start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spa therapy for patients with respiratory disease. Analysis of 1934 patients admitted at Misasa Medical Branch for last 20 years from 1982 to 2001
kn-title=呼吸器疾患に対する温泉療法　―最近20年間の入院症例1934例を対象に―
en-subtitle=
kn-subtitle=
en-abstract=Analysis of 1934 patients with respiratory disease
admitted at Misasa Medical Branch for last 20 years from 1982 to 2001 was performed every 5 years. Of al patients with respiratory disease, 1641 patients had asthma and chronic obstructive pulmonary disease (COPD). 
1. Of 1641 patients showing obstructive ventilatory dy
sfuncion, 1226 (74.7%) patients fad asthma.
The frequency of asthma in all patients with respiratory
disease was 53. 8% for the first 5 years from 1982, 71. 7% (271/378) for the second five years, 73.6% (433/588) for'The third 5 years from 1992, and 53.9% (465/862) for the last five years from 1997. 
2. The frequency of steroid-dependent intractable asthma (SDIA) was from 29. 0% to 41. 3% except the frequency (68.4%) for the first 5 years. The frequency of pulmonary
emphysema in those with COPD was very low (4.7%;5/106) for the first 5 years and the frequency (20.2%;174/862, for the last 5 years) tended to increase. The frequency of patients
over age 60 was 30.1% for the first 5 years, and showed a tendency to increase, and 68.0% for the last 5 years. 
3. The frequency of patients from distant areas outside Totton prefecture was larger compared to the frequency inside Totton prefecture (853/1641;52.0%). The number of patients from Okayama, Osaka, Hyogo, Tokyo, Ehime, Yamaguchi, and Kyoto was larger than the number from other distant areas.
kn-abstract=1982年1月より2001年12月までの20年間に当院へ入院した呼吸器疾患患者1934例のうち閉塞性換気障害を示す肺疾患1641例(気管支喘息BA+慢性閉塞性呼吸器疾患COPD)を対象に,5年間ごとに年齢,地域分布などの経年変化について検討を加えた｡　
1.最近20年間に当院へ入院した閉塞性換気障害を示す呼吸器疾患1641例のうち,気管支喘息は1226例(74.7%)であった｡閉塞性呼吸器疾患のなかで気管支喘息の占める割合は,最初の5年間では106例中
57例(53.8%),1987年からの5年間では71.7% (271/378),1992年からの5年間では73.6% (433/588)で,最近の5年間では53.9% (465/862)と最近ではその割合がやや低下する傾向が見られた｡　
2.全ての気管支喘息のなかでステロイド依存性重症難治性喘息(SDIA)の割合は,最初の5年間をのぞけばほぼ横ばいで最近の5年間では35.3%であった｡COPDのなかでの肺気腫の割合は,近年増加の傾向を示し,最初の5年間の4.7% (5/106)に対して最近の5年間では20.2% (174/862)であった｡　
3.年齢別検討では,閉塞性換気障害を示す全ての症例のうち60才以上の症例の割合は,最初の5年間では30.1%であったが,その後増加の傾向を示し,最近の5年間では68.0%であった｡　
4.地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,この20年間の鳥取県外(遠隔地)からの入院患者は1641例中853例(52.0%)であった｡また,岡山,大阪,広
島,兵庫,東京,愛媛,山口,京都などからの入院症例が多い傾向が見られた｡なお,入院患者の出身県は,35都道府県に及んでいた｡
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=2
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=3
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=4
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=5
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=6
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典教
kn-aut-sei=西田
kn-aut-mei=典教
aut-affil-num=7
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=8
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院
en-keyword=気管支喘息 (asthma)
kn-keyword=気管支喘息 (asthma)
en-keyword=肺気腫 (pulmonary emphysema)
kn-keyword=肺気腫 (pulmonary emphysema)
en-keyword=温泉療法 (Spa therapy)
kn-keyword=温泉療法 (Spa therapy)
en-keyword=高齢患者 (aged patients)
kn-keyword=高齢患者 (aged patients)
en-keyword=遠隔地 (distant area)
kn-keyword=遠隔地 (distant area)
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=9
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=HRCT上の肺のLow Attenuation Areaおよび肺機能により評価された高齢者善喘息の特徴
kn-title=% Low attenuation area (% LAA) of the lungs on high resolution computed tomography (HRCT), associated with pulmonary function in elderly patients with asthma
en-subtitle=
kn-subtitle=
en-abstract=気管支喘息80例(全例非喫煙者)を対象に,high resolution computedt omography (HRCT)上の肺の-950HU以下のLow attenuation area (LAA)の臨床的意義について, 患者年齢, CT number,残気率(% RV),拡散能(% DLco)を含む肺機能検査,白血球のコイコトリエンB4,C4の産生能などとの関連のもとに検討を加えた｡
1.% LAAは,年齢が高くなるにつれて増加する傾向を示し,60才以上の症例の% LAAは,49歳以下の症例に比べ有意に高い値を示した｡また,CT numberも,年齢が高くなるにつれて有意の増加を示した｡
2.% FVC,% FEV1.0およびFEV1.0%値は,いずれも70才以上の症例で49歳以下の症例に比べ有意に低い値を示した｡
3.残気率(% RV)は,年齢が高くなるにつれて増加する傾向を示し,70才以上の症例の% RVは,50-59才および49才以下の症例の% RVに比べ有意に高い値を示した｡
4.一方,拡散能(% DLco)は,年齢が高くなるにつれて有意に低下する傾向を示し,70才以上の症例の% DLcoは,50-59才および49才以下の症例のDLcoに比べ有意に低い値を示した｡
5.% LAAと% RVとの間には有意の相関が見られたが,% LAAと% DLco,および% LAAと換気機能(% FVC,% FEV1.0,FEV1.0%)との間には関連は見られなかった｡
6.白血球のLTB4およびLTC4の産生能においては年齢による差は見られなかった｡これらの結果は,% LAAが年齢とともに増加すること,そして% LAAは% RVと密接な関連を有していることを示している｡
kn-abstract=The clinical significance of low attenuation area <-950 HU of the lungs on high - resolution computed tomography (HRCT) was evaluated in 80 patients with asthma in relation to patient age, CT number, pulmonary function including % residusal volume (% RV) and % DLco, and generation of leukotrienes B4 and C4 by leucocytes. 
1. The % LAA (<- 950 HU) of the lungs showed a tendency to increase significantly with aging; the % LAA was significantly larger in elderly patients over the age of 60 years than in those under the age of 49 years. The CT number was also significantlyincreased with aging.
2. The values of % FVC, % FEV1.0, and FEV1.0% were
significantly decreased in elderly patients over age 70 compared with the values in those under age 49. 
3. The value of % residual volume (% RV) tended to increase significantly with aging; the value in patients over the age of 70 years was significantly larger in those between the ages of 50 and 59 (p<O.OOl). and under the age of 49
years (p<O.OOl). 4. The % DLco value significantly decreased with aging; the value in patients over age 70 was significantly lower than the value in those between the ages
of 50 and 59 (p<O.Ol) and under age 49 (p<O.OOl).
5. A significant correlation was observed between % LAA of the lungs and % RV (r=O. 67, p<0.001), however. any
significant correlations were not observed between % LAA and the values of % FVC, % FEV1.0, and FEV1.0% .
6. The generation of LTB4 and LTC4 by leucocytes was not
significantly related with patient age. The results suggested that % LAA of the lungs on HRCT tended to increse with
aging, accompanied with a significant increase in % RV.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典教
kn-aut-sei=西田
kn-aut-mei=典教
aut-affil-num=6
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=7
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=8
ORCID=

