-name=樋口祥光 kn-aut-sei=樋口 kn-aut-mei=祥光 aut-affil-num=26 ORCID= en-aut-name=YahataKatsumi en-aut-sei=Yahata en-aut-mei=Katsumi kn-aut-name=八幡勝美 kn-aut-sei=八幡 kn-aut-mei=勝美 aut-affil-num=27 ORCID= en-aut-name=ImaiHarujiro en-aut-sei=Imai en-aut-mei=Harujiro kn-aut-name=今井春路郎 kn-aut-sei=今井 kn-aut-mei=春路郎 aut-affil-num=28 ORCID= en-aut-name=KameyamaIchiro en-aut-sei=Kameyama en-aut-mei=Ichiro kn-aut-name=亀山一郎 kn-aut-sei=亀山 kn-aut-mei=一郎 aut-affil-num=29 ORCID= en-aut-name=ArijiSumiro en-aut-sei=Ariji en-aut-mei=Sumiro kn-aut-name=有地澄郎 kn-aut-sei=有地 kn-aut-mei=澄郎 aut-affil-num=30 ORCID= en-aut-name=FujimoriYasuhiko en-aut-sei=Fujimori en-aut-mei=Yasuhiko kn-aut-name=藤森恭彦 kn-aut-sei=藤森 kn-aut-mei=恭彦 aut-affil-num=31 ORCID= en-aut-name=NakagawaSyoso en-aut-sei=Nakagawa en-aut-mei=Syoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=32 ORCID= en-aut-name=HiranoYutaka en-aut-sei=Hirano en-aut-mei=Yutaka kn-aut-name=平野寛 kn-aut-sei=平野 kn-aut-mei=寛 aut-affil-num=33 ORCID= en-aut-name=KobayashiToshinari en-aut-sei=Kobayashi en-aut-mei=Toshinari kn-aut-name=小林敏成 kn-aut-sei=小林 kn-aut-mei=敏成 aut-affil-num=34 ORCID= en-aut-name=SeidoIchiro en-aut-sei=Seido en-aut-mei=Ichiro kn-aut-name=清藤一郎 kn-aut-sei=清藤 kn-aut-mei=一郎 aut-affil-num=35 ORCID= en-aut-name=TanabeIsao en-aut-sei=Tanabe en-aut-mei=Isao kn-aut-name=田辺功 kn-aut-sei=田辺 kn-aut-mei=功 aut-affil-num=36 ORCID= en-aut-name=TakedaKazuhisa en-aut-sei=Takeda en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=37 ORCID= en-aut-name=HayashiShinichiro en-aut-sei=Hayashi en-aut-mei=Shinichiro kn-aut-name=林愼一郎 kn-aut-sei=林 kn-aut-mei=愼一郎 aut-affil-num=38 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=13 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=14 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=17 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=18 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=19 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=20 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=21 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=22 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=23 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=24 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=25 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=26 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=27 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=28 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=29 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=30 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=31 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=32 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=33 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=34 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=35 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=36 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=37 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=38 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=389 end-page=406 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Seminal Vesiculogram in Male Sterility kn-title=男子不妊症における精嚢腺レ線像の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seminal vesicles were atrophied or not developed according to the lowering of the androgenic activities of the testis an I found tuberculous infection in them frequently. And it is well-known such conditions result in the disturbance of the sperm nutrition and the sperm passage which lead to the male sterility respectively. From these points, I have been, for the past seven years, observing the rentogenologic forms of semlnal vesicles about male sterility of 106 cases, and found out their morphological variations. On the classifications of seminal vesiculograms, there have been many reports, but could not be found that of seminal vesiculograms about male sterility. Then, it is intended to classify the forms of seminal vesicles of my cases as follows. 1. great main tubes with large laminated diverticula 2. great main tubes with or without small diverticula 3. simple main tubes with large laminated diverticula 4. simple main tubes with or without small diverticula 5. main tubes, dilated abnormally, demarcated poorly or irregularly, and no shaped seminal vesicles by means of the difficulties in injection of contrast medias into the vas deferens (stricture, obstruction or absence of it) The writer utilized vasopuncture of scrotal region and through the vas deferens injected Urografin and Urokolin-M into seminal vesicles. As table (2-16) shows, in seminal vesicles type No. 1 of the classification commanded a plurality (49.5%), Type No. 2 is the second (28.3%) and in Ampulla ductus deferentis, type No. 1 is first in number (60.6%) and type No. 2 next (19.2%). Seminal vesicles in male sterility are well-grown, and the angle of inclination of them have a tendency to be small (on an average 27.3 degree). Author's original classification of type No. 5 is 5.5%. But tuberculous findings in seminal vesicles are seen in few cases, on the contrary the abnormal dilatation of main tubes found frequently. en-copyright= kn-copyright= en-aut-name=NambaKatsuichi en-aut-sei=Namba en-aut-mei=Katsuichi kn-aut-name=難波克一 kn-aut-sei=難波 kn-aut-mei=克一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=407 end-page=429 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Study of the Extrapyramidal Motor Syndrom A clinical study and the ChE activity on the brain of the parkinsonian rats and mice induced by some Phenothiazine-Derivatives and Bulbocapnine kn-title=実験的錐体外路症候群に関する研究 薬物により惹起されたParkinsonismusネズミの臨床ならびに基底核領域ChE活性の選択的阻害について en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) In order to study the experimental Parkinsonism, some Phenothiazine-Derivatives, e. g. Chlorpromazine 30 mg/Kg., Perphenazine 15 mg/Kg.. Trifluoperazine 5 mg/Kg.. Fulphenazine 5 mg/Kg.. Thioproperazine 10 mg/Kg.; and Bulbocapnine 15 mg/Kg. which had been used for study of the experimental catatonia customally, were injected into the peritoneum of the Cb-strain of male mice and the Wister-strain of male rats. Above 90% of the rats and mice showed parkinsonism after the abministration of these drugs. 2) The parkinsonian rats and mice showed sluggish movements, abnormal postures, catalepsia-like-syndroms e. g. passivity, negativism, fixation, rigidity of muscles, vegetative signs and tremor. Rigidity of muscles was objectively proved by application of the priciple of the Wartenberg's fixation of position test which was adopted to identify parkinsonism clinically and the principle of the Richter's grasp reflex and by appearence of the normal motor units at a strech reflex of the M. Gastrocunemius in the electromyography. 3) As the preliminary experiment, three methods to assay the activity of ChE were each compared using brain homogenates. These were the manometric assay by Ammon's method, the electrometric assay using "glass electrode" PH-meter by the modified Michel's method and the spectrophotometric assay by the modified Takahashi Shibata's method. Among these assay, the electrometric assay was the most accurate method to detect the activity of ChE of the brain. Following studies were carried out using this electrometric assay. 4) The ChE activity of the whole cerebrum of parkinsonian mice induced medicamentally was measured and compared with that of normals using the electrometric assay. All of the Phenothiazine-Derivatives inhibited the ChE activity of the whole cerebrum. But Bulbocapnine did not. 5) The brain of the parkinsonian Wister strain of male rats was separated into two parts. One included the cortical area, the another included the basal ganglia. The ChE activity of both parts was measured by the electrometric assay. In the parkinsonian rats induced by Phenothiazine-Derivatives, the ChE activity of the cortical area was within normal limits but that of the basal gangliar area was remarkably inhibited. Bulbocapnine exaggerated the ChE activity in the cortical parts, while contrastedly inhibited the ChE activity in the basal ganglia. 6) Referring to the correlation of the inhibitory effect and the structures of the Phenothiazine-Derivatives, -CF(3) base which was replaced with 3'-H on the phenothiazine nucleus, had a relatively higher inhibitory effect than the another. Piperazinyl base which attached to the side chain of the Phenothiazine nucleus, had also relatively higher imhibitory effects. 7) The problems occured here were discussed. Especially the correlation between parkinsonism and the possible roles of the cholinergic system, regarding to the change of the behavior of animals and the inhibition of the ChE activity or the basal ganglia of the parkinsonian rats were discussed. en-copyright= kn-copyright= en-aut-name=KurodaKunihiko en-aut-sei=Kuroda en-aut-mei=Kunihiko kn-aut-name=黒田邦彦 kn-aut-sei=黒田 kn-aut-mei=邦彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=191 end-page=195 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Three Cases of Struma Ovarii Underwent Laparoscopic Surgery with Definite Preoperative Diagnosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Struma ovarii is a rare neoplasm that accounts for approximately 0.3ｵ of ovarian tumors. Due to its ultrasound morphology, which is quite similar to that of malignant ovarian carcinoma, most struma ovarii cases are open operated with laparotomy rather than laparoscopy. We present 3 cases of struma ovarii, which were diagnosed preoperatively by imaging studies and removed by laparoscopic surgery. All patients were premenopausal women between ages 31?50. The magnetic resonance imaging (MRI) findings were complex masses composed of multiple cysts and solid components with T2-hypointense regions as well as multiple T1-hyperintense cystic areas, findings that are typical for struma ovarii. A combination of plain computed tomography (CT), positron emission tomography (PET)-CT, and scintigraphy was useful for diagnosis. Laboratory examination revealed elevated serum thyroglobulin, which led to the diagnosis of struma ovarii. Laparoscopic surgeries were performed without rupturing the tumors. Although it has been difficult to differentiate between struma ovarii and malignant tumors by conventional methods, recently MRI techniques appear make it possible to diagnose struma ovarii preoperatively from the abovementioned imaging characteristic, together with laboratory data. As for treatment, we think laparoscopy could be successful for struma ovarii, but the surgeon must be careful not to rupture the tumor intra-abdominally in order to prevent dissemination, which could lead to malignancy. en-copyright= kn-copyright= en-aut-name=Binti Md NorNurliza en-aut-sei=Binti Md Nor en-aut-mei=Nurliza kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KusumotoTomoyuki en-aut-sei=Kusumoto en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoueSeiji en-aut-sei=Inoue en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraKeiichiro en-aut-sei=Nakamura en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SekiNoriko en-aut-sei=Seki en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HongoAtsushi en-aut-sei=Hongo en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KodamaJunichi en-aut-sei=Kodama en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HiramatsuYuji en-aut-sei=Hiramatsu en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=struma ovarii kn-keyword=struma ovarii en-keyword=ovarian neoplasms kn-keyword=ovarian neoplasms en-keyword=MRI kn-keyword=MRI en-keyword=laparoscopic surgery kn-keyword=laparoscopic surgery END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=811 end-page=820 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serum Hepatitis Resulted from Blood Transfusion kn-title=輸血による血清肝炎について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In recent years there have been many cases, with increasing frequency, of serum hepatitis resulted from blood transfusion. The purpose of this study was to investigate the incidence, clinical feature, prognosis and prophylaxis of serum hepatitis followed by blood transfusion. The results obtained were as follows; 1) Incidence of serum hepatitis among the patients who had blood transfusion at local institutions in Okayama City was 3.3% in 1957 and 4.7% in 1958, on the other hand, at Okayama University Hospital in 1958 it was 5.0% in the First Surgical Division, 5.4% the Second Surgery and 5.2% OBGYN respectively. The patients with serum hepatitis had received the amount 2,600 to 1,120 cc of blood, whereas 810 to 1,120 cc in the cases who never developed serum hepatitis after blood transfusion. 2) Mean incubation period was 72.8 days ranging 19 to 180 days calculated from the date of last blood transfusion. Prodremal stage varied from 1 to 20 days, average 6.1 days, icteric stage 7 to 15 days, average 35.8 days, and convalescent stage 7 to 200 days, average 30.0 days. 3) Characteristic initial symptoms were anorexia, malaise and jaundice by which fairly number of the cases noticed the onset of the disease. Few had febrile course but low grade in most of the cases. 4) Laboratory data were obtained from the 20 cases of serum hepatitis admitted to our First Mebical Division. Serum bilirubin showed the maximum level on the 10 th day, average 13.0 mg% . No significant changes were noted in peripheral blood picture but for a slight initial monocytosis. SGO-T and SGP-T presented a elevation earlier than that of serum bilirubin, maximum on or about the 5 th day and then decreased abruptly. Serum colloidal liver function tests; in initial stage, positive Takata's reaction in 51.%, positive CCF 46% and TTT 58% were noted, but even after 100 th day Takata's reaction was positive in 25% of the cases. 5) Follow-up studies were made on 49 serum hepatitis cases discharged from our hospital with complete recovery. 69% of these had subjective symptems in some sort or another. Enlargement of the liver was noted in 20% of the cases. 33 cases were studied with special reference to liver function tests and liver biopsy. It was revealed that 43% of the cases still had impairment of liver function and that by means of liver biopsy, postnecrotic cirrhosis was found 9.1% of the cases. Therefore, the prognosis of serum hepatitis of this type was considered to be grave. 6) For the purpose of prophylaxis, 300 to 600 mg of gamma globulin was simultaneously administered on blood transfusion in 38 cases. Inspite of this, 4 cases suffered from serum hepatitis later on, and no definite prophylactic effect of gamma globulin was noted. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=3 ORCID= en-aut-name=YamamotoShigeru en-aut-sei=Yamamoto en-aut-mei=Shigeru kn-aut-name=山本繁 kn-aut-sei=山本 kn-aut-mei=繁 aut-affil-num=4 ORCID= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=5 ORCID= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=6 ORCID= en-aut-name=KusudoHiroshi en-aut-sei=Kusudo en-aut-mei=Hiroshi kn-aut-name=楠戸宏 kn-aut-sei=楠戸 kn-aut-mei=宏 aut-affil-num=7 ORCID= en-aut-name=OnoNobuhiro en-aut-sei=Ono en-aut-mei=Nobuhiro kn-aut-name=小野延宏 kn-aut-sei=小野 kn-aut-mei=延宏 aut-affil-num=8 ORCID= en-aut-name=KobashiNobuo en-aut-sei=Kobashi en-aut-mei=Nobuo kn-aut-name=小橋暢夫 kn-aut-sei=小橋 kn-aut-mei=暢夫 aut-affil-num=9 ORCID= en-aut-name=AsadaKiyotaka en-aut-sei=Asada en-aut-mei=Kiyotaka kn-aut-name=浅田清隆 kn-aut-sei=浅田 kn-aut-mei=清隆 aut-affil-num=10 ORCID= en-aut-name=KajiMasayoshi en-aut-sei=Kaji en-aut-mei=Masayoshi kn-aut-name=加地正義 kn-aut-sei=加地 kn-aut-mei=正義 aut-affil-num=11 ORCID= en-aut-name=KitagawaToshinori en-aut-sei=Kitagawa en-aut-mei=Toshinori kn-aut-name=北川紀典 kn-aut-sei=北川 kn-aut-mei=紀典 aut-affil-num=12 ORCID= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=13 ORCID= en-aut-name=TakakiTadateru en-aut-sei=Takaki en-aut-mei=Tadateru kn-aut-name=高木直輝 kn-aut-sei=高木 kn-aut-mei=直輝 aut-affil-num=14 ORCID= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=15 ORCID= en-aut-name=NagoshiKazuma en-aut-sei=Nagoshi en-aut-mei=Kazuma kn-aut-name=名越一馬 kn-aut-sei=名越 kn-aut-mei=一馬 aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=13 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=14 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=431 end-page=445 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies On Diencephalo-Pituitary-Adrenocortical Function in Depressive Psychosis 1. On Urinary Steroid Patterns kn-title=抑うつ状態における間脳-下垂体-副腎皮質系機能に関する研究 T. 尿中Steroid像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although there are many reports concerning the endocrinological studies in mental diseases, no general agreement has yet been reached. Investigating the depressive psychosis, the author gave a special consideration to the problem whether there are any specific relations between the urinary corticoid patterns and clinical state. Twenty-four hour urines were collected from 20 males and 20 females, both healthy persons (ranging 22-47 years old in age, the average being adout 25 years) as controls, and 28 cases of depressive psychosis, consisted of 14 males and 14 females (ranging 22-68 years old, 42 years in average) composed of 4 reactive, 2 agitated and 5 brain arteriosclerotic depressive state. Measurements were taken on total neutral 17-ketosteroid (17-KS), total 17-hydroxycorticoid (17-OHCS) and free and conjugated forms of the latter. 17-KS was measured by the modified Holtorff and Koch's method and Bongiovanni's method. The results are as follows: (Every value shows mean and standard deviation). 1. Dialy excretion of total 17-KS in the controls was 7.63±2.71 mg/day for males and 5.67-1,67 mg/day for females. The difference between both sexes is thought to be significant from the statistical standpoint. Daily control excretion of 17-OHCS of males was 6.13±1.74 mg/day as the total amount, 0.88±0.51 mg/day as free form, 5.26±1.57 mg/day as conjugated form, 8.12±4.95 as the ratio of conjugated form/free form (C/F), and 86.18±6.28 as the percentage of conjugated form/total (C/T%); that of females was 5.48±2.07 mg/day as total, 0.65±0.42 mg/day as free form, 4.83±1.84 mg/day as conjugated form, 9.50±4.85 as C/F and 88.06±5.87 as C/T%. The difference between sexes appears to be insignificant. 2. Depressive group: Total 17-KS was 5.42±2.83 mg/day for males and 4.97±2.05 mg/day for females, being lower than normal value, and the former was significant but the latter insignificant from the statistical standpoint. Total 17-OHCS was 5.42±2.86 mg/day for males and 3.83±1.68 mg/day for females, being lower than normal value, which means that the former is insignificant while the latter significant. Free 17-OHCS was 2.17±1.18 mg/day for males and 1.19±0.82 mg/day for females, 2 times or more than normal value, and those of both sexes were significant. Conjugated 17 OHCS was 3.25±1.90 mg/day for males and 2.64±1.92 mg/day for females, lower than normal value, being significant for both sexes. 3. In comparing all the depressive groups with small groups of 2 agitated, 4 reactive and 5 cerebral arteriosclerotic depressives, there were no significant differences but the two agitated in the small groups showed the lowest values of all the depressives, namely, total 17-KS, total 17-OHCS, conjugated from and C/F ratio all proved to be much lower than those in the other depressives. 4. Total 17-OHCS values of 5 cases after treatment were found to have been increased, free 17-OHCS decreased, and conjugated form increased. As the result of the increase in the C/F and C/T % , the corticoid patterns approached the normal. 5. The author investigated the relation of corticoid patterns and liver dysfunction, then depressive psychosis and schizophrenia. Incomparing schrzophrenia with depressive psychosis, 17-KS value of the latter was found to approximate that of acute schizophrenics and total 17-OHCS value of the latter to that of chronic schizophrenics in both sexes. From these findings it seems that depressive psychosis indicates the diencephalo-pituitary-adrenccortical dysfunction more significantly than schizophrenia. en-copyright= kn-copyright= en-aut-name=TsujiHarunori en-aut-sei=Tsuji en-aut-mei=Harunori kn-aut-name=辻治憲 kn-aut-sei=辻 kn-aut-mei=治憲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=821 end-page=830 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sulfur Metabolism in Infants Part I. Some Suggestion for the Quautative Analysis of Total Sulfur in Milk, Faces and Urine and the Total Sulfur Contents in Various Milk kn-title=乳児の硫黄代謝に関する研究 第1編 乳汁，屎及び尿中の総硫黄定量法の考案並びに各種乳汁中の総硫黄量 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are numerous articles concerning the estination of total sulfur in organic substances and yet the results obtained hitherto are not by any means quite satisfactory. The gratest difficulty encountered in the estination of sulfur seems to lie in the insufficient ashing of the substance. Therefore, the author studied various ashing metheds and finally modified Bethge's wet ashing in the following manner: 1, Ammoniated vanadium (NH(4)VO(3)) is added as an oxidizing catalyst. 2. As an indicator of the complete oxidation potassium chromate (K(2)Cr(2)O(7)) is used. 3. The ratio of acid mixture is set in the proportion of three parts perohloric acid to two parts nitric acid. 4. The reduction mixture is placed into an ampule filled with pitrogan immediately after it is prepared and is sealed tightly, and the quantity of the mixture to be added is increased. By the modified method mentioned above it has been possible to raise the recovery rate of sulfur added as much as 95.4 per Gent, proving that this method is sufficiently useful for the estimation of the total sulfur in milk, urine and faces. In the estimations of total sulfur of various milk such as breast milk, milk on the market and 18% solution of regulated powered milk the average contents of total sulfur have been found to be 11.7 mg and 31.8 mg per dl respectively. en-copyright= kn-copyright= en-aut-name=HamadaGibun en-aut-sei=Hamada en-aut-mei=Gibun kn-aut-name=濱田義文 kn-aut-sei=濱田 kn-aut-mei=義文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小児科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=831 end-page=844 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sulfur Metabolism in Infants Part 2. The Sulfur Metabolism in Infants under Breast Feeding and in Infants under Artifical Feeding kn-title=乳児の硫黄代謝に関する研究 第2編 天然及び人工栄養児の硫黄代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By the new method as described in Part I the author studied the sulfur and nitrogen metabolism in infants under breast feeding and in infants under artificial feeding, and obtained the following results. 1. In the infants under breast feeding at the age of 1-2 months, 3-4 months, and 5-6 months old the average sulfur retention at each period has bead 25.7, 33.7, and -0.53 per cent respectively. Similarly in the infants under artificial feeding at the same age range the average retenrion has beed 35.1, 48.6 and 40.4 per cent respectively. 2. In the case of the infants under breat feeding at the age of 5-6 months old the quantity of sulfur retained gives a negative value, but this seems to be due to an increased urinary excretion of sulfur in the process of the conversion of cartilage to bone. 3. The nitrogen retention rate shows no difference due to feeding methods. 4. Nitrogen-sulufr ratio (N/S) of the retention differs according to the method of feeding. Namely, the ratio N/S in infants under breast feeding is 25.2 while that in infants under artificial feeding is 18.8. 5. N/S values of the retention in infants under breast feeding are higher than those in infants under artificial feeding. This fact indicates that sulfur in breast milk is more effective than that in cow's milk for increasing the quantity of nitrogen to be retained, and this in turn seems to be due to the action of cystine-sulfur contained in breast milk. en-copyright= kn-copyright= en-aut-name=HamadaGibun en-aut-sei=Hamada en-aut-mei=Gibun kn-aut-name=濱田義文 kn-aut-sei=濱田 kn-aut-mei=義文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大挙医学部小児科学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=197 end-page=202 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Proximal Vertebral Body Fracture after 4-Level Fusion Using L1 as the Upper Instrumented Vertebra for Lumbar Degenerative Disease: Report of 2 Cases with Literature Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Some cases with lumbar degenerative diseases require multi-level fusion surgeries. At our institute, 27 and 4 procedures of 3- and 4-level fusion were performed out of a total 672 posterior lumbar interfusions (PLIFs) on patients with lumbar degenerative disease from 2005 to 2010. We present 2 osteoporotic patients who developed proximal vertebral body fracture after 4-level fusion. Both cases presented with gait disability for leg pain by degenerative lumbar scoliosis and canal stenosis at the levels of L1/2-4/5. After 4-level fusion using L1 as the upper instrumented vertebra, proximal vertebral body fractures were found along with the right pedicle fractures of L1 in both cases. One of these patients, aged 82 years, was treated as an outpatient using a hard corset for 24 months, but the fractures were exacerbated over time. In the other patient, posterolateral fusion was extended from Th10 to L5. Both patients can walk alone and have been thoroughly followed up. In both cases, the fracture of the right L1 pedicle might be related to the subsequent fractures and fusion failure. In consideration of multi-level fusion, L1 should be avoided as an upper instrumented vertebra to prevent junctional kyphosis, especially in cases with osteoporosis and flat back posture. en-copyright= kn-copyright= en-aut-name=YasuharaTakao en-aut-sei=Yasuhara en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiYuichi en-aut-sei=Takahashi en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KumamotoShinji en-aut-sei=Kumamoto en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakaharaMasayuki en-aut-sei=Nakahara en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YonedaKotaro en-aut-sei=Yoneda en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NiimuraTatsuomi en-aut-sei=Niimura en-aut-mei=Tatsuomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanoueTakashi en-aut-sei=Tanoue en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KusumegiAkira en-aut-sei=Kusumegi en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SennariTakashi en-aut-sei=Sennari en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HijikataYasukazu en-aut-sei=Hijikata en-aut-mei=Yasukazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ManabeHiroaki en-aut-sei=Manabe en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MiyoshiYasuyuki en-aut-sei=Miyoshi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=OgawaKoichi en-aut-sei=Ogawa en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NishidaKenki en-aut-sei=Nishida en-aut-mei=Kenki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=2 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=3 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=4 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=5 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=6 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=7 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=8 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=9 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=10 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=11 en-affil= kn-affil=Department of Neurological Surgery, Okayama University Hospital affil-num=12 en-affil= kn-affil=Department of Neurological Surgery, Okayama University Hospital affil-num=13 en-affil= kn-affil=Department of Neurological Surgery, Okayama University Hospital affil-num=14 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital affil-num=15 en-affil= kn-affil=Department of Spinal Surgery, Shinkomonji Hospital en-keyword=degenerative lumbar scoliosis kn-keyword=degenerative lumbar scoliosis en-keyword=osteoporosis kn-keyword=osteoporosis en-keyword=pedicle fracture kn-keyword=pedicle fracture en-keyword=posterior lumbar interbody fusion kn-keyword=posterior lumbar interbody fusion en-keyword=vertebral body fracture kn-keyword=vertebral body fracture END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=447 end-page=460 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Diencephalo-Pituitary-Adrenocortical Function in Depressive Psychosis U. On Blood Corticoid Patterns kn-title=抑うつ状態における間脳-下垂体-副腎皮質系機能に関する研究 U. 血中Steroid像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=As the result of investigation of the urinary steroid patterns in depressive psychosis in previous communication, the author has been able to demonstrate the decreased excretion of total 17-ketosteroid (17-KS) and total 17-hydroxycorticoid (17-OHCS), increased excretion of free 17-OHCS and decreased excretion of conjugated 17-OHCS. Following these results, the ratio of conjugated form/ free form (C/F) and the percentage of conjugated form/total 17-OHCS (C/T%) seem to have very significant changes in comparison with those in the control. In the present study the author investigated 17-OHCS in plasma of depressive psychosis. The plasma specimens were secured from 10 males and 12 females, all healthy persons (in the age range of 18-47 years old and 23 years in average) for controls, and 12 male and 10 female depressives (ranging 22-64 years in age, the average being 41 years). Measurements were taken on total, free and conjugated forms of 17-OHCS by Nelson-Samuel's and Bongiovanni's methods and for the hydrolysis of conjugated form beef-liver β-glucuronidase was employed. The results are as follows: (Every value shows mean and standard deviation. 1. Total 17-OHCS values were 30.77±10.23 γg/dl for controls and 44.34±21.18 γg/dl for depressives, and those of free form were 10.36±5.00 γg/dl in controls and 23.88±11.17 γg/dl in depressives, those of conjugated form were 20.41±10.59 γg/dl in controls and 20.93±11.43 γg/dl for depressives and C/F ratio was 2.35±1.59 in controls and 0.95±0.48 in depressives. 2. In comparison with depressives and controls, the total 17-OHCS was higher than normal value, being significant from the statistical standpoint. The value of free form was about 2 times higher than the normal, showing significant difference between the two. The C/F ratio in depressives, however, was about half of the normal value. 3. In comparing all the depressives with the small groups of 4 reactive and 4 cerebral arteriosclerotic depressives, there could be found not any specific differences among them. 4. In the four cases with improvement after treatment it was found that total 17-OHCS was increased, free form decreased and conjugated form increased. As the result of these changes, C/F ratio was also increased and the corticoid pattern approached the normal value. 5. The decrease in C/F values was characteristic common both to schizophrenia and depressive, but a difference between the two was found in the fact that, whereas the C/F value was decreased due to a decrease in conjugated form in schizophrenia, it was diminished as the result of a marked increase in free form in the depressive. A discussion was made on the meaning of these findings. 6. In the comparative values of 17-OHCS in the blood and urine of 15 cases, measured simultaneously, it was found that the increase of free 17-OHCS in the blood induced an increase of the free 17-OHCS in the urine, thus directly causing the diminution of C/F value. In addition, it was clarified that an increase of total blood 17-0HCS did not necessarily mean its increase in the total urinary content, and also there was no parallel increase in its values of conjugated form in blood and in urine. In order to explain this point, a discussion was made on the role played by the diencephalon, hyophysis and liver function as well as on the pathological factors. en-copyright= kn-copyright= en-aut-name=TsujiHarunori en-aut-sei=Tsuji en-aut-mei=Harunori kn-aut-name=辻治憲 kn-aut-sei=辻 kn-aut-mei=治憲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=845 end-page=854 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytological Studies on the Aspirated Fluid with the Phase-Contrast Microscope Part 1. Cytological Studies on the Normal Ascites of Human and Various Animals kn-title=位相差顕微鏡(PCM)観察による穿刺液の細胞学的研究 第1編 人並びに各種動物の正常腹水の細胞学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Comparative studies were carried on the normal ascitic cells, especially on phagocytes that occupy the major portion of ascitic cells, aspirated from mammalians such as mice, rats, rabbits, dogs, cats, and human as well as from chicken by the pressure method with a phase contrast microscope and also with moving pictures of these various cells. As the results the following conclusions were arrived at: 1. The majority of mouse phagocytes have the characteristics similar to those of monocytes and histiocytes. 2. In the higher animals such as rats and rabbits a greater portion of them show flagellar pseudopodia and the aggregating tendency of highly reflactile granules and the distribution of mitochondria along the groove of the nucleus. And their nuclear membrane is thin and the nuclei are solid with a complicated shape, and the nuclear substance is soft but without any nucleoles. All of these findings become quite similar to those of monocytes, and in dogs and cats they can hardly be distinguished from monocytes. In the case of normal human phagocytes most of them show degeneration but even these cells reveal the characteristics very close to those of monocytes but far different from those of histiocytes. Even in the chicken phagocytes an unexpectedly large portion of them possess marked characteristics of monocytes. 3. As for the movement of these cells it is minimal, differing from blood monocytes this point, but it seems that this is due to the adaptation peculiar to the circumstances as ascites. From these findings it can be concluded that the ascitic cells possess characteristics far different from those of histiocytes but extremely similar to those of monocytes. en-copyright= kn-copyright= en-aut-name=KamuraJunta en-aut-sei=Kamura en-aut-mei=Junta kn-aut-name=嘉村淳太 kn-aut-sei=嘉村 kn-aut-mei=淳太 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=203 end-page=212 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Molecular Aspects of Eye Evolution and Development: From the Origin of Retinal Cells to the Future of Regenerative Medicine en-subtitle= kn-subtitle= en-abstract= kn-abstract=A central issue of evolutionary developmental biology is how the eye is diverged morphologically and functionally. However, the unifying mechanisms or schemes that govern eye diversification remain unsolved. In this review, I first introduce the concept of evolutionary developmental biology of the eye with a focus on photoreception, the fundamental property of retinal cells. Second, I summarize the early development of vertebrate eyes and the role of a homeobox gene, Lhx1, in subdivision of the retina into 2 domains, the neural retina and retinal pigmented epithelium of the optic primordium. The 2 retinal domains are essential components of the eye as they are found in such prototypic eyes as the extant planarian eye. Finally, I propose the presence of novel retinal cell subtypes with photosensory functions based on our recent work on atypical photopigments (opsins) in vertebrates. Since human diseases are attributable to the aberration of various types of cells due to alterations in gene expression, understanding the precise mechanisms of cellular diversification and unraveling the molecular profiles of cellular subtypes are essential to future regenerative medicine. en-copyright= kn-copyright= en-aut-name=OhuchiHideyo en-aut-sei=Ohuchi en-aut-mei=Hideyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=eye kn-keyword=eye en-keyword=development kn-keyword=development en-keyword=evolution kn-keyword=evolution en-keyword=opsin kn-keyword=opsin en-keyword=photoreceptor kn-keyword=photoreceptor END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=213 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors Influencing Breast Density in Japanese Women Aged 40-49 in Breast Cancer Screening Mammography en-subtitle= kn-subtitle= en-abstract= kn-abstract=A relatively large number of women in their 40s with high-density breasts, in which it can be difficult to detect lesions, are encountered in mammography cancer screenings in Japan. Here, we retrospectively investigated factors related to breast density. Two hundred women (40-49 years old) were examined at the screening center in our hospital. Multivariate analysis showed that factors such as small abdominal circumference, high HDL cholesterol, and no history of childbirth were related to high breast density in women in their 40s undergoing mammography. Other non-mammographic screening methods should be considered in women with abdominal circumferences ＜76cm, HDL-C >53mg/dl, and no history of childbirth, as there is a strong possibility of these women having high-density breasts that can make lesion detection difficult. en-copyright= kn-copyright= en-aut-name=KawaharaMichiko en-aut-sei=Kawahara en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoShuhei en-aut-sei=Sato en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IdaYukiko en-aut-sei=Ida en-aut-mei=Yukiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WatanabeMasao en-aut-sei=Watanabe en-aut-mei=Masao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujishimaMamoru en-aut-sei=Fujishima en-aut-mei=Mamoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshiiHiroaki en-aut-sei=Ishii en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HoriKeisuke en-aut-sei=Hori en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Radiology, Tsuyama Central Hospital affil-num=2 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Radiology, Tsuyama Central Hospital affil-num=4 en-affil= kn-affil=Department of Radiology, Tsuyama Central Hospital affil-num=5 en-affil= kn-affil=Department of Radiology, Tsuyama Central Hospital affil-num=6 en-affil= kn-affil=Department of Radiology, Okayama University Hospital affil-num=7 en-affil= kn-affil=Department of Gastroenterology, Okayama University Hospital affil-num=8 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=high-density breasts kn-keyword=high-density breasts en-keyword=abdominal circumference kn-keyword=abdominal circumference en-keyword=high-density lipoprotein cholesterol kn-keyword=high-density lipoprotein cholesterol en-keyword=childbirth kn-keyword=childbirth en-keyword=mammography kn-keyword=mammography END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=461 end-page=472 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Anti-leukemic Agents on Hematopoietic Functions of Bone Marrow 1. A Study on the Roller Culture Method of Bone-Marrow Cell Suspension kn-title=抗白血病剤の骨髄造血機能に及ぼす影響に関する研究 第1編 骨髄細胞浮游廻転培養法に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of a comparative study on the influences of various anti-leukemic agents on the erythropoietic function of bone marrow, a roller culture method was performed to culture the cell suspensions of human and rabbit bone marrow. In the course of the incubation, the author observed the changes in the erythrocyte counts, number of nucleated cells, hemoglobin content, percentage of orthochromic erythroblasts, and increment index of orthochromic erythroblasts. As the results, it has been recognized that in this culture method bone marrow erythroblasts mature and differentiate in the same fashion as in in vivo. Therefore, it is assumed that, when human or rabbit bone marrow is cultured by this method in the media containing chemical substances or sera, it is possible to observe their direct influences on the erythropoietic functions of bone marrow. en-copyright= kn-copyright= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=889 end-page=899 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physiological Studies on the Metabolic Activities of Streptomycin-Resistant B. Dysentheriae. 1. The Carbohydrate Metabolism of Streptomycin-Resistant Sh. flexneri 2a kn-title=ストレプトマイシン耐性赤痢菌の生理学的研究 第1編 ストレプトマイシン耐性赤痢菌駒込ＢVの糖代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The resistance to streptomycin should be demonstrated by some differencies in metabolic reactions detectable by comparisons made between resistant and susceptible bacteria. This paper is concerned with the examination of the glucose metabolism of streptomycin-susceptible and streptomycin-resistant strains of Sh. flexneri 2a. The resistant strains was obtained by serial transfers in progressive levels of streptomycin. This resistant variant could withstand at least 10,000γ per ml of streptomycin. 1) The oxidative abilitys of the resistant strains is considerably less on pyruvate among the components of the citric acid cycle than is that of the susceptible strain. 2) Pyruvic acid, lactic acid, and acetic acid accumulates during the oxidation of glucose by resistant and susceptible strains. The amount of pyruvic acid produced from glucose by resistant strain is more than that by susceptible strain. In the rate of consumptions of glucose between resistant and susceptible strains there is much less difference. 3) No significant difference between both strains is detected in anaerobic metabolism of glucose. 4) Resistant strains which has grown on continued subculture by serial transfer in the medium not containing streptomycin possess still these properties. This culture was also found to be resistant to at least 10,000γ per ml of streptomycin. 