JaLCDOI 10.18926/AMO/56932
FullText URL 73_4_307.pdf
Author Takahashi, Sho| Akagi, Teiji| Toh, Norihisa| Takaya, Yoichi| Nakagawa, Koji| Nishii, Nobuhiro| Ito, Hiroshi|
Abstract The follow-up of patients with adult congenital heart disease (ACHD) at a specialized medical unit is necessary for the patients’ appropriate medical care. However, limited information is available about cardiovascular events among ACHD patients. Here we investigated the type and frequency of cardiovascular events in ACHD patients in relation to disease complexity. We retrospectively analyzed the cases of 535 patients (median age 35 years) referred to our ACHD center between 2014 and 2017. We divided the patients into 3 groups based on their disease complexity. To evaluate the relationship between disease complexity and cardiovascular events, we performed univariate and multivariate survival analyses. The Simple, moderate, and complex disease groups accounted for 62%, 19%, and 19% of the patients, respectively. Apart from events related to atrial septal defect (ASD) trans-catheter treatment, the frequency of cardiovascular events was dependent on the disease complexity (event-free survival rates at 3 years were 85%, 65%, and 58%, respectively). The hazard ratios were 4.0 and 5.1 in the moderate and complex groups, respectively. With the exception of scheduled transcatheter intervention, cardiovascular events were strongly related to the disease complexity of original heart disease. However, cardiovascular events were not rare even in the simple ACHD group.
Keywords congenital heart defect congenital in adults hospitalization cardiovascular event
Amo Type Original Article
Published Date 2019-08
Publication Title Acta Medica Okayama
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 307
End Page 313
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439953
JaLCDOI 10.18926/AMO/56931
FullText URL 73_4_299.pdf
Author Hiranaka, Takaaki| Nishida, Keiichiro| Konishiike, Taizo| Ozaki, Toshifumi| Mikasa, Motohiko|
Abstract The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union rate were evaluated. The mean duration of follow-up was 56.3 months (range 24-197). At the final follow-up, the average Constant-Murley score was 58 (range 40-76). Forward elevation was 126° on average (range 35°-180°). Twenty-three cases (88%) showed bone union between the tuberosities and the shaft at an average follow-up of 4.1 months (range 4-5 months) after surgery. Non-union was noted in 1 case, and bone resorption was noted in 2 cases. The bone union rate and the clinical outcome of our procedure were relatively favorable
Keywords humeral head replacement tuberosity-overlapping technique bone union of tuberosities cable wire cementless stem
Amo Type Original Article
Published Date 2019-08
Publication Title Acta Medica Okayama
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 299
End Page 305
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439952
JaLCDOI 10.18926/AMO/56930
FullText URL 73_4_285.pdf
Author Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
Abstract Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
Keywords glioma cytoskeletons invasion microtubules
Amo Type Review
Published Date 2019-08
Publication Title Acta Medica Okayama
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 285
End Page 297
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439951
Author Zhou, Xiaoyu| Tanaka, Ryoji| Yamanaka, Masahiro| Sakaguchi, Chie| Nakamura, Eizo|
Keywords highly siderophile elements desilicification isotope dilution method high resolution ICP-MS N-TIMS
Note This fulltext will be available in Apr 2020
Published Date 2019-03-20
Publication Title Geostandards and Geoanalytical Research
Publisher John Wiley
ISSN 16394488
NCID AA11984494
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
DOI 10.1111/ggr.12280
Related Url isVersionOf https://doi.org/10.1111/ggr.12280
FullText URL NatCom_10_1_3022.pdf
Author Belay, Iyasu Getachew| Tanaka, Ryoji| Kitagawa, Hiroshi| Kobayashi, Katsura| Nakamura, Eizo|
Published Date 2019-07
Publication Title Nature Communications
Volume volume10
Issue issue1
Publisher Springer Nature Publishing AG
Start Page 3022
ISSN 20411723
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 31289264
DOI 10.1038/s41467-019-10832-7
Related Url isVersionOf https://doi.org/10.1038/s41467-019-10832-7
JaLCDOI 10.18926/OER/56912
Title Alternative J. H. Clapham, An Economic History of Modern Britain, vol. 3, Machines and National Rivalries (1887-1914), with an Epilogue (1914-1929), Outline, Chap.8
FullText URL oer_051_1_059_083.pdf
Author Ichinose, Atsushi|
Publication Title Okayama Economic Review
Published Date 2019-07-16
Volume volume51
Issue issue1
Start Page 59
End Page 83
ISSN 2433-4146
language 日本語
Copyright Holders Copyright © 2019 岡山大学経済学会
File Version publisher
JaLCDOI 10.18926/OER/56911
FullText URL oer_051_1_035_058.pdf
Author Matsuo, Nobushige|
Publication Title Okayama Economic Review
Published Date 2019-07-16
Volume volume51
Issue issue1
Start Page 35
End Page 58
ISSN 2433-4146
language 日本語
Copyright Holders Copyright © 2019 岡山大学経済学会
File Version publisher
JaLCDOI 10.18926/OER/56910
Title Alternative The Japan-China Economic Relations in GVC from the Perspective of Trade in Value Added: Using Japan-China GVC input-output table
FullText URL oer_051_1_019_034.pdf
Author Teng, Jian| Feng, Junshi|