en-aut-name=NakaiMutsuo
en-aut-sei=Nakai
en-aut-mei=Mutsuo
kn-aut-name=中井睦郎
kn-aut-sei=中井
kn-aut-mei=睦郎
aut-affil-num=9
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=10
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院
en-keyword=low attenuation area of the lung
kn-keyword=low attenuation area of the lung
en-keyword=CT number
kn-keyword=CT number
en-keyword=residual volume
kn-keyword=residual volume
en-keyword=DLco
kn-keyword=DLco
en-keyword=aging
kn-keyword=aging
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=16
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=気管支喘息における気管支肺胞洗浄液中の細胞成分に対する加齢および副腎皮質ホルモンの影響
kn-title=Effects of aging on bronchoalveolar lavage (BAL) cells in patients with asthma
en-subtitle=
kn-subtitle=
en-abstract=気管支喘息81例を対象に,気管支肺胞洗浄(BAL)液中の細胞成分,特にリンパ球,好中球および好酸球に対する加齢および副腎皮質ホルモ
ンの影響について検討を加えた｡
1.BAL液中のリンパ球頻度は,69才以下の症例では加齢とともに増加する傾向を示し,60-69才の年齢層では,39才以下および40-49才の年齢層の症例に比べ有意に高い値を示した｡　
2.BAL液中の好中球および好酸球頻度と加齢との間には関連が見られなかった｡　
3.BAL液中のリンパ球頻度は,69才以下の症例では,ステロイド依存性重症難治性喘息(SDIA)に比べ,ステロイド非使用例で有意に高い値を示し,50-59才の年齢層ではその差は有意であった｡　
4.BAL液中好中球頻度は,ステロイド非使用例に比べSDIA症例において高い値を示し,60-69才の年齢層ではその差は有意であった｡　
5.BAL液中好酸球頻度は,ステロイド使用の有無との関連は見られなかった｡これらの結果は,BAL液中リンパ球および好中球頻度は加齢や副腎皮質ホルモン投与の影響を受けるが,BAL液中好酸球額度には影響しないことを示唆している｡
kn-abstract=Effects of aging and glucocorticoid therapy on bronchoalveolar lavage (BAL) cells, particularly lymphocytes, neutrophils and eosinophils, were examined in 81 patients
with asthma. 
1. The proportion of BAL lymphocytes tended to increase with aging in asthmatics under age 69 years, and the proportion was significantly higher in patients with asthma between the ages of 60 and 69 than in those under age 39 and between the ages of 40 and 49. 
2. The proportions of BAL neutrophils and eosinophils were not related to aging. 
3. The proportion of BAL lymphocytes was higher in patients without glucocorticoid therapy than in those with steroid-dependent intractable asthma (SOIA) in those under age 69 years. In patients between the ages of 50 and 59, the proportion of BAL lymphocytes was significantly higher in patients without glucocorticoids than in those with SOIA. 
4. The proportion of BAL neutrophils was higher in patients without glucocorticoid therapy than in those with SOIA, and the difference was significant in patients between the ages of 60 and 69. 
5. The proportion of BAL eosinophils was not related to glucocorticoid therapy. These results suggest that the proportion of BAL lymphocytes and neutrophils is affected by aging and glucocorticoid therapy, but not BAL eosinophils.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典教
kn-aut-sei=西田
kn-aut-mei=典教
aut-affil-num=6
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=7
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院
en-keyword=aging
kn-keyword=aging
en-keyword=asthma
kn-keyword=asthma
en-keyword=glucocorticoid therapy
kn-keyword=glucocorticoid therapy
en-keyword=BAL cells
kn-keyword=BAL cells
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=23
end-page=30
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=高齢者気管支喘息の臨床病態におけるロイコトリエンB4,C4の役割.　気道過敏性とFEV1.0%との関連
kn-title=The role of leukotrienes B4 (LTB4) and C4 (LTC4) in pathophysiology of asthma in the elderly. Relationship to bronchial hyperresponsiveness and FEV1.O%
en-subtitle=
kn-subtitle=
en-abstract=気管支喘息67例を対象に, Ca ionophoreA23187刺激時の白血球からのロイコトリエンB4(LTB4)およびC4 (LTC4)の産生を観察し,高齢者喘息の臨床病態におけるLTB4,LTC4の役割について検討した｡　
1.LTB4の産生は,気管支喘息において肺気腫および健康人に比べ有意に高い値を示した｡LTC4の産生も同様に気管支喘息において,肺気腫,健康人に比べ有意に高い値30を示した｡LTB4,LTC4いずれの産生も,肺気腫症例において健康人と比べ有意に高い値が観察された。　