5) It is suggested that streptomycin-resistant and susceptible strains dissimilates glucose mainly by way of Embden-Myerhof pathway, and also have Warbung-Dickens pathway as an alternate pathway. 6) Streptomycin-susceptible strain growes more rapidly than streptomycin-resistant strain in shaking culture. 7) These results suggests that streptomycin-resistant strain is more fermentative in the metabolism of glucose than streptomycin-susceptible strain, and a significant difference between streptomycin-resistant and streptomycin susceptible strains exists in pyruvate metabolism and its terminal respiration system. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=495 end-page=516 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Anti-leukemic Agents on the Hematopoietic Functions of Bone Marrow 3. Influences of Various Anti-leukemic Agents on Thrombopoietic Function of Normal Human and Guinea Pig Bone Marrow kn-title=抗白血病剤の骨髄造血機能に及ぼす影響に関する研究 第3編 正常海?及び健康人骨髄栓球系造血機能に及ぼす各種抗白血病の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to compare the influences of various anti-leukemic agents on the bone marrow thrombopoiesis, the clinical tissue culture of bone marrow from normal guinea pigs and healthy persons was conducted. Various anti-leukemic agents were added to the culture media at the maximum concentration where they would not inhibit the bone marrow growth in culture, and observations were carried out to see the influences of these agents on the function of megakaryocytes of bone marrow. As the results, the author arrived at the follwing conclusions. 1. Urethane. Nitromin. Demecolcin, Actinomycin C and Mitomycin C inhibit the thrombopoietic function of bone marrow to a high degree. 2. Thio-TEPA, 8-Azaguanine, Carzinophilin, and Chromomycin demonstrate a moderate inhibitory action on the thrombopoietic function of bone marrow. 3. 6-MP slightly inhibits the thrombopoietic function of bone marrow. 4. Myleran, and the combined use of 6-MP and Prednisolone show no inhibitory effect on the thrombopoietic function of bone marrow. 5. On the other hand, Prednisolone alone rather augments the bone marrow thrombopoietic function. en-copyright= kn-copyright= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=901 end-page=913 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physiological Studies on the Metabolic Activities of Streptomycin-Resistant B. dysentheriae U. The Pyruvate Metabolism and its Terminal Respiration System of Streptomycin-Resistant Sh. flexneri 2a kn-title=ストレプトマイシン耐性赤痢菌の生理学的研究 第2編 ストレプトマイシン耐性赤痢菌駒込ＢVのピルビン酸代謝と終末呼吸系 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Following the previous reports, the author carried out the experiment to elucidate the difference in the pyruvate oxidation and its terminal respiration system between resistant and susceptible Sh. flexneri 2a. 1) The oxidation rate of pyruvate by resistant strain is considerably less at every pH than by susceptible strain. The pH optimum for oxidation of pyruvate of resistant strain is pH 5.6-6.0, whereas that of susceptible strain is pH 7.0-7.5. 2) The consumption rate on pyruvic acid substrate by resistant strain is significantly less than by susceptible strain. 3) Both resistant and susceptible strains oxidizes pyruvic acid via succinate. Pyruvate accumulates during the oxidation of the tricarboxylic acid cycle intermediates such as succinate, malate, fumarate, α-ketoglutarate by resistant and susceptible strains. 4) Aspartic-glutamic transamination has been demonstrated in susceptible strain under aerobic condition with both aspartic acid and glucose added. 5) The oxidation of pyruvate of susceptible strain can be accerelated more rapidly by divalent metal ions such as Mg??, Fe??, Mn?? than that of resistant strain. 6) Panthotenate accerelates more reasonably the respiration of pyruvie acid by susceptible strain than by resistant strain. 7) The significance of these results in relation to the presence of the citric acid cycle in the organism is discussed, and it is considered possible that an significant difference in metabolic activities between resistant and susceptible strains exists in the metabolic pathway from pyruvate to succinate in the citric acid cycle. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=219 end-page=225 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Thrombocytopenia at Birth Is a Predictor of Cholestasis in Infants with Small for Gestational Age en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cholestasis and thrombocytopenia are complications that affect infants born small for gestational age (SGA). In SGA infants, other vital organs develop at the expense of the liver, and the thrombopoietin produced by the liver is low, often resulting in cholestasis. We hypothesized that thrombocytopenia at birth can be used to predict cholestasis in very-low-birth-weight infants (VLBWIs) with SGA. This retrospective cohort study enrolled VLBWIs with SGA admitted to a tertiary neonatal intensive care unit. A platelet cutoff value predictive of cholestasis was determined using receiver operating characteristic analysis. Multivariate logistic regression analysis was performed to evaluate the platelet cutoff value, and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Regarding the onset of cholestasis, survival analysis was performed by calculating the adjusted hazard ratios (HRs) and 95% CIs. A total of 87 infants were evaluated, and the platelet cutoff value was determined as 88×10(3) cells/μl. The adjusted OR for this platelet cutoff value was 10.52 (95% CI 2.26-55.93, p＝0.003), and the adjusted HR was 7.76 (95% CI 2.51-23.50, p＝0.0006). Thrombocytopenia is a useful predictor for cholestasis in VLBWIs with SGA. en-copyright= kn-copyright= en-aut-name=MaruyamaHidehiko en-aut-sei=Maruyama en-aut-mei=Hidehiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraMakoto en-aut-sei=Nakamura en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YonemotoNaohiro en-aut-sei=Yonemoto en-aut-mei=Naohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KageyamaMisao en-aut-sei=Kageyama en-aut-mei=Misao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Neonatology, National Hospital Organization Okayama Medical Center affil-num=2 en-affil= kn-affil=Department of Neonatology, National Hospital Organization Okayama Medical Center affil-num=3 en-affil= kn-affil=Department of Epidemiology and Biostatistics, National Center of Neurology and Psychiatry Translational Medical Center affil-num=4 en-affil= kn-affil=Department of Neonatology, National Hospital Organization Okayama Medical Center en-keyword=cholestasis kn-keyword=cholestasis en-keyword=platelet kn-keyword=platelet en-keyword=small for gestational age kn-keyword=small for gestational age en-keyword=thrombocytopenia kn-keyword=thrombocytopenia en-keyword=very low birth weight kn-keyword=very low birth weight END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=517 end-page=521 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Tietze's Disease Results of new treatmeut with Steroids-hormon kn-title=副腎皮質ホルモンによるTietze氏病の新治療法について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first description of the Tietze's disease was given in 1921 by Tietze himself. His presentation was based on a study of four personally observed patients, having a painful, non-suppurative swelling at the sternal end of the ribs. We don't have had the favorable treatment, including the surgical resection of ribs and deep x-ray therapy, however. Recently we had six cases with this syndrom in our department and gave the Hydrocortisone 25 to 50 mg or Predonine 5 to 10 mg by local injection, which showed the excellent results. Also preferable were the local anaesthesia with 2% Xylocain prior to steroid-injection and regional cold formentation for one or two days after steroid-injection. We have to differentiate this syndrom from other conditions and believe that this treatment is the first choice because of the simplicity of the procedure. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= en-aut-name=YasuharaGoro en-aut-sei=Yasuhara en-aut-mei=Goro kn-aut-name=安原五郎 kn-aut-sei=安原 kn-aut-mei=五郎 aut-affil-num=2 ORCID= en-aut-name=SatoMinoru en-aut-sei=Sato en-aut-mei=Minoru kn-aut-name=佐藤実 kn-aut-sei=佐藤 kn-aut-mei=実 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=227 end-page=237 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Comprehensive Analysis of 174 Febrile Patients Admitted to Okayama University Hospital en-subtitle= kn-subtitle= en-abstract= kn-abstract=Primary care physicians often encounter patients with fever of unknown origin and without apparent causes. Recent advances in laboratory medicine have facilitated diagnostic procedures;however, it is still difficult to determine the critical febrile factor at an early stage. We reviewed the medical records of 174 patients who were admitted due to a chief complaint of fever (＞37.5℃) to our hospital during the period from 2004 to 2010. The patients were categorized into patients with infection, inflammation, neoplasm and drug-induced fever. Based on the analysis done by category, it was revealed that the patient's age, body temperature and duration of fever were closely related to the final diagnosis. Serum CRP levels were significantly low in the nonbacterial infection group, while serum levels of sIL-2R were high in neoplasm and drug-induced cases. CRP level on admission was weakly but significantly correlated with body temperature, while duration of fever was inversely related to body temperature. The effectiveness of PET-CT and tissue biopsy for diagnosis was considerably high, particularly in the categories of neoplasm and nonspecific inflammation, respectively, though the effectiveness of bacterial culture was low. Thus, a careful review of physical and laboratory information including body temperature, CRP level, duration of fever, gender difference and history of medication is indispensable for diagnosis. Stepwise categorization and disease classification by comprehensive and systemic checkup are very helpful for determining the causes of fever. en-copyright= kn-copyright= en-aut-name=RyukoHiromasa en-aut-sei=Ryuko en-aut-mei=Hiromasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences en-keyword=computed tomography (CT) kn-keyword=computed tomography (CT) en-keyword=C-reactive protein (CRP) kn-keyword=C-reactive protein (CRP) en-keyword=fluorodeoxyglucose positron emission tomography (FDG-PET) kn-keyword=fluorodeoxyglucose positron emission tomography (FDG-PET) en-keyword=fever of unknown origin (FUO) kn-keyword=fever of unknown origin (FUO) en-keyword=soluble interleukin-2 receptor (sIL-2R) kn-keyword=soluble interleukin-2 receptor (sIL-2R) END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=915 end-page=919 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Comparative Study on the Tryptophan Metabolism of Streptomycin-sensitive and Streptomycin-resistant Shigella flexneri kn-title=赤痢菌のストレプトマイシン耐性変異とトリプトフアン代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There has been very little experimental work on the tryptophan metabolism of streptomycin-resistant bacteria. The authors performed this experiment in order to find out the differencies of the tryptophan metabolism between streptomycin-sensitive and streptmycin-resistant Shigella flexneri 2a. The results were as follows: 1. When streptomycin-resistant strains were grown in the streptomycin-containing medium, they have quantitatively lower tryptophanase activity than streptomycin-sensitive strains. 2. Streptomycin-resistant strains restores tryptophanase activity when streptomycin is absent in the growth medium, but they are resistant to streptomycin (10,000γ/ml). 3. Tryptophanase activity of both strains is inhibited slightly by divalent metal ions such as Mg, Fe, and Mn, but the inhibitive action of Cu is very remarkable. Natrium azide and arsenite have no effect. Vitamin B(6) and 2.4-dinitrophenol accerelates indole production from tryptophan by this organism. 4. Of the the various antibiotics aureomycin inhibits most markedly tryptophanase activity and chloromycetin does slightly, but streptomycin has no influence. 5. Tryptophanase is an adaptive enzyme, and considered to have essentially no relation to streptomycin-resistant mutation. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=NishiiEmiko en-aut-sei=Nishii en-aut-mei=Emiko kn-aut-name=西井笑美子 kn-aut-sei=西井 kn-aut-mei=笑美子 aut-affil-num=2 ORCID= en-aut-name=TakahashiManabu en-aut-sei=Takahashi en-aut-mei=Manabu kn-aut-name=高橋学 kn-aut-sei=高橋 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=HonmatuKakushi en-aut-sei=Honmatu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=239 end-page=244 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Diagnosis of Hypovascular Hepatic Lesions Showing Hypo-intensity in the Hepatobiliary Phase of Gd-EOB- DTPA-enhanced MR Imaging in High-risk Patients for Hepatocellular Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this study was to evaluate the histologic diagnosis of hypovascular hepatic lesions showing hypointensity on hepatobiliary phase images of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI (EOB-MRI). In 38 patients with hepatocellular carcinoma (HCC) after curative treatments and 18 patients with liver cirrhosis, 105 hypovascular nodules that were hypointense at the hepatobiliary phase of EOB-MRI were biopsied and the clinical usefulness of these EOB-MRI findings for the diagnosis of HCC was examined. Of the 105 nodules (median diameter＝12mm), 78 (74.3%), 11 (10.5%), and 16 (15.2%) were diagnosed as HCC, dysplastic, and non-neoplastic, respectively. The positive predictive value (PPV) of hypointensity at the hepatobiliary phase of EOB-MRI for the diagnosis of HCC increased to 77-90% when combined with the following factors: washout appearance on the delayed phase of triple-phase CT, hyperintensity in diffusion-weighted image of MRI, or the appearance of a hypoechoic part in ultrasonography. PPV increased to 100% when all 3 factors were positive. A relatively large proportion of hypovascular lesions that showed hypo-intensity in the hepatobiliary phase were confirmed to be HCC, and the accuracy of HCC increased when combined with other imaging findings. en-copyright= kn-copyright= en-aut-name=NakamuraShinichiro en-aut-sei=Nakamura en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KobayashiYoshiyuki en-aut-sei=Kobayashi en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OhnishiHideki en-aut-sei=Ohnishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToshimoriJunichi en-aut-sei=Toshimori en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KuwakiKenji en-aut-sei=Kuwaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HagiharaHiroaki en-aut-sei=Hagihara en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TakayamaHiroki en-aut-sei=Takayama en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Departments of Gastroenterology and Hepatology Okayama University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=hepatocellular carcinoma kn-keyword=hepatocellular carcinoma en-keyword=hypovascular kn-keyword=hypovascular en-keyword=diagnosis kn-keyword=diagnosis en-keyword=gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid kn-keyword=gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid en-keyword=magnetic resonance imaging kn-keyword=magnetic resonance imaging END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=523 end-page=532 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 1. Staining Mechanism of Cancer Cells By Fluorescent NTS Dye kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第1編 螢光色素NTSによる癌細胞の染色機序に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of elucibating the staining mechanism of fluorescent NTS dye that deeply stains cancer cells, some model experiments were conducted using fluorescent NTS dye mixed with a variety of proteins to pursue the manner of staining by means of stripping method at varying pHs as well as by paper electrophoresis. In addition, staining of cells was performed with the use of Ehrlich ascites tumor cells, MH-134 ascites liver cancer cells, normal rabbit liver cells, normal rabbit leucocytes, lymph nodes and peripheral blood of gastric cancer bearing patients, and human pus, and the following results were obtained. 1. Static electrical binding seems to play a principal role in the combination of fluorescent NTS dye with various proteins. 2. Cancer cells are stained deeply with the fluorescent NTS dye at higher pH range as compared with normal cells. 3. From these findings it has been clarified that, although fluorescent NTS dye is a suitable material for staining cancer cells, as young cells with abundant basophilic proteins possess specificity, fluorescent NTS dye is not necessarily so satisfactory a material with respect to its specificity to cancer cells. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=921 end-page=926 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Streptomycin on the Metabolic Activities of Bacteria kn-title=微生物の代謝に対するストレプトマイシンの作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This experiment was attempted to investigate the inhibitory action of streptomycin. The organism used is Shigella flexneri 2a. The results are as follows: 1) Even under a level of 200γ/ml streptomycin, it cannot inhibit the oxidation of pyruvate, succinate, fumarate, malate, glutamate, and aspartate by whole cell suspensions. 2) When glutamate is added to a cell suspension that has previously been permitted to oxidize fumarate, an immediate increase in oxygen consumption is observed. This increase is scarcely prevented by streptomycin. 3) The oxidatin of a mixture of glucose, glutamate, and 10(-3)M Mg(++) by a cell suspension is prevented by streptomycin level of 200γ/ml. 4) Streoptomycin prevents especially aerobic growth of this organism in the synthetic medium and results in an increased accumulation of pyruvate as a metabolic product. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=MatsumotoToyozi en-aut-sei=Matsumoto en-aut-mei=Toyozi kn-aut-name=松本豊治 kn-aut-sei=松本 kn-aut-mei=豊治 aut-affil-num=2 ORCID= en-aut-name=HonmatsuKakushi en-aut-sei=Honmatsu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=927 end-page=931 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Comparative Study on the Effect of Aureomycin, Chloromycetin, and Streptomycin on the Bacterial Respiration kn-title=微生物の呼吸に対するオーレオマイシン，クロロマイセチン及びストレプトマイシンの作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This experiment was performed to investigate the effect of aureomycin, chloromycetin, and streptomycin upon the oxidation of several substrates by Sh. flexneri 2a and E. coli communis. The results are as follows: 1) A level of 200γ/ml aureomycin markedly inhibits the oxygen uptake with substrates such as glucose, pyruvate, glutamate, and aspartate. The inhibitory rate has no relation to the preincubation time of a mixture of aureomycin and a cell suspension. 2) A high concentration (200γ/ml) of chloromycetin slightly inhibits the oxidation of amino acids such as glutamate and aspartate. The inhibitory rate has a relation to the preincubation time of a mixture of chloromycetin and whole cell suspensions. 3) A level of 200γ/ml streptomycin slightly inhibits the oxidation of glutamate and aspartate by E. coli, but it does not affect the oxidation of glucose and pyruvate by this organism. The oxidation of proposed substrates by Sh. flexneri 2a is not also prevented by streptomycin. Even though streptomycin is added to the original cell suspension before the substrates and preincubated for an hour, the results are the same. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=MatsumotoToyozi en-aut-sei=Matsumoto en-aut-mei=Toyozi kn-aut-name=松本豊治 kn-aut-sei=松本 kn-aut-mei=豊治 aut-affil-num=2 ORCID= en-aut-name=HonmatsuKakushi en-aut-sei=Honmatsu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=3 ORCID= en-aut-name=AkiyamaKengi en-aut-sei=Akiyama en-aut-mei=Kengi kn-aut-name=秋山健二 kn-aut-sei=秋山 kn-aut-mei=健二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=245 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of 7 α1-adrenoceptor Antagonists in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia:A Short-term Crossover Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=A crossover study was conducted to identify the best α1-adrenoceptor (α1AR) antagonist for individual patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). One hundred thirteen patients (mean age 70.8 years) were enrolled. All patients met BPH clinical study guidelines. Seven agents were utilized:tamsulosin 0.2mg, silodosin 8mg, urapidil 60mg, naftopidil 50mg, prazosin 1mg, terazosin 2mg, and doxazosin 1mg. Patients were initially prescribed tamsulosin or silodosin for a week and then urapidil for a week. Two weeks later, they were prescribed the better of the 2 agents for a week and a new agent for the next week. This cycle was repeated until all 7 agents were tested. Efficacy was evaluated with the International Prostate Symptom Score. The agent rankings were doxazosin (25 [22%]), silodosin (22 [19%]), urapidil (19 [17%]), naftopidil (17 [15%]), terazosin (12 [11%]), tamsulosin (11 [10%]), prazosin (7 [6%]). Only 12 patients (11%) changed agents after the crossover study was completed. The major reason was adverse events (83%). We found that each of the 7 α1AR antagonists has its own supporters. Further, the one-week crossover study was useful in identifying the best agent for the treatment of each individual with LUTS. en-copyright= kn-copyright= en-aut-name=ArakiTohru en-aut-sei=Araki en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MondenKoichi en-aut-sei=Monden en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Araki Urological Clinic affil-num=2 en-affil= kn-affil=Araki Urological Clinic affil-num=3 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=alpha-1 blockers kn-keyword=alpha-1 blockers en-keyword=alpha1-adrenoceptor antagonists kn-keyword=alpha1-adrenoceptor antagonists en-keyword=lower urinary tract symptoms kn-keyword=lower urinary tract symptoms en-keyword=benign prostatic hyperplasia kn-keyword=benign prostatic hyperplasia en-keyword=crossover study kn-keyword=crossover study END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=253 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Septic Pulmonary Embolism Induced by Dental Infection en-subtitle= kn-subtitle= en-abstract= kn-abstract=Dental infection can be an important source for septic pulmonary embolism (SPE), but only a few cases of SPE accompanying dental infection have been reported. The aim of this study was to characterize the clinical features of SPE induced by dental infection. Patients who fulfilled the diagnostic criteria described in the text were recruited in a retrospective fashion. All 9 patients were men, with a median age of 59 years (range:47 to 74 years). Eight patients had chest pain (88.9%), 5 had a preceding toothache (55.6%) and 3 had preceding gingival swelling (33.3%). Blood cultures obtained from 7 patients were negative. Periodontitis was found in all of the cases, periapical periodontitis in 5 cases, and gingival abscess in 3 cases. The median duration of hospitalization was 15 days, and symptoms were mild in some cases. In addition to antimicrobial therapy, tooth extraction was performed in 3 cases, tooth scaling in 6. SPE induced by dental infection has prominent clinical characteristics such as male preponderance, chest pain, preceding toothache, and mild clinical course. en-copyright= kn-copyright= en-aut-name=ShiotaYutaro en-aut-sei=Shiota en-aut-mei=Yutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaniguchiAkihiko en-aut-sei=Taniguchi en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YuzurioSyota en-aut-sei=Yuzurio en-aut-mei=Syota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HoritaNaokatsu en-aut-sei=Horita en-aut-mei=Naokatsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HosokawaShinobu en-aut-sei=Hosokawa en-aut-mei=Shinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WatanabeYoichi en-aut-sei=Watanabe en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TohmoriHidetoshi en-aut-sei=Tohmori en-aut-mei=Hidetoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OnoTetsuya en-aut-sei=Ono en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Respiratory Diseases, Kure Kyosai Hospital affil-num=2 en-affil= kn-affil=Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Respiratory Diseases, Kure Kyosai Hospital affil-num=4 en-affil= kn-affil=Department of Respiratory Diseases, Kure Kyosai Hospital affil-num=5 en-affil= kn-affil=Department of Respiratory Diseases Okayama Red Cross General Hospital affil-num=6 en-affil= kn-affil=Department of Respiratory Diseases Okayama Red Cross General Hospital affil-num=7 en-affil= kn-affil=Department of Dentistry and Oral Surgery, Kure Kyosai Hospital affil-num=8 en-affil= kn-affil=Department of Internal Medicine, Kure Kyosai Hospital en-keyword=bacteremia kn-keyword=bacteremia en-keyword=chest pain kn-keyword=chest pain en-keyword=multiple nodular shadows kn-keyword=multiple nodular shadows en-keyword=periodontitis kn-keyword=periodontitis en-keyword=septic pulmonary embolism kn-keyword=septic pulmonary embolism END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=533 end-page=538 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 2. Quantitative Estimation of Nucleoprotein in Cancer Cells by Microspectrophotometer kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第2編 Microspectrophotometerによる癌細胞核蛋白の定量的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In his previous report (1) the author clarified that fluorescent NTS dye stains cancer cells more deeply at higher pH (pH 11.0) than normal cells and deduced the main reason for this to be due to the increased amount of nucleoprotein and a higher electrical potential of cancer cells. However, there emerges a question whether the amount of nucleoprotein of cancer cells is actually increased and this neads to be settled by quantitative estimation of basophilic protein per cell. Therefore, in order to ascertain this point, basophilic protein of Ehrlich ascites tumor cells, MH-134 ascites liver cancer cells. HeLa cells in culture, lymph nodes of gastric cancer bearing patients, and peripheral luecocytes of normal mice were stained with acid fast green FCF stain by Alfert's method, and the quantitative estimation of the protein per cell was conducted with microspectrophotometer. As the result it was confirmed that these cancer cells contain a larger quantity of the basic protein than lymph node. From these findings it has become clear that the fluorescent XTS. which is an acidic dye, stains cancer cells at a higher pH than normal cells because they contain a greater amount of basic protein than normal cells. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=259 end-page=263 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=“Hook and Roll Technique” Using an Articulating Hook Cautery to Provide a Critical View during Single-incision Laparoscopic Cholecystectomy en-subtitle= kn-subtitle= en-abstract= kn-abstract=We describe a new simple and easy technique called the "Hook and roll technique" (HRT) that uses an articulating hook cautery to provide a critical view during single incision laparoscopic cholecystectomy (SILC). A 2-cm incision is made at the umbilicus to insert three 5-mm trocars or a multichannel port. After dissection of the serosa of the dorsal and ventral sides of the gall bladder, including Calot's triangle, the angled tip of the hook cautery is inserted between the cystic artery and duct with its tip placed dorsally. The tip is then rotated in a clockwise manner to avoid bile duct injury, allowing the connective tissue between them to be hooked, coagulated and cut. This procedure is repeated several times, followed by dissection between the cystic artery and the liver bed to achieve a critical view. From December 2008 to May 2011, 121 patients underwent SILC using HRT in our hospital without any serious complications. This technique is suitable for SILC, as it is consists of simple procedures that can be performed safely and easily, even by left hand in a cross-over approach, and it allows complete dissection of Calot's triangle to achieve a critical view without using any dissector under dangerous in-line viewing. en-copyright= kn-copyright= en-aut-name=IdaniHitoshi en-aut-sei=Idani en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakanoKanyu en-aut-sei=Nakano en-aut-mei=Kanyu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsamiShinya en-aut-sei=Asami en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KubotaTetsushi en-aut-sei=Kubota en-aut-mei=Tetsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomotoSatoshi en-aut-sei=Komoto en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuroseYohei en-aut-sei=Kurose en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KuboShinichiro en-aut-sei=Kubo en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NojimaHiroki en-aut-sei=Nojima en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HiokiKatsuyoshi en-aut-sei=Hioki en-aut-mei=Katsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KinHitoshi en-aut-sei=Kin en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakakuraNorihisa en-aut-sei=Takakura en-aut-mei=Norihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=2 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=3 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=4 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=5 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=6 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=7 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=8 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=9 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=10 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital affil-num=11 en-affil= kn-affil=Department of Surgery, Fukuyama City Hospital en-keyword=critical view of safety kn-keyword=critical view of safety en-keyword=single incision laparoscopic cholecystectomy kn-keyword=single incision laparoscopic cholecystectomy en-keyword=articulating hook cautery kn-keyword=articulating hook cautery END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=265 end-page=269 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Large Ulceration of the Oropharynx Induced by Methotrexate-Associated Lymphoproliferative Disorders en-subtitle= kn-subtitle= en-abstract= kn-abstract=We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis. en-copyright= kn-copyright= en-aut-name=HanakawaHiroyuki en-aut-sei=Hanakawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OritaYorihisa en-aut-sei=Orita en-aut-mei=Yorihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoYasuharu en-aut-sei=Sato en-aut-mei=Yasuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UnoKinya en-aut-sei=Uno en-aut-mei=Kinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Uno-kin ENT hospital affil-num=5 en-affil= kn-affil=Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=ulceration kn-keyword=ulceration en-keyword=methotrexate kn-keyword=methotrexate en-keyword=oropharynx kn-keyword=oropharynx en-keyword=lymphoproliferative disorders kn-keyword=lymphoproliferative disorders END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=933 end-page=942 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A CLINICAL STUDY OF THE INTRAVENOUS THIAMYLAL SODIUM ANESTHESIA FROM THE STANDPOINT OF THE BLOOD AND INTERSTITIAL FLUID PART I CHANGES IN BLOOD AND INTERSTITIAL FLUID BY INTRAVENOUS THIAMYLAL SODIUM ANESTHESIA kn-title=体内水分電解質分布とThiamylal Sodium静脈麻酔との関係に関する臨床的研究 第1編 Thiamylal Sodium静脈麻酔前後における体内水分電解質分布の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty-one patients were anesthetized by intravenous injection of thiamylal sodium and changes in blood and interstitial fluid were observed before and after anesthesia. 1) The specific gravity of blood and plasma, plasma protein and hematcrit slightly increased after intravenous administration of thimylal sodium, while the water content of blood and pleasma decreased. 2) Among the plasma electrolytes, plasma nartrium and chloride decreased, while plasma pottasium increased. 3) A decrease of plasma volume and an increase of interstitial fluid were observed. 4) The changes of factors mentioned above is regarded to be caused not only by blood concentrasion but also by transmission of plasma fluid to extracellular fluid. en-copyright= kn-copyright= en-aut-name=MatsudaSumizo en-aut-sei=Matsuda en-aut-mei=Sumizo kn-aut-name=松田住蔵 kn-aut-sei=松田 kn-aut-mei=住蔵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=4 article-no= start-page=271 end-page=276 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Negative Pressure Wound Therapy Incorporating Early Exercise Therapy in Hand Surgery:Bag-type Negative Pressure Wound Therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the postoperative treatment of hand surgery, it is important to start exercise therapy as early as possible. In conventional negative pressure wound therapy, the fingers are immobilized by the film dressing covering the wound and hand, thereby preventing sufficient rehabilitation. Here, we devised a bag-type negative pressure wound therapy that makes it possible to start finger exercises almost immediately, and we applied it to 4 patients:one each with hand burns, symmetrical peripheral gangrene, a crush injury accompanied by extensive skin defects and a fingertip degloving injury. The duration of the bag-type negative pressure wound therapy ranged from three to eight weeks, and good granulation was achieved, so that a skin graft was not required. In addition, particularly in the case of the fingertip degloving injury, good nail regeneration was achieved. Except for the case of symmetrical peripheral gangrene, a good range of joint motion with a percent total active motion (%TAM) of 94.7% or more was achieved. Our therapy was performed by inserting the hand into a sealing bag;sufficient exercise therapy was made possible by expanding the bag during rehabilitation. en-copyright= kn-copyright= en-aut-name=HasegawaKenjiro en-aut-sei=Hasegawa en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=negative pressure wound therapy kn-keyword=negative pressure wound therapy en-keyword=early exercise therapy kn-keyword=early exercise therapy en-keyword=wound healing kn-keyword=wound healing en-keyword=hand surgery kn-keyword=hand surgery END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=875 end-page=882 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=La Respiration de la Chauve-Souris pendant l'Hibernation kn-title=冬眠中ノ蝙蝠(Chiroptera)ノ瓦斯代謝ニ及ボス環境温度ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=L'auteur examine sur l'influence que la temp?rature ambiante excerce sur l'intensit? de la respiration de la Chauve-Souris pendant l'hibernation. Les resultats sont ainsi qu'il suit: 1) Pendant la p?riode d'hibernation, la quantit? d'oxyg?ne absorb? et d'acide carbonique exhal? et le chiffre du quotient respiratoire, chez la Chauve-Souris, augmente et diminue avec la temp?rature ambiante. 2) En jugeant au point du vue de la respiration, l'?tat l?thargique est tr?s profond et stable ? la temp?rature basse (au-dessous de 10°C). Mais, au dessus de 10°C, le sommeil est variable et superficiel, et l'animal reveille entre 15-20°C. L'?change gazeux est ?normement augmente, pendant le reveil d'hibernation, avec aussi en croissant le quotient respiratoire. en-copyright= kn-copyright= en-aut-name=KosakaHisasi en-aut-sei=Kosaka en-aut-mei=Hisasi kn-aut-name=小坂壽 kn-aut-sei=小坂 kn-aut-mei=壽 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=943 end-page=949 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A CLINICAL STUDY OF THE INTRAVENOUS THIAMYLAL SODIUM ANESTHESTA FROM THE STANDPOINT OF THE BLOOD AND INTERSTITIAL FLUID PART II THE RELATIONSHIP BETWEEN THE ANESTHESIA DURATION AFTER ADMINISTRATION OF THIAMYLAL SODIUM AND BLOOD AND INTERSTITAL FLUID kn-title=体内水分電解質分布とThiamylal Sodium静脈麻酔との関係に関する臨床的研究 第2編 体内水分電解質のThiamylal Sodium静脈麻酔における麻酔時間に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty-one patients were anesthetized by intravenous injection of thiamylal sodium and the relationships between the duration of anesthesia and the blood and interstitial fluid were studied. 1) A parallel correlation was seen between the anesthesia duration and the water content of plasma. 2) A reverse correlation was found between the sleeping time of anesthesia and quantity of the total plasma protein. 3) No interrelatiohships were found between the duration of anesthesia and hematerit, water content of blood, serum natrium, serum chloride, serum pottasium and plasma volume. 4) A reverse correlation was seen between the sleeping time of anesthesia and the interstitial fluid volume. en-copyright= kn-copyright= en-aut-name=MatsudaSumizo en-aut-sei=Matsuda en-aut-mei=Sumizo kn-aut-name=松田住蔵 kn-aut-sei=松田 kn-aut-mei=住蔵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1342 end-page=1349 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von operierter Felsenbeingeschwulst kn-title=顳?骨岩様部腫瘍ノ1新種 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Es handelt sich um einen Fall von rechtsseitiger Felsenbeingeschwulst, dessen Diagnose klinisch, namentlich radiologisch klar gestellt wurde. Die Operation fand ganz frei im Felsenbeink?rper eine Tumormasse, die in histologischen Hinsichten zur Gruppe Verocays Neurinom geh?rt. en-copyright= kn-copyright= en-aut-name=IshijimaTatsu en-aut-sei=Ishijima en-aut-mei=Tatsu kn-aut-name=石島達 kn-aut-sei=石島 kn-aut-mei=達 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學精神病學教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=539 end-page=551 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 3. Accelerative Effect of Various Surfactants on the Permeability of Cancer Cell Membrane kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第3編 諸種界面活性物質の癌細胞膜透過性亢進作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In previous reports 1 and 2, the author experimentally verified te fundamental staining mechanism of fluorescent NTS dye by its deposits in various cells. In the present experiment an attempt has been made to see whether it is possible to perform supra-vital staining with this fluorescent NTS dye. At the same time observations have been carried out on the staining behaviors (or changes) induced by the accelerated permeability of cell membrane in the course of supra-vital staining with concurrent use of various surfactants (surface active substances), and the results are summarized as follows. 1, It has been found that flurorescent NTS dye, being an acidic dye, has affinity to denatured protein, revealing a staining mechanism similar to eosin, and it stains degenerated cells deeply. 2. It has also been elucidated that in the course of supra vital staining with acidic dyes such as fluorescent NTS dye and eosin, even when the medium pH is raised to 7.2, on the addition of such surfactants as Tween 80, saponin, osvan, linoleic acid, OX (an anti-tumor agent of unsaturated fatty acids from Xray-irradiated rabbit liver) the dye readily permeates the cell membrane and thus the entire cell is uniformly stained positively. 3. These surfactants accelerate the permeability of the dye through the cell membrane as their concentration is raised, but in the case with saponified solution of fatty acids such as linoleic acid and OX at a certain range of concentration they bind chemically with intracellular organellae, bringing about changes in protein electrical charge of the organellae and as the result the cell becomes no longer stainable. Therefore, this point needs to be taken into consideration when the supra-vital staining of cells is attempted with concurrent use of surfactants of fatty acid series. 4. With fluorescent NTS dye and eosin supra-vital staining has been tried on Ehrlich ascites tumor cells, liver cells, epithelial cells of intestine, and ascites cells. It has been demonstrated that there is at least some difference in the accelerative effect of surfactants on the permeability of cell membrane depending on the kind of the substances. The accelerating effect of osvan, which is cationic surfactant, is especially marked. In the case of Tween 80 (a non-ionic surfactant) its effect is weak. In the case of OX. it imparts a greater permeability to Ehrlich ascites tumor cells rather than to epithelial cells of intestine. From these results, it seems that to a certain extent the basis has been established for introducing selectively some of charged substances into tumor cells depending upon the use of these surfactants. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=883 end-page=891 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Portioleukoplakie kn-title=子宮腟部「ロイコプラキー」ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eine besondere Bedeutung haben in neuester Zeit durch die Forschungen von Hinselmann die als Leukoplakie bezeichneten Befunde der Portio erhalten. Es handelt sich dabei um weisslich gef?rbte Bezirke auf der Schleimhaut der Portio, deren Farbe durch verhornende Massen des Portioepithels bedingt ist und die man meistens schon makroskopisch erkennen kann. Hinselman hat sie mit dem Kolposkop eingehend erforscht. Es liegen auch bereits eine Anzahl einwandfreier Beobachtungen durch Hinselmann selbst und andere Autoren vor, die den ?bergang von Leukoplakie zum Karzinom sicher erweisen. Wenn man aber die Literatur durchsieht, ist man erstaunt ?ber die geringe Ausbeute an Portioleukoplakie. In Japan ist nur ein einziger Fall mitgeteilt. Ich hatte drei in unserer Klinik zur Behandlung vorliegende F?lle klinisch, makroskopisch und histologisch genau untersucht. Mikroskopisch fand sich ein wahres Stratum corneum mit stark abgeplatteten Epithelien, darunter ein Stratum granulosum und ein stark verdicktes Stratum Malpighi. Das basale Relief des erkrankten Teils ist stellenweise unruhiger als in den normalen Abschnitten. Es bestand auch bereits in Form von einzelnen Zapfenbildungen eine gewisse Neigung zur Wucherung ins subepitheliale Bindegewebe. Meine Erfahrungen legen uns die Pflicht auf, schon allein unter klinischen Gesichtspunkten den Portioleukoplakien eine besondere Bedeutung f?r die Fr?herkennung des Karzinoms beizumessen. Ob die 100%ige karzinomat?se Entwicklung der Leukoplakie sich in Zukunft wird halten lassen, ist nicht die wesentliche Frage. M?gen es auch nur 50% oder noch weniger sein, unter allen Umst?nden w?rden immer solche Stellen entfernt werden m?ssen, da wir es der Leukoplakie nicht ansehen k?nnen, wie ihre Weiterentwicklung sein wird und nicht daf?r garantieren k?nnen, dass die Frau in Kontrolle bleibt. en-copyright= kn-copyright= en-aut-name=YamamotoHideo en-aut-sei=Yamamoto en-aut-mei=Hideo kn-aut-name=山本英雄 kn-aut-sei=山本 kn-aut-mei=英雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=892 end-page=898 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Einfl?sse der ophthalmologischen Behandelungen zur Vitalf?rbbarkeit des vorderen Augengewebes (III. Mitteilung.) Operative Momente kn-title=臨牀的眼處置ノ前眼部組織ノ生體染色性ニ及ボス影響ニ就テ 第3報 手術的處置 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser hat vorher im ersten Kapitel die Einfl?sse der pharmakologischen Behandlungen und im zweiten der physikalischen auf die Vitalf?rbbarkeit des Vorderaugengewebes mitgeteilt. In diesem dritten hat er ?ber bie Einfl?sse der Paracentese und der Sclerotomia posterior auf die desselben ebenfalls mit den Kaninchen experimentiert und daraus folgende Schl?sse gezogen. 1) Sowohl Paracentese, als auch Sclerotomia posterior bef?rdern die Vitalf?rbbarkeit des Vorderaugengewebes. 2) Die in diesem Experiment nachgewiesene Vitalf?rbbarkeitsbef?rderung ist wohl haupts?chlich als Folge des entz?ndlichen Reizes, d. h. Verst?rkung des Farbstoff speicherungsverm?gens und der Farbstoffkonzentration im Ortsgewebe, betrachtet zu werden. en-copyright= kn-copyright= en-aut-name=OhmoriSo en-aut-sei=Ohmori en-aut-mei=So kn-aut-name=大森操 kn-aut-sei=大森 kn-aut-mei=操 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學病理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=951 end-page=958 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of OX (unsaturated fatty acidextract) on Ehrlich's Ascites Tumor cells kn-title=工ールリッヒ癌に及ぼすOXの影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In view of the fact that there may be two possible actions in radiation distrurbaces in vivo, namely, one acting directly and the other acting indirectly, and on the assumption that these actions, persisting quite a long time after irradiation, induce specific substance in the irradiated nimals, Yamamoto of our department, has succeeded in isolating unsaturated fatty acid substance (OX) specific to the irradiated animals. With the purposa to find out what influences this substance (OX) will have on Ehrlich's ascites tumor cell, the author studied its effect on the number, mitotic phases and DNA ontents of the cancer cells. Test animals used are 80 mice each wighing about 15-20g. To these animals 0.2cc cell suspension of Ehrlich's ascites tumor cell is transplanted intraperitoneally and one week after the transplantation 0.2cc of 2%-, 1%-, 0.5%- OX substance is injected intrapeitoneally to these animals. By observing the changes in the cell counts, mitotic phase, and the DNA contents in each cell (with spectrophotometry) at the intervals of 1, 3, 6, 9, 12, and 24 hours after the injection of OX substance, and the following results were obtained: The number of cancer cells has been found markedly decreased; nomely, after one hour it is down to 78 per cent of the original count; down to 44per cent after 9 hours; and clown to 46.2 per cent after 24 hours. As for the mitotic phases, metaphase, anaphase telophase have been increased and the number of cells undergoing mitosis is diminished. Moreover, as for the DNA contents per cell, there can be observed an increase ni the number of cells with a markedly small amount of DNA, while the cells undergoing duplication due to mitosis have been found decreased in number. From these facts it is concl ded that OX substance acts on Ehrlich's ascites tumor cells as to induce the following disturbances: (1) cell destruction, (2) impairment of the activity in mitotic apparatus, (3) disturbance of the DNA synthesis, and (4) elicits atypical cell divistion. en-copyright= kn-copyright= en-aut-name=ItamiMotoya en-aut-sei=Itami en-aut-mei=Motoya kn-aut-name=伊丹尤也 kn-aut-sei=伊丹 kn-aut-mei=尤也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=959 end-page=993 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of Respiratory Enzyme Inhibitors on Infection of Rickettsia kn-title=各種呼吸酵素阻害剤のRickettsiaの感染に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using several kinds of respiratory enzyme inhibitors, the author studied the effect of the inhibitors on infection of rickettsia to mouse. The investigations were carried out in vitro and in vivo and the observations were made from day to day. Moreover, the characters of rickettsia were investigated by the re-inoculation to normal mouse from the culture. The following results were obtained. 1) The infection of rickettsia were found to be suppressed by previous in vitro treatment of rickettsia with any enzyme inhibitors tested, but the suppression effect was varied by hind of inhibitors, its concentration, duration of its action and the concentration of rickettsial suspension. The infection capacity of enzyme inhibitor treated-rickettsia showed a decrease in cases of 5 hours treatment of 10-20 mg malonate, of 1.0 mg monojodo acetic acid or of 1.0 mg fluoride. However, the affection of these inhibitors was vary specific, and found to have caused merely a reduction of infection capacity or a suppression of infection instead of to caused an inactivation of rickettsia. 2) On the contrary the inhibitors did not show an inhibitory effect to the infection of the rickettsia, if the inhibitors were administrated to the mouse to be tested before the attack of rickettsia. Accordingly a fairly difinite infection and the successive multiplication of rickettsia were observed on the previousely inhibitor-treated mouse; upon rare occasions the infection was found to be severe on these treated mouse. 3) The effect of inhibitors also studied by obeorving properties of re-inoculated rickettsia to normal mouse, the rickettsia was taken from the culture on the previously inhibitor-treated mouse. The multiplication of re-inoculated rickettsia was measured by means of LD(50) curve, and was demonstrated that the appearance of symptomes and the days to death after the infection was somewhat delayed on the treated animal compared to the control; but the occurences were almost in the same way as in the control except a short delay of the time. Hence, the affected metabolism of host cell and metabolic system of animal required to multiplication of the rickettsia were supposed to show so much definite effect to the suppression of infection. en-copyright= kn-copyright= en-aut-name=KiyotoMasahiro en-aut-sei=Kiyoto en-aut-mei=Masahiro kn-aut-name=清遠正博 kn-aut-sei=清遠 kn-aut-mei=正博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=899 end-page=907 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Einfluss der Narkotica auf die Wirkung des Veratrin, Cocain und Pikrotoxin auf den D?nndarm in situ bei Kaninchen kn-title=「ヴエラトリン」，「コカイン」及ビ「ピクロトキシン」ノ生體家兎腸管ニ於ケル作用ニ及ボス麻痺毒ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In der vorigen Mitteilung wurde nachgewiesen, dass Veratrin, Cocain und Pikrotoxin auf den im K?rper befindlichen D?nndarm des Kaninchens in kleineren Dosen eine hemmende Wirkung aus?ben, welche auf die Erregung der hemmenden Zentren von sympathischer Natur zur?ckgef?hrt werden kann. Die hemmende Wirkung dieser Gifte wird verst?rkt, wenn dem Tiere voher Urethan, Paraldehyd und kleinere Dosen von Chloralhydrat verabreicht werden. Dagegen wird diese v?llig beseitigt und macht einer erregenden Wirkung Platz, wenn das Tier mit Luminal, Veronal und gr?sseren Dosen von Chloralhydrat vorbehandelt wird. Auf Grund diese Tatsachen und der Analogie betreffs des Wasser-und Zuckerzentrums kann mit Wahrscheinlichkeit angenommen werden, dass die hemmenden Zentren f?r den Darm sich im Zwischenhirn befinden, wo sie durch sog. Basisnarkotica gel?hmt werden, und dass die L?hmung der Hirnrinde durch die sog. Rindennarkotica eine Erregung der betreffenden Zentren zur Folge hat. en-copyright= kn-copyright= en-aut-name=KunishoKaoru en-aut-sei=Kunisho en-aut-mei=Kaoru kn-aut-name=國正薫 kn-aut-sei=國正 kn-aut-mei=薫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=995 end-page=998 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hemolytic, Anemia-Inducing Substance in Cancer Tissue kn-title=癌組織中の溶血性細胞毒に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 1959 we discovered that a hemolytic, anemia-inducing substance is produced in the animals exposed to X-rays. Since then we have found that when this substnce is injeted intravenously into animals, there occur disturbances in the blood, spleen and bone marrow. And also it has become clear that this substance brings about Heinz's body appearance in erythrocytes. As Heinz's body also appears in cancer anemia and it is transformed into hemolysin, it may be assumed that the hemolytic, anemia-inducing substance is contained also in cancer tissue. Upon such assumption we have compared the hemolytic capacity of the extract obtained from the fresh gastric cancer tissue resscted at operation with that of the extract from normal gastric tissue. As the result, we have recognized that this hemolytic, anemia-inducing substance is contained considerably in cancer tissue. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=NobukiSigeo en-aut-sei=Nobuki en-aut-mei=Sigeo kn-aut-name=信木茂生 kn-aut-sei=信木 kn-aut-mei=茂生 aut-affil-num=2 ORCID= en-aut-name=SiakuTakeru en-aut-sei=Siaku en-aut-mei=Takeru kn-aut-name=塩飽健 kn-aut-sei=塩飽 kn-aut-mei=健 aut-affil-num=3 ORCID= en-aut-name=AkagiKeiko en-aut-sei=Akagi en-aut-mei=Keiko kn-aut-name=赤木瑩子 kn-aut-sei=赤木 kn-aut-mei=瑩子 aut-affil-num=4 ORCID= en-aut-name=SiakuMidori en-aut-sei=Siaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=5 ORCID= en-aut-name=IgutiYosiko en-aut-sei=Iguti en-aut-mei=Yosiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=6 ORCID= en-aut-name=TanimotoJunichi en-aut-sei=Tanimoto en-aut-mei=Junichi kn-aut-name=谷本潤一 kn-aut-sei=谷本 kn-aut-mei=潤一 aut-affil-num=7 ORCID= en-aut-name=KojimaSumikazu en-aut-sei=Kojima en-aut-mei=Sumikazu kn-aut-name=小島澄一 kn-aut-sei=小島 kn-aut-mei=澄一 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=553 end-page=564 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 4. Influences of Surfactants on the Effect of Antitumor Agents kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第4編制癌剤の抗腫瘍性に及ぼす界面活性物質の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the previous papers it was reported that surfactants (surface active substances) accelerate the permeability of the cell membrane. This paper describes the results of several experiments, conducted on the assumption that, when the permeability of the cell is artificially accelerated with surfactants, some of anti-tumor agents would have more ready access into cancer cells, resulting in a greater anti-tumor effect. The results may be summarized as follows. 1. In intraperitoneal injections of saponified surfactants such as Tween 80, saponin, osvan, and OX, no marked prolongation of survival can be observed, except with OX, but the similar injections of Mitomycin C combined with Tween 80 or OX clearly show an enhanced anti-tumor effect. In other words, Mitomycin C administered in conjunction with Tween 80 or OX seems to be more readily introduced into carcinoma cells. On the other hand, there is no appreciable effect in the concurrent use of Thio-TEPA with surfactants. 2. When the peritoneal cavity of the mice is washed with the mixed solution of Mitomycin C and Tween 80 or with that of Mitomycin C and OX soon after transplantation of Ehrlich ascites carcinoma (after the lapse of 4 hours and 48 hours), likewise a marked prolongation of survival has been observed. In short, clinically at the suture following the gastric cancer resection, it is reasonable to assume that the washing of the peritoneal cavity with the mixture of Mitomycin C and surfactant solution would help to bring about a better prognosis. 3. Actually, when the mixed solution of Mitomycin C and surfactant is diffusely injected at the site of the tumor of superficial type in the patient bearing mammary recurrent cancer, a dramatic effect has been atained on the tumor without injury to normal tissues. As has been described in the foregoing, anti-tumor agents, when used along with surfactants, have been verified, experimentally and clinically, to accelerate the permeabilty of the cancer cell membrane, resulting in a more ready access of the anti-tumor agent into the cancer cells. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=908 end-page=915 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Einfluss der Hirnstamm- und Hirnrindennarkotica auf die Blutzuckerregulation (II. Mitteilung.) ?ber den Einfluss auf die Hyperglyk?mie durch Adrenalin und Glukoseninfusion, sowie auf die Insulinhypoglyk?mie kn-title=腦幹及ビ皮質麻醉藥ノ血糖調節作用ニ及ボス影響ニ就テ（第2報）末梢性過血糖竝ニ「インシユリン」低血糖ニ及ボス影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In der vorigen Mitteilung wurde berichtet, dass Veronal und Luminal auf das Zuckerzentrum im Hirnstamm l?hmend wirken, w?hrend Urethan und Chloralhydrat es nicht l?hmen. In der vorliegenden Arbeit wurde am Kaninchen der Eiufluss dieser Gifte auf die Hyperglyk?mie durch Adrenalin und Glukoseninfusion sowie auf die Hypoglyk?mie durch Insulin untersucht. 1) Veronal und Luminal verst?rken die Hyperglyk?mie durch Adrenalin und Glukoseninfusion sowie die Hypoglyk?mie durch Insulin. 2) Urethan und Chloralhydrat ?ben auf die Hyperglyk?mie durch Adrenalin und Glukoseninfusion keinen deutlichen Einfluss aus, auf die Insulinhypoglyk?mie wirken sie antagonistisch. Aus obigen Tatsachen k?unte gefolgert werden: dem Zuckerzentrum kommt eine Funktion zu, die Hyperglyk?mie durch Adrenalin bzw. Glukoseninfusion sowie die Hypoglyk?mie durch Insulin antagonistisch zu regulieren; Veronal und Luminal heben durch ihre l?hmende Wirkung auf das Zuckerzentrum diese regulierende Funktion des Zuckerzentrums auf. Urethan und Chloralhydrat zeigen in den angegebenen Dosen keine solche Wirkung, was daraufhindeutet, dass sie auf das Zuckerzentrum nicht l?hmend wirken. en-copyright= kn-copyright= en-aut-name=TachibanaKatsuo en-aut-sei=Tachibana en-aut-mei=Katsuo kn-aut-name=橘捷夫 kn-aut-sei=橘 kn-aut-mei=捷夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=916 end-page=960 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studien ?ber die Entwicklung der Nierenanlage, besonders uber die morphologischen Verh?ltnisse bei Kaninchenembryonen kn-title=腎臟原基ノ發生ニ就テ 家兎胎兒ニ於ケル檢索 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Schon seit langer Zeit wurden ?ber die Entwicklung der Nierenanlage von vielen Autoren allerhand Forschungen angestellt, leider ist diese jedoch in vielen Punkten morphologisch noch nicht erkl?rt. Ich habe daher unter der Leitung von Herrn Prof. Shikinami Untersuchungen ?ber die morphologische Entwicklung der Kaninchenembryonen vorgenommen, bei denen ich als Material 40 St?cke benutzte, die ich der Bequemlichkeit halber in 12 Stadien einteilte. Mit dem Material wurde nach der in unserem Laboratorium gew?hnlich angewandten Methode verfahren, es wurde n?mlich Fixierung in Zenker's L?sung oder Formol, St?ckf?rbung mit Borax-Karmin, Einbettung in Paraffin vorgenommen und es wurden Serienschnitte von 10μ Dicke angefertigt. Die wichtigen Teilen dieser Serienschnitte wurden mitels des Edinger'schen Zeichenapparates 75-150 fach vergr?ssert und nach Born-Peter'schen Verfahren als genaue Rekonstruktionsmodelle hergestellt. Diese rekonstruierten Modelle wurden mit mikroskopischen Beobachtungen verglichen, und es ergaben sich folgende Resultate: Wie bei V?geln und anderen S?ugetieren stammen auch bei Kaninchen die Sekretions- und Ausleerungssysteme aus zwei Mutterb?den, und besonders. 1) Die Nieren-Knospe, die erste Anlage des Ausleerungssystems, bildet sich. zuerst beim etwa 4.5mm langen, 37 Ursegmente aufweisenden Embryo, 11 Tage nach der Begattung, an der dorsomedialen Wand der Endstelle des Urnierenganges aus, bevor der Urnierengang in die Kloake ausm?ndet. 2) Die Nierenknospe verl?ngert sich allm?hlich, ihr Ende vergr?ssert sich auch, und es lassen sich morphologisch das prim?re Nierenbecken und der Ureter voneinander unterscheiden, wie es bei einem etwa 6.5mm langen Embryo mit 48 Ursegmenten, wenn 12 Tage nach der Begattung verlaufen sind, bemerkt wird. 3) Der Ureter verl?ngert sich kranialw?rts und geht ungef?hr in die Mitte des Nierenbeckens ?ber. Dieser ?bergangsteil kehrt sich anfangs ventralw?rts, aber wegen der Drehung der Nierenanlage allm?hlich nach innen. Caudalw?rts m?ndet der Ureter urspr?nglich an der dorsomedialen Seite der Endstelle des Urnierenganges aus, aber gem?ss dem Fortschritte der Entwieklungsstadien verschiebt sich seine Ausm?ndung auf die dorsale Seite, kommt zugleich allm?hlich in die N?he der Kloake und ?ffnet sich schliesslich beim 13.0mm langen Embryo, 15 Tage nach der Begattung, unabh?ngig von dem Urnierengange in dieselbe. Diese Lageverschiebung der Ureterm?ndung ist dadurch bedingt, dass sich die R?hrenwand des Caudalteils des Urnierenganges zur Kloakenwand mit dem Entwicklungsfortschritte der Kolake vergr?ssert. 4) Beim 8.5mm langen Embryo von 14 Tagen gehen prim?re Sammelr?hre von dem Nierenbecken aus, ihre Ausgangsmassnahmen sind aber unregelm?ssig, bis 4 Paar Sammelr?hre von der ventralen und dorsalen Seite des Nierenbeckens typisch vorspringen. 5) Wenn 4 Paar Sammelr?hre typisch vorspringen, gehen wieder neue prim?re Sammelr?hre von den kranialen und caudalen Endst?cke des Nierenbeckens aus. Und diese prim?ren Sammelr?hre produzieren weiter sekund?re und terti?re Sammelr?hre, wie es beim 13.0mm langen Embryo von 15 Tagen bemerkt wird. 6) Die Verzweigung der Sammelr?hre schreitet immer weiter fort, so dass man beim 13.5mm langen Embryo von 16 Tagen schon quint?re Sammelr?hre erkennen kann. In diesem Entwicklungsstadium verbinden sich auch die Sammelr?hre an ihren Endteilen mit Harnkan?lchen, wodurch die Kommunikation zwischen den Sammelr?hren und Harnkan?lchen ganz vollendet wird. 7) Die Verzweigung der Sammelr?hre tritt immer regelm?ssig dichotomisch auf, und es l?sst sich bei ihr gew?hnlich im rechten Nierenbecken ein st?rkerer Fortschritt beobachten. 8) Das metanephrogenen Gewebe bildet sich zuerst beim etwa 5.5mm langen, 43 Ursegmente besitzenden Embryo, 11.5 Tage nach der Begattung, von der caudalen Partie des nephrogenen Gewebes aus. 9) Beim 6.5mm langen, 48 Uresegmente zeigenden Embryo von 12 Tagen teilt sich das metanephrogene Gewebe in zwei Zonen, in eine dichte Innenzone und eine lockere Aussenzone. Die erstere umgibt das Nierenbecken als Epithelialmantel, die letztere umh?llt die erstere noch von aussen und erstreckt sich in der Form eines Zellstranges kranialw?rts. Aber beim 4.0mm langen Embryo von 13 Tagen ist dieser Zellstrang schon nicht meter wahrnehmbar; so verschwindet die Aussenzone sofort, nachdem sie die Innenzone umh?llt hat, ohne sich nach oben zu erstrecken. 10) In der Zeit, wo die prim?re Sammelr?hre vom Nierenbecken herauswachsen, sind ihre Endst?cke von der Innenzone des metanephrogenen Gewebes umgeben, zentralw?rts aber verlieren sie these H?lle, wesbalb die zentralen Teile der Sammelr?hre und der Stammteil des Nierenbeckens direkt von der Aussenzone umh?llt sind. 11) Beim etwa 13.0mm langen Embryo von 15 Tagen bildet die Innenzone des metanephrogenen Gewebes, die butf?rmig die Spitze der Sammelr?hre umh?llt, die Zellkugeln, ferner die Zellbl?schen, die Anlagen der Harnkau?lchen in ihrem zentralw?rts umgekebrten Ende. 12) Beim etwa 13.5mm langen Embryo von 16 Tagen kommen endlich die Harnkan?lchen, die sich zuerst hakenf?rmig und dann weiter S-f?rmig umbilden, in Verbindung mit den Endstucken der Sammelr?hre.13) Diese Verbindung geht immer an den terti?ren bis quint?ren Sammelr?hren vor sich, die prim?ren und sekund?ren Sammelr?hre beteiligen sich nicht daran. 14) Von disen Verbindungen zwischen den Sammelr?hren und Harnkan?lchen kann ich beim etwa 13.5mm langen Embryo von 16 Tagen in der linken Nierenanlage 33, und in der rechten 31 z?hlen. 15) W?hrend der Entwicklung ver?ndert die Nierenanlage ihre Lage von caudal nach kranial, inzwischen f?hrt sie auch eine zweifache Ver?nderung der Achsenrichtung "(1) eine nach der Mit telebene, und (2) eine nach der Horizontalebene gerichtete Achsenver?nderung" und eine zweifache Rotation "(1) eine dorso-laterale Rotation mit der L?ngsachse und (2) eine kranio-ventrale Rotation wit der Queracbse" aus. 16) Die Differenz zwischen der Lage der linken und der rechten Nierenanlage wird zuerst beim 13.0mm langen Embryo von 15 Tagen sichtbar, bei welchem das rechte Nierenbecken 60μ h?her kranial w?rts liegt als das links. Diese Differenz betr?gt beim 13.5mm langen Embryo von 16 Tagen schon 0.13mm. en-copyright= kn-copyright= en-aut-name=OfujiToshiharu en-aut-sei=Ofuji en-aut-mei=Toshiharu kn-aut-name=大藤利治 kn-aut-sei=大藤 kn-aut-mei=利治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室胎生學研究室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=565 end-page=574 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Hypersplenism Part 1 Experimental Splenic Anemia by Abdominal Sympathectomy of Splenic Branches kn-title=脾機能亢進症に関する実験的研究 第1編 腹部交感神経脾臓枝切断による実験的脾性貧血に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=After the abdominal sympathectomy of splenic branches in nomal rabbits, the auther studied the blood and bone marrow pictures and iron metaborism, and obtained the following results. 1) In the peripheral blood picture a transient decrease in the erythrocyte count, hemoglobin content and platelet count could be observed. 2) In the bone marrow picture an increase and inhibition of maturation in the erythroid system could be observed. 3) Serum iron decreased conspicuously. However, the depot iron was as usual or increased a little. 4) In the bone marrow picture a little decrease in Sideroblast could be observed. 5) In the serum and spleen extracts, the existence of anemia producing toxic factor could not be observed. 6) From these observation, the author concluded that the principal cause of this anemia produced by ligating splenic and coronary Veins of the stomach lay in the inhibition on the mobilization of depot iron. en-copyright= kn-copyright= en-aut-name=TsuyunoYoshihiko en-aut-sei=Tsuyuno en-aut-mei=Yoshihiko kn-aut-name=露野嘉彦 kn-aut-sei=露野 kn-aut-mei=嘉彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=961 end-page=991 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serologische Studien ?ber mit Formalin Vorbehandelte rote Blutk?rperchen und Serum (I. Mitteilung.) ?ber den Einfluss von Formalin anf die Blutk?rperchenresistenz kn-title=血球竝ニ血清ニ及ボス「フオルマリン」ノ影響ニ就テ（第1報）赤血球ノ抵抗ニ及ボス「フオルマリン」ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser untersuchte zuerst die Resistenz der roten Blutk?rperchen gegen hypo- und hypertonische Salzl?sung. S?ure, Alkali, Normal- und Immunh?molysine, und zwar die von normalen und mit Formalin vorbehandelten roten Blutk?rperchen von Kaninchen, Meerschweinchen, Ziegen, Hunden, Schweinen, Rindern und H?hnern, sodann pr?fte er in der gleichen Weise die roten Blutk?rperchen nach der Milz-exstirpation. 1) Bei den roten Blutk?rperchen h?ngt die Ver?nderung der Resistenz gegen hypotonische Kochsalzl?sung von der Konzentration des zugesezten Formalin ab, weil die vorbehandelten Roten bei schwacher L?sung stark labiler, dagegen bei hoch konzentrierter L?sung viel resistenter geworden sind. 2) Es ist bemerkenswert, dass die Formalin-konzentration bei zirca 0.4% am st?rksten auf die roten Blutk?rperchen einwirkt. 3) Die roten Blutk?rperchen von verschiedenen Tierarten zeigen eigent?mliche Resistenzen gegen hypotonische Kochsalzl?sung. Sie stehen dabei in der Reihenfolge: H?hner, Meerschweinchen, Kaninchen, Hunde, Schweine, Rinder und Ziegen. Bez?glich der Formalin-Wirkung auf verschiedene rote Blutk?rperchen besteht dieselbe Reihenfolge wie bei hypotonischer Salzl?sung, n?mlich: H?hner, Meerschweinchen, Kaninchen, Hunde, Schweine, Rinder und Ziegen. 4) Formol-fixierte rote Blutk?rperchen zeigen geringere Resistenz gegen S?ure und Alkali als normale unbehandelte rote Blutk?rperchen. 5) Formol-fixierte rote Blutk?rperchen werden auch viel labiler gegen Immun-h?molysin, Normal-h?molysin und die Komplementwirkung. 6) Nach der Milz-exstirpation werden die roten Blutk?rperchen von operierten Tieren (bei Kaninchen und Ziege) resistenter gegen hypotonische Salzl?sung, S?ure, Alkali und H?molysinwirkung. Diese gesteigerte Resistenz wird jedoch durch Formalin-l?sung mehr oder weniger beeinflusst. en-copyright= kn-copyright= en-aut-name=KoizumiMichinori en-aut-sei=Koizumi en-aut-mei=Michinori kn-aut-name=小泉道徳 kn-aut-sei=小泉 kn-aut-mei=道徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=992 end-page=1012 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anatomical and Histological Observations of the Heart of Tachypleus tridentatus kn-title=日本産「カブトガニ」Tachypleus tridentatusノ心臟ノ解剖學的竝ニ組織學的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The anatomy and histology of the heart of Limulus Polyphemus have been described by Patten and Redenbaugh, Milne-Edwards and Walter Meek, but they are not in complete agreement. In the case of Branchio cardiac canal, for instance, Milne-Edwards reported six pairs of veins but Patten and Redenbaugh five pairs. There is little recorded work on the anatomy and histology of the heart of Tachypleus tridentatus in Japan, and although Dr. Nukada and Dr. Hoshino made brief anatomical and histological description for the purpose of Physiological study, they also disagree on some points. The former maintains and the later denies the presence of Volhof and Spezifische Muskelfasern. On account of these discrepancies, I made certain studies in comparison with previous results and some researches into new ground. Most of the materials were fixed in formalin and after subsequent treatment in the usual manner, the specimens were embedded in paraffin, trimmed and cut in transverse serial sections and longitudinal sections with thicknesses of 5.0, 25.0, and 50.0 microns. The sections were stained with Eosin-H?matoxylin and Nissl's method was used. A model was prepared according to Born-Peter's method of wax-plate reconstruction. From the results of my experiments, the following summary and conclusions were made: 1) The heart of Tachypleus tridentatus is a long tubular organ consisting of one ventricle, situated longitudinally on the lower part of median line of the carapace. It lies in a large pericardial sinus and is pupported by three holding tissues, Ligamentum suspensoria cordis superior, Alary muscle, and Veno-pericardiac muscle. 2) Around the heart is a large pericardial sinus, enclosed by a pericardium. Pericardium is a thin menbrane consisting of connective tissue fibres. There are eight pairs of Ostia on the dorsal wall of the heart, and they are the doors by which the blood in the pericardial sinus enters the heart. 3) There are eleven arteries leading off from the heart; one pair of Aortic arches and Arteria frontalis from the frontal end of the heart, and four pairs of Arteriae laterales arise from the lateral wall of the heart. Each artery has a valve. The aortic valve, much like a vertebrate Semilunar valve, lies upon the dorsal wall of the heart at the base of the Aortic arches. The Arteriae laterales are supplied with paired Semilunar valves at their points of origin from the heart. Each valve consists of connective tissues. 4) Pericardial sinus has veins, namely Branchio cardiac canal. I found five pairs of Branchio cardiac canal. I could not recognize six-pairs as described by Milne-Edwards. 5) The structure of the cardiac walls is composed of three layers. The outer most layer consists of the longitudinal elastic conective tissue fibres. The middle layer is the Basement membrane consisting of annular connective tissue fibres. The inner most layer is the circular muscular layer consisting of cross-striated muscular fibres. No membrane limiting the lumen, corresponding to the Endocardium of the mamalian heart is present. The cross-striated muscular fibres of Tachypleus tridentatus, resemble the mammalian heart, branching and anastomosing with each other, so form a syncytium. Also the individual muscular fibres are much like those of nammals, having nuclei surrounded by sarcoplasm and the fibrils make numerous bundles or Cohnheim's field. I think that the muscular fibres have no sarcolemma. 6) The author could not recognize the existence of Volhof and Spezifische Muskelfasern which were Dr. Nukada. 7) An median Cardiac nerve and one pair of Lateral cardiac nerves lie longitudinally on the heart. The branches of these two kinds of cardiac nerves anastomosing with each other, thus make the Cardiac nerve plexus. Median Cardiac nerve communicates with the centre by the Segmental cardiac nerve, Haemal nerve and Ventral cord. The structure of the nerve fibre consists of neurolemma and axis cylinder. There is no medullary sheath. The median cardiac nerve fibers possess the ganglion cells. en-copyright= kn-copyright= en-aut-name=KochiTakeshi en-aut-sei=Kochi en-aut-mei=Takeshi kn-aut-name=河内武 kn-aut-sei=河内 kn-aut-mei=武 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室胎生學研究室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1013 end-page=1042 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serologische Studien ?ber die Serumlipoide. (I. Mitteilung.) kn-title=血清類脂體ノ免疫學的研究（第1報）血清類脂體免疫ニヨル抗體ノ生産ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HirotaTeruki en-aut-sei=Hirota en-aut-mei=Teruki kn-aut-name=廣田照輝 kn-aut-sei=廣田 kn-aut-mei=照輝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=999 end-page=1004 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Effect of Yakult (Cow's Milk Fermented by Some Sort of “Family Lactbacillaceae” Commonly Sold as a Soft Drink) Part I. Fluctuation of pH. of the Stool After Drinking Yakult kn-title=乳酸菌ヤクルトの臨床効果に就て（第二報）（抗結核化学療養患者に於ける変化） 其の一 市販ヤクルト飲用による糞便pHの変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to determine the fluctuation of pH. of the stool after drinking "Yakult", cow's milk fermented by some sort of "Family Lactbacillaceae", the authors made normal adults and patients with lung tuberculosis drinking one bottle (60 cc) a day of Yakult successively, and estimated the pH. of their stool colorimetrically and obtained following results. 1. In the case of normal adults taking a bottle (60 cc) of Yakult a day successively, no marked fluctuation can be recognized. 2. In the case of patients with lung tuberculosis receiving drug treatment (chemotherapy) pH. range was 6.0~7.0 namely marked difference from normal adults can be recognized. 3. In the case of patients with lung tuberculosis receiving chemotherapy, after drinking Yakult, pH. of their stool become equal with that of normal adults'. By drinking Yakult marked effect was recognized. en-copyright= kn-copyright= en-aut-name=NanbaHisao en-aut-sei=Nanba en-aut-mei=Hisao kn-aut-name=難波寿夫 kn-aut-sei=難波 kn-aut-mei=寿夫 aut-affil-num=1 ORCID= en-aut-name=OonisiHiroyuki en-aut-sei=Oonisi en-aut-mei=Hiroyuki kn-aut-name=大西弘之 kn-aut-sei=大西 kn-aut-mei=弘之 aut-affil-num=2 ORCID= en-aut-name=TanakaYosio en-aut-sei=Tanaka en-aut-mei=Yosio kn-aut-name=田中義夫 kn-aut-sei=田中 kn-aut-mei=義夫 aut-affil-num=3 ORCID= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=医療法人謳生会病院 affil-num=2 en-affil= kn-affil=医療法人謳生会病院 affil-num=3 en-affil= kn-affil=医療法人謳生会病院 affil-num=4 en-affil= kn-affil=医療法人謳生会病院 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=575 end-page=581 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Hypersplenism Part 2 Experimental Splenic Anemia by Ligating Splenic Veins and Coronary Veins of the Stomach kn-title=脾機能亢進症に関する実験的研究 第2編 脾静脈及び胃冠状静脈結紮による実験的脾性貧血に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=After ligating splenic and coronary veins of the Stomach in normal rabbits, the author studied the blood and bone marrow pictures and iron metaborism, and obtained the following results. 1) In the peripral blood picture a transient little decrease in the erythrocyte count, hemoglobin content and platelet count could be observed. 2) In the bone marrow picture an increase and inhibition of mataration in the erythroid system could be observed. 3) Serum iron decreased conspicuously. However, the depot iron increased a little. 4) In the bone marrow picture a decrease of Sideroblast could be observed. 5) In the serum and spleen extracts, the existence of anemia producing toxic factor could be recognized. 6) From these observation, the author concluded that the principal cause of this anemia produced by the abdominal sympathectomy of splenic branches lay in the inhibition of maturation of the erythroblast as result of the inhibitory action of the toxic factor on the mobilization of depot iron. en-copyright= kn-copyright= en-aut-name=TsuyunoYoshihiko en-aut-sei=Tsuyuno en-aut-mei=Yoshihiko kn-aut-name=露野嘉彦 kn-aut-sei=露野 kn-aut-mei=嘉彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1005 end-page=1009 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Effect of Yakult (Cow's Milk Fermented by Some Sort of “Family Lactbacillaceae” Commonly Sold as a Soft Drink) Part II. Fluctuation of Vitamin B(1) in the Urine After Drinking Yakult kn-title=乳酸菌ヤクルトの臨床効果に就て（第二報）（抗結核化学療養患者に於ける変化） 其の二 市販ヤクルト飲用による尿中ビタミンB1の消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to determine the fluctuation of vitamin B(1) in the urine after drinking "Yakult", cow's milk fermented by some sort of "Family Lactbacillaceae", the authors made normal adults and patients with lung tuberculosis drink one bottle (60 cc) a day of Yakult successively, and estimated their content of vitamin B(1) in their urine polarographically and with paper chromatography. Results are as follows. 1. In the case of one bottle (60 cc) of Yakult successively, there occurs a little increment of vitamin B(1) content in their urine of normal adults comparing with tuberculous patients receiving chemotherapy. 2. In the case of taking one bottle of Yakult, no marked effect can be recognized in their urine of tuberculous patients receiving chemotherapy. However, when three bottles (180 cc) of Yakult are given every day, marked increase of vitamin B(1) can be observed even in their urine of the patients, and also impeding factor in polarographical estimation disappears, proving that Yakult is considerably effective in improving vitamin B(1) metabolism. en-copyright= kn-copyright= en-aut-name=NanbaHisao en-aut-sei=Nanba en-aut-mei=Hisao kn-aut-name=難波寿夫 kn-aut-sei=難波 kn-aut-mei=寿夫 aut-affil-num=1 ORCID= en-aut-name=OonisiHiroyuki en-aut-sei=Oonisi en-aut-mei=Hiroyuki kn-aut-name=大西弘之 kn-aut-sei=大西 kn-aut-mei=弘之 aut-affil-num=2 ORCID= en-aut-name=AritiSigeru en-aut-sei=Ariti en-aut-mei=Sigeru kn-aut-name=有地茲 kn-aut-sei=有地 kn-aut-mei=茲 aut-affil-num=3 ORCID= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=2 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=3 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=4 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1043 end-page=1057 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchung ?ber die Farbenreaktion und die Jodmetrie von oxydierbaren Substanzen (I. Mitteilung.) Bestimmung der oxydierbaren Substanzen mittels Farbenreaktion und Jodmetrie kn-title=動植物組織内ニ於ケル被酸化物質ニ就テ（第1報）被酸化物質ノ呈色反應ヨード法ニヨル測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser mass die Reduktionsf?higkeit der oxydierbaren Substanzen von tierischen und pflanzlichen Geweben mittels Farbenreaktion und Jodmetrie, im Verein mit einigen Studien ?ber ihre Physikalisch-chemischen Eigenschaften. 1) Die Farbenreaktion und die Jodmetrie vom Wasserextrakt und Pressaft zeigen in den meisten F?llen einen parallelen Zusammenhang, aber ihr Reaktionsgrad ist je nach der Art des untersuchten Materials verschieden. 2) Die oxydierbaren Substanzen gehen in Alkohol, Aceton und die L?sung einer Cyanverbindung ?ber, aber nicht in Ether. Sie werden von basischem Bleiacetat gef?llt, nicht aber von neutralem Bleiacetat oder von Phosphorwolframs?ure. 3) Diese oxydierbaren Substanzen sind sehr labil gegen Sonnenlicht, Wasserstoffsuperoxyd. Ihr Widerstand gegen W?rme ist verschieden, und zwar ist diejenige Substanz, die die beiden Farben- und Jodreaktionen deutlich zeigt, thermostabil. 4) Der Glutathionengehalt ist im pflanzlichen Gewebe geringer als im tierischen, und der Jodverbrauch der Glutathione ist geringer als derjenige der die Glutathione enthaltenden oxydierbaren Substanzen. 5) Der Wasserextrakt aus den Wurzeln der Lotuspflanze, Kiefernadeln, Orang- oder Eichenbl?ttern zeigt Zuckerreaktionen; daraus kann man eine Art von Osazon darstellen, dessen Schmelzpunkt zwischen 204° und 208°C liegt. 6) Die oxydierbaren Substanzen werden von Tierkohle adsorbiert, aber nicht von Bolus alba. Sie k?nnen Filtrierpapier, kollodiummembran, Fischskin und Pergamentpapier durchpassieren. 7) Die Rindensubstanz der gesunden Nebenniere hat die F?higkeit, Silber stark zu reduzieren. en-copyright= kn-copyright= en-aut-name=KonisiM. en-aut-sei=Konisi en-aut-mei=M. kn-aut-name=小西眞尚 kn-aut-sei=小西 kn-aut-mei=眞尚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1058 end-page=1062 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber ein Distomum aus dem Darm von Megalobatrachus japonicus kn-title=大山椒魚ノ腸管ニ寄生スルLiolope copulansニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Liolope copulans, eine Art von Trematoden, wurde 1897 von G. W. M?ller im Verdauungstraktus von Megalobatrachus japonicus gefunden und wurde von L. Cohn beschrieben. Wir fanden auch dasselbe Spezimen in grosser Anzahl im Darm einiger Megalobatrachus japonicus aus Provinz Okayama. Unsere Beobachtungen weichen aber in einigen Punkten von der Cohnschen wesentlich ab. Wir fassen unsere Resultate kurz zusammen wie folgt: 1) Die Gr?sse des K?rpers misst durchschnittlich 1.8mm. (1.52-2.28mm) 1. und durchschnittlich 0.97mm. (0.72-1.06mm.) br.; unserer Wert ist etwas gr?sser als der Cohnsche, welcher 1.5mm 1. und 0.75mm br. betr?gt. 2) Cohn beschreibt f?lschlich, dass “ein Oesophagus fehlt.” Nach unserer Beobachtung ist der Oesophagus ganz kurz; betr?gt ca. 0.014mm. 3) Der Exkretionsporus liegt dorsalw?rts kurz vor dem Hinterende des K?rpers. Die Exkretoinsblase ist ein ganz merkw?rdiges Gebilde wegen ihrer Besoderheit des Baues. Der Endteil der Exkretionsblase, welcher direkt mit dem Exkretionsporus verbindet, teilt sich bald in zwei Schenkeln, rechts und links. Jeder Schenkel teilt sich wieder in zwei Schenkeln. Diese vier Schenkeln verlaufen fast parallel nach vorn entlang jedes Darmschenkels. Je zwei Schenkeln in jeder Seite anastomosiert sich kurz hinter dem Mundsaugnapf wieder und bildet je einen geschlossenen Ring in jeder Seite. Ein Sammelkanal m?ndet sich etwas r?ckw?rts im vorderen Zipfel jeder Exkretionsblase ein. Dieser Befund widerspricht sich allerdings von dem Cohnschen ab. 4) Die dickschaligen Eier mit einem Deckel sind charakteristischer Weise Nierenform. Sie messen durchschnittlich 0.138mm 1. und durchschnittlich 0.068mm br. en-copyright= kn-copyright= en-aut-name=KagawaSakae en-aut-sei=Kagawa en-aut-mei=Sakae kn-aut-name=香川榮 kn-aut-sei=香川 kn-aut-mei=榮 aut-affil-num=1 ORCID= en-aut-name=KuyamaShosaku en-aut-sei=Kuyama en-aut-mei=Shosaku kn-aut-name=久山正策 kn-aut-sei=久山 kn-aut-mei=正策 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=277 end-page=283 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relationship between Orthodontic Expertise and Perception of Need for Orthodontic Treatment for Mandibular Protrusion in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aims of this study were to investigate how the Peer Assessment Rating (PAR index) predicts the perceived need for orthodontic treatment of mandibular protrusion in Japanese subjects, and to elucidate whether the perceived need for treatment was affected by the raters? orthodontic expertise. The subjects were 110 dental students and 32 orthodontists. We showed them casts of 10 untreated mandibular protrusion cases and gave them a questionnaire in which they had to describe their perceptions of the orthodontic treatment needs using a 10-point visual analog scale (VAS). The PAR index was used for cast evaluation. The PAR index scores showed significant correlations with the VAS scores. In casts with a low PAR score, there were no differences in the VAS scores between orthodontists and students. In casts with a PAR score greater than 23, the orthodontists perceived a significantly greater treatment need than did the students;for scores of 22, 28, and 29, students who had received orthodontic treatment themselves were more likely to perceive the treatment need. The PAR index is a good clinical predictor for assessing the perceived treatment needs for mandibular protrusion. Perception of the need for orthodontic treatment for mandibular protrusion depended on the degree of orthodontic expertise in Japanese subjects. en-copyright= kn-copyright= en-aut-name=MurakamiTakashi en-aut-sei=Murakami en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiAkihito en-aut-sei=Fujii en-aut-mei=Akihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawabataYuya en-aut-sei=Kawabata en-aut-mei=Yuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakakuraHiroaki en-aut-sei=Takakura en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamaueRie en-aut-sei=Yamaue en-aut-mei=Rie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Tarek Abdulsamad Ali Balam en-aut-sei=Tarek Abdulsamad Ali Balam en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KurodaShingo en-aut-sei=Kuroda en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawanabeNoriaki en-aut-sei=Kawanabe en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KamiokaHiroshi en-aut-sei=Kamioka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashiroTakashi en-aut-sei=Yamashiro en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=YA dental clinic affil-num=3 en-affil= kn-affil=Undergraduate student, Dental School, Okayama University affil-num=4 en-affil= kn-affil=Undergraduate student, Dental School, Okayama University affil-num=5 en-affil= kn-affil=Undergraduate student, Dental School, Okayama University affil-num=6 en-affil= kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Orthodontics and Dentofacial Orhtopedics, The University of Tokusima Graduate School of Oral Sciences affil-num=8 en-affil= kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=orthodontic expertise kn-keyword=orthodontic expertise en-keyword=treatment need kn-keyword=treatment need en-keyword=PAR index kn-keyword=PAR index en-keyword=mandibular protrusion kn-keyword=mandibular protrusion END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1063 end-page=1068 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Action of Electricity upon Organisms (2nd. Report.) Haemolysis by Electric Current kn-title=電流ノ生物ニ對スル作用ニ就テ（第2報）電流ニヨル溶血現象ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied on the haemolytic action of the electric current upon the red blood corpuscles of rabbits, suspended in the 0.9% NaCl solution. He confirmed the following facts. 