Publication Title Okayama Economic Review
Published Date 2019-07-16
Volume volume51
Issue issue1
Start Page 19
End Page 34
ISSN 2433-4146
language 日本語
Copyright Holders Copyright © 2019 岡山大学経済学会
File Version publisher
JaLCDOI 10.18926/OER/56909
Title Alternative The Revolutionary Forces in Marx’s Theory and Marxism : Development? or Distortion?
FullText URL oer_051_1_001_018.pdf
Author Ota , Yoshiki|
Abstract 1. Diffusion of Marxism and inflation of the concept “proletariat”</br> The concept of “proletariat” is the central concept of Marxism. However, its content varies according to times and regions. For Marx and Engels, proletarias are workers who work in the capitalist large industries, they overthrow the rule of capitalists through the revolution and are the subjects of the construction of society in the future. Kautsky put workers in small factories and small farmers into the category of proletariat. Lenin overestimated capitalist development in Russia and included farmers without horses into proletariat. In Mao Zedong, agricultural workers, rumpen, handmade workers, peasants, clerks and peddlers are also allowed to participate in the revolution. The concept of proletariat is inflated. As the region moves away from the center of the world system, the scope of participants in the revolution has been expanded.</br> 2. “Proletariat” in Marx’s view on social development</br> In Marx, proletariat is given a privileged position as a revolutionary subject in the capitalist society. In the “formulation” of historical materialism, modern bourgeois society is given a privileged position in human history. Proletariat is privileged in dual sense. In this formulation, there is no social antagonism in the future society that Marx believes. This future society should be called a “community without law and state”. It is recognized that the development of capitalist production increases the number of workers and the ordinary electoral system increases possibilities of acquiring a working-class regime. Still, Capital insists that the revolution is inevitable. Marx and Engels never abandoned “revolutionism” throughout their lives.</br> 3. Marx’s revolutionary strategy and British working class</br> For Marx and Engels, England is a typical country of capitalistic development, giving models to other countries.However, the English working class in the mid-19th century was not “revolutionary”. The English labor movement during this period had been internalized under the guidance of the “labor aristocrat”. Working class was integrated as “nation”. While cooperating with the reformists politically, Marx was argueing revolutionism in scientific books. While cooperating with the reformists politically, Marx was advocating revolutionism in Capital. In modern bourgeois society, it is usual that labor classes are integrated into a system as “nation” and labor movement is to become reformistic, but Marx could not analyze this situation as a problem of upper structure of capitalism in general. In England Marx cooperated with the reformist labor movement, but could not abandon his revolutionism.</br> 4. Reform Movement and Revolutionism: German Revisionism Controversy and Russian Party Organization Controversy</br> At the German Social Democratic Party, there was coexistence of reformistic practice and ideology of revolutionism. Kautsky was a personal expression of this coexistence. He adhered to revolutionism, but acknowledged that socialist consciousness was brought into labor movement from the outside historically. Bernstein claimed that revolutionism is an obstacle to workers’ reform movement. In the controversy concerning the organization of the Russian Social Democratic Party, from the standpoint of revolutionalism, Lenin argued that “external injection” is necessary because the workers’ reform movement and the revolutionary socialist movement are not directly connected. The revolutionary forces are not necessarily the product of the capitalist big industry. Those who have abilities to resist the capitalist system, they can participate in the socialist revolution through the “external injection” of the revolutionary party. It can be said that the logic of “external injection” made it possible to disseminate Marxism to the semi-periphery and periphery.</br> 5. Conclusion</br> The Marxist revolution theory is understood as the theory of “revolution of developed countryies”. This is because it assumes the proletariat produced by the capitalist big industry as the revolutionary subject. In the case of Marx, its understanding is correct. However, the successful acquisition of the regime by the Marxist was in “backward countries”. It can be said that the key to solving this paradox was in the unreality of the concept of “proletariat” at the core of Marx’s revolutionism. Marx’s “proletariat” has no realities in the working class in center of modern capitalit world system (“developed capitalist countries”). On the other hand, various anti-systemic forces were formed as a revolutionary subject entity or “proletariat” by “external injection” of the revolutionary parties in semi-periphery and periphery (the “backward areas”). Rosa Luxemburg called as “clique management (Cliquenwirtschaft)” the regime that such forces could aquire. Under the “clique management” system, people remained in the object of governance and never became the subject.