2.LTB4,LTC4の産生は,70才以上の喘息症例において,他の年齢層の症例に比べより高い値が示されたが,推計学的な有意差は見られなかった｡　
3.高齢者を含めいずれの年齢層の気管支喘息においても,LTC4の産生は発作時に,非発作時に比べ有意の亢進が見られたが,LTB4に関しては発作時,非発作時の間に有意の差は見られなかった｡　
4.気道の過敏性は,年齢が高くなるにつれて低下する傾向が見られた｡そして,この気道の過敏性はLTB4産生とある程度関連していることが示されたが,LTC4との関連は見られなかった｡　
5.FEV1.0%値は,ある程度LTC4産生亢進と関連があることが示された｡
以上の結果より,70才以上の喘息においても,LTB4,LTC4がその発作時病態に重要な役割を果していることが示唆された｡
kn-abstract=The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 67 patients with asthma. 
1. The generation of leukotriene B4 (LTB4) by leucocytes was significantly more increased in patients with asthma than in those with pulmonary emphysema (PE) and healthy subjects. The generation of leukotriene C4 (LTC4) was also signficantly more increased in patients with asthma compared to the generation in those with PE and healthy subjects. The generation of both LTB4 and LTC4 was significantly more increased in patients with PE than in healthy subjects. 
2. The generation of both LTB4 and LTC4 was larger in patients with asthma over age 70 than in those of other age
groups, however, the difference was not significant. 
3. The generation of LTC4 was significantly higher in attack stage than in non-attack stage in all age groups of patients with asthma, however, the generation of LTB4 was not significantly different between the two stages. 
4. Bronchial hyperresponsiveness to methacholine in patients
with asthma tended to decrease with aging, and the bronchial hyperresponsiveness was to a certain extent correlated with the generation of LTB4, but not LTC4. 
5. The generation of LTC4 was correlated with value of FEV1.0%. These results may suggest that both LTB4 and LTC4 participate in the pathophysiology of asthma in the elderly.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典教
kn-aut-sei=西田
kn-aut-mei=典教
aut-affil-num=6
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=7
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院
en-keyword=asthma
kn-keyword=asthma
en-keyword=LTB4
kn-keyword=LTB4
en-keyword=LTC4
kn-keyword=LTC4
en-keyword=FEV1.0%
kn-keyword=FEV1.0%
en-keyword=bronchial hyperresponsiveness
kn-keyword=bronchial hyperresponsiveness
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=31
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Non-invasive study for peripheral circulation in patients with diabetes mellitus
en-subtitle=
kn-subtitle=
en-abstract=糖尿病患者における閉塞性動脈硬化症の合併を早期に診断,予知,予防する目的で末梢循環障害の程度を非侵襲的にかつ客観的に測定することを試みた｡非侵襲的測定方法としてサーモグラフィーとレ-ザードップラー血流計を同時に用い,得られた結果を数量化した｡症例は,下肢に冷え症,しびれ感,下肢痛を有した51歳から82歳までの
27症例(平均年齢67.4歳)であった｡性別は,男性14例,女性13例,HbA1Cは6.8%-13.0%,辛均9.5%であった｡サーモグラフィーで得られた結果は回復率として数量化して表示された｡回復率の算出方法は回復率-【20℃冷水負荷後の27℃以上の体表面温度のサーモグラフィーの画素(pixel)の総数】÷【36℃の温水負荷後の27℃以上の体表面温度のサーモグラフィーのPixelの総数】×100%で求めた｡
サ-モグラフィーにより測定された回復率は0%-93.5%の範囲にあった｡平均は34.0%であった｡レーザードップラー血流計により20℃冷水負荷後に測定された血流量は0.91-5.36ml/min/100g tissueの範囲にあった｡平均は2.04mi/min/100g tissueであった｡得られたサーモグラフィーの回復率とレ-ザードップラ-血流計の血流量との間には正の相関関係を認めた(p<0.0001,r=0.634)0 36℃の温水負荷後に測定された血流量とサーモグラフィーの回復率との間には20℃冷水負
荷後同様に相関関係(p-0.0002,r=0.483)を認めたが,相関係数は20℃冷水負荷後に比較して低値であった｡性別と回復率との間には男性28%,女性40%で女性の方が回復率が高い傾向にあったが,2群間に有意差を認めなっかた｡年齢と回復率の間には正の相関関係(p<0.0001,r=0.187)を認めたが相関係数は低値であった｡HbA1Cと回復率との間には正の相関関係(p<0.001,r=0.041)を認めたが相関係数は低値であった｡一方,性別と血流量との間には男性2.03,女性2.05ml/min/100g tissueで女性の方が血流量が多い傾向にあったが,2群間に有意差を認めなかった｡年齢と血流量との間には正の相関関係(p<0.0001,r=0.110)を認めたが相関係数は低値であった｡HbA1Cと血涜量との間には負の相関関係(p<0.0001,r=-0.179)を認めたが相関係数は低値であった｡36℃温水負荷時の血流量を100%とした時の20℃冷水負荷時の血流量の割合を求めたところ38.1%〜122%の範囲にあった｡
平均は80.6%であった｡冷水負荷後の血流量の温水負荷時との比と回復率との間には正の相関関係を認めた(p<0.0001,r=0.502)｡このことは,末梢血流量が冷水負荷後,速やかに冷水負荷前値に回復するか,あるいはさらに前値よりも上回って増加する症例においては末梢皮膚温度の回復率が高いことが示された｡