1) Red blood corpuscles were haemolysed only by the constant current, but never by the alternating current, if the alternation is sufficiently frequent. 2) In regard to the relationship between the strength of the electric current and its duration holds good the Weiss-Hoorweg's formula for the excitation of muscle and nerve. 3) It is highly probable that the alkalinity, which has been produced in the neighbourhood of the negative Pole, plays the important r?le on the electrical haemolysis. en-copyright= kn-copyright= en-aut-name=MoriNobutane en-aut-sei=Mori en-aut-mei=Nobutane kn-aut-name=森信胤 kn-aut-sei=森 kn-aut-mei=信胤 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1069 end-page=1093 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Action of Electric Current upon Organisms (3rd. Report.) On the Alternation of Permeability of Cell-membranes by Electric Current kn-title=電流ノ生物ニ對スル作用ニ就テ（第3報）電流刺戟ニヨル細胞膜ノ透過性ノ變化ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The auther studied on alternation of permeability of cell-membranes by electric current and reached to the following results. 1) Plasmolysis of epithelial cells of Tradescantia virginica by hypertonic solution (0.5-1.0%) of sodium chloride will be stopped at the neighbourhood of the cathode by passing through of the electric current. 2) In the neighbourhood of cathode potassium-ions escape from the cells into the surrounding medium. It will be so understanded that the damage of semipermeability of the cell-membranes allows passage of anion and potassium-ion escapes in balance of it. Same thing occurs on the muscle cutaneus dorsi of frog. 3) Potassium-escape can be observed on the resting muscle of frog when the temperature of bathing fluid exceeds 29-32°C. en-copyright= kn-copyright= en-aut-name=MoriNobutane en-aut-sei=Mori en-aut-mei=Nobutane kn-aut-name=森信胤 kn-aut-sei=森 kn-aut-mei=信胤 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1094 end-page=1108 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Zucker-, Fettstoffwechsel und die passive Anapbylaxie bei experimenteller Kaninchenclonorchiasis sinensis (2. Mitteilung.) Experimentelle Untersuchung ?ber den Fettstoffwechsel bei der Kaninchenclonorchiasis kn-title=實驗的肝臟「ヂストマ」病家兎ニ於ケル糖代謝，脂肪代謝竝ニ被働性過敏症ニ就テ 第2報 脂肪代謝ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser, der den Zuckerstoffwechsel bei der experimentellen Kaninchenclonorchiasis untersucht hatte (diese Zeitschrift Nr. 542, 1935.), studierte diesmal den Fettstoffwechsel bei Kaninchenclonorchiasis. Er stellte Tributyrinspaltungsversuche mit dem Leberbrei aus kranken und normalen Kaninchen an und weiter ebensolche Versuche mit Glyzerinauszug des Pankreaspulvers vom Rinde unter Zusatz von Leberextrakt aus normalen oder kranken Kaninchen. Die Resultate der Versuche sind folgende: 1) Die tributyrinspaltende Wirkung des Leberbreies von kranken Kaninchen wurde bei pH 8.043 und 38°C stark gebemmt. 2) Die Wirkung der Rinderpankreaslipase wurde durch Zusatz von Leberextrakt aus kranken Kaninchen auch hemmend beeinflusst, w?hrend bei Zusatz von Leberextrakt aus normalen Kaninchen fast kein Einfluss bemerkbar war. 3) Nach den obigen Versuchsresultaten nimmt Verfasser an, dass der Fettstoffwechsel bei Kaninchenclonorchiasis wesentlich gest?rt werden m?sste. en-copyright= kn-copyright= en-aut-name=UyenoHiroshi en-aut-sei=Uyeno en-aut-mei=Hiroshi kn-aut-name=上野博 kn-aut-sei=上野 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=285 end-page=292 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Is Presence or History of Extracolonic Primary Malignancy a Risk for Colorectal Neoplasia? An Analysis of Patients Who Underwent Colonoscopy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Whether presence or history of extracolonic primary malignancy is a risk for colorectal neoplasia is not fully known. In this study, 26,452 first-time colonoscopy cases were examined using a colonoscopy database. Among the analyzed subjects, 3,026 (11%) subjects had history or concomitance of extracolonic primary malignancy, while the remaining 23,426 subjects did not. Colorectal neoplasia was observed in 39% of all the subjects. A crude comparison showed that the prevalence of any type of colorectal neoplasia was higher in subjects with extracolonic malignancy than in those without (42% vs. 39%, p＝0.0012). However, after adjusting for confounding factors, the odds ratios (ORs) of subjects with extracolonic malignancy for having colorectal neoplasia, advanced neoplasia, and cancer were all less than 1.0, and all significantly different from those of subjects without extracolonic malignancy. Analysis according to the type of extracolonic malignancy revealed that gastric cancer cases had a significantly lower risk for colorectal advanced neoplasia (OR:0.81;95% CI:0.67-0.99). Among major malignancies, only esophageal squamous cell cancer cases had increased risk for colorectal neoplasia (OR:1.66;95% CI:1.20-2.29). Patients with presence or history of extracolonic malignancy did not carry a higher risk of occurrence of colorectal neoplasia. en-copyright= kn-copyright= en-aut-name=AkitaMitsuhiro en-aut-sei=Akita en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KajiEisuke en-aut-sei=Kaji en-aut-mei=Eisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakemotoKoji en-aut-sei=Takemoto en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NagaharaYasuhiro en-aut-sei=Nagahara en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamamotoHiroshi en-aut-sei=Yamamoto en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatoJun en-aut-sei=Kato en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Tsuyama Central Hospital affil-num=5 en-affil= kn-affil=Nihon Kokan Fukuyama Hospital affil-num=6 en-affil= kn-affil=Kurashiki Central Hospital affil-num=7 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Second Department of Internal Medicine, Wakayama Medical University en-keyword=colorectal cancer kn-keyword=colorectal cancer en-keyword=colonoscopy kn-keyword=colonoscopy en-keyword=risk factor kn-keyword=risk factor en-keyword=database kn-keyword=database END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1109 end-page=1118 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=尿道淋疾竝ニ其ノ合併症ニ對スル「ゴノブロカノン」ノ應用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山本春海 kn-aut-sei=山本 kn-aut-mei=春海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學皮膚科泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1123 end-page=1142 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vergleichungsstudien ?ber die verschiedenen Trockenmittel kn-title=各種除濕劑ノ比較研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Um praktisch die Wirkung der Entfeuchtung bei geschlossenem Raum zu studieren, stellten wir in das dicht geschlossene Laboratoriumzimmer einen mit Papier ?berzogenen Glaskasten (1cm) ein, mit dem man eine bestimmte Temperatur und Feuchtigkeit erzeugen kann. Die relative Feuchtigkeit im Versuchskasten wird durch Einf?hrung von Wasserdampf auf ?ber 90% gesteigert, dann wird eine bestimmte Menge von verschiedenen Trockenmitteln (Calcium chloratum purum f?r Analyse von Isizu, Calcium chloratum siccum f?r Trocknung, Calcium chloratum siccum neutrale von Merck, I. D. Trockenmittel, Adsole, Schwefels?ure, und Wolle) in den Kasten eingef?hrt. Die Wirkung der Trockenmittel wird zeitlich durch verschiedene Psychrometer (Augustsche, Assmannsche, Fuessche, Lambrechtsche Psychrometer) untersucht. Dabei werden die Katawerte mit einem Wett-katathermometer bestimmt. Da die relative Feuchtigkeit von der Ver?nderung der Temperatur abh?ngt, wurden alle Untersuchungen immer in einer bestimmten Temperatur ausgef?hrt. Diese Versuche wurden im Sommer (bei 30 C) und im Winter (bei 10 C) angestellt, weil die Wirkung der Trockenmittel durch die Temperatur mehr oder minder beeintr?chtigt wird. 1) Bei hoher Temperatur im Sommer, d. h. bei 30 C, zeigt sich Calcium chloratum in bezug auf Lufttrockung am st?rksten, dann folgen I. D. Trockenmittel, Adsole, Schwefels?ure und Wolle. 2) Bei niedriger Temperatur im Winter, d. h. bei 10 C, abfeuchtet Calcium chloratum am st?rksten, es folgend I. D. Trockenmittel und Adsole. Unter Calcium chloratum wirkt als Trockenmittel das Calcium chloratum purum f?r Analyse am st?rksten, diesem folgt Calcium chloratum siccum neutrale von Merck, Calcium chloratum siccum steht hinter diesen ziemlich weit zur?ck. 3) Es ist bemerkenswert, dass die Absorptionskraft f?r die Luftfeuchtigkeit haupts?chlich von der Fl?chengr?sse der Absorptionsmittel abh?ngig ist. Wenn man also gekl?mpftes Calcium chloratum siccum fein zerbricht, so steigt seine Absorptionskraft auf die des Calcium chloratum purum f?r Analyse. 4) In der gleichen Weise kann man durch verteilte Anwendung des Trockenmittels viel bessere Resultate erzielen als bei einmaligem Gebrauch desselben. 5) Die Trockenmittel zeigen ihre Absorptionskraft bei hoher Temperatur im Sommer deutlich st?rker als bei niedriger Temperatur im Winter. en-copyright= kn-copyright= en-aut-name=OhtaharaKazuyoshi en-aut-sei=Ohtahara en-aut-mei=Kazuyoshi kn-aut-name=大田原一祥 kn-aut-sei=大田原 kn-aut-mei=一祥 aut-affil-num=1 ORCID= en-aut-name=IshiharaTadayuki en-aut-sei=Ishihara en-aut-mei=Tadayuki kn-aut-name=石原忠之 kn-aut-sei=石原 kn-aut-mei=忠之 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1143 end-page=1159 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Beeinflussung der Senkungsgeschwindigkeit und der Resistenz der Erythrozyten durch perorale Darreichung von Brennpetroleum bei Kaninchen kn-title=石油ヲ投與セラレタル家兎ノ赤血球沈降反應及ビ血球抵抗 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei der peroralen Darreichung des Bernpetroleums bei Kaninchen, und zwar 1cc pro Kilo, wurden keine toxischen Erscheinungen wie Appetitlosigkeit, Diarrhoe u. s. w. klinisch nachgewiesen, die Senkungsgeschwindigkeit der roten Blutk?rperchen erh?hte sich jedoch 6 bis 9 Tage nach der Darreichung und die Resistenz derselben gegen hypotonische Kosalzl?sung verminderte sich ziemlich. Als einen wesentlichen Faktor f?r diese Ver?nderung der Erythrozyten k?nnte man Cholesterin?mie nach Brennpetroleumzufuhr, die Hiromoto in dem oben genannten Institut zuerst bemerkt hatte (noch nicht publiziert), ansehen. Weiter best?tigte Verfasser, dass die unscharfen Zone fast regelm?ssig bei der Bestimmung der Senkungsgeschwindigkeit auftrat, was auf die Vermehrung der jungen Erythrozyten zur?ckzuf?hren ist. Diese 3 Erscheinungen des Blutes verloren sich allm?hlich wieder im Verlaufe von 6 bis 9 Tagen nach der Darreichung des Brennpetroleums. en-copyright= kn-copyright= en-aut-name=MomonoiKwanji en-aut-sei=Momonoi en-aut-mei=Kwanji kn-aut-name=桃井寛次 kn-aut-sei=桃井 kn-aut-mei=寛次 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=293 end-page=303 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibitory Function and Working Memory in Attention Deficit/Hyperactivity Disorder and Pervasive Developmental Disorders:Does a Continuous Cognitive Gradient Explain ADHD and PDD Traits? en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the relationship between attention deficit/hyperactivity disorder (AD/HD) and pervasive developmental disorders (PDD), we investigated the common features and differences of these disorders in neuropsychological profiles. The subjects were 4 groups of Japanese boys aged 6 to 15 years, categorized by diagnosis:AD/HD (n＝20), PDD with comorbid AD/HD (PDD＋:n＝16), PDD without comorbid AD/HD (PDD−:n＝8), and typically developing (n＝60). We evaluated executive function (EF) through verbal and visuospatial memory tasks, the Go/NoGo task, and the color-word matching Stroop task. We performed a categorical analysis to estimate the effects of the 3 disorders on EF and a dimensional analysis to estimate the effects of symptom scales on EF. We found that the AD/HD and PDD＋ subjects had negative effects on verbal working memory and intra-individual response variability. The severity of these impairments was positively correlated with the inattentiveness score. The subjects with a PDD＋ or PDD− diagnosis had poorer scores on interference control;the severity of this impairment was correlated with the PDD symptom score. Impairments in visuospatial working memory were detected in the AD/HD and PDD− groups but not in the PDD＋ group. Impairments in inhibition of the pre-potent response were noted in all 3 categories. AD/HD and PDD share neuropsychological features, though each disorder has a specific impairment pattern. Our findings partially support the idea that AD/HD and PDD are on a spectrum. en-copyright= kn-copyright= en-aut-name=TakeuchiAkihito en-aut-sei=Takeuchi en-aut-mei=Akihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OginoTatsuya en-aut-sei=Ogino en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HanafusaKaoru en-aut-sei=Hanafusa en-aut-mei=Kaoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MorookaTeruko en-aut-sei=Morooka en-aut-mei=Teruko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkaMakio en-aut-sei=Oka en-aut-mei=Makio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhtsukaYoko en-aut-sei=Ohtsuka en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Children Studies, Faculty of Children Studies, Chugokugakuen University affil-num=3 en-affil= kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Human Ecology, Okayama University Graduate School of Environmental Science affil-num=7 en-affil= kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=attention deficit/hyperactivity disorder kn-keyword=attention deficit/hyperactivity disorder en-keyword=pervasive developmental disorder kn-keyword=pervasive developmental disorder en-keyword=executive function kn-keyword=executive function en-keyword=working memory kn-keyword=working memory en-keyword=color-word matching Stroop task kn-keyword=color-word matching Stroop task END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=583 end-page=589 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Hypersplenism Part 3 The Effects of Splenic Toxic Factor on White Cell Series kn-title=脾機能亢進症に関する実験的研究 第3編 実験的貧血家兎脾毒性因子の白血球系に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=By the simple method of bone marrow tissue culture, the author studied on the effects on white blood cells of bone marrow by adding serum and spleen extracts of the rabbits with experimental splenic anemia, and obtained the following results. 1) In the group of rabbits with the abdominal sympathectomy of splenic branches, a little inhibition of tissue growth and a little decrease of the wandering velocity of pseudoeosinophils could be observed. 2) In the other group, both tissue growth and wandering velocity formed a contrast, and the specially efficient difference could not be observed. 3) From these observation, the author observed that the splenic toxic factor produced in the experimental anemic rabbits acted directly upon the bone marrow, and caused a increase in the leucocyte and the inhibition of the motor function. en-copyright= kn-copyright= en-aut-name=TsuyunoYoshihiko en-aut-sei=Tsuyuno en-aut-mei=Yoshihiko kn-aut-name=露野嘉彦 kn-aut-sei=露野 kn-aut-mei=嘉彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1011 end-page=1022 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Gastric Ulcer Induced by Hormonal Disharmony Part 1. On the Influence of Some Changes in Blood Component Upon the Gastric Ulcer Induced by Adrenalectomy kn-title=ホルモン失調性胃潰瘍の実験的研究 第1編 ホルモン失調性胃潰瘍と血液性変化との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The relationship between the ulceration in the glandular stomach of rats, induced by adranalectomy, and the substitution therapy or the changes in blood components has been investigated. As agents for the substitution therapy after adranalectomy physiologic saline solution, cortisone and DOCA were used. During the substitution therapy, non-protein nitrogen in whole blood, protein and sodium-potagsium concentration in serum were determined. When the abnormality of sodium-potassium balance in the serum after adrenalectomy was corrected by the administration of physiologic saline solution or cortisone (0.1-0.15/mg/day/100g B.W.), ulceration could be prevented. However, when the excessive substitution therapy by cortisone (5 mg/bay/animal) was done, it was failed to prevent the induction of ulceration. When DOCA was used excessively and sodium-potassium balance in serum was under the state of disharmony, no ulceration was found. And it was recognized that the ulceration and the change in the none protein nitrogen or protein was not intimately correlated. Through these experiments, it has been, therefore, surmized that the gastric ulceration following adranalectomy was mainly influenced by the sort of substitution therapy, rather than by the alteration of certain specific factor in the blood components. en-copyright= kn-copyright= en-aut-name=KondoHidemi en-aut-sei=Kondo en-aut-mei=Hidemi kn-aut-name=近藤日出海 kn-aut-sei=近藤 kn-aut-mei=日出海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=591 end-page=616 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Anticancer Chemotherapy Especially on the effect of anticancer agents and anticancer supporting substances on the metabolism of cancer bearing mice PART T The effect of anticancer agents and anticancer supporting substances on the hosts of malignant tumor and its correlation with enzyme metabolism kn-title=癌の化学療法に関する研究 特に制癌剤並びに制癌強化剤の担癌生体内代謝に及ぼす影響に就いて 第1編 制癌剤および制癌強化剤の抗腫瘍性効果,並びに担癌生体酵素代謝に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In is known that cancer research has been concentrated to make a correlation between cancer and its bearing hosts. An attempt was made to study anticancer effect and enzyme metabolism under the administration of anticancer agents and their supporting substances in order to destruct cancer cells and increase biological resistance of its bearing mice. The results obtained are as follows: 1) Marked prolongation in survival period and inhibition of ascites were obtained in cancer bearing mice under mitomycin administration, but the administration of its large dosage in contrast, inhibited a prolongation of survival period and also made a loss of body weight. The combined administration of anticancer agents and their supporting substances manifested the most remarkable prolongation in survival period. Amongst three anticancer supporting substances, orotic acid made the greatest prolongation of survival period as well as marked inhibition of ascites. Glucuronic acid made the same results in less degree. 2) Mitomycin had a marked effect to inhibit the depression of catalase activity in liver and kidney of cancer bearing group, although mitomycin itself had a tendency to decrease catalase activity in liver and kidney of normal group. 3) Anticancer supporting substances, orotic acid and glucuronic acid markedly increased catalase of liver in normal group and inhibited the tendency of its decrement in cancer bearing group. 4) Anticancer agents showed the same tendency to saccinic dehydrogenase activity as to catalase. 5) S-GOT and S-GPT slightly increased in cancer bearing group. They were intensively improved under the combined administration of anticancer agents and their supporting substances. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1023 end-page=1030 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Gastric Ulcer Induced by Hormonal Disharmony Part 2. On the Influence of Some Chemical Components Changes in the Gastric Wall Upon the Gastric Ulcer Induced by Adrenalectomy kn-title=ホルモン失調性胃潰瘍の実験的研究 第2編 ホルモン失調性胃潰瘍と組織水分及び塩類代謝との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this part, the changes in the concentration of water, sodium and potassium in the wall of the fore-stomach, glandular stomach, intestine and muscle of the rat, treated in the same manner as stated in the Part 1, were determined. And the relationship between these changes and the ulceration of the glandular stomach was studied. Water content in the every tissue of the rat, in either non-treated or treated by physiologic saline solution after adrenalectomy, was increased, but not in the rat treated by the other agents. And it was recognized that the ulceration and the change of water content in the gastric wall were not intimately corelated. The changes of sodium and potassium contents in these digestive organ were not identiccal, and no regulation was observed there. And it was recognizes that the ulceration and the change of sodium and potassium content in the gastric wall after adrenalectomy were not intimately corelated. en-copyright= kn-copyright= en-aut-name=KondoHidemi en-aut-sei=Kondo en-aut-mei=Hidemi kn-aut-name=近藤日出海 kn-aut-sei=近藤 kn-aut-mei=日出海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1031 end-page=1043 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Disorders in Vascular Factor and its Prevention in Reference to Hemorrhagic Tendency Following Massive Transfuions of Preserved Blood Part I: Studies on the Mechanism of Disorders in Vascular Factor kn-title=保存血大量輸血に伴う血管因子障害とその対策 前編 成因に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=About on hemorrhagic tendency following massive transfusions of preserved blood, dynamics of mesenteric capillaries, changes in capillary resistance and platelets, and bleeding time were studied experimentally and clinically. Following transfusions, peripheral capillaries were dilated and the blood stream become slow and pooling. Endothelial damages, increase in the permeability and escaping of red blood cell through the wall were observed. Capillary resistance was decreased in the early stage of transfusions and was closely related to the injected blood volume. Striking decrease in number of platelets and prolongation of bleeding time were also recognized in almost all of the cases. It was surmizd that the main factor of hemorrhagic tendency was increase in the permeability or the fragility predisposed by changes in capillary wall with reduction in platelet counts due to blood transfusion itself. en-copyright= kn-copyright= en-aut-name=HiraoYoshishige en-aut-sei=Hirao en-aut-mei=Yoshishige kn-aut-name=平尾喜茂 kn-aut-sei=平尾 kn-aut-mei=喜茂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1045 end-page=1059 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Disorders in Vascular Factor and its Prevention in Reference to Hemorrhagic Tendency Following Massive Transfusions of Preserved Blood Part U: Studies on the Prophylaxis and Therapy of Vascular Disorders kn-title=保存血大量輸血に伴う血管因子障害とその対策 後編 治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Concerning the vascular disorders caused by massive transfusions of preserved blood, the influence of several treatments on the vascular system was estimated by the capillary resistance, hyaluronidase diffusion ratio, platelet count and bleeding time. There was a striking effect on the improvement of the vascular disorders as continuous injection of intravenous hydrocortisone. Fresh blood and platelet transfusions improved the vascular impairments, same as in adrenochrome. And an effectiveness was observe, even in alternated transfusion of the fresh and the presrved blood. ε-Aminocapronic acid was useful for the correction of vascular disorder due to fibrinolysis. Moreover thromboplastin preparations, such as Manetol, and Naphthionic acid were also effective. It was proposed that those measures described above should be performed as prophylaxis before or during blood transfusions, rather than as a therapeutics after transfusions. en-copyright= kn-copyright= en-aut-name=HiraoYoshishige en-aut-sei=Hirao en-aut-mei=Yoshishige kn-aut-name=平尾喜茂 kn-aut-sei=平尾 kn-aut-mei=喜茂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=617 end-page=632 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Anticancer Chemotherapy Especially on the effect of anticancer agents and anticancer supporting substances on the metabolism of cancer bearing mice PART U The effect of anticancer agents and their supporting substances on nucleic acid metabolism of malignant tumor and on cancer cell proliferation kn-title=癌の化学療法に関する研究 特に制癌剤並びに制癌強化剤の担癌生体内代謝に及ぼす影響について 第2編 制癌剤および制癌強化剤の担癌生体核酸代謝に及ぼす影響,並びに癌細胞分裂像との相関に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nucleic acid metabolism of tumor itself and liver in cancer bearing mice, DNA matabolism of intraperitoneal free cancer cells were measured by microspectrophotometer (MSP) and their correlation with cancer cell proliferation were analyzed under administrations of anticancer agents and their supporting substances. The results obtained are as follows: 1) The ratio of RNA to DNA is approximately 2.6 in liver of normal mice. DNA was considerably increased in cancer bearing group, and was about 2.5 times greater than that of normal group. 2) Mitomycin inhibited DNA metabolism of tumor, also inhibited DNA assimilation in liver of tumor bearing mice. Anticancer supporting substances, esfecially orotic acid, in contrast, could hardly cause any change in DNA metabolism of tumor, but slightly increased RNA metabolism. 3) With regard to nucleic acid metabolism in cancer cells, DNA inhibited cell counts were increased and octoploid cell counts were decreased in case of mitomycin administration. On the other hand, three peak type of cellular arrangement was obtained in case of the administration of supporting substances, showing disturbance of DNA assimilation process. 4) Mitomycin caused disturbance of cell proliferation in early stage of administration course, and also abnormal proliferation and cell destruction. The supporting substances, on the other hand, did not cause any disturbance in process of normal proliferation but accelerated the original degeneration process of tumor eclls as if to drive tumor cells to the final stage of necrosis. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1061 end-page=1089 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Catalase Activity of Liver and Plasma Protein Fraction at varions carcinolytic Processes kn-title=各種制癌過程における肝Catalase活性度および血漿蛋白分屑像の推移に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rabbits bearing Brown-Pearce tumor in liver or muscle were examined and the following results were obtained. 1. As the growth of the tumor progressed, catalase activity of the liver was remarkably depressed and albumin and α-globulin decreased and β-, γ-globulin and Φ-fraction increased in plasma electrophoresis. 2. Injury of reticuloendothelial system of the liver by x-ray irradiation with 1000r on the liver depressed catalase activity of the liver and decreased albumin and β-, γ-globulin and increased α-globulin in plasma electrophoresis. Transplantability of the tumor and mortality were elevated. 3. Carcinolytic agents played the same role on catalase activity of the liver and plasma protein fraction as x-ray irradiation with 1000r on the liver. They are accounted for a gift to the reticuoloendothelial system of the liver. Carcinolytic effect was not observed in Carcinophylin, Mitomycin and Azan. 4. Activation of reticuloendothelial system of the liver by x-ray irradiation with 60r showed carcinolytic effect and the same pattern as that of natural healing was observed in plasma electrophoresis, but catalase activity of the liver was slightly depressed. 5. In cases of natural healing or intransplantable cases, catalase activity of the liver was elevated and plasma protein fraction showed the change from the pattern of tumor growth to the pattern of its recovering process. γ-globulin increased in early stadium. 6. Immunity inhibited the tumor growth markedly and elevated catalase activity of the liver and showed the same pattern in electrophoresis as the cases of natural healing. 7. γ-globulin is considered to play an important role in carcinolytic process, while it does not show carcinolytic effect by itself. en-copyright= kn-copyright= en-aut-name=MimuraHisashi en-aut-sei=Mimura en-aut-mei=Hisashi kn-aut-name=三村久 kn-aut-sei=三村 kn-aut-mei=久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1091 end-page=1096 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anti-inflammatory Effect and Histamine-release Inhibitory Effect of Some Derivatives of Acetanilide and Pyrazolone kn-title=Acetanilide及びPyrazolone系二，三誘導体の抗炎症作用とHistamine遊離抑制作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three acetanilide and two pyrazolene derivatives were tested for anti-inflammatory effect on the edema of rat's hind-paws induced by the local injection of dextran, hyaluronidase, formaldehyde, histamine and 5-hydroxyptamine, and for histamine-release inhibitory effect on the rat receiving an intraperitoneal injection of ovomucoid which increases urinary output of histamine as a result of histamine release in the whole body. Phenacetin, acetanilide, aminopyrine, aminopropylone and butazolidine served as controls. GP-I, one of the pyrazolone derivatives (for formula cf. table 1), showed fairly marked supression on all 5 kinds of edema with effects comparable to aminopyrine and butazolidine. Acetanilide derivatives tested, also exerted marked inhibition on the edema other than by hyaluronidase or formaldehyde. All the compounds inhibited the histamine release due to ovomucoid injection, but no graded difference could be seen. en-copyright= kn-copyright= en-aut-name=YamasakiHidemasa en-aut-sei=Yamasaki en-aut-mei=Hidemasa kn-aut-name=山崎英正 kn-aut-sei=山崎 kn-aut-mei=英正 aut-affil-num=1 ORCID= en-aut-name=KondoKazuji en-aut-sei=Kondo en-aut-mei=Kazuji kn-aut-name=近藤和二 kn-aut-sei=近藤 kn-aut-mei=和二 aut-affil-num=2 ORCID= en-aut-name=UdaTeruo en-aut-sei=Uda en-aut-mei=Teruo kn-aut-name=宇田昭夫 kn-aut-sei=宇田 kn-aut-mei=昭夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部薬理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部薬理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部薬理学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=633 end-page=644 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Anticancer Chemotherapy Especially on the effect of anticancer agents and anticancer supporting substances on the metabolism of cancer bearing mice- PART V The effect of anticancer agents and their supporting substances on serum protein metabolism in the hosts of malignant tumor and also on serum electrolytes kn-title=癌の化学療法に関する研究 特に制癌剤並びに制癌強化剤の担癌生体内代謝に及ぼす影響に就いて 第3編 制癌剤および制癌強化剤の担癌生体血清蛋白代謝に及ぼす影響,並びに血清電解質代謝との相関に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Metabolisms of serum protein and electrolytes in cancer bearing mice were studied to correlate with the effect of anticancer agents and their supporting substances administration. The results obtained are as follows: 1) Serum albumin was decreased in course of cancer progress, which was in negative correlation with ascites increment. 2) Serum Ca tended to decrease, K to increase and Na to fluctuate erratically. 3) The combined administration of anticancer agents and their supportiog substances improved more the liver function to accelerate the assimilation of serum protein and the anticancer resistance, and also improved more serum Ca metabolism than single administration of the anticancer agents in cancer bearing mice. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1097 end-page=1106 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluorescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 1. Fundamental Study on Fluorochrominized Bone Marrow Tissue Culture kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第1編 螢光培養法（Fluorochrominized Bone Marrow Tissue Culture）に関する基礎的実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Of late many investigators have come to study blood cells with fluorescence microscope, but most of these works are carried out by supravital staining method only. Therefore, the author has attempted vital observations of bone marrow cells under the fluorescence microscope by adding fluorescent dye, acridine orange, to the medium of the simple tissue culture, the method devised in our department. For this study some fundamental studies have been conducted concerning the toxicity of dye, the selection of barrier filters, the secondary fluorescence of cells, and the influence of exciting rays on the cell growth; and obtained the following results. 1. After studying the relative growth rate, the cell density index, and the wandering velocity of neutrophils it has been found that. tissue culture is possible at low concentration, under 10(-4) of the medium with acridine orange. 2. Barrier filter, OG5 , is the most suitable one for the observation of the secondary fluorescence of the cell. 3. The concentration of the acridine orange medium at which the most distinct picture of fluorescence obtainable is at 10(-4) , and the concentration at 10(-5) is the minimum at which fluorescence can be recognized. 4. The ill effect on cells due to exciting rays may be eliminated by avoiding successive exposure to the rays. 5. The author has devised a medium for the bone marrow tissue culture, consisted of a drop of serum and a drop of physiological saline solution containing 80 γ / cc vitamin B(12) and 0.2 mg / cc acridine orange, and has designated this as the simple method of fluorochrominized bone marrow tissue culture. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1160 end-page=1172 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Zucker-, Fettstoffwechsel und die passive Anaphylaxie bei experimenteller Kaninchenclonorchiasis sinensis (3. Mitteilung.) Der Anaphylaxieversuch bei Kaninchenclonorchiasis kn-title=實驗的肝臟「ヂストマ」病家兎ニ於ケル糖代謝，脂肪代謝竝ニ被働性過敏症ニ就テ 第3報 被働性過敏症ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei der Clonorchiasis sinensis treten, wie allgemein bekannt, eine deutliche pathologisch-histologische Ver?nderung der Leber, Zirkulationsst?rung im Pfortadersystem, Ikterus etc. auf. So hat Verfasser, der in der I. und 2. Mitteilung ?ber die St?rung des Zucker- und Fettstoffwechsels bei experimenteller Kaninchenclonorchiasis sinensis berichtet hatte, in dieser Mitteilung einen passiven Anaphylaxieversuch, den er an den mit dieser Krankheit infizierten Kaninchen ausgef?hrt hat, beschrieben. Sowohl normale wie auch erkrankte erwachsene Kaninchen wurden zuerst mit Antirinderkaninchenimmunserum sensibilisiert. Allen diesen Tieren wurde nach einer Inkubationszeit von 24 Stunden eine gleiche Einheitsmenge Antigen reinjiziert, dann wurde der Blutdruck an der Carotis mit dem Quecksilbermanometer und Kimographion und der Serumpr?zipitintiter der Versuchstiere vor und nach der Reinjektion beobachtet. Bei den normalen Kaninchen trat bald nach der Reinjektion eine deutliche und typische Blutdrucksenkung auf, w?hrend sich bei den erkrankten Kaninchen keine oder eine nur geringe und atypische Blutdrucksenkung erkennen liess. Was die Abnahme des Pr?zipitintiters nach der Reinjektion anbelangt, so war sie bei gesunden und infizierten Tieren fast gleich. en-copyright= kn-copyright= en-aut-name=UyenoHiroshi en-aut-sei=Uyeno en-aut-mei=Hiroshi kn-aut-name=上野博 kn-aut-sei=上野 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=645 end-page=648 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Case Report of Ulcerative Colitis at right Colon kn-title=右側結腸に発生した潰瘍性大腸炎の治験例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been known that there are numerous reports in Europe and America but few in Japan with regard to ulcerative colitis of which the first report was done by Wilks and Moxon in 1875, especially to segmental ulcerative colitis. This is the report of one case of our experience. The colitis was localized at right colon with typical pseudopolyposis and was undergone surgery resulting in a complete cure. Segmental ulcerative colitis tends to originate at right colon and extend toward both oral and anal directions, and it is, therefore, mandatory to resect it surgically when it is localized at right colon, so-called at the stage of the right-sided colitis. In order to fulfill it with making the early diagnosis, the x-ray examination should be very carefully done at right colon in clinically suspected case of ulcerative colitis without any abnormal finding at romanoscopic examination. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= en-aut-name=SatoMinoru en-aut-sei=Sato en-aut-mei=Minoru kn-aut-name=佐藤実 kn-aut-sei=佐藤 kn-aut-mei=実 aut-affil-num=2 ORCID= en-aut-name=SasakiSumizi en-aut-sei=Sasaki en-aut-mei=Sumizi kn-aut-name=佐々木澄治 kn-aut-sei=佐々木 kn-aut-mei=澄治 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=649 end-page=663 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 1 Intracarotid Sodium Amobarbital Injection Effect on Experimentally Produced Focal Epileptogenic Discharge of Cat kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第1編 実験的てんかん焦点に対するアモバルビタールソーダ頸動脈注射の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty adult cats were utilized for this study under unanesthetized condition. Penicillin was locally given in various parts of cortex and subcortical nucleus or thalamus to elicit epileptogenic discharges and sodium amobarbital was intracarotidly injected to give arise transient functional depression of hemisphere. EEG was followed up in the course of this experiment. 1) Local application of penicillin into cortex or subcortical nucleus or thalamus considerably elicited epileptogenic discharges. 2) In case of focal cortical epileptogenic discharge, the first spike appearing at the neighbouring area of the focus was followed to be associated with the synchronous spike discharge at the opposite side and then the focal seizure discharge was built. The discharge was occaionally interrupted by the interictal state, building, in some of the cases, the final stage of generalized seizure discharge. 3) So was noted in its appearance and process in case of focal subcortical epileptogenic discharge. But there was a more tendency of transmission of its activity to the opposite side in comparison with the cortical epileptogenic discharge. 4) The epileptogenic discharge originated from unilateral cortical focus was abolished or inhibited by means of ipsilateral intracarotid injection of 5 to 10 mg sodium amobarbital, but was not affected by the contralateral administration. However, either side of the injection could not inhibit the discharge activity after it became a focal seigure discharge. 5) Subcortically elicited epileptogenic discharge, in contrast, could not be interfered by either side of the intracarotid administration. 6) In cases of both focal cortical and subcortical discharge, intracarotid injection of sodium amobarbital manifested a tendency of flattening and slowing of back ground activity at the injected side, but not at the opposide side. 7) The intracarotid administration could not activate the epileptogenic discharges either from cortex and subcortex. en-copyright= kn-copyright= en-aut-name=YagiTakeshi en-aut-sei=Yagi en-aut-mei=Takeshi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1107 end-page=1117 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Flucrescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 2. Vital observations on Blood Cells of Normal Persons by Means of Fluorochrominized Bone Marrow Tissue Culture kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第2編 螢光培養法（Fluorochrominized Bone Marrow Tissue Culture）による正常人血液細胞の生態観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the present experiment the author conducted the bone marrow tissue of normal persons by the simple method of fluorochrominized bone marrow tissue culture as established in Report 1, and observed the growth zone and various bone marrow cells appearing in the zone. 1. The cells are dense in the central part of the growth zone, and the density gradually decreases towards the periphery, giving off reddish orange fluorescence diffusely with yellow and green fluorescent spots scattered in this zone. 2. Cytoplasma, is green, while mitochondria and various granules give off yellowish green or reddish orange fluorescence. However, the fluorescence of mitochondria is quite trivial, and the nuclei and nucleoles are green but nucleoles give off fluorescence earler than the nuclei. 