Publication Title Okayama Economic Review
Published Date 2019-07-16
Volume volume51
Issue issue1
Start Page 1
End Page 18
ISSN 2433-4146
language 日本語
Copyright Holders Copyright © 2019 岡山大学経済学会
File Version publisher
Title Alternative Challenge to hand-rear of the common marmoset
FullText URL poalas_035_026_028.pdf
Author Hashimoto, Haruna|
Abstract In mid July 2018, the common marmoset bred in Okayama University gave birth to a triplet. It is very difficult to raise three infants. We selected the most heaviest one of her siblings, and we call her “POCKE”. We brought her up on the bottle for 80 days from the birth instead of her own mother. After 81 days, she finaly weand. Now she has become attached to human, but we hope that she gets back to their original community, as a “common” marmoset.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2019-06
Volume volume35
Start Page 26
End Page 28
language 日本語
File Version publisher
Title Alternative Biochemical Evaluation of Maternal Stress by Separating Infant Mice for Animal Experiments
FullText URL poalas_035_022_025.pdf
Author Yata, Norio|
Abstract Corticosterone, the glucocorticoid in rodents, is released from adrenal cortex in response to stress. Sometimes, for use in experiments, infants may be separated from their mother mouse. We studied the stress of mother mouse when she separates from infants. As a result, the concentration of corticosterone in the blood of the mother mouse tended to increase, by pulling her infants apart. In the case of using infant mice for animal experiments, it was suggested that it is necessary to consider the maternal stress.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2019-06
Volume volume35
Start Page 22
End Page 25
language 日本語
File Version publisher
Title Alternative What kind of environmental enrichment does mother mouse want?
FullText URL poalas_035_018_021.pdf
Author Ishihara, Sumire|
Abstract Environmental enrichment, whose material is commercially available, is today thought to improve animal welfare, for instance, control of stress. There were some reports that these report contribution of suppression of stress, which the mother mice suffer during nursing their pup. However, the effects on stress-suppression by introducing the enrichment materials is unknown. In this study, determined plasma and urinary corticosterone in the mother mice with or without the materials from their making to weaning.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2019-06
Volume volume35
Start Page 18
End Page 21
language 日本語
File Version publisher
Title Alternative Species identification of a laboratory strain belonging to the family Arvicolinae
FullText URL poalas_035_012_017.pdf
Author Takahata, Satoshi| Isemura, Natsumi| Mekada, Kazuyuki|
Abstract This study investigated the taxonomic status of a laboratory strain belonging to the family Arvicolinae for which the wild species name is unknown. This vole strain, though considered formerly a Lemming, was distinguishable from any Lemmus species by features of its appearance, skull and molar morphology, and conventional chromosomal pattern. Subsequently, we read the nucleotide sequence of the mitochondrial cytochrome b (Cyb) gene and constructed a molecular phylogenetic tree. We found that this vole strain belongs to the same clade as Microtus guenthe
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2019-06
Volume volume35
Start Page 12
End Page 17
language 日本語
File Version publisher
JaLCDOI 10.18926/AMO/56873
FullText URL 73_3_279.pdf
Author Makimoto, Go| Nishimori, Hisakazu| Kondo, Reiko| Yanai, Hiroyuki| Sugimoto, Morito| Oda, Naohiro| Kubo, Toshio| Hotta, Katsuyuki| Tabata, Masahiro| Kiura, Katsuyuki| Maeda, Yoshinobu|
Abstract Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.