糖尿病患者における末梢循環障害の程度をサーモグラフィーとレーザ-ドップラー血流計を同時に用い非侵襲的にかつ客観的に測定することが可能であった｡今後,両者の併用は糖尿病患者における閉塞性動脈硬化症の合併の早期診断,予知,予防に役立つことのみならず,末梢循環障害の程度に応じた治療とその効果について定量的な評価に有用な方法と考えられた｡
kn-abstract=The purpose of this study is to establish a new, non - invasive diagnostic technique for peripheral circulation in patients with diabetes mellitus in the early stage of arteriosclerosis obliterans (ASO) as one of the complications of diabetes mellitus. We observed peripheral circulation quantitatively by thermography and Laser- Doppler blood flowmetry. The body surface peripheral circulation in 27 patients with diabetes mellitus, including 14 males and 13 females with a mean age of 67.4 years (range from 51-82 years), and with a mean hemoglobin A1C (HbA1C) 019.5% (range from 6.8%-13.0%), and who were suffering coldness, numbness or pain in their feet, was examined using thermography and Laser- Doppler blood flowmetry. Thermographic results
were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio= [Total counts of thermography (Pixels) over temperature (T) after cold -loading] + [Initial counts over T after hot-loading] Xl00 (%). Results of recovery ratios for 27 cases were 0% - 93.5%, and the average was 34.0%. At the same time, the blood flow after cold -loading was 0.91 - 5. 36ml/min/lOOg tissue and the average was 2.04ml/min/l00g tissue. We found that the recovery ratio
and the blood flow were correlated (r=O. 634, p<O. 0001). The recovery ratio for males was 28.4% and that of females was 39.9%, and there was a tendency for the recovery ratio of females to be higher than males, however, this was not statistically significant. There was a correlation between the recovery ratio and age (r=O.187, p < 0.0001), although, the correlation was low. There was also a slight correlation between the recovery ratio and HbA1C (r=0.041, p<O.OOl). On the other hand, the blood flow of males was 2. 03ml/min/lOOg tissue and that of females was 2.05. There was a tendency for the recovery ratio of females to be higher than males.
however. the correlation was not significant. There was a correlation between blood flow and age (r=O. 110, p<0 . 0001) , however, the correlation was low. There was also a
slight negative correlation between blood flow and HbA1C (r=-0.179, p<O.OOOl). The ratio of the blood flow after cold -loading at 20t divided by the blood flow after hot -loading at 36 C was 38.1 %-122%, and the average was 80.6%. There was correlation between this ratio and the recovery ratio (r=0.502, p<O.OOOl). The case of the peripheral blood flow recovered immediately to the amount of the hot-loading or
access amount of hot-loading after cold-loading, and had a high recovery ratio of thermography. This might mean that the cooled body surface was warmed by overcirculation of blood flow to keep body temperature at 30C in the mean of homeostasis. We showed that thermography and Laser- Doppler blood flowmetry were useful for non - invasive study to separate patients with poor peripheral circulation. We recommend that these methods for evaluation of further treatment, such as with Prostaglandin E1, on peripheral circulation in patients with diabetes mellitus and ASO.
en-copyright=
kn-copyright=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=1
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典教
kn-aut-sei=西田
kn-aut-mei=典教
aut-affil-num=6
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=7
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=9
ORCID=