3, In young cells green fluorescence of cytoplasma is marked, and it grows less distinct as they mature whereas reddish orange granules tend to increase along with the maturation of cells and their size is variegated. 4. In myelogenous cells reddish orange fluorescence of granules is characteristic while yellowish green fluorescence of the nuclei in lymphocytic cells. In mouocytic cells a variety of fluorescence such as green cytoplsama and reddish orange granules agglomerating around the nucleus can be recognized, and likewise fluorescence specific to each cell type can be observed in other cells. 5. The green fluorescence of cytoplasma of erythroblasts is gradually lost along with maturation, and no fluorescence can be recognized in erythrocytes, while substantia reticulofilamentosa of reticulocytes present red fluorescence. 6. When two barrier filters, GG 4 and OG 4 are used together, it is easy to differentiate cells of the erythroblast series from cells of the leucocyte series. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=665 end-page=673 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 11 Intracarotid Sodium Amobarbital Injection Effect on Human EEG kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第2編 アモバルビタールソーダ頸動脈注射の脳波基礎律動に及ぼす影響に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An attempt was made to analyze the changes of EEG secondary to the intracarotid injection of 50 to 100 mg of sodium amobarbital: 33 trials on 20 patients. 1) There appeared to be a marked change in all cases; limited or dominant ipsilaterally to the side of administration. 2) The latter was found in 22 out of 33 trials, and noted at the records of the frontal leads. 3) The change was composed of high amplitude and low frequency or of low amplitude and high frequency or of the mixed of both, occurring at 3 to 6 seconds after the onset of the injection and gradually disappearing to regain the normal state within 30 minutes. 4) These changes, especially the high amplitude and slow waves immediately after the injection at the same side were markedly noticed when the injection was in large dosage and in high speed. 5) There was no difference in such changes given arise by either side of administration in the same patient. 6) It is to be noted that there were no hazardous complications at the intracarotid injection of 10 % sodium amobarbital under sufficient attention. en-copyright= kn-copyright= en-aut-name=YagiTakeshi en-aut-sei=Yagi en-aut-mei=Takeshi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1119 end-page=1132 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluorescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 3. A Study on Degeneration of Leucocytes and on the Relationship between Cell Function and Fluorescence kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第3編 白血球の変性並に細胞機能と螢光との関係に関する研究 附.全編の総括 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By performing the simple method of fluorochrominized bone marrow tissue culture the author observed the degeneration picture of leucccytes, and also studied changes in fluorescence in the cells cultured under an adverse condition but added with acridine orange. The following are the results of the present experiment. 1. It has been found that the majority of commonly-known findings by supravital staining are proven to be degeneration picture of cells. 2. As for the degeneration signs, the swelling and fading of reddish orange granules can be pointed out, while in cytoplasma vacuoles either stained or unstained with acridine orange, abnormal processes, the reddening or green swelling of cytoplasma can be recognized: The nuclei have agglutinated chromatin and have become yellow, red, and swollen in green color, and in nucleoles green swelling or reddening can be observed. 3. In the degeneration picture likewise each cell type present different fluorescence. 4. When cells become shrunk, the fluorescence is red, while when cells are swollen, it is green. 5. In the cells with decreased function reddish orange granules fade quickly and their nuclei turn yellow. 6. Those cells that have lost the fluorescence of their granules, and those that have red cytoplasma and red nuclei as well as those with their nuclei green and swollen as all-dead cells. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=675 end-page=693 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 111 Differentiation of Primary and Secondary Bilaterally Synchronous Spike and Wave Complex kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第3編 1次的及び2次的両側同期性棘徐波複合の鑑別に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intracarotid injection of 50 to 100 mg of 5 to 10 % sodium amobarbital was given to 30 cases of epileptics, and change of the abnormal EEG was followed. 1) Unilateral focal cortical epileptogenic spikes were abolished by the ipsilateral administration, but not by the contralateral. 2) Amongst the cases of bilaterally synchronous spike and wave complex, two types of marked responses were obtained at the administration. One group manifested an abolishment of the complex from all leads of both hemispheres by administration on one side, but a transient inhibition of the spike component from the ipsilateral hemisphere by administration on the other side. This appears to indicate the complex originates from unilateral cortical focus which is located at the first side. This group may correspond with the secondary bilateral synchrony. 3) Another group manifested a transient inhibition of the spike component from ipsilateral hemisphere without abolishment of the complex at either side of administration. This may correspond with the primary bilateral synchrony, the so-called "ceutrencephalic origin". 4) No activation of characteristic abnormal activities in epileptics was found at the intracarotid injection of sodium amobarbital. en-copyright= kn-copyright= en-aut-name=YagiTakashi en-aut-sei=Yagi en-aut-mei=Takashi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1155 end-page=1178 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Lymphoid Tumors of Mice Induced by 20-Methylcholanthrene Part 2. Studies on the Process of Development of Lymphocytic Leukemia kn-title=2-Methylcholanthreneによるハツカネズミリンパ性腫瘍の研究 第2編 リンパ球性白血病の成立過程に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After inducing lymphocytic leukemia by painting the skin of the mice of dba strain and other group of uncertain origin with 20-methylcholanthrene, the author carried out tissuc cultures of bone marrow, lymph nodes, and spleen of these test animals and also cytological and histological examinations for purpose of clarifying the origin and development of lymphocytic leukemia. On the basis of the peripheral blood pictures, the author classified the development of lymphocytic leukemia into the following three stages, i.e., (1) preleukemic stage (with leucopenia but no lymphoblasts in the peripheral blood), (2) initial stage of leukemia (with slight leucocytosis and a few lymphoblasts in the peripheral blood), and (3) advanced stage of leukemia (with marked leucocytosis and many lymphoblasts in the peripheral blood). The following are the results and conclusions of the present experiment. (1) The changes in the peripheral blood pictures observed during the preleukemic stage as described in Part I, that is, leucopenia and lymphopenia, are caused by the arrest of maturation in lymph follicles of the spleen and by hypoplasia of lymph nodes. Eosinophilia can be observed in bone marrow of every single case and the stimulation of the reticuloendothelial system is believed to be one of its causes. Lymphoblasts of the peripheral blood during the initial stage of leukemia are mainly derived from the spleen. The distribution curve of the greatest diameters of lymphocytes in the peripheral blood gradually shifts to the right as lymphocytic leukemia develops. This phenomenon coincides with the increase in large lymphocytes during the preleukemic stage and with the appearance of lymphoblasts during the initial stage of leukemia. (2) In tissue cultures, the bone marrow, spleen, thymus, and lymph nodes of leukemic mice show the growth patterns specific to acute lymphocytic leukemia, though these ars not so typical in mice as in men. Namely, the margin of growth zone is sharply defined, the density of cells is very high, and the growth zone is consisted mainly of lymphoblasts with some mature lymphocytes. In the preleukemic stage, the spleen shows relatively leukemic growth pattern, but the lymph nodes show hypoplasia or slight hyperplasia, In the initial stage of leukemia, the spleen shows the leukemic growth pattern, but the lymph nodes and thymus show hyperplasia or leukemic growth pattern. In the advanced stage of leukemia, the spleen, lymph nodes, thymus, and the bone marrow begin to show the leukemic growth pattern. (3) Cytomorphologically, leukemic cells appear first of all in the lymph follicles of the spleen, and they increase in the lymph nodes and bone marrow along with progress of leukemia. The lymphoblats in the lymph nodes during the preleukemic and initial stages of leukemia are little atypical, but they show prominent nucleoli and lobulation of the nucleus in the advanced stage and also mitochondria increase in number. The distribution curve of the greatest diameters of lymphocytes in the lymph nodes shifts gradually to the right through the development of lymphocytic leukemia as in the case of peripheral blood. (4) In autopsy findings, there can be observed a slight enlargement of spleen in the preleukemic stage, moderately enlarged spleen and slightly enlarged lymph nodes in the initial stage, and marked enlargement of spleen, lymph nodes, and liver in the advanced stage. (5) Histologically, the lymph follicles of spleen are enlarged due to the proliferation of reticulum cells and lymphoblasts in the preleukemic stage. Lymph nodes show hypoplasia or slight hyperplasia. Namely, lymphocytic leukemia can be understood to be circumscribed to the spleen in this stage. In the initial stage, lymphoblasts infiltrate diffusely through the whole spleen and lymph nodes show hyperplasia or gradual enlargement of germinal centers due to the proliferation of lymphoblasts with the formation of lymph follicles. In the bone marrow, diffuse infiltration of leukemic cells can be observed. In the advanced stage, spleen, lymph nodes, and thymus become totally leukemic, and leukemic cells metastasize to various other organs including bone marrow, liver, and kidneys through the hematogenous and lymphogenous channels. (6) Leukemia sets in about the time when papilloma appears on the skin, and by the time when papilloma begins to be transformed into skin cancer most of the mice with lymphocytic leukemia die. The mice with skin carcinoma show myelogenous leukemoid reaction, and some of them reveal the complication of reticulosis or reticulosarcomatosis. en-copyright= kn-copyright= en-aut-name=OkadaKoichi en-aut-sei=Okada en-aut-mei=Koichi kn-aut-name=岡田耕一 kn-aut-sei=岡田 kn-aut-mei=耕一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1179 end-page=1195 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Lymphoid Tumors of Mice Induced by 20-methylcholanthrene Part 3. Studies on the Relationship between Lymphocytic Leukemia and Lymphocytic Leukosarcomatosis kn-title=20-Methylcholanthreneによるハツカネズミリンパ性腫瘍の研究 第3編 リンパ球性白血病,リンパ球性白血肉腫症,リンパ肉腫症の異同に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With lymphoid tumors (lymphocytic leukemia and lymphocytic leukosarcomatosis) induced in the mice of uncertain origin by smearing with 20-methylcholanthrene, the author tried to clarify the relationship between lymphocytic leukemia and lymphocytic leukosarcomatosis by performing bone-marrow and lymph-node tissue cultures in combination with cytological examinations, and obtained the following results. (1) Lymphocytic leukosarcomatosis is mostly aleukemic, and the percentage of lymphoblasts in the peripheral blood is low. Some cases of lymphocytic leukosarcomatosis reveal a marked increase of large lymphocytes in the peripheral blood. (2) The lymph nodes and bone marrow of aleukemic lymphocytic leukosarcomatosis consist mostly of lymphosarcoma cells with the greatest diameters of more than 15.3μ and marked lobulation of the nucleus. These cells are thought to be derived from Amano's "lymphogonia". In addition, in the lymph nodes and bone marrow of aleukemic lymphocytic leukosarcomatosis, there can also be found little atypical lymphoblasts with the greatest diameters of less than 15.3μ, what may be considered as leukemic cells. and it seems that those lymphoblasts found in the peripheral blood of leukosarcomatosis are derived from these leukemic cells. (3) The lymph nodes and bone marrow of aleukemic lymphocytic leukosarcomatosis are consisted mostly of lymphosarcoma cells, while, in leukemic lymphocytic leukosarcomatosis and lymphocytic leukemia, the percentage of leukemic cells increases and the percentage of lymphosarcoma cells decreases. (4) In the bone-marrow and lymph-node tissue cultures, aleukemic lymphosarcomatosis generally presents the growth pattern resembling tumor, while leukemic lymphocytic leukosarcomatosis shows the growth pattern exactly similar to that of acute lymphocytic leukemia. (5) In autopsy findings, lymphocytic leukosarcomatosis shows more remarkable enlargement of lymph nodes than lymphocytic leukemia. Histologically, in aleukemic lymphocytic leukosarcomatosis there is little tendency of lymphoblast infiltration and metastasis to the liver and kidneys. (6) Since aleukemic and leukemic leukosarcomatosis can transform progressively to lymphocytic leukemia, all these are believed to be essentially the same disease. en-copyright= kn-copyright= en-aut-name=OkadaKoichi en-aut-sei=Okada en-aut-mei=Koichi kn-aut-name=岡田耕一 kn-aut-sei=岡田 kn-aut-mei=耕一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1173 end-page=1190 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Embryonalentwicklung von Paragonimus westermanni kn-title=肺臟「ヂストマ」ノMiracidiumノ發育 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verf. studierte die Miracidiumentwicklung von Lungendistoma haupts?chlich mit dem gef?rbten Schnittpr?parate derselben Larve, die er aus der Distomeneier k?nstlich gebr?tet hatte. Nach seiner genaueren Beobachtung vertritt er die Ansicht, dass diese Larve in ihrer Entwicklung mit der Schistosomalarve eine sehr grosse Analogie hat, weil alle K?rperteile und H?llmembrane dieses Wurmes sich in fast gleicher Entstehungsweise wie bei der Schistosomalarve entwickeln. Aber einige Organe z. B. die einzellige Dr?se und der linsenartige K?rper scheint sich bei dieser Larve nicht zu entwickeln. en-copyright= kn-copyright= en-aut-name=WatanabeMasumi en-aut-sei=Watanabe en-aut-mei=Masumi kn-aut-name=渡邊眞澄 kn-aut-sei=渡邊 kn-aut-mei=眞澄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1197 end-page=1201 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of the Unsaturated Fatty Acid Fraction from the Liver of Irradiated Rabbit on the Fertilization and Cell Division kn-title=放射線照射家兎肝より抽出せる細胞毒のウニ卵及び精子に与える影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effect of unsaturted fatty acid fraction from the liver of irradiated animal on fertilization and cell division of sea urchin egg (Hemicentrotas tulcherrimus) have been observed. The sperms exposed to the substance for 5 minutes decrease in their mortility and lost the fertilization acivitity resuting in the lose of their ability for the formation of fertilizing membrae in eggs. The eggs exposed to this substance after fertilization present the stop or the delay in their cleavage. Such an action on eggs becomes marked when the concentration of this substance increases. The most susceptible stage seems to be the metaphase at which the chromosoms are arrested on the equatolial plate loosing the tendency to move toward the poles. These effects of this substace can be seen even after removing the peroxide as equally in the original substance. en-copyright= kn-copyright= en-aut-name=SenoSatimaru en-aut-sei=Seno en-aut-mei=Satimaru kn-aut-name=妹尾佐知丸 kn-aut-sei=妹尾 kn-aut-mei=佐知丸 aut-affil-num=1 ORCID= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=2 ORCID= en-aut-name=UtsumiKozo en-aut-sei=Utsumi en-aut-mei=Kozo kn-aut-name=内海耕慥 kn-aut-sei=内海 kn-aut-mei=耕慥 aut-affil-num=3 ORCID= en-aut-name=ShiakuMidori en-aut-sei=Shiaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=4 ORCID= en-aut-name=AkagiKeiko en-aut-sei=Akagi en-aut-mei=Keiko kn-aut-name=赤木瑩子 kn-aut-sei=赤木 kn-aut-mei=瑩子 aut-affil-num=5 ORCID= en-aut-name=IguchiYoshico en-aut-sei=Iguchi en-aut-mei=Yoshico kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=6 ORCID= en-aut-name=UenoHisako en-aut-sei=Ueno en-aut-mei=Hisako kn-aut-name=上乃寿子 kn-aut-sei=上乃 kn-aut-mei=寿子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=2 article-no= start-page=397 end-page=401 dt-received= dt-revised= dt-accepted= dt-pub-year=1931 dt-pub=19310228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die motorische Nervenendigung im Herzmuskel beim Kaninchen kn-title=心筋ニ於ケル運動性神經終末ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Bezug auf die motorische Nervenendigung im Herzmuskel sind die Berichte der mehreren Autoren verschiedenartig. Einige behaupten, dass die motorische Nervenfaser an der Oberfl?che der Muskelfaser endigt, w?hrend nach anderen sie innerhalb der Muskelfaser ihr Ende findet. Um diese Frage zu l?sen hat der Verfasser die Nervenendigung im Herzmuskel beim Kaninchen mittelst der Silberimpr?gnation nach R. y. Cajal und der supravitalen Methylenblauf?rbung untersucht. Es ergibt sich, dass terminals Nervenfasern von ca. 100-150μ L?nge an der Oberfl?che gewisser Muskelfasern, besonders in der N?he des Muskelkerns mit sehr feinen kn?pfchenartigen Verdickungen endigen, was als echte motorische Nervenendigung im Herzmuskel gilt (Fig. 5, 6 u. 7). en-copyright= kn-copyright= en-aut-name=OkadaShinichi en-aut-sei=Okada en-aut-mei=Shinichi kn-aut-name=岡田眞一 kn-aut-sei=岡田 kn-aut-mei=眞一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1203 end-page=1208 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Nature of X-Ray Disturbance Part I. Effect of Unsaturated Fatty-Acid Fraction Extracted from X-Ray Irradiated Rabbit-Liver on Succinic Dehydrogenase System of Ehrlich-Ascites-Tumor Cells kn-title=X線照射時に発生せる細胞毒の研究について 第一編 X線照射家兎より抽出した不飽和脂肪酸分画のEhrlich腹水癌,正常肝のコハク酸脱水素系に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are many investigations on the disturbances caused by x-rays but these works are consisted mainly of histo-morphological researches and rerely from the viewpoint of the acting mechanism of cells. More recently Lea, Barron et al, however, have studied the histochemical changes in the animals irradiated with x-rays and they have clarified the direct action of x-ray irradiation to a certain extent. In our laboratory Dr. Yamamoto has succeeded in isolating a certain cytotoxin from unsaturated fatty acid fraction, an extract of the liver of the rabbits exposed to x-rays. In the subsequent studies with this cytotoxin it has been found that this substance has an inhibitory action on the mitosis of tumor cells. Therfore, we have carried out a series of experiments to see the effect of this substance, in the presence of succinic dehydrogenase, on the respiration of Ehrlich-ascites-tumor cells. As the result it has been confirmed that this cytotoxin possesses an action as to depress both the respiration of the cancer cell and that of normal liver cells. en-copyright= kn-copyright= en-aut-name=ShiakuMidori en-aut-sei=Shiaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1209 end-page=1221 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Effect of the Various Extracts In the Course of Infection with Infectious Hepatitis Virus. I) The Effect of the Various Bacterial Extracts II) The Effect of the Organ Extracts of the Animal kn-title=流行性肝炎ウイルス感染過程に及ぼす諸種抽出物質の影響について (I) 細菌性抽出物質の影響 (II) 動物臓器抽出物質の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influence of the various extracts of various bacteria and organs of animals on the infections aspect of hepatitis virus was studied by the histopathological findings in the inoculated mice. According to the results of experiments, some extracts showed inhibitory action and someone revealed promoting effect, but also others were no influence on the course of infection. It was nucleic acid and nucleo protein that were extracted from cholera vibrio which was inhibitory effect. The Proteins which were extracted from Typhoid bacillus showed raising effect on the sensitivity of the mouse against the infectious hepatitis virus. It will be found more effective substances which have inhibitory action, if further studies are performed on the other various substances. en-copyright= kn-copyright= en-aut-name=TakahashiManabu en-aut-sei=Takahashi en-aut-mei=Manabu kn-aut-name=高橋学 kn-aut-sei=高橋 kn-aut-mei=学 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1223 end-page=1226 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Significance of Blood Sedimentation Rate in Disseases of Cancer kn-title=癌疾患と赤血球沈降反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Change of blood sedimentation rate before and after therapy were examined in 50 patients of cancer. 1) Before therapy, only 6 patients (12%) were normal extent. 2) It was cancer of lung which tendency to increase was much more stronger than otlrers. 3) Cases in which couse after therapy (Operaeion or X. ray therapy) was good, blood sedimentation rate returned to normal extent. 4) It will be find out complication, if periodic examination of blood sedimentation rate after operation was performed. en-copyright= kn-copyright= en-aut-name=TakahashiManabu en-aut-sei=Takahashi en-aut-mei=Manabu kn-aut-name=高橋学 kn-aut-sei=高橋 kn-aut-mei=学 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=香川県立中央病院外科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1227 end-page=1241 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Fibrinolysis Following Massive Transfusion of Preserved Blood, and on the Treatment Part 1. Experimental and clinical studies on the mechanism of fibrinolysis kn-title=保存血大量輸血に伴う出血傾向に対する線維素溶解現象の発現とその対策 第1編 保存血大量輸血時の線維素溶解現象発現機序に対する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The mechanism of fibrinolysis following massive transfusion of preserved blood was investigated, clinically and experimentally. Results obtained were as follows: 1. Fibrinolytic activity was not seen in the preserved blood, and the fibrinolysis observed in the transfusion of preserved blood was derived from preserved blood itself which acted upon as a stress, but it was slight in the degree. On the other hand, the fibrinolysis was relatively remarkable in the cases undertaking sugical procedures, especially a pulmonary operation, and etc. However, it was not considered that either one of above cases would become to develop a hemorrhagic tendency. 2. Fibrinogen level did not show a remarkable change with a massive transfusion of preserved blood, but was decreased in the cases operated upon the organs being high in the thromboplastin level and became a cause of a hemorrhagic tendency. 3. A hemorrhagic tendency was not always observed even in the cases showing highly positive fibrinolysis, but it was thought to be cased by the defects in platelet, vascular and coagulation factors of many kinds, in conjuction with the changes in general and local conditions of patients, and with surgical procedures. The fibrinolysin, however, promoted the development of hemorrhagic tendency following the disturbances in vascular and various kinds of coagulation factors. en-copyright= kn-copyright= en-aut-name=OnoMasayosi en-aut-sei=Ono en-aut-mei=Masayosi kn-aut-name=小野晶美 kn-aut-sei=小野 kn-aut-mei=晶美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1243 end-page=1253 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Fibrinolysis Following Massive Transfusion of Preserved Blood, and on the Treatment Part U. Experimental Studies on the Treatment of Fibrinolysis Following Massive transfusion of Preserved blood kn-title=保存血大量輪血に伴う出血傾向に対する線維素溶解現象の発現とその対策 第2編 保存血大量輸血時の線維溶解現象発現に対する対策 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Therapeutic and prophylactic measures against a fibrinolysis following massive transfusion of preserved blood was studied, and following results were obtained. 1. Administration of ε-aminocaplonic acid, ACTH, and cortisone prevented a fibrinolysis following massive transfusion of preserved blood. 2. These therapeutics, especially, showed a marked preventive effect when they were applied together at early stage. 3. At the same time in the cases administed together with thromboplastin and adrenochrome preparations of every kinds as well as fresh blood, fibrinolysis was not completely prevented, but those were expected to inhibit other disturbance in coagulation mechanism accompanied with the above phenomenon. en-copyright= kn-copyright= en-aut-name=OnoMasayosi en-aut-sei=Ono en-aut-mei=Masayosi kn-aut-name=小野昌美 kn-aut-sei=小野 kn-aut-mei=昌美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1255 end-page=1260 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Infulences of free Amino acid on Glucose Metabolism in the Brain. Part V. Infulences of Continuing Administration of Amino Acid on Glucose Metabolism in the Cerebral Cortex of Rabbit with Convulsion kn-title=脳のglucose代謝におよぼすamino酸の影響に関する研究 第3編 痙攣家兎大脳皮質のglucose代謝およびそれにおよぼすamino酸連続投与の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Convulsions were repeatedly caused by electrical stimulation in rabbits. Total free amino acids contents in these rabbits showed no fluctation, while glucose metabolism decreased like as in those with latent cerebral local anaphylaxis and human epileptics. The glucose utilization was cured to normal level by continuing injection of Glutamic acid, GABA, and Asparagine, but total amino-N changed scarecely. It is an important fact, that free amino-N content increased by GABA injection in rabbits with convulsion. en-copyright= kn-copyright= en-aut-name=YamamotoYasuhisa en-aut-sei=Yamamoto en-aut-mei=Yasuhisa kn-aut-name=山本泰久 kn-aut-sei=山本 kn-aut-mei=泰久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=739 end-page=742 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Three Cases of Oesophageal Hiatus Hernia kn-title=最近我々の遭遇せる食道裂孔ヘルニアの3例に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are sometimes patients of oesophageal hiatus hernia who visit our clinic complaining gastrointestinal disturbances similiar to stomach cancer or gastric ulcer and symptoms of breast disease. Recently we came upon three of these cases so as would like to report. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=NishishitaSoichi en-aut-sei=Nishishita en-aut-mei=Soichi kn-aut-name=西下創一 kn-aut-sei=西下 kn-aut-mei=創一 aut-affil-num=2 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=3 ORCID= en-aut-name=TanadaMasatada en-aut-sei=Tanada en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部癌研究所/岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=川崎病院/川崎癌研究所放射線科/岡山大学医学部 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1191 end-page=1199 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber eine neue Art von Trematoden, Exorchis major n. sp., welches als Zwischenwirt Plecoglossus altivelis hat kn-title=鮎ヲ中間宿主トスル1新吸蟲Exorchis major n. sp.ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser sammelt viele Plecoglossus altivelis aus Okayama Provinz und verschiedenen bekannten Heimaten von ganzen Japan und untersuchte die enzystierte Zerkarien, welche sich bei ihnen ern?hren. Er fand die enzystierte Zerkarie von Metagonimus yokogawai, Echinokasmus perfoliatus, Echinokasmus japonicus und die eines unbekannten Trematodes. Nach genauen Untersuchuugen ?ber die letztere erkannte er, dass ihre Mutter ein neues Trematodes war, und ein anderes als Exorchis oviformis Kobayashi, obwohl sie denselben Endwirt und dieselbe biologischen Eigenschaften hatte. Verfasser benannte sie Exorchis major n. sp. und stellte den Bau des K?rpers mit einem Bild eingehend dar. en-copyright= kn-copyright= en-aut-name=HasegawaTsuneji en-aut-sei=Hasegawa en-aut-mei=Tsuneji kn-aut-name=長谷川恒治 kn-aut-sei=長谷川 kn-aut-mei=恒治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=4 article-no= start-page=733 end-page=743 dt-received= dt-revised= dt-accepted= dt-pub-year=1933 dt-pub=19330430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber Urticaria Pigmentosa kn-title=色素性蕁麻疹ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neuerdings habe ich 2 F?lle von Urticaria Pigmentosa beobachtet. Der erste Fall, 9-monatiger weiblicher S?ugling, hat zahlreiche papul?se Eruption an den verschiedenen Hautteilen ausgenommen von dem Handteller und der Fusssohle. Bei der histologischen Untersuchung wurde ein charakteristischer Mastzellentumor in der Kutis, wie es Unna zuerst beschrieb, nachgewiesen. Der zweite Fall bezog sich auf in 1 j?hriges M?dchen, das ausschlisslich leicht br?unliche Pigmentflecke am Hals, an der Brust und am Bauch zeigte. Auch diesmal wurde histologisch eine m?ssige Anh?ufung von Mastzellen, was es weniger auffallend als bei dem ersteren, in der Papillarschicht konstatiert. Urticaria Pigmentosa wird selten in Japan gefunden, nur 43 F?lle mit Einschluss meiner F?lle wurdeo bisher mitgeteilt. Beide Gescblechter erkranken daran in fast gleicher H?ufigkeit. Das Leiden beginnt bei dem Unnaschen Typus innerhalb einiger Monate nach der Geburt und bei dem Jadassohn-R?naschen nach der Pubert?tszeit. Bez?glich der Lokalisation der Effloreszenz wird der Rumpf am h?ufigsten befallen, seltener auch das Gesicht mitafficiert, w?brend der behaarte Kopfteil, der Handteller und die Fusssohle meistens frei bleiben. Jucken kann selten fehlen. Statistisch wird der Typus Unna etwa doppelt so viel wie der Typus Jadassohn-R?na beobachtet. en-copyright= kn-copyright= en-aut-name=HigakiRitsuo en-aut-sei=Higaki en-aut-mei=Ritsuo kn-aut-name=檜垣律夫 kn-aut-sei=檜垣 kn-aut-mei=律夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學皮膚科泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1200 end-page=1216 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die histologische Ver?nderung der Herzmuskulatur, Unterkieferdr?se, Ohrspeicheldr?se, Leber, Niere, und Milz, die durch Amylnitrit zutage tritt kn-title=亞硝酸「アミール」ノ爲メ起ル心筋,顎下腺，耳下腺，肝臟，腎臟竝ニ脾臟ノ組織學的變化ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei Kaninchen injizirte der Verfasser Amylnitrit in die Ohrvene, und zwar zuweilen so viel bis die Tiere sterben, zuweilen nur ein Zehntel der Dosis letalis. Im letzteren Falle t?tete der Verfasser die Tiere 20 Minuten, 1, 3, 6, 12, 24, 48 und 72 Stunden nach der Injektion. Nach Sterben der Tiere wurde ein St?ck jedes Organes m?glichst schnell herausgenommen und histologisch untersucht. Ausserdem unterband der Verfasser bei Kaninchen die Milzarterie oder Milzvene und t?te die Tiere bald danach durch Luftembolie oder durch die Injektion des Amylnitrites, um ihren Milzbefund mit der Folgeerscheinung der einfachen Injektion zu vergleichen. Daraus ergibt sich das Folgende: 1) Nach Injektion des Amylnitrites erweitern sich gr?ssere Blutgef?sse im Herzen, in der Unterkieferdr?sen, Ohrspeicheldr?se, Niere und Milz, wobei sich die Intima, die glatten Muskelfasern der Media, sowie das Bindegewebe der Adventitia in ihrer verd?nnten Wand dehnen. Die glatten Muskelfasern vereinigen sich stellenweise und bilden kleine B?ndel, die locker vorhanden sind. In der Leber sicht man diesen Zustand 20 Minuten nach der Injektion, w?hrend die Gef?sse des Herzens und der Niere sich unmittelbar nach der Injektion erweitern und schon nach 20 Minuten eine Wiederherstellung zeigen. Die kleinen Gef?sse, besonders Kapillaren und kleine Venen eweitern sich sehr verschiedenartig je nach dem Organe, indem der Grad und die Dauer der Erweiterung eine grosse Schwankung zeigen. Die Gef?sserweiterung in der Unterkieferdr?se, Ohrspeicheldr?se, Niere und Milz tritt unmittelbar nach der Injektion auf und springt in die Augen 20 Minuten lang, w?hrend sie nach einer Stunde zur?cktritt. Dagegen dauert sie im Herzen 12 Stunden, in der Leber 6 Stunden und im Nierenglomerulus sogar 48 Stunden lang, wobei ihr Grad im Herzen am st?rksten ist. 2) Amylnitrit l?sst die Parenchymzellen verschiedener Organe aufquellen und die Speichelsekretion bef?rdern. Die Herzmuskelfasern zeigen bis 20 Minuten nach der Injektion keine deutliche Ver?nderung, doch quellen sie eine Stunde nach der Injektion auf und zeigen eine lockere Struktur. 3 Stunden nach der Injektion sind sie infolge der starken Erweiterung der Blutkapillaren stark gedr?ckt, aber von der 24 Stunden nach der Injektion an tritt die Gef?sserweiterung in den Hintergrund und die Faseranschwellung wird wieder deutlich, was 48 Stunden nach der Injektion sein Maximun erreicht. In der Unterkieferdr?se vermindern sich die gr?bere K?rnchen der Dunkelzellen bald nach der Injektion und von der 1 Stunde nach der Injektion an zeigen die Netzmaschen in den Hellenzellen verschiedene Gr?sse nach und nach, wobei die Dunkelzellen selbst sich verkleinern, w?hrend die Hellenzellen eine Anschwellun zeigen, was 12 Stunden nach der Injektion am deutlichsten zu sehen ist. In der Parotis werden die Granula der Dr?senzellen direkt nach der Injektion gr?ber und erf?llen den ganzen Zellleib 12 Stunden sp?ter. Jedoch an der 24 Stunde nach der Injektion verschwinden sie g?nzlich und machen feinen K?rnchen Platz, wobei die Zelle sich verkleinert. In der Leber schwellen die meisten Leberzellen unmittelbar nach der Injektion an, aber 20 Minuten sp?ter werden sie durch die erweiterten Blutkapillaren gedr?ckt und verkleinert. Die Zellen behalten diesen Zustand eine Zeitlang, nur dass ihre Kerne eine Anschwellung zeigen. Nach 12 Stunden tritt die Erweiterung der Kapillaren zur?ck und die Leberzellen quellen wieder auf, indem sie sich dicht ber?hren. In der Niere fangen die Blutkapillaren unmittelbar nach der Injektion sich zu erweitern an, und die Harnkan?lchen werden eine Zeitlang gedr?ckt. Besonders zeigt der Glomerulus eine lange Zeit die Anschwellung. Von der 1 Stunde nach der Injektion an erweist das Harnkan?lchen durch seine ganze L?nge eine starke Anschwellung, aber von der 24 Stunde nach der Injektion an tritt die Wiederherstellung auf, indem das Kan?lchen sich von seinem Endgebiet allm?hlich verkleinert. In der Milz erweitern sich die intranodularen Arterien, die H?lsenarterien und die Venensinus unmittelbar nach der Injektion, wobei das retikul?re Gewebe fadenartig wind und gr?ssere Maschen zeigt. Dieser Zustand dauert nur eine Kurze Zeit. Nach einer Stunde quellen die W?nde der intranodularen Arterie, der H?lsenarterie, sowie das retikul?re Gewebe auf, was nach 6 Stunden in die Augen springt, indem die F?den des Retikulms miteinander verschmelzen und eine solide Masse bilden, w?hrend die intranodularen Arterien und die H?lsenarterien eine verdickte Wand und ein schmales Lumen zeigen. Dabei enth?lt der Milzsinus nur die Lymphozyten, verliert fast alle Erythrozyten, die aber den Venensinus erf?llt. Dieser Zustand ist 48 Stunden nach der Injektion am deutlichsten. Die genannte Anschwellung der Arterienwand und des retikul?ren Gewebes tr?gt zur Verhinderung des Blutstromes in der Milz bei. 3) Wenn man die Milzarterie oder die Milzvene unterbindet oder darauffolgend Amylnitrit injiziert, so tritt stets keine Erweiterung der milzgef?sse auf, sondern man sieht eine Anschwellung der Gef?sswand und des retikul?ren Gewebes. Diese Tatsache ist darauf zuruckzuf?hren, dass Amylnitrit in allen diesen F?llen in die Milz nicht hineintritt. Dasselbe gilt auch f?r den Fall der Venenunterbindung, denn in diesem Falle Blutstaung verhindert das Eintreten des Amylnitrites in die Milz selbst, wenn es injiziert wird. Auf Grund der genannten Tatsache ist der Verfasser der Meinung, dass die gef?sserweiternde Wirkung des Amylnitrites keine zentrale, sondern eine Peripherische ist. 4) Durch Einf?hrung des Amylnitrites in den Tierk?rper wird der peripherische Parasympathicus in erster Linie erregt, was die Gef?sserweiterung f?r Folge hat. Dann quellen die Zellen verschieder Organe auf, wobei die Speichelsekretion bef?rdert wird. In gewissen Organen zeigt die Blutgef?sswand eine starke Verdickung, die das Gef?sslumen betr?chtlich verengert. en-copyright= kn-copyright= en-aut-name=TakemotoIwao en-aut-sei=Takemoto en-aut-mei=Iwao kn-aut-name=竹本巖 kn-aut-sei=竹本 kn-aut-mei=巖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1217 end-page=1242 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Einfluss des Kupfers auf die Gallensteinbildung kn-title=銅ノ膽石形成ニ及ボス影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ich habe neuerdings in einigen forschungsberichten gelesen, dasz eine betr?chtliche Menge Kupfer im Gallenstein enthalten ist und dasz, wenn man verschiedenen Tieren Kupfer per os einzunehmen gebt, bei ihnen der Gallenstein sich bildet. Jedoch habe ich noch keine genauere Untersuchung der Beziehung zwischen Kalzium (ein wichtiger Gallensteinbestandteil) und Kupfer gefunden, wenn das auch immer zur Unzul?nglichkeit meiner Kenntnis zur?ckzuf?hren sein mag. Deshalb habe ich die M?glichkeit der Gallensteinbildung untersucht, indem ich in der hypercalc?mischen und anderen verschiedenen Perioden gesunden H?nden Kupfer gegeben. Ich k?nne so aus meinen Experimenten schlieszen, dasz das Kupfer einen gewissen Einflusz auf die Gallensteinbildung aus?be. Ich bin nun davon ?berzeugt, dasz das Resultat meiner Arbeit einmal zur Neuheit unserer Wissenschaft geh?ren wird. en-copyright= kn-copyright= en-aut-name=TsurumiTakao en-aut-sei=Tsurumi en-aut-mei=Takao kn-aut-name=鶴身孝雄 kn-aut-sei=鶴身 kn-aut-mei=孝雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=305 end-page=309 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Double Congenital Fistulae with Aneurysm Diagnosed by Combining Imaging Modalities en-subtitle= kn-subtitle= en-abstract= kn-abstract=Congenital coronary pulmonary artery fistula (CAF) is rare, and systemic-to-pulmonary artery fistula (SPAF) is even more so. Furthermore, congenital coronary pulmonary fistula associated with congenital SPAF is extremely rare. As far as we know, CAF and SPAF connected with an aneurysm have not been described very often. We described an 83-year-old woman with an aneurysm originating from a CAF connected to an aortopulmonary artery fistula. Chest radiography revealed a shadow at the left edge of the heart line. Multi-detector-row computed tomography (MDCT) with contrast enhancement and coronary cine angiography revealed that the shadow was an aneurysm connected to a tortuous fistula at the left anterior descending coronary artery. The aneurysm was formed by congenital coronary pulmonary and aortopulmonary artery fistulae. Echocardiography revealed predominantly systolic blood flow in the fistula from the left anterior descending coronary artery (LAD). Although neither MDCT, echocardiography nor coronary angiography alone could provide a comprehensive image of the anomaly, including the hemodynamics in the fistulae and their relationship with surrounding organs and tissues, their combination could provided important facts the led to a deeper understanding of this very uncommon occurrence. en-copyright= kn-copyright= en-aut-name=TachibanaMotomi en-aut-sei=Tachibana en-aut-mei=Motomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MukouharaNaoki en-aut-sei=Mukouhara en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HiramiRyouichi en-aut-sei=Hirami en-aut-mei=Ryouichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujioHideki en-aut-sei=Fujio en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YumotoAkihisa en-aut-sei=Yumoto en-aut-mei=Akihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WatanukiYutaka en-aut-sei=Watanuki en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HayashiAiko en-aut-sei=Hayashi en-aut-mei=Aiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SuminoeIsao en-aut-sei=Suminoe en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KoudaniHiroshi en-aut-sei=Koudani en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Cardiology, Himeji Red Cross Hospital affil-num=2 en-affil= kn-affil=Department of Cardiology, Himeji Red Cross Hospital affil-num=3 en-affil= kn-affil=Department of Cardiology, Himeji Red Cross Hospital affil-num=4 en-affil= kn-affil=Department of Cardiology, Himeji Red Cross Hospital affil-num=5 en-affil= kn-affil=Department of Cardiology, Himeji Red Cross Hospital affil-num=6 en-affil= kn-affil=Department of Clinical Laboratory, Himeji Red Cross Hospital affil-num=7 en-affil= kn-affil=Department of Clinical Laboratory, Himeji Red Cross Hospital affil-num=8 en-affil= kn-affil=Department of Clinical Laboratory, Himeji Red Cross Hospital affil-num=9 en-affil= kn-affil=Department of Clinical Laboratory, Himeji Red Cross Hospital en-keyword=coronary pulmonary artery fistula kn-keyword=coronary pulmonary artery fistula en-keyword=aortopulmonary artery fistula kn-keyword=aortopulmonary artery fistula en-keyword=aneurysm kn-keyword=aneurysm END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1243 end-page=1269 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serologische Studien ?ber mit Formalin vorbehandelte rote Blutk?rperchen und Serum (II. Mitteilung.) ?ber den Einfluss des Formalin auf die Antigenit?t der roten Blutk?rperchen kn-title=血球竝ニ血清ニ及ボス「フオルマリン」ノ影響ニ就テ（第2報）血球抗原性ニ及ボス「フオルマリン」ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In der ersten Mitteilung habe ich haupts?chlich den direkten Formalin-einfluss auf die roten Blutk?rperchen in bezug auf die Resistenz?nderung behandelt. Hier will ich in diesem Teil die Antigenit?t der mit Formalin vorbehandelten roten als Antigene sowohl zur Reaktion als auch zur Antik?rperbildung ber?hren. Zweitens will ich ?ber die Komplementbindung zwischen vorbehandelten Roten und H?molysinen handeln, weil stark formalisierte Rote bei der H?molysinwirkung unver?ndert bleiben. 