Keywords urothelial carcinoma uroplakin III s-pancreas-1 antigen carbohydrate antigen 19-9 chemotherapy
Amo Type Case Report
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 279
End Page 284
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235978
JaLCDOI 10.18926/AMO/56872
FullText URL 73_3_273.pdf
Author Hayata, Kei| Masuyama, Hisashi| Eto, Eriko| Mitsui, Takashi| Tamada, Shoko| Eguchi, Takeshi| Maki, Jota| Tani, Kazumasa| Ohira, Akiko| Washio, Yosuke| Yoshimoto, Junko| Hasegawa, Kosei|
Abstract Nager syndrome is a rare disease involving severe micrognathia and upper limb shortening. In this report, we describe a case in which micrognathia of the fetus was suspected based on the observation of upper limb shortening during detailed B mode and 3D/4D ultrasonographic observation, and combined fetal MRI and 3D-CT led to a prenatal diagnosis of Nager syndrome. Upon birth, because severe micrognathia caused airway obstruction and made it difficult to spread the larynx for intubation, effective ventilation could not be carried out and a tracheostomy was necessary. Since a differential diagnosis of Nager syndrome can be made based on the fact that micrognathia typically co-occurs with upper limb shortening, it is possible to diagnose the disease before birth and prepare for life-saving measures accordingly.
Keywords Nager syndrome acrofacial dysostosis micrognathia jaw index SF3B4
Amo Type Case Report
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 273
End Page 277
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235977
JaLCDOI 10.18926/AMO/56871
FullText URL 73_3_269.pdf
Author Tsuboi, Ichiro| Araki, Motoo| Fujiwara, Hiroyasu| Iguchi, Toshihiro| Hiraki, Takao| Arichi, Naoko| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Kubota, Risa| Nishimura, Shingo| Sako, Tomoko| Takamoto, Atsushi| Wada, Koichiro| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Yanai, Hiroyuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Shiina, Hiroaki| Kanazawa, Susumu| Nasu, Yasutomo|
Abstract Nephron-sparing treatment should be offered whenever possible to avoid dialysis in allograph cases. Cryoablation is a new treatment option for treating small-sized renal cell cancer (RCCs). We report a case of RCC arising in a kidney allograft treated by cryoablation. To our knowledge, this is the first case in Asia of RCC in a renal allograft treated using cryoablation. Contrast-enhanced CT-guided percutaneous renal needle biopsy and cryoablation were used to identify the RCC, which could not be identified by other techniques. The postoperative course was uneventful. Contrast-enhanced CT also showed no recurrence or metastases at the 6-month follow-up.
Keywords cryoablation partial nephrectomy renal cell carcinoma renal allograft renal transplantation
Amo Type Case Report
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 269
End Page 272
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235976
JaLCDOI 10.18926/AMO/56870
FullText URL 73_3_263.pdf
Author Shimoyama, Yuichiro| Umegaki, Osamu| Ooi, Yukimasa| Shigemoto, Sho| Agui, Tomoyuki| Kadono, Noriko| Minami, Toshiaki|
Abstract A previously healthy 40-year-old Japanese male was urgently admitted with a 2-month history of dysphagia, 30-kg weight loss, and fever. Human immunodeficiency virus (HIV) antibodies and cytomegalovirus antigenemia were positive. Pneumocystis pneumonia and cytomegalovirus pneumonia were suspected. The patient was diagnosed with acquired immune deficiency syndrome (AIDS). Cytomegalovirus antigenemia became negative 20 days after the positive result. On hospital day 41, he experienced cardiopulmonary arrest. The clinical diagnosis was fulminant type 1 diabetes mellitus. He later developed hypoglycemia and was diagnosed with adrenal insufficiency accompanied by septic shock. He died of multiple organ failure 29 h post-admission to our ICU.