en-aut-name=OchiKoji
en-aut-sei=Ochi
en-aut-mei=Koji
kn-aut-name=越智浩二
kn-aut-sei=越智
kn-aut-mei=浩二
aut-affil-num=10
ORCID=

en-aut-name=TsujiTakao
en-aut-sei=Tsuji
en-aut-mei=Takao
kn-aut-name=辻孝夫
kn-aut-sei=辻
kn-aut-mei=孝夫
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=10
en-affil=
kn-affil=医学部臨床検査医学

affil-num=11
en-affil=
kn-affil=医学部第一内科
en-keyword=diabetes mellitus (糖尿病)
kn-keyword=diabetes mellitus (糖尿病)
en-keyword=peripheral circulation (末梢循環)
kn-keyword=peripheral circulation (末梢循環)
en-keyword=thermography (サーモグラフィー)
kn-keyword=thermography (サーモグラフィー)
en-keyword=Laser-Doppler blood flowmetry (レーザードプラー血流計)
kn-keyword=Laser-Doppler blood flowmetry (レーザードプラー血流計)
en-keyword=blood flow (血流量)
kn-keyword=blood flow (血流量)
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=38
end-page=44
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The generation of leukobienes B4 (LTB4) and C4 (LTC4) and bronchial hyperresponsiveness in patients with asthma and spa therapy
en-subtitle=
kn-subtitle=
en-abstract=気管支喘息30例を対象に,温泉療法によるロイコトリエンB4 (LTB4),C4 (LTC4)産生の変動および気道過敏性と臨床効果との関連について検討を加えた｡　
1.温泉療法の臨床効果は,著効8例(26.7%),有効16例(53.3%),やや有
効あるいは無効6例(20.0%)であった｡　
2.メサコリンに対する気道過敏性は,やや有効あるいは無効例で高い傾向が見られたが,著効,有効例と比べ有意の差は見られなかった。
3.LTC4産生はやや有効あるいは無効例において著効例(P<0.01)や有効例(P<0.001)に比べ有意に高い値が示された｡しかし,LTB4産生では臨床効果との関連は見られなかった｡　
4.著効例および有効例では,温泉療法後にLTB4産生の有意の低下
傾向が見られたが,無効例では有意の変動は見られなかった.また,LTB4産生に関しては温泉療法の臨床効果にかかわらず有意の変動は見られなかった｡これらの結果より,気管支喘息に対する温泉療法の臨床効果は,LTC4産生とある程度関連していることを示唆しているものと考えられる｡
kn-abstract=Changes in the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes after spa therapy were examined in 30 patients with asthma. 
1. The efficacy of spa therapy was marked in 8 (26.7%), and moderate in 16 (53.3%) of 30 patients with asthma, and slight or no efficacy of the therapy was observed in the residual 6 patients (20.0%). 
2. Bronchial reactivity to methacholine was the highest in
patients with slight or no efficacy of spa therapy, however. there were no significant differences among the three groups classified by clinical efficacy. 
3. The generation of LTC4 was significantly higher in patients with slight or no efficacy compared with the
generation in those with marked (p<O. 01) and moderate efficacy (p<O. 001). However, there were no signifcant differences in the generation of LTB4 among them. 
4. The generation of LTC4 signifcantly decreased in patients with marked and moderate efficacy after spa therapy. but not in those with slight or no efficacy. The generation of LTB4 was not significantly different before and after spa therapy among patients with marked, moderate, and slight or no efficacy. These results show that the efficacy of spa therapy for patients with asthma is closely related to the generation of LTC4 by leucocytes.
en-copyright=
kn-copyright=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=1
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=2
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典教
kn-aut-sei=西田
kn-aut-mei=典教
aut-affil-num=6
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=7
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院
en-keyword=asthma
kn-keyword=asthma
en-keyword=spa therapy
kn-keyword=spa therapy
en-keyword=bronchial hyperresponsiveness
kn-keyword=bronchial hyperresponsiveness
en-keyword=LTB4
kn-keyword=LTB4
en-keyword=LTC4
kn-keyword=LTC4
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=45
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=脂質代謝に関連した気管支喘息患者における白血球ロイコトリエン産生能に対するα-リノレン酸食の効果
kn-title=Effects of alpha -linolenic acid-rich supplementationon leukotriene generation by leucocytes in patientswith asthma associated with lipometabolism
en-subtitle=
kn-subtitle=
en-abstract=エゴマ油のようなα-リノレン酸食が他のn-3系不飽和脂肪酸食において報告されてきた様に喘息患者の白血球ロイコトリエン(LTs)産生能を抑制すると考えられる｡そこでエゴマ油(n-3系脂肪酸)を摂取した気管支喘息患者の臨床所見を比較することによって白血球ロイコトリエン(LT)C4の抑制に影響する因子を検討した。A群はエゴマ油摂取により白血球LTC4の産生能が抑制された群であり､B群は白血球LTC4の産生能が抑制されなかった群である｡A群では食事摂取2週後(P<0.05),4週後(P<0.05)に白血球LTC4産生能が低下した｡逆にB群では摂取4週後有意に増加した(P<0.05)0 2群間で食事摂取4遡後に白血球LTC4産生能に有意差がみられた(P<0.05)｡ピークフロー値(PEF)､努力性肺活量(FVC)､1秒量(FEV(1))といった呼吸機能はA群において食事摂取4週後に有意に上昇した(P<0.05)｡食事摂取前のPEF､FVC､FEV(1)､V(25)はA群,B群の2群間で有意差がみられた｡A群において血清総コレステロール､低比重リポ蛋白(LDL)コレステロール､リン脂質は食事摂取4週後に有意に低下した｡食事摂取前の血清総コレステロール､中性脂肪､高比重リポ蛋白コレステロール､LDLコレステロール､リン脂質において2群間に有意差がみられた｡血清中性脂肪､LDLコレステロールは食事摂取4週後2群間に有意差がみられた｡気管支喘息患者のある群へのエゴマ油食はLTC4産生能を抑制し､それには呼吸機能や脂質代謝といった臨床因子が関連していると考えられた｡