1) Die Bindung zwischen H?molysin oder H?moagglutinin und 10% Formol-fixierten roten Blutk?rperchen ist schw?cher als die mit unbehandelten Erythrocyten, doch kann man durch Immunisierung mit Formol-fixierten Roten H?molysine oder H?moagglutinine bei Kaninchen erzeugen. 2) Auf 10% Formol-fixierte rote Blutk?rperchen reagieren die H?molysine ganz negativ bei Anwesenheit des Komplementes, bei der Agglutination sieht man jedoch eine, wenn auch sehr schwache Reaktion. 3) 10% Formol-fixierte rote Blutk?rperchen absorbiert das H?molysin, besonders der damit gebildete Antik?rper, welcher bei der H?molysinwirkung ganz intakt bleibt. Man kann daher bei diesem Versuch durch die Formalin-wirkung auf die Zustandsspezifit?t schliessen. 4) 10% Formol-fixierte rote Blutk?rperchen habe ich in folgender Weise als Antigene f?r die Komplementbindungsreaktion verwandt; Ich liess 10% Formol-fixierte rote Blutk?rperchen Emulsion, Komplement und H?molysine, bei 37°C. 1 Stunde lang stehen und nahm nach der Zentrifugierung die Abgusse vor. Zu diesen Abg?ssen f?gte ich wieder ein h?molytisches System und digerierte bei 37°C. 2 Stunden lang. Nach dieser Behandlung konnte ich die Reaktion wie bei der gew?hnlichen Komplementbindung beurteilen. Die Formol-fixierten roten Blutk?rperchen von 5%iger Emulsion brechen sich mit dem Komplement bei Anwesenheit des entsprechenden Antigens (H?molysin) am st?rksten. Der Titer der Komplementbindung steht etwas niedriger (zirca 1/4) als der H?molysintiter bei dem gleichen Immumserum. 5) Mit 10% Formol-fixierten Stroma kann man auch bei Kaninchenimmunisierung H?molysin und H?moagglutinin erzeugen. en-copyright= kn-copyright= en-aut-name=KoizumiMichinori en-aut-sei=Koizumi en-aut-mei=Michinori kn-aut-name=小泉道徳 kn-aut-sei=小泉 kn-aut-mei=道徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1270 end-page=1286 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Klinische Beobachtungen der Pankreasfunktion bei verschiedenen Pankreaskrankheiten kn-title=各種膵臟疾患ニ於ケル膵機能ノ臨牀的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fr?her habe ich schon festgestellt, dass die Zuckertoleranz bei einem gesunden Hunde 0.2 Gramm 40%ige Traubenzuckerl?sung f?r jedes eine Kilogramm von dessen K?rpergewicht ist. Noch weiter habe ich, indem ich ihn dann mit verschiedenen Mengen des Traubenzuckers parenteral belastet, solches gefunden dasz sich die Pankreasfunktion am deutlichsten zeigt, wenn man es in der Zuckertoleranz tut. Sodann habe ich einerseits mittels dieser parenteralen Zuckerbelastungsprobe Ver?nderungen der Zuckerassimilation bei dem Hunde mit dem partiell exstirpierten Pankreas oder mit der experimentellen Pankreasneklose geforscht und andererseits die Funktion des Pankreas beobachtet. Um diese ergebnisse zur klinischen Diagnose anzuwenden, habe ich weiter eine andere Probe angestellt, indem ich einigen Kranken mit akutem, chronischem Pankreatitis oder mit Pankreaskrebs die der Toleranz nahe liegende Menge des Zuckers (0.2 Gramm 40%ige Trauben zuckerl?sung f?r jedes eine Kilogramm des K?rpergewichts) gegeben. Dabei habe ich gefunden, dasz das Pankreatitis eine besondere Belastungskurve hat und dasz diese Kurve, wenn man sie zur Differentialdiagnose anwendet, ganz nutzbar ist. ?brigens bin ich auch zu einem interessanten Resultat gekommen, als ich diese Methode w?hrend der Anfangszeit des Pankreaskrebses gebraucht. Die sog. parenterale Zuckertoleranzbelastungsprobe kann also als eine nutzbare Methode gelten, um die Krankheiten des Pankreas zu untersuchen. en-copyright= kn-copyright= en-aut-name=ItamiMasao en-aut-sei=Itami en-aut-mei=Masao kn-aut-name=伊丹正雄 kn-aut-sei=伊丹 kn-aut-mei=正雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1287 end-page=1336 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Morphologischeentwicklung und den mikroskopische Beobachtungen des Chordadorsalis (I. Mitteilung.) ?ber die V?geln, besonders bei den Embryonen von Anas domestica kn-title=鳥類脊索(Chordadorsalis)ノ形態學的發生竝ニ組織學的研究（第1報）家鴨ニ於ケル觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verfasser hat bei morphologischen Studien ?ber die Bildung der Chorda dorsalis dei dem Entenkeimlinge und durch die Feststellungen bei den mikroskopischen Beobachtungen die folgenden Resultate gewinnen und ver?ffentlichen k?nnen. 1) Die Chorda dorsalis des Entenkeimlings, von dessen Urwirbeln nur einer 24 Stunden nach dem Beginn des Br?tens erst gez?hlt wird, beginnt auf der Stelle der 280μ vom Scheitel des Embryos von der Vertiefung der Bauchwand, der Mittelrinne vor dem Gehirn zur Oralseite nur ein kleines St?ck des Scheitels zeigend. Die wagrecht geschnittene Fl?che der Chorda dorsalis in diesem Stadium ist eigentlich ein aus 5-8 Zellen entstehender Zellenstrang. Diese betreffenden Zellen sind im allgemeinen etwa w?rfelf?rmig, aber einige darunter sind rund oder schiefrund; abgesehen davon sind alle gleichartig reich an Protoplasmen. Es ist gesehen nat?rlich, dass das Chordagewebe aus den Mesodermzellen trennen. 2) Die normale Gestalt der Chorda dorsalis bildet binnen 40 Stunden die Zahl der Urwirbel, die auf f?nf beschr?nkt ist, im allgemeinen die schiefrundliche Stange, im besonderen aber die rundliche, und darauf folgt die Verwandlung, dass die mitte der Chorda dorsalis zur rundlichen Stange umgestaltet wird und die beiden Oral und Kaudalseiten schiefrund ausgedehnt werden. Die mit den 42 Stunden des Br?tens verlaufenen acht Urwirbeln schon ?ber den Embryo hinauswachsende Chorda dorsalis bildet mit Ausnahme eines kleinen Teils derselben in ihrer ganzen L?nge eine rundliche Stange und zugleich zeigen die peripheren Durchmesser der Chorda dorsalis an deren Oral und Kaudalseite in ihrer Gr?sse nur einen kleinen Unterschied. W?hrend beim Embryo mit der in 60 Stunden entstehenden Urwirdelzahl 21-23 der periphere Durchmesser des Nervenrohrs kaudalw?rts nach und nach abnimmt, kann der Durchmesser der Chorda dorsalis in ihrer ganzen L?nge ungef?hr gleich bestimmt werden. 3) Die schwach entwickelten Chorda, dorsalis Zellen haben keine Koalitionskraft, sind isoliert und dabei findet soger die mitotische Zellteilung ?berm?ssigerweise statt, und die Entstehung der von der Verdickung der festen Zellenbasis veranlassten Membrana limitans propria wird im Verlauf von 38 Stunden nach dem Beginn des Br?tens im Embryo bemerkt. 4) Was das Verh?ltnis der Entfernung zwischen der Chorda dorsalis, der Neuralplatte (Neuralrinne, Neuralrohr), der Bauchwand-zusammen mit (N) bezeichnet-und dem Mesoderm (Vorderdarm)-mit (D) bezeichnet-betrifft, so sind dei der Chorda dorsalis im Stadium der 38. Stunde des Br?tens d. h. bis zum Embryo mit den vier Urwirbeln N und D jedweder an der Bauchseite und R?ckseite der Chorda dorsalis angef?gt, aber je nach dem Anwachsen des Keimlings trennen sich N und D von der Chorda dorsalis, jedoch ist der Grad der Trennung bei N nicht so auffallend wie bei D zur Zeit der Erscheinung der Arteria dorsalis. In der 60 Stunde des Br?tens f?gen sich Chorda dorsalis und N nur mit Ausnahme von einem Teil der Oralseite von Anfang bis Ende aneinander und laufen zusammen. 5) Die zwischen einer Reihe Zellen auf der Bauchseite der Chorda dorsalis und dem Urdarmdach allein stehende Hypochorda ist beim Embryo im Stadium der drei Urwirdel zu sehen. 6) Die Evolution der Chorda-Scheide als homogenes Gewebe in der Peripherie der Membrana limitans propria ist zuerst beim Embryo der f?nfzehnz?hligen Urwirbel zu sehen, und dann beim allm?hlich sich vervollkommenden Embryo dehnt sie sich nach den beiden Richtungen der Oralseite und Kaudalseite aus und auch dabei ist sie sehr deutlich zu sehen. Die bis zum Embryo mit den 23 Urwirbeln sichtbare Chorda-Scheide entspricht meiner Aussicht nach der vom Herrn Kuhlenbeck genannten "plasmatischen, fibrill?ren Membran". 7) Die Bildung des Ceutralcanals geschieht im Embryo mit achtz?hligen Urwirbeln in der 42. Stunde des Br?tens und Je nach der langsamen Vermehrung der Urwirbelzahl, verl?ngert sick auch allm?hlich die Achse des Kauals. Beim Embryo mit den 20 Urwirbeln erreicht die L?ngsrichtung 50-80μ. 8) In dem Oralgebiet oder dem Kaudalgebiet der Chorda dorsalis n?hern sich die Plasmadesmen vom Mesoderm zum Rande der Chorda dorsalis, und die Plasmastreifen gehen getrennterweise auseinauder und finden ihren Ablauf in die organisation der Chorda dorsalis. Diese Erscheinung ist Haupts?chlich in einem schlecht entwickelten Embryo zu finden. 9) Der Gipfel der Chorda dorsalis beginnt beim Embryo erst in dor 40. Stunde des Brutens sich vorzubeugen. 10) Keilf?rmige Zellen, welche sich der L?ngsrichtung der Chorda dorsalis gegen?ber geldrollenartig und regelm?ssig anreihen, vereinigen sich aber unregerm?ssig miteinauder am Ende ihrer inneren Seite. 11) Der Teil, wo die Differenzierung in der Chorda dorsalis am h?chsten ist, entspricht dem Wanderungsteil des Rhombencephalons und R?ckenmarks ; die oral und Kaudalseiten bleiben immer am unentwickelsten. 12) Die Verlagerungsachse der Chromosomen der R?ckenstrangszellen zur R?ckenstrangsachse scheint, wie Herr Kuhlenbeck behauptet, zu den Folgenden drei Hauptrichtungen zugeleitet zu werden, d. h. a. Tangentiale Richtung. b. Parallele Richtung. c. Senkrechte Richtung. 13) Sobald sich die Chorda dorsalis der Nervenrinnen wand n?hert, sinkt die spissige Kante herunter und bildet sich, als ob sie den R?ckenstrang im Empfang n?hme. 14) Wenn auch sich die Kaudalw?rts organisierten R?ckenstrangszellen mit den sich im peripheren Organ befinden und auch organisierten vermischen, (oder mit den das periphere Organ organisierenden Zellen), die R?ckenstrangsbildung abbauen und verwirrend verschwinden, findet dies doch am sp?testen statt, dass sie mit dem Entoderm in Kongrezation geraten. 15) In der 60. Stunde des Br?tens ist die Vacuolisierung noch nicht zu bemerken, dagegen sind die nach meiner Benennung sogenannten "der H?hlenbildung und Wanderung f?higen Zellen" hie und da zerstreut zu beobachten. en-copyright= kn-copyright= en-aut-name=MizunoBunjiro en-aut-sei=Mizuno en-aut-mei=Bunjiro kn-aut-name=水野文次郎 kn-aut-sei=水野 kn-aut-mei=文次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室胎生學研究室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1337 end-page=1341 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber zwei F?lle von Rippengumma kn-title=肋骨護謨腫ノ2治驗例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neuerdings beobachte der Verfasser zwei seltene F?lle von Rippengumma, welche als Rippencaries diagnostiziert und zuerst durch die Rippenresektion u. nach der Rezidiv durch die antiluetische Behandlung ausgeheilt sind. Der erste Fall war ein 35 j?hriger Barbier, der als Rippencaries diagnostiziert u. durch die Rippenresektion tempor?r geheilt ist, aber bald nachher bekam er Rezidev, dann perforierte der Local; so probierte Wassermannsche Reaktion, welche positiv reagierte. Der Patient wurde antiluetisch behandelt u. nach 45 Tagen geheilt ist. Der zweite Fall war ein 31 j?hriger Kaufmann, welcher von Anfang an als Rippengumma diagnostiziert durch Wa R. und denn durch die Rippenresektion u. antiluetische Kur ausgeheilt ist. Die Differentialdiagnose zwischen Rippencaries und Rippengumma ist f?r den Arzt ambulatorisch schwierige Aufgabe. Bei der Rippenerkrankung erinnert man zuerst gew?hnlich an Rippencaries, man trifft aber manchmal dem Rippengumma, obwohl es so selten ist. So soll man sich auch an Rippengumma erinnern, wenn der Verlauf als Tuberculose etwas anders ist. Dazu Wa R. oder R?ntgenphotographie als Hilfsdiagnostik sehr wichtig. Aber man kann durch probe antiluetische Kur die Diagnose klar zu stellen. en-copyright= kn-copyright= en-aut-name=UkitaKatsuzo en-aut-sei=Ukita en-aut-mei=Katsuzo kn-aut-name=浮田勝造 kn-aut-sei=浮田 kn-aut-mei=勝造 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1350 end-page=1365 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistische Betrachtung ?ber 200 Radikaloperationen der Hernienf?lle kn-title=「ヘルニア」根治手術200例ノ統計的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Die Statistik von 200 Bruchf?llen, die w?hrend 9 Jahre in unserem Institut der Radikaloperation unterworfen sind, zeigt folgende Resultate. 1) Die Morbidit?t des m?nnlichen und des weiblichen Geschlechtes: M?nner betragen 168, d. h. 8.4%, Frauen 32 d. h. 16%. Die Morbidit?t der linken und der rechten Seite: Rechte 132 d. h. 66%, linke 55 d. h. 27,5%. Radikal operierte Kranke von beiderseitigen Hernien 8. Unter 179 Leistenbruchkranken sind M?nner 163, Frauen 16. 2) Die Vergleichung der Erkrankungsalter des Leistenbruchs zeigt, dass der letztere im S?uglingsalter am meisten auftritt, dann allm?hlich abnimmt, aber im Junglingsalter sowie im Klimakterium zuzunehmen scheint. 3) Die postoperative Sterblichkeit zeigt 2,5% d. h. 5. Von diesen ist einer Patient von angeborenem Nabelbruch, alle andere sind nur solche Kranken, bei denen es durch Einklemmung zum Darmbrand kam und der Darm reseziert wurde. Keiner mit Hodensackbruch starb, w?hrend die Sterblichkeit der Leistenbruchkranken 8% und die der Schenkelbruchkranken 28,5% zeigte. Das r?hrt daher, dass die Geschwulst des Schenkelbruchs klein ist, so dass man sie oft erst dann bemerkt, nachdem die Einklemmung schon eingetreten ist. Das beruht auch darauf, dass er mit anderer akuten Bauchh?hlenerkrankung verwechselt werden kann, weil er sehr leicht den Darmwandbruch veranlasst. 4) In bezug auf das Alter bei der Radikaloperation befindet sich die Operationsh?ufigkeit der kleinen Kinder in der Neigung zur Vermehrung. 5) 51,8% von Bruchinhalt ist Darmst?ck und 45% Grossnetz, also diese beiden nehmen den gr?ssten Teil der s?mtlichen F?lle. Im ?brigen besteht der Inhalt bei 1 Fall aus Leber, bei 5 aus Hoden, bei 1 aus Eileiter und 13 sind von Hydrocele begleitet. 6) Die Fernergebnisse zeigen bei 150 untersuchten Kranken 0, 7% Rezidiv d. h. das von einem innere Leistenbruchfall. 7) Als Methode zur Radikaloperation benutzt man bein Erwachsenen vorwiegend Bassinis Verfahren, beim kleinen Kind sowie S?ugling Lucas Champoni?res-Methode. 8) Man gebraucht Seide als Nahtfaden. Catgut ruft eine gr?ssere Rezidiv-h?ufigkeit hervor. 9) Da der k?rperliche Arbeiter mehr zum Rezidiv neigt, so ist es n?tig, dass er sich wenigstens 3 Wochen lang nach der Operation ruhig h?lt. Sein Aufenthalt im Hospital soll 2 Wochen sein. en-copyright= kn-copyright= en-aut-name=HiraideShozo en-aut-sei=Hiraide en-aut-mei=Shozo kn-aut-name=平井出正三 kn-aut-sei=平井出 kn-aut-mei=正三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1269 end-page=1274 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of OX Substance of DNA Content and Mitotic Phase of Subcutaneously-Transplanted Yoshida Sarcoma Cells kn-title=皮下移植吉田腫瘍細胞のDNA量及びMitotic phaseに対するOX物質の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=After transplanting Yoshida sarcoma cells under the skin of the thigh of hybrid mice, the author injected 0.2cc of 2% unsaturated fatty acid fraction (denominated as OX substance) intramuscularly and observed the changes in the histological picture, in the mitotic phase as well as the changes in the quantity of DNA per cell, along with the lapse of time, and obtained the following results. 1. The histological pictures revealed the phenomena such as an increase in necrotic foci, a general diminution in stainability and indistinct cell boundary. 2. In counting the number of those cells with a relatively strong activity in cancer foci at various mitotic phases, it has been found that from 6 to 12 hours after the OX injection the number of the cells in metaphase is decreased and from 24 hours on the number of such cells approaches the normal. 3. In the estimation of DNA content per cell, from 6 to 12 hours after the OX injection the number of the cells undergoing a relatively active proliferation but with a decreased DNA content tends to increase but after 24 hours the content per cell approaches the normal level. en-copyright= kn-copyright= en-aut-name=IguchiYoshiko en-aut-sei=Iguchi en-aut-mei=Yoshiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1366 end-page=1374 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistische Betrachtung des Schenkelbruchs kn-title=股「ヘルニア」ノ統計的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Unter 200 Bruchkranken, die w?hrend 9 Jahre in unserem Institut der Radikaloperation unterzogen wurden, betragen Schenkelbruchkranke 16, also 8% von ihuen, einen relativ hohen Prozentsatz. Die Sterblichkeit der Schenkelbruchkranken bel?uft sich auf 28,5%, also 2 von 16, w?hrend die im ganzen 2,5% ist. Nachdem ich untersucht hatte, warum ihre Sterblichkeit so gross ist, und zugleich eine statistische Betrachtung angestellt hatte, bin ich zu folgenden Schl?ssen gelangt. Der Schenkelbruch tritt ?fters bei Frauen im postklimakterischen Alter auf und kommt h?ufig rechterseits zustande wie Leistenbruch. Da seine Einklemmungsh?ufigkeit im Verh?ltnis zu anderen Hernien hoch, seine Geschwulst klein ist, indem die grosse Mehrzahl der Kranken den Darmst?ck zum Inhalt macht und zwar h?ufig die Darmwandhernie hervoruft, die eine erhebliche Sterblichkeit zeigt und nur wenige Hoffnung auf Naturheilung zul?sst, so ist es ?usserst erforderlich, dass man m?glichst fr?h nach der Entdeckung seine Radikaloperation vornimmt. Auf diese Weise k?nnte man seine Einklemmungsh?ufigkeit sowie Sterblichkeit vermindern. Der Schenkelbruch macht nicht so komplizierte Operationsarten notwendig, weil seine postoperative Rezidivh?ufigkeit relativ gering ist. Es kommt nur darauf an, dass man den Bruchsack am Halsteil in einer m?glichst hohen Lage vollst?ndig exstirpiert. Was den Schenkelring betrifft, so gen?gt es, ihn mittels der einfachen Methode zu verschliessen. Bei der Operation der eingeklemmten Schenkelhernie, besonders solcher mit dem Inhalt des Darmst?cks sei man beim Schnitt des Bruchsacks, besonders seines Halsteils, am vorsichtigsten, da in diesem Fall die Darmwand durch Ausstreckung sehr verd?nnt und ?usserst verletzbar ist. en-copyright= kn-copyright= en-aut-name=HiraideShozo en-aut-sei=Hiraide en-aut-mei=Shozo kn-aut-name=平井出正三 kn-aut-sei=平井出 kn-aut-mei=正三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=743 end-page=746 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Primary Reticulum Cell Sarcoma of the Stomach; Report of a Case kn-title=胃細網肉腫症の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of primary reticulum cell sarcoma of the stomach was reported. The patient was a fifty-four year old housewife, with the chief complaints of epigastric pain and anorexia. The roentgen manifestations were consistent with gastric cancer, and total gastrectomy was performed. The lesion was localized in the stomach and histological examination revealed reticulum cell sarcoma. en-copyright= kn-copyright= en-aut-name=ShiakuTakeru en-aut-sei=Shiaku en-aut-mei=Takeru kn-aut-name=塩飽健 kn-aut-sei=塩飽 kn-aut-mei=健 aut-affil-num=1 ORCID= en-aut-name=OginoKeichiro en-aut-sei=Ogino en-aut-mei=Keichiro kn-aut-name=荻野敬一郎 kn-aut-sei=荻野 kn-aut-mei=敬一郎 aut-affil-num=2 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=3 ORCID= en-aut-name=HadaYoshihiro en-aut-sei=Hada en-aut-mei=Yoshihiro kn-aut-name=羽田良洋 kn-aut-sei=羽田 kn-aut-mei=良洋 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1463 end-page=1472 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Klinische Erfahrungen mit Pansekal kn-title=尿道淋ニ對スル「パンセカール」ノ臨牀的價値 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verf. hat die intraven?se Injektion von Pansekal bei 20 F?llen (7 F?lle von Urethritis gonorrhoica anterior acuta, 4 F?lle von Urethritis gonorrhoica totalis acuta, 4 F?lle von Urethritis gonorrhoica subacuta totalis, 5 F?lle von Urethritis gonorrhoica chronica totalis) ausprobiert, davon bei 10 F?llen Pansekal einmal jeden Tag, bei den anderen einmal jeden 2. Tag je 10cc eingespritzt und den weiteren Verlauf, die Nebenwirkungen etc. genau beobachtet. Die Heilwirkung von Pansekal ist eben so gut, wie die von Trypaflavin, Panseptin oder Isravin und die Nebenwirkungen sind viel seltener als bei den drei letzteren zu finden. Was die Intervalle zwischen den einzelnen Injektionen anbelangt, so scheint die t?gliche Injektion wirksamer zu sein als die alle 2 Tage vorgenommene. Im grossen und ganzen ist das Pr?parat f?r die Behandlung der Gonorrhoe als ein wirksames Heilmittel der lokalen Behandlung mit Antigonorrhoicum empfehlenswert. en-copyright= kn-copyright= en-aut-name=YamamotoHarumi en-aut-sei=Yamamoto en-aut-mei=Harumi kn-aut-name=山本春海 kn-aut-sei=山本 kn-aut-mei=春海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學皮膚科泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1293 end-page=1298 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Free Amino Acids in the Brains ? The Influence of Thyroidectomy on the Free Amino Acids and Related Compounds in the Brain of Rat kn-title=脳の遊離アミノ酸について(?)甲状腺剔除の脳遊離アミノ酸およびその関連物質におよぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to study the influence of thyroidectomy on the free amino acids and the related compounds the author performed the assay of 11 of these substances by ion exchange column chromatography, using the rat brains as the material. As the result it has been found that aspartic acid, glutamic acid, alanine, serine, N-acetylasparticacid, and glycerophosphoethanolamine, the substances that were decreased in the brains of hypophysectomized animals, have been maintained at the normal level on thyroidectomy. en-copyright= kn-copyright= en-aut-name=NishiokaHirosuke en-aut-sei=Nishioka en-aut-mei=Hirosuke kn-aut-name=西岡博輔 kn-aut-sei=西岡 kn-aut-mei=博輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=747 end-page=762 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Leukemoid Reaction in Mouse Induced by MY Sarcom Transplantation Part T. Studies on the tissue culture of bone marrow and spleen kn-title=MY肉腫移植による実験的類白血病反応に関する研究 第1編 骨髄並びに脾組織培養 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hematological and histological investigations were performed in mice with myelogenous type of leukemoid reaction induced by transplantation of MY sarcom. Thereafter, tissue culture of bone marrow and spleen were carried out. The following results were obtained. 1) Tissue culture of bone marrow. The growth patterns in bone marrow culture were always normal and did not display the leukemic type throughout the entire course of leukemoid reaction. The growth ratio of the pattern increased as leukemoid reaction progressed, while the cell density was fairly constant through the course of leukemoid reaction. Wandering velocity of the neutrophils was low in the early and intermediate stages and did not show difference from the controls in the advanced stage. Cytological observations by phase contrast microscopy, vital staining and fluorescence microscopy did not revealed any difference from normal marrow cells, nor atypism which was usually seen in leukemic cells. 2) Tissue culture of spleen. The normal pattern was always observed as seen in bone marrow tissue culture through the entire course of leukemoid reaction. The growth ratio increased as the reaction progressed. However, the cell density did not show difference from the controls. In leukemoid reaction, the lymphocytic cells were gradtally replaced by the neutrophilic cells. Therefore, 70 to 80 % of the cells in the growth zone of the splenic tissue culture were occupied by neutrophilic cells. In fluorescence tissue culture, the growth zone seen in leukemoid reaction displayed diffuse reddish orange color as a result of a large number of neutrophilic cells present, while the zone observed in controls showed diffuse yellowish green color owing to abundant lymphocytes. These findings were very helpful for differentiation of the splenic tissue in leukemoid reaction from the controls. The findings described above seemed to demonstrate the development of extramedullary hematopoiesis in the spleen. en-copyright= kn-copyright= en-aut-name=KaharaMasanori en-aut-sei=Kahara en-aut-mei=Masanori kn-aut-name=加原雅教 kn-aut-sei=加原 kn-aut-mei=雅教 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1375 end-page=1387 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vergleichende Studien ?ber die St?rke der Wirkung einiger neuer adrenalinverwandter Stoffe auf die f?rderuden und hemmenden Fasern des Sympathicus (I. Mitteilung): Versuche am ?berlebenden Kaninchendarm, Rattenuterus, Bronchialmuskel des Rindes, Detrusor und Trigonum der Kaninchenblase und am normalen und schwangeren Kaninchenuterus kn-title=2-3新「アドレナリン」類似體ノ催進及ビ抑制性交感神經纖維ニ對スル作用強度比較研究（第1報）家兎腸管，白鼠子宮，牛氣管支筋，家兎膀胱利尿筋及ビ三角部筋,家兎正常竝ニ妊娠子宮ニ對スル作用比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Um einige neue adrenalinverwandte K?rper, Aminoacetobrenzkatechin, Sympatol und Ephetonal, in ihrer Wirkung zu vergleichen, wurden Versuche an verschiedenen ausgeschnittenen glattmuskeligen Organen, wie Kaninchendarm, Rattenuterus, Bronchialmuskel des Rindes, Detrusor und Trigonum der Kaninchenblase und am normalen und schwangeren Kaninchenuterus angestellt. An diesen Organen zeigen diese 3 Stoffe eine fast reine Wirkung auf die sympathischen Nervenfasern, mit der Ausnahme, dass Sympatol und Ephetonal am Kaninchenuterus teilweise den Muskel anzugreifen scheinen. Am Kaninchendarm, Rattenuterus, Bronchialmuskel des Rindes und Detrusor des Kaninchens wirken diese 3 Gifte durch Reizung der hemmenden Fasern immer bemmend. Am Trigonum vesicae wirken sie in kleinen Konzentrationen durch Reizung der hemmenden Fasern hemmend und in h?heren Konzentrationen (mit Ausnahme von Ephetonal) durch Reizung der f?rdernden anregend. Am Kaninchenuterus wird ebenfalls bei allen Stoffen eine erregende Wirkung konstatiert. Die Wirkunsst?rke der 3 Stoffe auf die hemmenden Fasern schwankt zwar je nach den Organarten ziemlich, im allgemeinen aber ist Aminoacetobrenzkatechin am st?rksten, w?hrend Sympatol und Ephetonal sich nahestehen, beim Kaninchendarm jedoch ist Sympatol dem Ephetonal in der Wirkung weit ?berlegen. In der erregenden Wirkung am Trigonum und Kaninchenuterus ist auch Aminoacetobrenzkatechin am st?rksten, dann folgt Sympatol, und Ephetonal ist am schw?chsten. Am Trigonum wird sogar nach Ephetonal keine erregende Wirkung nachgewiesen. Es gibt sich also, dass diese 3 Stoffe ?hnliche Wirkungstypen haben, sodass die St?rke der hemmenden und f?rdernden Wirkung bei diesen 3 Stoffe etwa parallel geht. Im allgemeinen scheinen diese 3 Stoffe, wie Adrenalon und Ephedrin, eine besonders starke Wirkung auf die hemmenden Fasern des Sympathicus auszu?ben. en-copyright= kn-copyright= en-aut-name=TachibanaKatsuo en-aut-sei=Tachibana en-aut-mei=Katsuo kn-aut-name=橘捷夫 kn-aut-sei=橘 kn-aut-mei=捷夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1299 end-page=1306 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Free Amino Acids in the Brains XIII A Study on the Free Amino Acids in Various Parts of Human Brain kn-title=脳の遊離アミノ酸について(XIII) ヒト脳各部位の遊離アミノ酸およびその関連物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By means of ion exchange column chromatography the author carried out quantitative analyses of 14 kinds of free amino acids including the related compounds using the brain of the person who died of acute loss of blood. The parts of the brain used for the analysis were frontal cortex, corpus callosum, caudate nucleus, globus pallidus, thalamus, hypothalamus and medulla oblongata. The results are as follows. 1. In corpus callosum which contains little cellular components extremely minute quantities of phosphoethanolamine, aspartic acid, glutamic acid and γ-aminobutyric acid could be detected. 2. In globus pallidus a surprisingly large quantity of γ-aminobutyric acid could be found and it was far greater than that contained in hypothalamus. 3. In medulla oblongata only small quantities of phosphoethanolamine, aspartic acid, and glutamic acid could be detected. Likewise γ-aminobutyric acid was found not so abundant. This seems to be due to the fact that the present experiment was conducted with medulla oblongata including white matter. 4. Although only in a small quantity, cystathionine could be assayed in all these parts except globus pallidus and thalamus. 5. Even from the comparative biochemistry the present quantitative analyses gave an interesting contrast to the values obtainable in the brains of lower animals. 6. Although it was difficult to recognize any distinct difference in the pattern of amino acids between the adult brain and the infant brain, there was a clear-cut difference in the amino acid pattern of the adult brain and that of the fetal brain. Namely, in the adult human brain there exist far greater quantities of aspartic acid, glutamic acid, γ-aminobutyrie acid, and N-acetylaspartic acid than those in the fetal brain and conversely far less quantities of phosphoethanolamine and taurine than in the latter. Likewise tyrosine detected in the fetal brain could not be recognized in the adult human brain. en-copyright= kn-copyright= en-aut-name=NishiokaHirosuke en-aut-sei=Nishioka en-aut-mei=Hirosuke kn-aut-name=西岡博輔 kn-aut-sei=西岡 kn-aut-mei=博輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1388 end-page=1420 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Wechselbeziehung zwischen der Schilddr?se und der Milz (I. Mitteilung.) Forschungen ?ber junge Erythrozyten, insbesondere reticulierte Erythrozyten und ?ber die Senkungsgeschwindigkeit der Erythrozyten kn-title=甲状腺ト脾臟トノ相互關係（第1報）幼若赤血球殊ニ網状赤血球及ビ赤血球沈降速度ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neuerdings sind viele Arbeiten erschienen, in denen man sich mit der Erforschung der Wechselbeziehung zwischen der Schilddr?se und der Milz bei der blutbildenden Funktion des Knochenmarks besch?ftigt. Herr Sakai hat auch neulich gefolgert, dasz die unscharfe Zone bei der Sedimentierung der Erythrozyten aus reticulierten Erythrozyten bestehe und ein biologisches Ph?nomen sei, das die Steigerung der Erythrop?se im Knochenmark andeute. Infolgedessen habe ich nun untersucht, welche Einfl?sse die Schilddr?se und die Milz auf die Zahl der Erythrozyten, die Menge des H?moglobins, auf junge Erythrozyten, besonders reticulierte Erythrozyten, und auf die Senkungsgeschwindigkeit der Erythrozyten aus?ben, und weiter, welche Beziehungen zwischen den reticulierten Erythrozyten, der unscharfen Zone und der blutbildenden Funktion des Knochenmarks bestehen. Ich habe dabei Kaninchen als Versuchstiere ben?tzt, und zwar unter manchen verschiedenen Bedingungen. Ich habe z. B. bei dem einen Kaninchen die Milz, bei einem anderen die Schilddr?se, oder bei einem dritten die Schilddr?se und dann das erste mit der Homoiotransplantation der Schilddr?se, das zweite mit der Homoiotransplantation der Milz, mit der Injektion des Wasserextraktes des Milz usw. behandelt. Meine Untersuchungen f?hrten zu folgenden Resultaten: Abnahme der Erythrozytenzahl, Abnahme des H?moglobins, Zunahme der reticulierten Erythrozyten, Bef?rderung der Senkungsgeschwindigkeit der Erythrozyten und Auftreten der unscharfen Zone. Die obenerw?hnten Ver?nderungen der Erythrozyten sind auff?lliger bei der Exstirpation und der Homoiotransplantation der Schilddr?se als bei denen der Milz; die Injektion des Milz-wasser-extraktes zeigte eine besonders starke Wirkung. Diese Ver?nderungen bedeuten jedochkeine wesentlichen, sondern nur solche der Verh?ltnisse und werden nicht unmittelbar von der Schilddr?se und der Milz bewirkt. Daher bin ich bei diesem Versuch zu folgenden Ergebnissen gelangt: 1) Schilddr?se und Milz ?ben keine eigentliche Wirkung auf die Abnahme der Zahl der Erythrozyten und des H?moglobins, auf das Vorkommen der jungen, insbesondere der reticulierten Erythrozyten, auf die Senkungsgeschwindigkeit der Erythrozyten und das Erscheinen der unscharfen Zone aus. 2) Reticulierte Erythrozyten geh?ren zwar zu den jungen Erythrozyten, kommen jedoch unabh?ngig von der erythrop?tischen Funktion des Knochenmarks vor; es ist das also kein Anzeichen f?r eine gesteigerte erythropoetische Funktion, sondern es geschicht, wenn reticulierte Erythrozyten fr?hzeitig aus dem Knochenmark herauskommen. 3) Die unscharfe Zone und die reticulierten Erythrozyten, die man bei Sedimentierung der Erythrozyten trifft, treten bis zu einem gewissen Grade in proportionalem Verh?ltnis auf, es ist daher ein kausaler Zusammenhang zwischen den beiden anzunehmen. en-copyright= kn-copyright= en-aut-name=FujikawaTakeo en-aut-sei=Fujikawa en-aut-mei=Takeo kn-aut-name=藤河武雄 kn-aut-sei=藤河 kn-aut-mei=武雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=763 end-page=769 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Leukemoid Reaction in the Mouse Induced by MY Sarcom Transplantation Part U. Leukemoid-reaction inducing factor kn-title=MY肉腫移植による実験的類白血病反応に関する研究 第2編 類白血病反応発現因子 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Leukemoid-reaction inducing factor was searched in mice with myelogenous type of leukemoid reaction induced by MY sarcom. The following results were obtained. 1) Leukemoid reaction was not induced by subcutaneous injection of the extract of MY sarcom. Tissue culture of bone marrow of mice injected with the extract did not show difference from the controls. Therefore, it was presumable that the extract of MY sarcom did not contain leukemoid-reaction inducing factor. 2) Serum of mice with leukemoid reaction induced by MY sarcom was demonstrated to produce hyperplasia of the bone marrow of normal mice. This seemed to indicate that serum of the mice with leukemoid reaction contained leukemoid-reaction inducing factor. en-copyright= kn-copyright= en-aut-name=KaharaMasanori en-aut-sei=Kahara en-aut-mei=Masanori kn-aut-name=加原雅教 kn-aut-sei=加原 kn-aut-mei=雅教 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1421 end-page=1436 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Wechselbeziehung zwischen der Schilddr?se und der Milz (2. Mitteilung.) Forschungen ?ber die Erholung von An?mie kn-title=甲状腺ト脾臟トノ相互關係（第2報）貧血恢復ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Wie ich im 1. Mittilung ausgef?hrt habe, wirken Schilddr?se und Milz in Bezug auf Erythrozyten, H?moglobin, junge, besonders reticulierte Erythrozyten und bez?glich der Senkungsgeschwindigkeit der Erythrozyten, sodass sie sich nicht gegenseitig behindern. Ich habe also die Ver?nderungen der Erythrozytenzahl, der H?moglobinmenge und des Erscheinungs-prozents der reticulierten Erythrozyten untersucht, und zwar bei Kaninchen, die eine durch Aderlass hervorgerufene An?mie zeigten und daher in gesteigerter erythropoietischer T?tigkeit standen, und habe zugleich den Prozess der Erholung von dieser An?mie beobachtet, um die Wechselbeziehung zwischen der Schilddr?se und der Milz festzustellen. 1) Bei einem Kaninchen, dem die Milz exstirpiert wurde und das eine durch Aderlass hervorgerufene An?mie bekam, zeigte sich die Erholung von der An?mie gegen den Kontrollversuch bef?rdert. Reticulierte Erythrozyten kamen immer dem Grade der An?mie entsprechend vor. 2) Die Erholung von der An?mie ist nie von der Exstirpation der Schilddr?se beeinflusst worden. 3) Bei einem Kaninchen, das eine durch Aderlass hervorgerufene An?mie zeigte, dem die Milz exstirpiert war und das dann mit der t?glichen Injektion des Schilddr?senpr?parates behandelt wurde, worde die Erholung von der An?mie langsamer. 4) Ein Kaninchen, das eine durch Aderlass hervorgerufene An?mie zeigte, dem die Schilddr?se exstirpiert war, und dem t?glich ein biszchen Milzextrakt injiziert wurde, erholte sich von der An?mie langsamer. Dabei wurde auch das Vorkommen reticulierter Erythrozyten st?rker. 5) Die Schilddr?se beeinflusst die erythropoietische Funktion nicht. Die Milz hat eine die erythropoietische Funktion hindernde Wirkung. 6) Das Vorkommen reticulierter Erythrozyten bedeutet kein Anzeichen f?r eine gesteigerte erythropoietische Funktion des Knochenmarks. Bei der herabgesetzten treten sie zahlreich auf. en-copyright= kn-copyright= en-aut-name=FujikawaTakeo en-aut-sei=Fujikawa en-aut-mei=Takeo kn-aut-name=藤河武雄 kn-aut-sei=藤河 kn-aut-mei=武雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1437 end-page=1448 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber eine Wertbestimmungsmethode der Antieiweissera kn-title=蛋白性沈降素血清效價ノ一測定法ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YasuharaSetutaro en-aut-sei=Yasuhara en-aut-mei=Setutaro kn-aut-name=安原節太郎 kn-aut-sei=安原 kn-aut-mei=節太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1307 end-page=1311 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effects of OX (Uusaturated Fatty Acid Fraction From the Irradiated Rabbit Liver) on the Fertilization and Cleavage of Sea Urchin Egg kn-title=放射線照射家兎肝より抽出せる細胞毒のウニの受精及び卵割に与える影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of the OX substance, which was extracted from the liver of irradiated rabbits, on the sperm and egg, unfertilized and fertilized eggs of sea urchin (Hemicentrotus pulcherrimus) have been observed. 1. The sperms exposed to OX showed a decreased mortility and lost the ability to stimul to the egg to raise up fertilizing membrane suggesting the inability of giving physical shock to the egg surface or the damage of acrosome. 2. The unfertilized eggs exposed to OX retain the ability of the formation of fertiliging membrane and cleavage but showed remarkable delay in both the length of time for the membrane formation and cleavage. 3. The most sensitive effects on the fertilized eggs have been observed on the initial stage of fusion of sperm and egg nuclei and the metaphase. Immediately after the fertilization in the egg exposed to OX the fusion of sperm and egg nuclei was inhibited and in the cells on metaphase the cleavage was delayed by the prolonged period of transition from metaphase to telophase. 4. From the results with the consideration of the effects of X-rays on cleavage appearing in the past report the authors concluded the OX will be the essential substance representing the effects of X-rays on the cell cleavage. en-copyright= kn-copyright= en-aut-name=SenoSatimaru en-aut-sei=Seno en-aut-mei=Satimaru kn-aut-name=妹尾佐知丸 kn-aut-sei=妹尾 kn-aut-mei=佐知丸 aut-affil-num=1 ORCID= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=2 ORCID= en-aut-name=UtsumiKozo en-aut-sei=Utsumi en-aut-mei=Kozo kn-aut-name=内海耕慥 kn-aut-sei=内海 kn-aut-mei=耕慥 aut-affil-num=3 ORCID= en-aut-name=ShiwakuMidori en-aut-sei=Shiwaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=4 ORCID= en-aut-name=AkagiEiko en-aut-sei=Akagi en-aut-mei=Eiko kn-aut-name=赤木瑩子 kn-aut-sei=赤木 kn-aut-mei=瑩子 aut-affil-num=5 ORCID= en-aut-name=IguchiYoshiko en-aut-sei=Iguchi en-aut-mei=Yoshiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=6 ORCID= en-aut-name=KobayashiJunichi en-aut-sei=Kobayashi en-aut-mei=Junichi kn-aut-name=小林淳一 kn-aut-sei=小林 kn-aut-mei=淳一 aut-affil-num=7 ORCID= en-aut-name=UenoHisako en-aut-sei=Ueno en-aut-mei=Hisako kn-aut-name=上乃寿子 kn-aut-sei=上乃 kn-aut-mei=寿子 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1313 end-page=1318 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunological Studies on Ultracentrifuged-Fraction from Sal. Enteritidis Part I. The Preliminary Studies on Immunizing Effect Using Supernatant and Particulated Fractions kn-title=S.enteritidis超遠心分画物質の免疫学的研究 第1編 感染防禦実験のための予備的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to study biochemical and serological properties of supernatant (Sf) and particulated (Rf) fractions of Sal. enteritidis, the author prepared two fractions by ultracentrifugation of ground cell suspension of the growing cell of two organisms. The organisms used throughout this study were selected among several strains of Sal. enteritidis in the light of virulence to mouse and were MURASHIMA's strain, which showed the highest virulence and TAKATA's strain, showed the lowest virulence. The following results were obtained. 1) Nitrogen and carbehydrate contents were very low in Rf compaired to Sf, especially it was markedly low in the case of nitrogen. 2) Rf showed oxidative ability only to succinate and lactata among the substrate related to TCA cycle, but Sf could oxidize many substrates tested in various degree. However, Rf Sf and of TAKATA's strain could oxidize only succinate in high degree. 3) The specific enzyme activity of Rf was not affected by irradiation of ultraviolet ray, but was decreased to 1/3~1/4 by exposure to heat, 56℃ 30 min., or by action of formalin or mersonin. 4) Antigenic capacities differed only little between Rf and Sf in the light of aggulutinin production to rabbit serum. 