Keywords fulminant type 1 diabetes mellitus human immunodeficiency virus cytomegalovirus hypoglycemia
Amo Type Case Report
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 263
End Page 267
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235975
JaLCDOI 10.18926/AMO/56869
FullText URL 73_3_255.pdf
Author Seki, Daisuke| Takeshita, Nobuo| Seiryu, Masahiro| Deguchi, Toru| Takano-Yamamoto, Teruko|
Abstract Orthodontists need to understand the orthodontic risks associated with systemic disorders. Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant disorder with genetic and morphological variability. The risks of orthodontic treatment in ARS patients have been unclear. Here we describe the correction of an anterior open bite in a 15-year-old Japanese female ARS patient by molar intrusion using sectional archwires with miniscrew implants. An undesirable development of external apical root resorption (EARR) was observed in all intrusive force-applied posterior teeth during the patient’s orthodontic treatment, suggesting that ARS patients have a higher risk of EARR than the general population.
Keywords Axenfeld-Rieger syndrome external apical root resorption miniscrew implant anterior open bite
Amo Type Case Report
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 255
End Page 262
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235974
JaLCDOI 10.18926/AMO/56868
FullText URL 73_3_247.pdf
Author Yoshio, Kotaro| Wakita, Akihisa| Mitsuhashi, Toshiharu| Kitayama, Takahiro| Hisazumi, Kento| Inoue, Daisaku| Tajiri, Nobuhisa| Shiode, Tsuyoki| Akaki, Shiro| Kanazawa, Susumu|
Abstract We investigated the feasibility of simultaneous integrated boost (SIB) volumetric modulated arc therapy (VMAT) using elective nodal irradiation (ENI) for middle or lower esophageal cancer and compared it with three-dimensional conformal radiotherapy (3D-CRT). The study included 15 patients. The prescribed doses included a standard dose (50.4 Gy) and a high dose (60 Gy) for the planning target volume (PTV) of the involved lesions. The objective of the whole lung volume receiving ≥ 20 Gy (V20Gy) was < 30%, and the mean lung dose (MLD) was < 20 Gy. The volumes of the lung receiving 5 Gy (V5Gy) and the heart receiving 30-50 Gy (V30-50Gy) were kept as low as reasonably achievable. As a result, SIB-VMAT showed superior dose conformity for the PTV (p<0.001). Although the lung V5Gy was significantly increased (p<0.001), the V20Gy and MLD showed no significant increase. The heart V30-50Gy showed a > 20% reduction in the mean against 3D-CRTs. Our results demonstrate the feasibility of SIB-VMAT for the treatment of middle or lower esophageal cancer with ENI. Although attention should be paid to the low-dose area of the lungs, SIB-VMAT would be a promising treatment option with improved outcomes for esophageal cancer.
Keywords esophageal cancer middle and lower thoracic volumetric modulated arc therapy, 3D-CRT elective nodal irradiation
Amo Type Original Article
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 247
End Page 257
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235973
JaLCDOI 10.18926/AMO/56867
FullText URL 73_3_241.pdf
Author Utsumi, Masashi| Aoki, Hideki| Nishimura, Seitaro| Une, Yuta| Kashima, Hajime| Kimura, Yuji| Taniguchi, Fumitaka| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji|
Abstract Gallbladder carcinoma (GBC) is a common malignancy with a poor prognosis. With the average life expectancy increasing globally, the incidence of GBC is predicted to increase as well. We investigated the safety and feasibility of surgical treatment for elderly patients with GBC. We retrospectively compared clinical pathological data and treatment outcomes in 45 consecutive GBC patients (23 patients ≥ 75 years [elderly group] and 22 patients < 75 years [younger group]) who underwent curative resection at the Iwakuni Center from January 2008 to December 2017. The proportion of preoperative comorbidities and anticoagulant use was significantly higher in the elderly group. The American Society of Anesthesiologists score was higher in the elderly versus the younger group, and the elderly group had significantly shorter operation times. Reduced activities of daily living was more common in the elderly versus younger group. The percentage of radical resection and overall 3-year survival (66.6% younger vs. 64.4% elderly) were similar between the groups. Controlling Nutritional Status (CONUT) score ≥ 3 and R0 resection were identified as prognostic factors for overall survival rate among all patients. After careful patient selection,
Keywords elderly patient gallbladder carcinoma prognostic factor surgical treatment
Amo Type Original Article
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 241
End Page 246
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235972