kn-abstract=Dietary sources of a -linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with
asthma, as has been reported with the consumption of other long - chain n- 3 fatty a-cids.
The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n - 3 fatty acids). Group A consisted of patients in whom the leucocyte generation of dietary perilla seed oil LTC4 was suppressed by this procedure. Group B consisted of those in whom LTC4 generation was not suppressed. LTC4 generation by leucocytes significantly decreased in group A for two (P<0.05) and four weeks (P<O. OS), conversely, significantly increased in group B for four weeks (p<O. OS). The two study groups differed significantly in LTC4 generation by leucocytes after four weeks of dietary supplementation (P<0.05). Ventilatory parameters such as peak expiratory flow (PEF) , forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1.O)) increased significantly after four weeks of dietary supplementation in group A (P<0.05). Values of PEF, FVC, FEV(1.O) and V(25) between groups A and B significantly differed prior to dietary supplementation. Serum levels of total cholesterol, LDL- cholesterol and phospholipid were significantly decreased by dietary supplementation in group A after four weeks. Serum levels of total-choles
terol, triglyceride, HDL-Cholesterol, LDL-Cholesterol and phospholipid values between the two study groups differed significantly prior to dietary supplementation. Serum
levels of triglyceride and LDL- cholesterol differed significantly between the two study groups after four weeks of dietary supplementation.
The effects of dietary supplementation with perilla seed oil to patients with asthma by suppressing the generation of LTC4 is associated with clinical features such as respiratory function and lipometabolism.
en-copyright=
kn-copyright=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=1
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=4
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典教
kn-aut-sei=西田
kn-aut-mei=典教
aut-affil-num=6
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=7
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=9
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=10
en-affil=
kn-affil=岡山大学医学部第二内科
en-keyword=alpha -linolenic acid
kn-keyword=alpha -linolenic acid
en-keyword=leukotrieneC4
kn-keyword=leukotrieneC4
en-keyword=bronchial asthma
kn-keyword=bronchial asthma
en-keyword=lipometabolism
kn-keyword=lipometabolism
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=55
end-page=61
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Multidetector-CT findings of dissecting aortic aneurysum and coronary artery disease. Based on the case of dissecting aortic aneurysum and coronary artery disease.
kn-title=解離性大動脈瘤と冠動脈狭窄病変のマルチスライス(多列検出器型高速)CT画像診断(解離性上行大動脈瘤と狭心症を合併した一患者の診断と考察を元に)
en-subtitle=
kn-subtitle=
en-abstract=Multidetector-CT (MDCT) and CT-Angio hase proven to be extremely useful in diagnosis of dissecting aortic aneurysum (DM) and coronary artery disease (CAD) . We report a case of
DM complicated with CAD which was diagnosed by new MDCT.
kn-abstract=2000年になり多列検出器高速CT (Multi-detector CT,以下MDCT)が出現し,大動脈疾患や心電図同期での冠動脈狭窄病変診断への臨床応用が開始された.当院でも2001年7月からMDCTが稼動し,日常臨床診療に貢献している.
今回,解離性上行大動脈瘤(DeBakeyII)(以下DAA)と冠動脈疾患(LAD# 7の閉塞)を合併した患者を診療した.MDCTによるCT - Angiography (以下CTA)が両者の診断に非常に有用であった.患者の負担は100mlの末梢静脈内への造影剤の投与と約数十秒間の呼吸停止だけで,解離性大動脈瘤並びに冠動脈狭窄病変の診断にそれぞれ非常に有用であった.三次元診断の鮮明な画像が得られ,かつ低侵襲度のMDCT並びにCTAは,今後益々臨床の場で血管造影検査の強力なファーストチョイスの診療手段になると考える.
en-copyright=
kn-copyright=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=1
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=2
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=5
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=6
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=7
ORCID=