5) Rf gave less intense cutaneous reaction and was less virulent than Sf in examinations using rabbit, for the cutaneous test, and mouse, for the virulence test. en-copyright= kn-copyright= en-aut-name=YoshiokaTatsuji en-aut-sei=Yoshioka en-aut-mei=Tatsuji kn-aut-name=吉岡達治 kn-aut-sei=吉岡 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1453 end-page=1462 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vergleichende Studien ?ber die St?rke der Wirkung einiger neuer adrenalinverwandter Stoffe auf die f?rdernden und hemmenden Fasern des Sympathicus (II. Mitteilung): Versuche am Blutdruck, Kaninchenohr- und Froschschenkelgef?ss kn-title=2-3新「アドレナリン」類似體ノ催進及ビ抑制性交感神經纖維ニ對スル作用強度比較研究（第2報）家兎血壓及ビ末梢血管ニ對スル作用比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Die zum Versuche herangezogenen neuen adrenalinverwandten Stoffe, Aminoacetobrenzkatechin, Sympatol und Ephetonal, haben auf den Blutdruck des Kaninchens eine steigernde Wirkung, die durch eine gewisse Dosis von Ergotamin oder Yohimbin gehemmt wird, was auf ihre sympathische Natur hinweist. Nur wirkt Aminoacetobrenzkatechin in kleinenen Dosen in manchen F?llen herabsetzend und erst bei h?heren, wenn auch nicht stark, steigernd. Hinsichtlich der blutdrucksteigernden Wirkung ist Sympatol am st?rksten, dann folgen Aminoacetobrenzkatechin und Ephetonal. Bei Aminoacetobrenzkatechin kann durch Vorbehandlung mit Ergotamin oder Yohimbin eine Umkehrung herbeif?hrt werden, w?hrend dies bei den 2 anderen Stoffen nicht der Fall ist. Was die vasokonstriktorische Wirkung dieser Gifte am Kaninchenohr- und Froschschenkelgef?ss anbelangt, so ist sie im allgemeinen bei Aminoacetobrenzkatechin und Sympatol st?rker, bei Ephetonal schw?cher. Bei dem Froschschenkelgef?ss aber bewirkt Aminoacetobrenzkatechin nur eine leichte Verengerung, obwohl seine minimale Konzentration ziemlich klein ist. Diese Resultate stimmen mit denen der vorigen Mitteilung ?berein und f?hren zu demselben Schluss, dass zwischen der f?rdernden und hemmenden Wirkung dieser 3 Stoffe ein ziemlich Parallelismus besteht. Im allgemeinen scheinen diese 3 Stoffe eine besonders starke Wirkung auf die hemmenden Fasern des Sympathicus auszu?ben. en-copyright= kn-copyright= en-aut-name=TachibanaKatsuo en-aut-sei=Tachibana en-aut-mei=Katsuo kn-aut-name=橘捷夫 kn-aut-sei=橘 kn-aut-mei=捷夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1473 end-page=1479 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den K?rperbau des Miracidiums von Paragonimus westermanni kn-title=肺臟「ヂストマ」「ミラチヂウム」ノ構造ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Das Miracidium von Lungendistoma ist an Form und Gr?sse und auch an K?rperbau sehr ?hnlich dem von Fasciolidae und Schistosomidae. Aus der n?heren Beschreibung, die Prof. Dr. M. Suzuki und von dem Verfasser bearbeitet wurde, sind die folgenden Merkmale als charakteristisch aufzuz?hlen; dadurch kann man das Paragonimusmiracidium von dem der obenangegebenen beiden Arten unterscheiden. 1) Die Wimperepithelzellen sind 17 an der Zahl und in 4 Reihen angeordnet: in der vorderen Reihe 6, in der zweiten Reihe 7, in der dritten Reihe 3, und in der vierten Reihe nur eins. 2) An dem vorderen Ende des Wurmk?rpers ist ein R?ssel vorhanden wie bei den Fasciolidae. 3) Keine Augenflecke, aber ein Paar von Sinnesorganen, wie bei den Schistosomidae. 4) Nur ein Paar von Terminalzellen vorhanden. Der Exkretionskanal bei diesem Wurme ist charakterisiert durch eine glomerulusartige Windung in ihrem Verlaufe. 5) Die Exsistenz der einzelligen Dr?se und des linsenartigen K?rpers ist sehr zweifelhaft bei diesem Paragonimusmiracidium. en-copyright= kn-copyright= en-aut-name=WatanabeMasumi en-aut-sei=Watanabe en-aut-mei=Masumi kn-aut-name=渡邊眞澄 kn-aut-sei=渡邊 kn-aut-mei=眞澄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1480 end-page=1495 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Beitr?ge zur postmortalen Ver?nderung der Leichenleber in verschiedenen Zeiten kn-title=死後ニ於ケル肝臟ノ化學的變化補遺 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verfasser untersuchte die quantitativen Ver?nderungen des Reststickstoffs, des Phosphors und des Schwefels in der Kaninchenleber nach dem Tod des Versuchstieres. 1) Der Restsickstoff, Phosphor und Schwefel nahmen in der Leber mit der der Zeit nach dem Tode mehr und mehr zu. Die Zunahmegeschwindigkeit war je nach der Jahreszeit und der atomosph?rischen Feuchtigkeit w?hrend der Versuchszeit sehr verschieden. Im allgemeinen war sie im Sommer am gr?ssten, weniger gross im Herbst und Fr?hling und am kleinsten im Winter. 2) Im Winter zeigte der Schwefel bis zu 40 Tagen und der Phosphor bis zu 50 Tagen nach dem Tode mehr oder weniger Zunahme. Nach diesem Zeiten waren bei diesen Stoffen keine Weiteren Quantitativen Ver?nderungen zu bemerken. 3) Das Maximum des Reststickstoffes fand sich im Sommer. en-copyright= kn-copyright= en-aut-name=MomonoiKwanji en-aut-sei=Momonoi en-aut-mei=Kwanji kn-aut-name=桃井寛次 kn-aut-sei=桃井 kn-aut-mei=寛次 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1319 end-page=1327 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunological Studies on Ultracentrifuged-Fractions from Sal. Enteritidis Part U. The Protective Antigenicity of Supernatant and Particulated Fractions kn-title=S.enteritidis超遠心分劃物質の免疫学的研究 第2編 感染防禦実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using the same method described in the part I, the author prepared supernatant (Sf) and particulated (Rf) fractions from MURASHIMA's strain and TAKATA's strain respectively. And studied the protective antigenicity of these fractions. The results obtained were as follows. 1) No productive antigenicity was observed on the inoculatoin of Sf. However, the inoculation of Rf could give sufficient immunity by a single intraveneous inoculation: interperitoneal inoculation was inferior than intraveneous one in its effect. 2) By repeated inoculation of Rf from the highly virulent strain the animal became sensitive to a challenge of bacteria. Meanwhile repeated inoculation of Rf from the less virulent strain could give immunity enough to overcome challenge. 3) The prcductive antigenicity of Rf was inactivated either by exposure to heat, 56℃ 30 min, or by action of formalin or mersonin. 4) Sufficient immunity to prevent oral infection was acquired by inoculation of Rf from the highly visulent strain. en-copyright= kn-copyright= en-aut-name=YoshiokaTatsuji en-aut-sei=Yoshioka en-aut-mei=Tatsuji kn-aut-name=吉岡達治 kn-aut-sei=吉岡 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=311 end-page=317 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Occult Compression Fracture of Metacarpal Head without Evidence of Avascular Necrosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a case of 4th metacarpal head collapse of a 19-year-old healthy man. MRI revealed T1 low and T2 high regions in the collapsed 4th metacarpal head, as well as in the right 3rd and left 4th metacarpal head. Our initial diagnosis was occult compression fracture due to avascular necrosis, known as Dieterich's disease. However, pathological findings of surgically resected right 4th metacarpal head were compatible with transient osteoporosis and metacarpal head fracture followed by active tissue repair. The autologous osteochondral transplants from costchondral junction survived and maintained their size and shape even at 10-year follow-up. en-copyright= kn-copyright= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashizumeHiroyuki en-aut-sei=Hashizume en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsukawaAkihiro en-aut-sei=Matsukawa en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HashizumeKenzo en-aut-sei=Hashizume en-aut-mei=Kenzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShimamuraYasunori en-aut-sei=Shimamura en-aut-mei=Yasunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TorigoeYasuyuki en-aut-sei=Torigoe en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Human Morphology,　Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Kasaoka Daiichi Hospital affil-num=3 en-affil= kn-affil=Department of Pathology and Experimental Medicine,　Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Orthopaedic Surgery,　Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Orthopaedic Surgery,　Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Torigoe Seikeigeka Clinic affil-num=7 en-affil= kn-affil=Department of Orthopaedic Surgery,　Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=occult compression fracture kn-keyword=occult compression fracture en-keyword=metacarpal head kn-keyword=metacarpal head en-keyword=avascular necrosis kn-keyword=avascular necrosis en-keyword=osteochondral autograft kn-keyword=osteochondral autograft END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=319 end-page=324 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation of Enteric-coated Capsules of Beclomethasone Dipropionate for Patients with Intestinal Graft-versus-Host Disease and a Case Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs. en-copyright= kn-copyright= en-aut-name=MurakawaKiminaka en-aut-sei=Murakawa en-aut-mei=Kiminaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoTomoaki en-aut-sei=Sato en-aut-mei=Tomoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Pharmacy, Okayama University Hospital affil-num=2 en-affil= kn-affil=Department of Pharmacy, Okayama University Hospital affil-num=3 en-affil= kn-affil=Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Pharmacy, Okayama University Hospital affil-num=5 en-affil= kn-affil=Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Pharmacy, Okayama University Hospital en-keyword=beclomethasone kn-keyword=beclomethasone en-keyword=intestinal graft-versus-host disease kn-keyword=intestinal graft-versus-host disease en-keyword=enteric-coated capsule kn-keyword=enteric-coated capsule en-keyword=in-hospital formulation kn-keyword=in-hospital formulation END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1329 end-page=1341 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alklphosphate Poisoning Part 1. Clinical Effects of PAM on Parathion Poisoning kn-title=有機燐剤中毒に関する研究 第1編 Parathion中毒に対するPAMの臨床効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=On 39 cases of parathion poisoning treated with PAM (pyridine-2-aldoxime methiodide) the author obtained the following results. 1. From cholinesterase determinations and clinical findings PAM has been found to be the most effective drug available at present for the treatment of parathion poisoning. 2. The effect appears promptly within 30--40 minutes of the treatment. 3. By administering PAM such symptoms as disturbance of consciousness, muscular fasciculation, salivation, bronchial secretion, convulsions, vomiting, and rasping in the lung, all disappear easily. Apart from these there may persist for quite same time such subjective symptoms as headache, miosis, pallor, quick breathing, speech difficulty, slow pupillary reflex, and numbness of limbs, but these are not dangerous. 4. If no improvement at all occurs after the administration of PAM, the case may be suspected as not paration poisoning. 5. As for the method of administration, 1.0 g PAM (40 ml 2.5% aqueous solution) is administered intravenously, and if no prompt effect appears another dose of 1.0 g PAM will be sufficient. 6. Occasionally vomiting accompanies the PAM injection, but it is considered as due to parathion, and there can be observed otherwise no other side-effect. 7. There is no need of concurrent use of atropine, and even in severe case the dose of atropine should be limited to 0.5-1.0 mg to suppress secretion. The use of a large amount of atropine, on the contrary, brings about the danger of atropine poisoning. 8. In extremely severe cases where even 2.0 g PAM shows little effect, PAM in the amount up to 4-5 g may be additionally given along with atropine. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=799 end-page=804 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=About Two Case of Stomach Cancer Patients Complicating Armoured Pericard kn-title=胃癌に合併せる装甲心の2例について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently we have been two stomach cancer patients complicating armoured pericard. These two cases are diagnosed by X-ray examination as "armoured pericard" which would be easily differentiated from calcification of mediastinal pleura etc. by means of lateral or oblique projection radiography and tomography, and could be fit for gastrectomy. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=NishishitaSoichi en-aut-sei=Nishishita en-aut-mei=Soichi kn-aut-name=西下創一 kn-aut-sei=西下 kn-aut-mei=創一 aut-affil-num=2 ORCID= en-aut-name=ShiakuTakeru en-aut-sei=Shiaku en-aut-mei=Takeru kn-aut-name=塩飽健 kn-aut-sei=塩飽 kn-aut-mei=健 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1496 end-page=1509 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von tuber?ser Hirnsklelose kn-title=結節性腦硬化症ノ1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser berichten hier ?ber einen seltenen Fall von sog. tuber?ser Hirnsklerose. Der Kranke war ein 15 j?hriger J?ngling. Von Kindheit an zeigten sich bei ihm einige Symptome der tuber?sen Hirnsklerose, d. h. Adenoma sebaceum und Geistesarmut u. s. w. Am 23. August 1932 klagte er ganz pl?tzlich ?ber Bauchschmerzen, es trat Erbrechen, Bewustseintr?bung und Fieber von ca. 39° bis 40°C, auf. Am 28. August starb er unter Symptomen von acuter Encephalitis und wurd am n?chsten Tage seziert. Die pathologischanatomischen Befunde machten klar, dass es sich bei diesem Falle um eine tuber?se Hirnsklerose mit mehreren Tumoren, die sich an Hirn, Niere Herzen, Lunge und Haut fanden, handelte. Der Tumor am Gehirn stammte aus dem Vorderhorn des rechten Seitenventrikels. Bei tuber?ser Hirnsklerose sind Lipom des Herzens und Adenom der Lunge, wie sie in Unserem Falle beobachtet worden sind, ?usserst selten und bis in der japanischen medizinischen Literatur noch nicht beschrieben worden. Verfasser sind der Ansicht, dass diese Tumoren und die Ver?nderung des Gehirns Missbildungen sind; im Hiublick auf das Verhalten der Hyperplasie der Zellen kann ein Teil der krankhaften Erscheinungen als Gewebsmissbildung und ein Teil als echte geschwulstm?ssige Ver?nderung gelten. en-copyright= kn-copyright= en-aut-name=KikuzawaT. en-aut-sei=Kikuzawa en-aut-mei=T. kn-aut-name=菊澤隆尚 kn-aut-sei=菊澤 kn-aut-mei=隆尚 aut-affil-num=1 ORCID= en-aut-name=TakigawaK. en-aut-sei=Takigawa en-aut-mei=K. kn-aut-name=瀧川克巳 kn-aut-sei=瀧川 kn-aut-mei=克巳 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學柿沼内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=805 end-page=815 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part T Effects of Parabiosis on Water, Sodium and Potassium Contents in the Brain of ep-Mouse kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第1編 ep系マウス大脳の含水量およびNa,K含有量におよぼすparabiosisの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parabiosis was performed between an ep-mouse, having had convulsive seizures, and a CF(1)-mouse, one of normal other species, and biochemical changes in the brain induced by this procedure were investigated. The results of this experiment were as follows: 1. Water content in the brain of the ep-mouse was larger than in the one of the CF(1). It was decreased 6 days after the procedure to the level between the contents in the ep-and the CF(1)-mice of preparabiosis period. At the 12 th postparabiosis day, both contents were decreased to regain the preparabiosis level of the CF(1). The variation in the course was due to the change of the free water content but not due to the bound water content. 2. Total sodium content in the ep-mouse was remarkably large in contrast to the one in the CF(1)-mouse. It was gradually decreased to the level of the CF(1) at the 12 th postparabiosis day. 3. Total potassium content in the ep-mouse was also markedly large in contrast to the one in the CF(1)-mouse, and it followed the tendency of the variation as sodium content. en-copyright= kn-copyright= en-aut-name=MasukawaSadahiko en-aut-sei=Masukawa en-aut-mei=Sadahiko kn-aut-name=増川禎彦 kn-aut-sei=増川 kn-aut-mei=禎彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=325 end-page=331 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Phalloplasty with an Innervated Island Pedicled Anterolateral Thigh Flap in a Female-to-Male Transsexual en-subtitle= kn-subtitle= en-abstract= kn-abstract=Since 2001, we have been performing phalloplasty with a radial forearm free flap as the flap of first choice in female-to-male transsexuals (FTMTS). In the present case, a 22-year-old FTMTS with a negative Allen test, we achieved good results by performing phalloplasty with an innervated island pedicled anterolateral thigh flap using the "tube within a tube" technique, in which the penis and urethra are constructed with a single flap. While phalloplasty with an island-pedicled or free anterolateral thigh flap has been reported previously, the present case seems to be the first of phalloplasty with an innervated island-pedicled anterolateral thigh flap using the "tube within a tube" technique. As compared to a forearm flap, use of an innervated island-pedicled flap may have the following advantages in phalloplasty:1) no need for a microsurgical technique;2) no scars at noticeable sites;3) small functional loss in the flap donor area;4) no sacrifice of major blood vessels. Thus, this technique seems to be a useful clinical alternative for phallic reconstruction. en-copyright= kn-copyright= en-aut-name=HasegawaKenjiro en-aut-sei=Hasegawa en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Plastic and Reconstractive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Plastic and Reconstractive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Plastic and Reconstractive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=gender identity disorder kn-keyword=gender identity disorder en-keyword=sex reassignment surgery (SRS) kn-keyword=sex reassignment surgery (SRS) en-keyword=phalloplasty kn-keyword=phalloplasty END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=5 article-no= start-page=227 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Percutaneous sclerotherapy for venous malformations using polidocanol under fluoroscopy. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

This retrospective study evaluated the safety and efficacy of using polidocanol with X-ray fluoroscopy for percutaneous sclerotherapy of venous malformations of the limbs, head, and neck. The subjects were 16 of 18 patients who presented to our department with venous malformations. Two patients were excluded because they were unlikely to benefit from the treatment. Of the 16 included in the study, 1 could not be treated because of inaccessibility, and another was lost to follow-up. Among the 14 cases that we were able to follow-up, 11 cases had had pain as their primary symptom. Following treatment, this symptom remained unchanged in 1 patient, was improved in 4, and had disappeared in 6; however, there was a recurrence of pain for 3 of these patients. Two patients had sought treatment for cosmetic purposes; following treatment, the lesion disappeared in one and showed a significant reduction in the other. The remaining patient presented with a primary symptom of mouth bleeding, which disappeared following treatment. There were no critical complications. Percutaneous sclerotherapy of venous malformations using polidocanol is safe and effective, and permits repeat treatments. The efficacy is especially good for resolving pain, and complications are minor. It is desirable to use fluoroscopy for these procedures

en-copyright= kn-copyright= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasuiKotaro en-aut-sei=Yasui en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HyodoTsuyoshi en-aut-sei=Hyodo en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MukaiTakashi en-aut-sei=Mukai en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DendoShuichi en-aut-sei=Dendo en-aut-mei=Shuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KoshimaIsao en-aut-sei=Koshima en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University affil-num=10 en-affil= kn-affil=Okayama University affil-num=11 en-affil= kn-affil=Okayama University en-keyword=venous malformation kn-keyword=venous malformation en-keyword=sclerotherapy kn-keyword=sclerotherapy en-keyword=polidocanol kn-keyword=polidocanol en-keyword=fluoroscopy guidance kn-keyword=fluoroscopy guidance END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1343 end-page=1349 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphate Poisoning Part 2. Toxicity and In Vivo Distribution of PAM (pyridine-2-aldoxime methiodide) kn-title=有機燐剤中毒に関する研究 第2編 PAM (pyridine-2-aldoxime methiodide) の毒性並に生体内分布 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the use of any drug there always arise problems of its effect and side-effect as well as its toxicity and distribution in vivo. Therefore, the author studied these problems on PAM from various angles and obtained the following results. 1. The median lethal dosage (LD(50)) of PAM on mice has been found to be: 159 mg/kg in the case of intravenous administration; 247 mg/kg in peritoneal injection; 340 mg/kg in subcutaneous injection; and 1960 mg/kg in oral administration, proving that the limit is sufficiently within the range of commonly used drugs. 2. Histological changes occurring after PAM adminstration are consisted mainly of disturbances in the circulatory system, namely, hyperemia, congestion and slight hemorrhage, but rarely of parenchymal disturbances. 3. When a large amount of PAM is administered to rabbits, there occurs a rise in the blood cholinesterase activity at first later followed by its fall. However, the fall being down to -25 per cent, it can not be considered as due to the toxicity of PAM. 4. In the oral adminstration of PAM to rabbits, PAM can be detected considerably in stomach, intestines, and in their contents, but it is distributed fairly evenly in other viscera. Moreover, in the case of the intravenous administration of PAM is also distributed in similar manner. It diminishes relatively promptly from the body fluid. Judging from these findings as well as from results of clinical observations, there is no danger of toxicity of PAM in the amount as used in our clinic. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1351 end-page=1357 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphat Poisoning Part 3. Effects of Oxime Compounds on Alkylphosphate Poisoning kn-title=有機燐剤中毒に関する研究 第3編 Oxime化合物の有機燐剤中毒に対する効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By selecting 4 oxime compounds possessing pyridine nucleus in the molecular construction, namely, PATD, PPATD, PPAPD, and PAD, the author compared their therapeutic effects on alkylphosphate poisoning with the effect of PAM. 1. As for the therapeutic effect on alkylphosphate poisoning in mice, when administered in the maximum safety dose, PATD and PPATD are superior to PAM, but on scrutinous examinations there can be recognized not any significant difference. Effect of PPAPD is about the same as that of PAM. 2. Both PAM and PATD are most effective when administered concurrently with the intravenous administration of alkylphosphate, but as the time before or after the administration of alkylphosphate lengthens, the effect of drugs decreases proportionately. 3. Atropine used concurrently with these oxime compounds yields no better results than without it. 4. The effect of PATD is slightly more lasting than PAM, but the difference is not significant. 5. PATD has been proven to possess a reactivating action on rabbit blood cholinesterase just as PAM. Consequently it is assumed that the effective mechanism of both drugs is same. 6. When an equal dose of PAD and PAM is administered to the mice with ethylparathion poisoning, PAD is inferior to PAM in improving the mortality rate of the mice. 7. There seems to be no benefit in administering intramuscularly 15 mg/kg PAD concurrently with the administration of various oximes. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=333 end-page=342 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses. en-copyright= kn-copyright= en-aut-name=TazawaHiroshi en-aut-sei=Tazawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KagawaShunsuke en-aut-sei=Kagawa en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Center for Innovative Clinical Medicine, Okayama University Hospital affil-num=2 en-affil= kn-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=oncolytic adenovirus kn-keyword=oncolytic adenovirus en-keyword=autophagy kn-keyword=autophagy en-keyword=E2F1 kn-keyword=E2F1 en-keyword=microRNA kn-keyword=microRNA END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=343 end-page=349 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors Predicting Clinical Impairment after Surgery for Cervical Spinal Schwannoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cervical spinal schwannoma is benign, and outcomes after surgical resection are generally excellent. A surgical dilemma sometimes arises as to whether to perform total tumor removal, which carries a risk of sacrificing the nerve root, or subtotal removal, where the risk can be tumor recurrence. The purpose of this study was to identify factors with the potential to predict clinical impairment after surgery for cervical spinal schwannomas. Thirty cases of cervical schwannomas treated surgically in our institute were retrospectively reviewed;initial symptoms, tumor location, Eden classification, surgical method, functional outcome, and tumor recurrence were investigated. All permanent motor deficits were the result of resecting functionally relevant nerve roots (i.e., C5-8). The rate of permanent sensory deficit was 11% after C1-4 nerve root resection, and 67% after C5-8 nerve root resection. Permanent neurological deficits occurred in 14% of patients younger than 40 years and 38% of those older than 40. Dumbbell tumors were associated with the need for total or ventral nerve root transection, as well as with a high incidence of tumor recurrence. The incidence of permanent neurological deficit was significantly higher in patients undergoing C5-8 nerve root resection, and tended to be higher in those over 40. en-copyright= kn-copyright= en-aut-name=YamaneKentaro en-aut-sei=Yamane en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakigawaTomoyuki en-aut-sei=Takigawa en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OsakiSyuhei en-aut-sei=Osaki en-aut-mei=Syuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugimotoYoshihisa en-aut-sei=Sugimoto en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=cervical spinal schwannoma kn-keyword=cervical spinal schwannoma en-keyword=neurological deficit kn-keyword=neurological deficit en-keyword=nerve root resection kn-keyword=nerve root resection en-keyword=tumor resection kn-keyword=tumor resection en-keyword=tumor recurrence kn-keyword=tumor recurrence END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=351 end-page=358 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A New Navigation System for Minimally Invasive Total Knee Arthroplasty en-subtitle= kn-subtitle= en-abstract= kn-abstract=A computer-assisted navigation system to be used for total knee arthroplasties (TKAs) was reported to improve the accuracy of bone resection and result in precise implant placement, but the concomitant surgical invasion and time consumption are clinical problems. We developed a computed tomography (CT)-based navigation system (NNS) to be used for minimally invasive TKA. It requires only the reference points from a small limited area of the medial femoral condyle and proximal tibia through a skin incision to obtain optical images. Here we evaluated the usefulness and accuracy of the NNS in comparison with the commercially available BrainLAB image-free navigation system (BLS). In a clinical experiment, the registration times obtained with the NNS tended to be shorter than those obtained with the BLS, but not significantly so. The NNS group tended to be in the extended position in the sagittal plane of the distal femur within 3 degrees, and the BLS group showed rather flexed deviation in the sagittal plane of the anterior femur. en-copyright= kn-copyright= en-aut-name=YokoyamaYusuke en-aut-sei=Yokoyama en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeNobuhiro en-aut-sei=Abe en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraKazuo en-aut-sei=Fujiwara en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiMasahiko en-aut-sei=Suzuki en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakajimaYoshikazu en-aut-sei=Nakajima en-aut-mei=Yoshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SugitaNaohiko en-aut-sei=Sugita en-aut-mei=Naohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MitsuishiMamoru en-aut-sei=Mitsuishi en-aut-mei=Mamoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakashimaYoshio en-aut-sei=Nakashima en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery and Sport Medicine, Kawasaki Hospital, Kawasaki Medical School affil-num=3 en-affil= kn-affil=Department of Intelligent Orthopaedic System, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Research Center for Frontier Medical Engineering, Chiba University affil-num=5 en-affil= kn-affil=School of Engineering, The University of Tokyo affil-num=6 en-affil= kn-affil=School of Engineering, The University of Tokyo affil-num=7 en-affil= kn-affil=School of Engineering, The University of Tokyo affil-num=8 en-affil= kn-affil=Nakashima Medical Co., Ltd affil-num=9 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=total knee arthroplasty kn-keyword=total knee arthroplasty en-keyword=navigation system kn-keyword=navigation system en-keyword=minimally invasive surgery kn-keyword=minimally invasive surgery END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=359 end-page=367 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Jurkat Cells Using Bio-phantoms en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis. en-copyright= kn-copyright= en-aut-name=KatashimaKazunori en-aut-sei=Katashima en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AshidaMasakazu en-aut-sei=Ashida en-aut-mei=Masakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SasakiTakanori en-aut-sei=Sasaki en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TaguchiTakehito en-aut-sei=Taguchi en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuzakiHidenobu en-aut-sei=Matsuzaki en-aut-mei=Hidenobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MurakamiJun en-aut-sei=Murakami en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YanagiYoshinobu en-aut-sei=Yanagi en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HisatomiMiki en-aut-sei=Hisatomi en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HaraMarina en-aut-sei=Hara en-aut-mei=Marina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatoHirokazu en-aut-sei=Kato en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OhmuraYuichi en-aut-sei=Ohmura en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KobayashiTomoki en-aut-sei=Kobayashi en-aut-mei=Tomoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=HaradaSosuke en-aut-sei=Harada en-aut-mei=Sosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=TakemotoMitsuhiro en-aut-sei=Takemoto en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=OhnoSeiichiro en-aut-sei=Ohno en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=MimuraSeiichi en-aut-sei=Mimura en-aut-mei=Seiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=AsaumiJunichi en-aut-sei=Asaumi en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= affil-num=1 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University affil-num=12 en-affil= kn-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University affil-num=13 en-affil= kn-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University affil-num=14 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=15 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=16 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=17 en-affil= kn-affil=Central Division of Radiology, Okayama University Hospital affil-num=18 en-affil= kn-affil=Central Division of Radiology, Okayama University Hospital affil-num=19 en-affil= kn-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=ADC kn-keyword=ADC en-keyword=apoptosis kn-keyword=apoptosis en-keyword=necrosis kn-keyword=necrosis en-keyword=hyperthermia kn-keyword=hyperthermia en-keyword=cell density kn-keyword=cell density END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=369 end-page=375 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High Level of CXCR4 in Triple-Negative Breast Cancer Specimens Associated with a Poor Clinical Outcome en-subtitle= kn-subtitle= en-abstract= kn-abstract=Despite high sensitivity to chemotherapy, the prognosis for triple-negative breast cancer (TNBC) remains poor because of its high rate of metastasis and low sensitivity to endocrine therapy. CXCR4 expression has been reported in many subtypes of human breast cancers, but it remains unknown whether CXCR4 is expressed in TNBC and whether CXCR4 expression in TNBC could be a prognostic indicator. TNBCs tissues were formalin fixed, paraffin embedded and hematoxylin-eosin (H&E) stained. Immunohistochemical staining was utilized to determine the CXCR4 expression in those specimens. Statistical analyses were performed using SPSS16.0 software to reveal the correlation of CXCR4 expression in TNBC specimens and cancer recurrence and cancer-related death. Our results showed that there was a strong association between CXCR4 overexpression and both menopause and the histological cancer grade of TNBC patients (p values were separately 0.004 and 0.001). The 5-y disease-free survival (DFS) and the 5-y overall survival (OS) were 57.69% and 58.33% for the low-CXCR4 group versus 42.11% and 44.74% for the high-CXCR4 group, respectively (p＝0.031 and 0.048). CXCR4 overexpression plays an important role in triple-negative breast cancers, and may be a predictor of poor prognosis. en-copyright= kn-copyright= en-aut-name=YuShaonan en-aut-sei=Yu en-aut-mei=Shaonan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WangXiaozhen en-aut-sei=Wang en-aut-mei=Xiaozhen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LiuGuifeng en-aut-sei=Liu en-aut-mei=Guifeng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ZhuXuewei en-aut-sei=Zhu en-aut-mei=Xuewei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ChenYan en-aut-sei=Chen en-aut-mei=Yan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Radiology, China-Japan Union Hospital, Jilin University affil-num=2 en-affil= kn-affil=Department of Cellular Biology, Health Science Center, Peking University affil-num=3 en-affil= kn-affil=Department of Radiology, China-Japan Union Hospital, Jilin University affil-num=4 en-affil= kn-affil=Department of Otolaryngology Head&neck Surgery, China-Japan Union Hospital, Jilin University affil-num=5 en-affil= kn-affil=Department of Endocrinology, Second Hospital, Jilin University en-keyword=CXCR4 kn-keyword=CXCR4 en-keyword=immunohistochemical staining kn-keyword=immunohistochemical staining en-keyword=triple-negative breast cancer kn-keyword=triple-negative breast cancer END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=817 end-page=825 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part U Effects of Parabiosis on Cholinesterase Activity and Acetylcholine Content in the Brain of ep-Mouse kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第2編 ep系マウス大脳のcholinesterase活性値およびacetylcholin含有量におよぼすparabiosisの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parabiosis was performed between an ep-mouse, having had convulsive seizures, and a CF(1)-mouse, one of the normal other species, and biochemical changes as to cholinesterase activity and acetylcholine content in the brain induced by this procedure were investigated. The results of this experiment were as follows: 1. Cholinesterase activity was significantly low in the brain of the ep-mouse compared with the CF(1)-mouse. This difference was averaged by parabiosis formation, and both activities were decreased to the preparabiosis level of the ep-mouse at the 12 th postparabiosis day. 2. Total acetylcholine content was definitely large in the brain of the ep-mouse compared with the CF(1)-mouse, but it was rapidly recovered to the preparabiosis level of the CF(1)-mouse. In contrast to it, the content in the CF(1)-mouse remained unchanged throughout the postparabiosis period. en-copyright= kn-copyright= en-aut-name=MasukawaSadahiko en-aut-sei=Masukawa en-aut-mei=Sadahiko kn-aut-name=増川禎彦 kn-aut-sei=増川 kn-aut-mei=禎彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=377 end-page=383 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Coverage of the Humeral Head by the Coracoacromial Arch: Relationship with Rotator Cuff Tears en-subtitle= kn-subtitle= en-abstract= kn-abstract=The pathogenetic roles of the coracoacromial arch in the development of rotator cuff tears are still controversial. This study compared the anteroposterior coverage of the humeral head by the coracoacromial arch between shoulders with and without full-thickness rotator cuff tears. Forty-two shoulders from 21 embalmed cadaveric specimens were macroscopically examined. Specimens were divided into 2 groups:shoulders with full-thickness cuff tears (tear group) and those with intact cuff tendons (normal group). The coverage angle of each component of the coracoacromial arch was measured using true lateral photographs. We also measured the angle of the total arc of the coracoacromial arch, as well as the angle of the anterior acromial projection. These data were compared between the tear group and the normal group. Although no significant differences were observed in the total arc of the coracoacromial arch between the groups, the tear group had significantly less coverage by the coracoacromial ligament than did the normal group (p＜0.05). Moreover, greater anterior acromial projection was observed in the tear group (p＜0.05). These results suggest that greater coverage of the bony structures on the rotator cuff may correlate with the development of rotator cuff tears. en-copyright= kn-copyright= en-aut-name=SakomaYoshimasa en-aut-sei=Sakoma en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SanoHirotaka en-aut-sei=Sano en-aut-mei=Hirotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShinozakiNobuhisa en-aut-sei=Shinozaki en-aut-mei=Nobuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ItoigawaYoshiaki en-aut-sei=Itoigawa en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamotoNobuyuki en-aut-sei=Yamamoto en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ItoiEiji en-aut-sei=Itoi en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Onomichi Municipal Hospital affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery, Tohoku University School of Medicine affil-num=3 en-affil= kn-affil=Department of Orthopaedic Surgery, Tohoku University School of Medicine affil-num=4 en-affil= kn-affil=Department of Orthopaedic Surgery, Tohoku University School of Medicine affil-num=5 en-affil= kn-affil=Department of Orthopaedic Surgery, Tohoku University School of Medicine affil-num=6 en-affil= kn-affil=Department of Orthopaedic Surgery, Tohoku University School of Medicine en-keyword=rotator cuff tear kn-keyword=rotator cuff tear en-keyword=coracoacromial arch kn-keyword=coracoacromial arch en-keyword=humeral head kn-keyword=humeral head en-keyword=anatomy kn-keyword=anatomy END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=827 end-page=833 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part V Effects of Parabiosis on Glutamic Acid, γ-Aminobutyric Acid (GABA) and Aspartic Acid Content in the Brain of ep-Mouse kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第3編 ep系マウス大脳のglutamic acid,γ-aminobutyric acidおよびaspartic acid含有量におよぼすparabiosisの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Biochemical changes as to amino acid metabolism were investigated in the brain of an ep-mouse, having had convulsive seizures, after parabiosis formation with a CF(1)-mouse, one of the normal other species, and the results of this experimeot were as follows: 1. Glutamic acid content was small in the brain of the ep-mouse compared with the CF(1)-mouse. They were approaching between the two levels 6 days after the procedure. Then, they were decreased below the preparabiosis level, showing insignificant defference between the both contents at the 12 th postparabiosis day. 2. GABA content was large in the brain of the ep-mouse compared with the CF(1)-mouse, but both contents were averaged between the levels 6 days after the procedure. They were recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day. 3. Aspartic acid content was slightly large in the brain of the ep-mouse compared with the CF(1)-mouse. The difference was minimized after the procedure, and recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day as in the case of GABA content. en-copyright= kn-copyright= en-aut-name=MasukawaSadahiko en-aut-sei=Masukawa en-aut-mei=Sadahiko kn-aut-name=増川禎彦 kn-aut-sei=増川 kn-aut-mei=禎彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=385 end-page=389 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Chiari Type I Malformation Caused by Craniometaphyseal Dysplasia en-subtitle= kn-subtitle= en-abstract= kn-abstract=Craniometaphyseal dysplasia is a rare genetic condition characterized by progressive thickening of bones in the skull and metaphyseal abnormalities in the long bones. This disorder often causes progressively symptomatic cranial nerve compression, but in rare cases foramen magnum stenosis may lead to quadriplegia. Chiari I malformation with craniometaphyseal dysplasia is extremely rare. The authors report on a 25-year-old woman with myelopathy due to Chiari I malformation along with craniometaphyseal dysplasia. There are only four previous case reports of this condition. The authors present here the fifth case report of this rare condition and summarize its characteristics. en-copyright= kn-copyright= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AratakiShinya en-aut-sei=Arataki en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugimotoYoshihisa en-aut-sei=Sugimoto en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakigawaTomoyuki en-aut-sei=Takigawa en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TetsunagaTomoko en-aut-sei=Tetsunaga en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital affil-num=2 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital affil-num=3 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital affil-num=4 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital affil-num=5 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital affil-num=6 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital en-keyword=craniometaphyseal dysplasia kn-keyword=craniometaphyseal dysplasia en-keyword=Chiari malformation kn-keyword=Chiari malformation en-keyword=cervicomedullary compression kn-keyword=cervicomedullary compression END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1359 end-page=1368 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphate Poisoning Part 4. Fluctuations of Visceral Cholinesterase in Alkylphosphate Poisoning and in the Cases Treated with Oxime Compounds kn-title=有機燐剤中毒に関する研究 第4編 有機燐剤中毒並にOxime治療による臓器Cholinesteraseの消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After studying disturbing actions of various alkylphosphates such as ethylparathion, methylparathion, EPN, TEPP, Pestox 3, malathon, diazinon and dipterex on cholinesterase of the brain, liver, spleen and muscles in mice, the author observed the reactivating effects on cholinesterase by administering PAM, PATD, PPATD, PPAPD, PAD, DAM, and MINA to these animals. The results are as follows. 