en-aut-name=NakaiMutsuo
en-aut-sei=Nakai
en-aut-mei=Mutsuo
kn-aut-name=中井睦郎
kn-aut-sei=中井
kn-aut-mei=睦郎
aut-affil-num=8
ORCID=

en-aut-name=MakinoHirofumi
en-aut-sei=Makino
en-aut-mei=Hirofumi
kn-aut-name=槇野博史
kn-aut-sei=槇野
kn-aut-mei=博史
aut-affil-num=9
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院放射線

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科腎･免疫･内分泌代謝内科学

affil-num=10
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院
en-keyword=解敵性大動脈瘤 (disecting aortic aneurysum)
kn-keyword=解敵性大動脈瘤 (disecting aortic aneurysum)
en-keyword=冠動脈 (coronary artery)
kn-keyword=冠動脈 (coronary artery)
en-keyword=狭心症 (anglna Pectoris)
kn-keyword=狭心症 (anglna Pectoris)
en-keyword=多列検出器CT(マルチスライスCT) (MDCT)
kn-keyword=多列検出器CT(マルチスライスCT) (MDCT)
en-keyword=CT血管造影 (CT-Angiography)
kn-keyword=CT血管造影 (CT-Angiography)
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=62
end-page=65
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two male steroid-dependent asthmatics treated with etidronate
kn-title=男性ステロイド依存性喘息患者に対する4年間のエチドロネート投与の経験
en-subtitle=
kn-subtitle=
en-abstract=We report an experience about administration of etidronate to male steroid-dependent asthmatics for a long time. For 4 years, two men with steroid-dependent asthma were treated with etidronate (200 mg / day, for 14 days) every 4 months and 25-hydroxyvitamin D3 (VD) together, and two patients were treated with VD alone. Vertebral fractures were evaluated by the lateral spinal X-ray films, and radial total bone mineral density (BMD) , trabecular BMD and the cortical BMD were measured by pQCT (Stratec XCT960) every four months. Trabecular and total BMD increased but cortical BMD decreased in the case 1 who was treated with both etidronate and VD. In the case 2 with etidronate
and VD treatments, total and trabecular BMD decreased, but reduction of these indices seemed to be more suppressed than that in two patients with VD alone. According to these
experiences, etidronate may be effective against the steroid-induced bone injury in men. Since periods treatment are not en-ough long to evaluate therapeutic effect of etid-ronate, we will have to continue the examination of these cases further more from now on.
kn-abstract=男性のステロイド依存性気管支喘息患者にエチドロネートを4年間の長期間にわたり投与した経験を得たので報告する｡症例は,男性のステロイド依存性気管支喘息で,エチドロネート200mg/日･14日間投与を4ケ月おきに4年間にわたり反復投与し,活性型ビタミンD製剤
(VD)投与と併用した2例と,活性型VD製剤を単独授与した2例｡椎体圧迫骨折数,境骨耗骨密度,海綿骨骨密度,皮質骨骨密度について,椎体X線像,PQCT(Stratec XCT960)を用いて4ケ月毎に測定し,48ケ月後の効果を検討した｡エチドロネートを投与した症例1では,総骨密度と海綿骨はやや増加を認め皮質骨密度は減少していた｡エチドロネートを授与した症例2では,総骨密度,海綿骨,皮質骨密度はいずれも減少を認めたが,VD単独投与した2例よりもやや減少が抑制されていたようであった｡VD単独投与した2例ではいずれの項目も減少を認めた｡これらの症例からは,エチドロネートは男性のステロイドによる骨傷害にも有効と考えられたが,現在投与継続途中であり,今後さらに検討を続ける必要がある｡
en-copyright=
kn-copyright=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=1
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=2
ORCID=

en-aut-name=TakataSingo
en-aut-sei=Takata
en-aut-mei=Singo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=3
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=4
ORCID=

en-aut-name=NishidaKazunori
en-aut-sei=Nishida
en-aut-mei=Kazunori
kn-aut-name=西田数典
kn-aut-sei=西田
kn-aut-mei=数典
aut-affil-num=5
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=6
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=7
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=9
ORCID=

en-aut-name=NakaiMutsuo
en-aut-sei=Nakai
en-aut-mei=Mutsuo
kn-aut-name=中井睦郎
kn-aut-sei=中井
kn-aut-mei=睦郎
aut-affil-num=10
ORCID=

en-aut-name=AkiyamaTsuneo
en-aut-sei=Akiyama
en-aut-mei=Tsuneo
kn-aut-name=穐山恒雄
kn-aut-sei=穐山
kn-aut-mei=恒雄
aut-affil-num=11
ORCID=

en-aut-name=HasegawaHisakazu
en-aut-sei=Hasegawa
en-aut-mei=Hisakazu
kn-aut-name=長谷川寿一
kn-aut-sei=長谷川
kn-aut-mei=寿一
aut-affil-num=12
ORCID=

en-aut-name=TsujiTakao
en-aut-sei=Tsuji
en-aut-mei=Takao
kn-aut-name=辻孝夫
kn-aut-sei=辻
kn-aut-mei=孝夫
aut-affil-num=13
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=6
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=7
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=8
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=9
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=10
en-affil=
kn-affil=岡山大学三朝分院放射線