1. In the organs of the animals administered with alkylphopshates in the amount about half LD(50), cholinesterase in various organs is decreased to 30-60 per eent of the normal level. It has been found that muscle cholinesterase is markedly disturbed in the ease of TEPP administration, while the disturbance of brain cholinesterase is markedly less in the administration of Pestox-3. 2. The brain cholinesterase disturbed by alkylphosphates can be brought back to a certain degree with administration of oxime cempounds. Especially in ethylparation poisening the effect is just as good as thaf of PAM, brining back almost to the normal level. 3. The recovery rate of the brain cholinesterase parallels most closely with the theapeutic effect, judging from the mortality rate. 4. The behavior of cholinesterase differs according to the combination of alltylphosphates and oixme compounds and to different organs, but with an exception of Pestex-3, cholinesterase recovers in some organ. Only in the case of DAM and MINA there can be observed no fluctutions at all exepting muscle cholinesterase. 5. The reactivating action of oximes on the vesceral cholinesterase is only transient. 6. PAD is less effective on alkylphospate poisonning than PAM, and the concurrent use of PAD with any one of quarternary oximes does not enhance the recovery of cholinesterase activity. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=391 end-page=395 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Thumb Polydactyly with a Floating Ulnar Thumb en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thumb polydactyly is reported to be the most common congenital anomaly of the hand in Japan. The floating type is not particularly rare, accounting for 0.9 to 15% of all cases of thumb polydactyly. However, to the best of our knowledge, there has been only one case of thumb polydactyly with a floating ulnar thumb, reported by Onizuka. Herein, we report a case very similar to that reported by Onizuka. In our case, the vessels feeding the floating ulnar thumb branched from the superficial palmar arterial arch, and X-rays revealed triphalangism. In surgery, we not only reconstructed the morphology of the thumb, but also tried to preserve the sensation in the reconstructed thumb by transposing the digital nerve of the floating ulnar thumb to the radial thumb. In addition to thumb polydactyly, our case also showed hypoplasia of the thenar muscles. en-copyright= kn-copyright= en-aut-name=HasegawaKenjiro en-aut-sei=Hasegawa en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Plastic and Reconstractive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Plastic and Reconstractive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Plastic and Reconstractive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=polydactyly kn-keyword=polydactyly en-keyword=floating ulnar thumb kn-keyword=floating ulnar thumb en-keyword=thumb hypoplasia kn-keyword=thumb hypoplasia END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=835 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of the Calcium Metabolism in the ep-Mouse Part 1 Calcium Content in Various Tissue and Urine of ep-Mouse kn-title=ep系マウスのCalcium代謝に関する研究 第1編 ep系マウスの組織Ca量および尿中排泄量に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Calcium content in the serum, bone, muscle, brain tissue and urine of the ep-mouse were measured. The results were as follows; 1) Urinary calcium excretion of the ep-mouse was higher than that of normal mouse. 2) As to the quantitative change of urinary calcium excretion of the ep-mouse in the days following birth, it was observed that the urinary calcium excretion was highest in the early stage of immaturity, thereafter gradually decreased in the late stage, then moderately increased again in the mature stage. 3) As to the quantitative change of urinary calcium excretion during convulsions, it was observed that the urinary calcium excretion decreased in one hour following the convulsion, then gradually increased, attaining the normal range within five hours. 4) No significant difference was found in the calcium content of serum, bone and brain of ep-mouse in comparison to normals, but decreased calcium content was observed in the muscle of ep-mouse. 5) Calcium content in the brain of ep-mouse increased a little during the convulsive stage as compared to that of nonconvulsive stage, but, after convulsion, it gradually reached the normal range. en-copyright= kn-copyright= en-aut-name=KakudaMasayoshi en-aut-sei=Kakuda en-aut-mei=Masayoshi kn-aut-name=角田正良 kn-aut-sei=角田 kn-aut-mei=正良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（田中）外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1369 end-page=1376 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pure Pulmonic Stenosis Report of Two Cases and Review of the Literature kn-title=純粋な肺動脈弁狭窄症二例報告と文献考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two typical cases of pure, isolated pnlmonic stenosis were studied by means of cardiac catheteriration during the past 12 months. On one of them the Brock type of valvulotomy was performed and this is the first case of pulmonic stenosis operated surgically in Korea. The results of the pulmonic valvulotomy was satisfactory initially. The patient had improved subjectively and venous pressure and circulation time returned to the normal level. However, 4 month postoperatively follow up study showed worsening of subjective symptoms again and re-catheterization was performed. There was an increased right ventricalar pressure. The reason of the failure of the operation was discussed. en-copyright= kn-copyright= en-aut-name=SohnIsaack en-aut-sei=Sohn en-aut-mei=Isaack kn-aut-name=孫宜錫 kn-aut-sei=孫 kn-aut-mei=宜錫 aut-affil-num=1 ORCID= en-aut-name=LimSung-yu.ll en-aut-sei=Lim en-aut-mei=Sung-yu.ll kn-aut-name=林成律 kn-aut-sei=林 kn-aut-mei=成律 aut-affil-num=2 ORCID= en-aut-name=LeeYoung-Lin en-aut-sei=Lee en-aut-mei=Young-Lin kn-aut-name=李永麟 kn-aut-sei=李 kn-aut-mei=永麟 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=国立Seoul大学校医科大学 affil-num=2 en-affil= kn-affil=国立Seoul大学校医科大学 affil-num=3 en-affil= kn-affil=国立Seoul大学校医科大学 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=841 end-page=847 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of the Calcium Metabolisum in the ep-Mouse Part 2 (45)Ca Metabolism in the ep-Mouse kn-title=ep系マウスのCalcium代謝に関する研究 第2編 ep系マウスにおける(45)Ca代謝に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=(45)Ca was injected into the abdominal cavity of normal mouse. Thereafter, (45)Ca incorporated in the blood, bone, brain, cartilago, muscle, spleen, liver and kidney was investigated, and it was observed that the concentration of (45)Ca incorporated in the various tissues was stablest 24 hours following the injection. Thus, investigations were carried out at this time to compare the concentration of (45)Ca in the various tissues of the ep-mouse to that of the normal mouse and its relative efect on the characfer of the convulsion. The results were as follows; 1) Blood (45)Ca content of the ep-mouse was higher than that of normal mouse, and this was not affected by convulsions. 2) There was no significant difference between the ep-mouse and normal mouse in (45)Ca content incorporated in the bone, nor any effect in the convulsive nature. 3) (45)Ca concentration incorporated in the brain of ep-mouse was markedly lower than that of normal mouse, this concentration was slightly increased by convulsion. 4) (45)Ca concentration incorporated in the muscle of ep-mouse was lower than that of normal mouse, and this concentration was slightly increased by convulsion. en-copyright= kn-copyright= en-aut-name=KakudaMasayoshi en-aut-sei=Kakuda en-aut-mei=Masayoshi kn-aut-name=角田正良 kn-aut-sei=角田 kn-aut-mei=正良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（田中）外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1377 end-page=1391 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Pentose Formation by Bacteria Part I Pentose Formation from Several Kinds of Carbon Sources kn-title=細菌による五炭糖の生成 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using St. aureus, sh. flexneri 2a and Sal. typhi 57, the author carried out the studies on pentose formation from glucose or other substrates. The following results were obtained. 1) A fairly large amount of pentose was formed and accemulated from glucose, gluconate, glycerophosphate, lactate or pyruvate in every strain of the bacteria tested in the presence of AM or DNP in corcentrations of 3×10(-4) and 10(-3)M. 2) Pentose was supposed to be formed from glucose through gluconate in the case of St. aureus, but was probably formed through C(3)-comound in the case of Sh. flexneri 2 a and Sal. typhi 57. 3) It was postulated that AM and DNP inhibited the break-down of pentose to C(3)-compound; however, did not inhibit the synthesis of pentose from C(3)-compound. Part U Effect of Changes in Culture Condition on Pentose Formation With the use of Sh. flexneri 2 a as test organism, the author investigated the effect of changes in culture condition on pentose formation and obtained the following results. 1) The bacterial cells cultured on glucose added media showed further oxidation of pyruvate to a less extent and was able to produce pentose to a greater extent from glucose and C(3)-compound in glucose metabolism. 2) The bacterial cells cultured on glucose and α, α-dipyridyl added media was more inferior in the further oxidation of pyruvate, and was more promoted pentose formation rate. 3) Pentose was produced to a greater extent under anaerobic condition than under aerobic condition. 4) From theee results, it could be stated that the suppresion of pyruvate oxidation accelerated the reaction rate which produced pentose from glucose through C(3)-compound. en-copyright= kn-copyright= en-aut-name=HonmatsuKakushi en-aut-sei=Honmatsu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=849 end-page=852 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of the Calcium Metabolism in the ep-Mouse Part 3 The Effect of Several Drugs on the (45)Ca Incorporation in the ep-Mouse Brain kn-title=ep系マウスのCalcium代謝に関する研究 第3編 ep系マウス脳への(45)Ca移行に及ぼす薬物の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two groups of the ep-mouse and normal mouse were subjected to intraperitoneal injection of (45)Ca, and simultaneous injections of ethylalcohol, histamine, Kallikrein, vitamin E or benzylimidazoline. Then, 6 hours after the administration, (45)Ca concentration incorporated in brain and liver was investigated. The results were as following; 1) (45)Ca concentration incorporated in brain was moderately increased, with administration of these, especially with Kallikrein and benzylimidazoline. 2) (45)Ca concentration incorporated in liver was remarkably increased with administration of ethylacohol, vitamin E, and remarkably with histamine, Kallikrein, benzylimidazoline. 3) With regard to increment in the ratio of (45)Ca incorporation into brain and liver after administration of peripheral vasodilatation on circulatory accelerator, significant difference was hardly recognized between ep-mouse and normal mouse. en-copyright= kn-copyright= en-aut-name=KakudaMasayoshi en-aut-sei=Kakuda en-aut-mei=Masayoshi kn-aut-name=角田正良 kn-aut-sei=角田 kn-aut-mei=正良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（田中）外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=397 end-page=402 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Case of Acute Superior Mesenteric Artery Embolism with Severe Ischemic Liver Injury Successfully Treated by Endovascular Treatment en-subtitle= kn-subtitle= en-abstract= kn-abstract=We describe an interesting clinical course of a patient who developed severe ischemic liver injury due to acute embolism of the superior mesenteric artery (SMA) and celiac artery. A 70-year-old man was hospitalized for abdominal pain and diarrhea. Abdominal computed tomography demonstrated a variant common hepatic artery arising from the SMA and multiple thromboembolic occlusions of visceral arteries, including the SMA and celiac artery. Laboratory data showed markedly elevated hepatic enzymes, which increased after admission despite the initiation of systemic anticoagulant and thrombolytic therapy. The patient was successfully treated by endovascular recanalization of the SMA occlusion via transcatheter embolus aspiration, thrombolysis, balloon angioplasty, and stent placement. Severe ischemic liver injury may occur in the setting of synchronous embolism of the SMA and celiac artery, and these phenomena may have a critical impact on the choice of treatment strategies and prognosis. Endovascular treatment appears to an effective treatment option. en-copyright= kn-copyright= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukazawaTakuya en-aut-sei=Fukazawa en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritaIchiro en-aut-sei=Morita en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SuehiroMitsuhiko en-aut-sei=Suehiro en-aut-mei=Mitsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawamotoHirofumi en-aut-sei=Kawamoto en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Diagnostic Radiology 2, Kawasaki Hospital, Kawasaki Medical School affil-num=3 en-affil= kn-affil=Department of General Surgery, Kawasaki Hospital, Kawasaki Medical School affil-num=4 en-affil= kn-affil=Department of General Surgery, Kawasaki Hospital, Kawasaki Medical School affil-num=5 en-affil= kn-affil=Department of General Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical School affil-num=6 en-affil= kn-affil=Department of General Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical School affil-num=7 en-affil= kn-affil=Department of General Surgery, Kawasaki Hospital, Kawasaki Medical School en-keyword=superior mesenteric artery kn-keyword=superior mesenteric artery en-keyword=celiac artery kn-keyword=celiac artery en-keyword=embolism kn-keyword=embolism en-keyword=liver ischemia kn-keyword=liver ischemia en-keyword=endovascular treatment kn-keyword=endovascular treatment END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=853 end-page=862 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of Convulsive Seizure Induced by Decadron Part 1 Studies of Convulsive Seizure Induced by Intrathecal of Decadron kn-title=デカドロン痙攣に関する実験的研究 第1編 デカドロン注射液の膸腔内投与により惹起される痙攣に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several sexual and adrenal hormones were injected intrathecally to a dog, mouse, and rat. And the effects of these substances on brain activity, especially on convulsive seizure, were investigated. The results of these investigations were as follows: 1) Aspecial type of tonic convulsion was observed after a short period of intra cysternal administration of Decadron. 2) The same type of convulsion was observed also in the case of the mouse or rat after the administration of Decadrin. 3) Spike waves were observed in the EEG findings during the convulsion induced by Decadron. 4) Acetylchorine content increased and ChE activity decreased in the Brain during the convulsion induced by Decadron. en-copyright= kn-copyright= en-aut-name=MiyakeShintaro en-aut-sei=Miyake en-aut-mei=Shintaro kn-aut-name=三宅新太郎 kn-aut-sei=三宅 kn-aut-mei=新太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（田中）外科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Assessment of Medical Expenditures for Sepsis:Differentiating between Cases with and without Ruled-out Diagnoses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Setting public health priorities requires precise estimation of the burden of disease, including disease-specific medical expenditure. Information on multiple and ruled-out diagnoses on health insurance claims (HICs) has been ignored in traditional analyses of disease-specific medical expenditures in Japan. This study reviewed 448 inpatients with at least one diagnosis of sepsis on their HICs, who were insured by corporate health insurance organizations making claims on services provided from April 2006 to March 2007 in Japan. Subjects in whom sepsis-related diagnoses were specified as “ruled-out” were compared with subjects in whom sepsis-related diagnoses were classified as “not-ruled-out” (i.e., subjects in whom sepsis was considered possibly or likely present). Direct medical expenditure, length of stay (LOS), cost per day, cost of antibiotics, and proportion of administered cephalosporin and carbapenems were significantly higher in subjects classified as not-rule-out. When using health insurance claims in Japan, the statistics of medical expenditures and LOS are influenced by procedures performed to rule out a diagnosis, as well as those performed to treat a confirmed diagnosis of sepsis. en-copyright= kn-copyright= en-aut-name=TaniharaShinichi en-aut-sei=Tanihara en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ImatohTakuya en-aut-sei=Imatoh en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MomoseYoshito en-aut-sei=Momose en-aut-mei=Yoshito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Preventive Medicine and Public Health, School of Medicine, Fukuoka University affil-num=2 en-affil= kn-affil=Department of Preventive Medicine and Public Health, School of Medicine, Fukuoka University affil-num=3 en-affil= kn-affil=Department of Preventive Medicine and Public Health, School of Medicine, Fukuoka University en-keyword=health insurance claims kn-keyword=health insurance claims en-keyword=length of stay kn-keyword=length of stay en-keyword=medical expenditures kn-keyword=medical expenditures en-keyword=ruled-out diagnoses kn-keyword=ruled-out diagnoses en-keyword=sepsis kn-keyword=sepsis END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=7 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mizoribine Inhibits the Proliferation of Renal Stem/Progenitor Cells by G1/S Arrest during Renal Regeneration en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration. en-copyright= kn-copyright= en-aut-name=HorimotoNaoya en-aut-sei=Horimoto en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitamuraShinji en-aut-sei=Kitamura en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsujiKenji en-aut-sei=Tsuji en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=cell biology kn-keyword=cell biology en-keyword=immunosuppression kn-keyword=immunosuppression en-keyword=stem cells kn-keyword=stem cells END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1407 end-page=1422 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Catalase Activity of Babteria kn-title=細菌のカタラーゼ活性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Part T Effect of Added Substance to the Media on Catalase Activity Using Sh. flexneri 2 a and Sal. typhi 57 as test organism, the author studied the effect on calase activity of bacteria by adding a certain kind of substance into culturing media, the following results were obtained. 1) The catalass activity was not influenced by the addition of lactate, pyruvate or succinate into media, but was decreased by addtion of glucose. 2) A marked decrease in the catalase activity was observed by addition of KCN or NaN(3), in dilution of 1/3×10(-4)M; whereas no change in other enzyme activity was observed by the addition of these substance. 3) The addition of α, α'-dipyridyl or oxine, in dilutions of 20-30 mg/L, showed marked decrease in oxidative ability of bacteria of pyruvarte, and the decrease in catalase activity was simultaneously observed only in Sh. flexneri. Part U Oxidation of glucose and alanine by catalase deficient bacteria Using Sh. flexneri 2 a, Sh. dysenteriae 4 and D. pneumoniae U, the author studied the enzymatic properties of the catalase active and inactive bacterial cells mentioned above by means of volumetric studies of glucose and alanine oxidation and also studied the effect of these cells on normal or acatalasemic erythrocytes, especially on hemoglobin of the erythrocytes. The following results were obtained. 1) As the cells of Sh. flexneri 2 a grown on KCN or NaN(3) added nutrient agar media was lacking catalase activity, the organism could'nt decompose H(2)O(2) produced throuth the course of glucose or alanine metabolism. So formed pyruvate by the metabolism was oxidized by H(2)O(2) inversely. And hemoglobin was oxidized to methemoglobin, when erythrocytes were added to the reaction media. 2) Sh. dysenteriae 4 is failing catalase and the production of H(2)O(2) was not detected at all or only scantily on the cells grown on any kind of media. 3) D. pneumoniae U is also failing catalase, but the production of H(2)O(2) was remarkably high. en-copyright= kn-copyright= en-aut-name=AkiyamaKenji en-aut-sei=Akiyama en-aut-mei=Kenji kn-aut-name=秋山健二 kn-aut-sei=秋山 kn-aut-mei=健二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=863 end-page=867 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of Convulsive Seizure Induced by Decadron Part 2 Studies of the Active Principle in Decadron Solution Effective in Inducing Convulsion kn-title=デカドロン痙攣に関する実験的研究 第2編 デカドロン注射液中の痙攣惹起成分に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Decadron solution for injection contains Dexamethasone-21-phosphate disodium, phenol, creatine, sodium citrate, sodium bisulfite, and sodium hydroxide. Therefore, the question of which substance of these is really effective for inducing convulsion, was investigated using mice. The results of the present studies were as follows: 1) Sodium citrate is the only substance in the Decadron solution which induces a convulsive seizure, similar to the Decadron Convulsion. 2) Erection the tail and tachypnea were observed in mice after administration of dexamethasone-21-phosphate disodium, but no convulsive seizure was recognized by dexamethasone-21-phosphate disodium itself. 3) In the case of simultaneously administered sodium citrate and Dexamethasone-21-phosphate, a Decadron type of convulsive seizure was observed. Therefore it was suggested that dexamethasone played the roll of an activat or for the convulsive seizure. en-copyright= kn-copyright= en-aut-name=MiyakeShintaro en-aut-sei=Miyake en-aut-mei=Shintaro kn-aut-name=三宅新太郎 kn-aut-sei=三宅 kn-aut-mei=新太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（田中）外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=869 end-page=875 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of Convulsive Seizure Induced by Decadron Part 3 Studies of the Mechanism of Inducing Convulsive Seizure by Decadron kn-title=デカドロン痙攣に関する実験的研究 第3編 デカドロン痙攣の作用機序に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The mechanism of inducing convulsive seizure by Decadron was investigated as followings: 1) No convulsive seizure was observed after apllying Decadron solution at the motor area of cerebral cortex, but the typical convulsive was observed only by administrating it directly at Nucleus caudatus. 2) The convulsion induced by Decadron could be inhibited by Ca. Mg and homocarnosine. 3) Amongst sodium citratum like substances, citric acid, L-malic acid and oxalic acid were found to elicit the convulsion as Deeadron induced convulsion, but such as malonic acid, fumaric acid, maleic acid, α-ketoglutaric acid, succinic acid, oxalacetic acid and acetic acid were not. 4) Therefore, it was suggested that citric acid conbined in a non ion "complex" with Ca or Mg which inhibited irritability of the mortor neuron. And on the other hand, dexamethasone played the roll of an activator for inducing convulsion. These reactions in the brain are the most impotant factors for inducing the convulsive seizure. en-copyright= kn-copyright= en-aut-name=MiyakeShintaro en-aut-sei=Miyake en-aut-mei=Shintaro kn-aut-name=三宅新太郎 kn-aut-sei=三宅 kn-aut-mei=新太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（田中）外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=877 end-page=891 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 1. Megakaryocytes in the Spleen of the Rodent (Mice, Rats, Guinea Pigs, and Rabbits) kn-title=脾組織培養法による脾内巨核球に関する研究 第1編 齧歯類（マウス，ラツテ，モルモツト，及び家兎）脾内巨核球について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Followings are the results of studies on megakaryocytes in the spleen of the rodent of the successive stages from the embryonic stage up to the adult. 1) In the rodent, megakaryocytes are always found in the spleen from the embryonic stage up to the adult, especially in large numbers in the infant. Among the rodent, the largest numbers of megakaryocytes are found in the spleen of mice, less in rats, and only very small numbers in guinea pigs and rabbits. 2) No significant morphological differences are noted between megakaryocytes in the spleen and those in the bone marrow. 3) By splenic tissue culture method, megakaryocytes in the spleen are found to have deformated movement, pseudopodial movement, and tentacle formation for the platelet separation as those in the bone marrow. 4) Megakaryocytes in the spleen of mice and rats have motility and ability of platelet formation from the embryonic up to the infant stage, but these functions are found to be decreased during the adolescent and adult life. In guinea pigs and rabbits, the functions of megakaryocytes in the spleen are decreased after the mid-embryonic stage. 5) A correlation is noted between the functions of the megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanide by the other. en-copyright= kn-copyright= en-aut-name=HanzawaAtsumasa en-aut-sei=Hanzawa en-aut-mei=Atsumasa kn-aut-name=半澤敦正 kn-aut-sei=半澤 kn-aut-mei=敦正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1439 end-page=1444 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Cell Toxin Produced by X-Ray Irradiation Part 2. The Morphological Changes and in Vivo Reactions of the Succinic Dehydrogenase System in Ehrlich Ascites Tumor Cells Induced by the Unsaturated Fatty Acid Fraction Extracted from the Rabbit Liver after X-ray Irradiation kn-title=X線照射時に発生せる細胞毒の研究について 第二編 X線照射家兎より抽出した不飽和脂肪酸分画のEhrlich腹水癌のコハク酸脱水素系に於ける形態学的変化並びに生体内反応について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Part 1. the author investigatad the effects of the unsaturated fatty acid fraction extracted from the rabbit liver after x-ray irradiation on the succinic dehydrogenase system in Ehrlich ascites tumor cells and in the normal rabbit liver, and it was concluded that although this fraction does not greatly affect the normal liver cells, at a higher concentration it seems to induce cell degeneration which in turn results in a decrease in the respiratory enzyme activity. In the present experiment the author studied the morphological changes brought about by this substance in Ehrlich ascites tumor cell and the in vivo changes induced by it in the succinic dehydrogenase system. In conducting this experiment the results obtained by Yamamoto et al. of our department were referred to. With respect to the morphological changes in the tumor cells, it was observed that this substance acting for a short period of time will accelerate the respiratory enzyme activity transiently while when acting for a longer period, it decreases the activity. These findings agree more or less well with the results in Part 1. Even in the in vivo reactions the respiratory enzyme activity in the tumor cells is elevated temporarily and when acting for a longer period of time this substance decreases the activity. From these findings it is concluded that this substance does elevate the respiratory enzyme activity transiently but when it acts for a longer period of time, it seems to bring about a fall in the activity and further acting directly on the respiratory enzymes it induces the disorder in respiration. en-copyright= kn-copyright= en-aut-name=ShiakuMidori en-aut-sei=Shiaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線科医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1445 end-page=1453 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Electrical Stimulation (In Vitro) on the Metabolism of the Brain Part 1. Influences of Electrical Stimulation (In Vitro) on the Cereral Tissue Respiration kn-title=電気刺戟（in vitro）の脳物質代謝におよぼす影響 第1編 電気刺戟（in vitro）の大脳組織呼吸におよぼす影響 en-subtitle= kn-subtitle= en-abstract=Using slices and homogenates of the cerebral cortex of albino rats in the K.R.P. solution with glucose and glutamic acids as substrate, the author studied the tissue respiration in vitro giving electrical stimualtion, and obtained the following results. 1. In the case with the use of homogenate with glucose the tissue respiration was accelerated about 70 per cent by the electrical stimulation. 2. The percentage of the acceleration in the tissue respiration by electrical Stimulation in the case of cerebral slices was 463 percent on the average with 12 mM glucose as substrate, and 270 per cent on the average with M/50 glutamic acid as substrate. 3. In addition, it seems that in the case using glutamic acid smaller slices yield higher acceleration of the tissue respiration. 4. Even without glucose as substrate the respiration is considerably accelerated by electrical stimulation. 5. In the case where the electrical stimulation is given by Augospel apparatus (a low frequency therapeutic apparatus) to the cerebral cortex slices with glucose as substrate, the percentage of the respiration acceleration was 244 per cent. kn-abstract=1) K. R. P.溶液中のダイコクネズミ大脳皮質切片及びホモジネートにin vitro電気刺戟を加え,ブドウ糖及びグルタミン酸基質における組織呼吸を調べた. 2) ブドウ糖基質ホモジネートでは,電気刺戟によつて,その呼吸は70%近く促進された. 3) 大脳皮質切片の電気刺戟による呼吸促進率は, 12mMブドウ糖基質では平均463%, M50グルタミン酸基質では平均270%であつた. 4) 尚,グルタミン酸基質の場合,切片の小さい方が呼吸促進率は大のようであつた. 5) 又,基質なしでも電気刺戟によつて相当の呼吸促進がみられた. 6) ブドウ糖基質大脳皮質切片に, Augospelによる電気刺戟を加えた場合の呼吸促進率は244%であつた. en-copyright= kn-copyright= en-aut-name=KumashiroHisashi en-aut-sei=Kumashiro en-aut-mei=Hisashi kn-aut-name=熊代永 kn-aut-sei=熊代 kn-aut-mei=永 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=17 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor en-subtitle= kn-subtitle= en-abstract= kn-abstract=The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. en-copyright= kn-copyright= en-aut-name=MoritouYuki en-aut-sei=Moritou en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=BabaNobuyuki en-aut-sei=Baba en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaguchiKouichi en-aut-sei=Takaguchi en-aut-mei=Kouichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SenohTomonori en-aut-sei=Senoh en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NaganoTakuya en-aut-sei=Nagano en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OhnishiHideki en-aut-sei=Ohnishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Health Service Center, Okayama University affil-num=4 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=5 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=6 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=7 en-affil= kn-affil=Department of Internal Medicine, Kagawa Prefectural Central Hospital affil-num=8 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=14 en-affil= kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=hepatic steatosis kn-keyword=hepatic steatosis en-keyword=genetic polymorphism kn-keyword=genetic polymorphism en-keyword=interferon kn-keyword=interferon en-keyword=HCV kn-keyword=HCV END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=893 end-page=902 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 2. Megakaryocytes in the Spleen of the Carnivora (Dogs and Cats) kn-title=脾組織培養法による脾内巨核球に関する研究 第2編 食肉類（イヌ及びネコ）脾内巨核球について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Among the mammalia, the carnivora (dogs and cats) was chosen to make studies mainly by our clinical tissue culture method on megakaryocytes in the spleen of the successive stage from newborn up to adult. Followings are the results. 1) In dogs and cats, megakaryocytes are found in the spleen from newborn up to adult. During newborn, dogs have more megakaryocytes in the spleen than cats, but the reverse comes to be true during the following stages. 2) In dogs and cats, no significant morphological differences are noted between megakaryocytes in the spleen and those in the bone marrow. 3) By splenic tissue culture method, megakaryocytes in the spleen are found to have motility as those in the bone marrow. Ability of platelet separation from megakaryocytes in the spleen are found during newborn and infancy (1 month of age) in dogs, and during newborn in cats. During the successive stages of growth, the functions of megakaryocytes are noted to be decreased. 4) A correlation is noted in dogs and cats between the functions of megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanied by the other. en-copyright= kn-copyright= en-aut-name=HanzawaAtsumasa en-aut-sei=Hanzawa en-aut-mei=Atsumasa kn-aut-name=半澤敦正 kn-aut-sei=半澤 kn-aut-mei=敦正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1455 end-page=1461 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Electrical Stimulation (In Vitro) on the Metabolism of the Brain Part 2. Influences of Electrical Stimulation (in vitro) on the Cerebral Nitrogen Metabolism kn-title=電気刺戟（in vitro）の脳物質代謝におよぼす影響 第2編 電気刺戟（in vitro）の大脳窒素代謝におよぼす影響 en-subtitle= kn-subtitle= en-abstract=Using homogenates and slices of the cerebral cortex obtained from albino rats the author studied the influences of electrical stimulation (in vitro) on the formation of ammonia (NH(3)) and obtained the following results. In the case of homogenate an increase in the NH(3) production was observed while with slices a decrease. Howevar, in the case of slices an acceleration in the production of glutamine could also be recognized. Thus, it is assumed that in the case of the slices the decrease in the NH(3) production is in reality due to NH(3) being consumed in the processes of the glutamine production. Therefore, it can be said that the electrical stimulation (in vitro) accelerates the synthesis of glutamine in the cerebral cortex slice. This fact has been confirmed also by the experiments conducted with the additicn of NH(3) ion and sodium glutamate. kn-abstract=ダイコクネズミ大脳ホモジネート及び,大脳皮質切片に, in vitroで電気刺戟を加え,アンモニヤ発生に及ぼす影響をみた.その結果,ホモジネートでは,アンモニヤ発生の増加をみ,切片では,アンモエヤ発生の減少がみられた.所が切片では同時にグルタミン生成の促進もみられた. 従つて切片の場合のアンモニヤ発生の減少と云うのは,実は生成されるアンモニヤが,グルタミンとしてとらえられる事によるのではないかと推論した.従つて電気刺戟(in vitro)は大脳皮質切片のグルタミン合成系を促進すると云うことになる. このことは更に,アンモニウムイオンとグルタミン酸ソーダを基質とした実験においても確かめられた. 又,α-Keto glntaric acidとNH4Clからのグルタミン酸生成系に通電しても,これを促進せしめるようであつた. en-copyright= kn-copyright= en-aut-name=KumashiroHisashi en-aut-sei=Kumashiro en-aut-mei=Hisashi kn-aut-name=熊代永 kn-aut-sei=熊代 kn-aut-mei=永 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=23 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preclinical Evaluation of MicroRNA-34b/c Delivery for Malignant Pleural Mesothelioma en-subtitle= kn-subtitle= en-abstract= kn-abstract=The microRNA-34s (miR-34s) have p53 response elements in their 5?-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM. en-copyright= kn-copyright= en-aut-name=UenoTsuyoshi en-aut-sei=Ueno en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukazawaTakuya en-aut-sei=Fukazawa en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KuboTakafumi en-aut-sei=Kubo en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SohJunichi en-aut-sei=Soh en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AsanoHiroaki en-aut-sei=Asano en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MuraokaTakayuki en-aut-sei=Muraoka en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanakaNorimitsu en-aut-sei=Tanaka en-aut-mei=Norimitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MakiYuho en-aut-sei=Maki en-aut-mei=Yuho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShienKazuhiko en-aut-sei=Shien en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FurukawaMasashi en-aut-sei=Furukawa en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=SakaguchiMasakiyo en-aut-sei=Sakaguchi en-aut-mei=Masakiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoHiromasa en-aut-sei=Yamamoto en-aut-mei=Hiromasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=TsukudaKazunori en-aut-sei=Tsukuda en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MiyoshiShinichiro en-aut-sei=Miyoshi en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of General Surgery, Kawasaki Medical School affil-num=4 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=14 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=15 en-affil= kn-affil=Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=mesothelioma kn-keyword=mesothelioma en-keyword=microRNA kn-keyword=microRNA en-keyword=microRNA-34b/c kn-keyword=microRNA-34b/c en-keyword=p53 kn-keyword=p53 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=1001 end-page=1007 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Three cases of WPW syndrome kn-title=WPW症候群の三例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three cases of WPW syndrome were reported. One was A-type and other two were B-type. In one of B-type supraventricular tachycardia was seen In E. K. G.. In another one of B-type, WPW was converted into normal pattern by administration of procaine amide. en-copyright= kn-copyright= en-aut-name=HaraokaSyoichi en-aut-sei=Haraoka en-aut-mei=Syoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=1 ORCID= en-aut-name=HashimotoYasuharu en-aut-sei=Hashimoto en-aut-mei=Yasuharu kn-aut-name=橋本恭治 kn-aut-sei=橋本 kn-aut-mei=恭治 aut-affil-num=2 ORCID= en-aut-name=NukadaKaname en-aut-sei=Nukada en-aut-mei=Kaname kn-aut-name=額田要 kn-aut-sei=額田 kn-aut-mei=要 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1-3 article-no= start-page=283 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Leukemoid Reaction in the Mouse Induced by Saponin Part 3. Studies on the vascular structure of the bone marrow kn-title=サポニン投与による実験的類白血病反応に関する研究 第3編 骨髄血管構造所見 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The detailed vascular structure of the bone marrow of saponin-treated mice was studied with clarified bone specimens (Spalteholz's method), because the technic appeared encouraging in elucidating the problems of the mechanism of both granulocytic liberation into the peripheral circulation and development of the extramedullary hematopoiesis. The results obtained were as follows. 1. In the normal control, unit sinuses were connected with each other, and a unit sinus net was primarily composed of 6 unit sinuses in a hexagon form, and many of these sinus nets were mutually connected to make up the complex network. The sinus wall was composed of a single layer of endothelial cells. The vascular system of the bone marrow was a completely closed system, no fenestrated vessel-walls being demonstrable in normal mice. 2. In saponin-treated mice the sinus network was disordered. There was enlargement or narrowing of the sinuses with destruction of their wall. These alterations were seen already at 24 hours after an injection of saponin to mice. At this stage, no extramedullary hematopoiesis was yet seen in spleen tissue culture or in histologic specimens of the spleen. It was considered, therefore, that saponin acted upon sinuses causing destruction of their thin walls. This was followed by the liberation of blood cells into the peripheral cirulation from the destructed sinuses. Finally, these blood cells were transported and multiplied in the organs such as the spleen and liver. The author believe that this is the mechanism of the extramedullary hematopoiesis (colonization theory). The simultaneous finding that megakaryocytes increased in number in the spleen, while their number decreased in the bone marrow gave support to this view. en-copyright= kn-copyright= en-aut-name=SatoTadashi en-aut-sei=Sato en-aut-mei=Tadashi kn-aut-name=佐藤端 kn-aut-sei=佐藤 kn-aut-mei=端 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END