affil-num=11
en-affil=
kn-affil=岡山大学三朝分院放射線

affil-num=12
en-affil=
kn-affil=住友製薬

affil-num=13
en-affil=
kn-affil=岡山大学大学院消化器感染症内科
en-keyword=エチドロネート
kn-keyword=エチドロネート
en-keyword=男性
kn-keyword=男性
en-keyword=ステロイド
kn-keyword=ステロイド
en-keyword=気管支喘息
kn-keyword=気管支喘息
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=66
end-page=70
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The relationship between the magnetic resonance imaging of the lumbar spine and lowback pain
kn-title=腰痛症患者における腰椎MRI画像所見の検討
en-subtitle=
kn-subtitle=
en-abstract=(Purpose) Magnetic resonance imaging (MRI) is essential to diagnosis of diseases which happen low back pain. The purpose of this study was to investigate the relationship between low back pain and the characteristics on MRI scans of the lumbar spine. (Materials and Methods) We performed MRI examinations of lumbar spine in 30 patients with low back pain and examined the prevalence of abnormal findings
on MRI scans of the lumbar spine in 30 patients with low back pain. (Results) Overall in present study, all patients with low back pain had abnormalities around the lumbar spines on MRI. Disc degeneration was present in one or
more lumbar levels in 27 (90% ) of all the subjects. The disc degeneration was most commonly observed at U/LS, where 18 (60% ) of all the subjects displayed evidence of disc degeneration. Disc herniation was found in 10 (33.3% ) of all the subjects. Nerve root compression at one level or more was observed in 8 (26.7% ) of the subjects. Compression fracture at one level or more was observed in 6 (20% )
of all the subjects. Spa therapy improved low back pain in 17 (56. 7% ) of the subjects. (Conclusion) All patients with low back pain had abnormalities around the lumbar spines on
MRI. Because spa therapy improved low back pain, morphological abnormalities on MRI scans don't always connect with functional abnormalities and symptoms.
kn-abstract=(目的) MRlは腰痛をきたす疾患の診断に必須な検査法である｡腰痛と腰椎MRl所見との関係を明らかにすることを目的として検討した｡(対象と方法)腰痛を訴えた30例を対象とし､腰椎MRl所見の頻度を調査した｡全例に温泉療法を施行した｡　
(結果)全症例において腰椎MRl上異常所見を認めた｡少なくとも1つ以上の椎間板の変性病変をもつ症例は30例中27例(90% )で､椎間板変性はL4/5levelで最も多く認められた(30例中18例)｡椎間板ヘルニア
を示す症例は30例中10例(33.3% )であった｡神経根圧迫を持つ症例は30例中8例(26.7% )であった｡腰椎圧迫骨折を持つ症例は30例中6例(20% )であった｡温泉療法により腰痛が改善した症例は30例中17例(56.7% )であった｡　
(結論)腰痛症患者は腰椎MR止異常所見を有した｡温泉療法により腰痛の改善を認めたので､MRL上で認めた形態学的異常は必ずしも機能的異常や症状に直結しないと思われた｡
en-copyright=
kn-copyright=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=1
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=2
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典数
kn-aut-sei=西田
kn-aut-mei=典数
aut-affil-num=3
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=4
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=5
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=6
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保�ｱ泰弘
kn-aut-sei=保�ｱ
kn-aut-mei=泰弘
aut-affil-num=7
ORCID=

en-aut-name=MifuneTakashi
en-aut-sei=Mifune
en-aut-mei=Takashi
kn-aut-name=御舩尚志
kn-aut-sei=御舩
kn-aut-mei=尚志
aut-affil-num=8
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=9
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=10
ORCID=

en-aut-name=NiiyaKenji
en-aut-sei=Niiya
en-aut-mei=Kenji
kn-aut-name=新谷憲治
kn-aut-sei=新谷
kn-aut-mei=憲治
aut-affil-num=11
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=6
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=7
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=8
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=9
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=10
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=11
en-affil=
kn-affil=岡山大学医学部第二内科

affil-num=12
en-affil=
kn-affil=岡山大学医学部第二内科
en-keyword=腰痛症 (Disc disease)
kn-keyword=腰痛症 (Disc disease)
en-keyword=MRl (Magnetic resonance imaglng)
kn-keyword=MRl (Magnetic resonance imaglng)
en-keyword=椎間板変性 (Lumbar spine)
kn-keyword=椎間板変性 (Lumbar spine)
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=71
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=QOL in RA patients
kn-title=RA患者のQOL ―　SF-36を用いて　―
en-subtitle=
kn-subtitle=
en-abstract=We have recently regarded the QOL as important.
SF-36 is a measure of HRQOL made as an international standard. We investigated the QOL in RA patients who under went rehabilitation in our hospital using SF-36. We calculated 8 items of SF-36 and compared those with  Japanese standards. All items in RA patients were lower than Japanese standards. PCS was 35.8 on average and MCS was 49.1 on average.
kn-abstract=近年QOLが重視されるようになってきている｡MOS short form 36 health survey (以下SF-36と略す)は,国際的レベルでの基準とされるべく開発された非疾患特異的HRQOL尺度である｡今回我々は当院でリハビリテーションをうけているRA患者を対象にSF-36を用いてQOL評価を行った｡SFl36の8項目をそれぞれ算出し,国民標準値との比較を行った.
すべての項目において標準値を下回っていたが,特に,日常役割機能(身体),日常役割機能(精神),身体の痛み,身体横能において大きな開きを認めた｡また,PCSは平均35.8であり,MCSは平均49.1であった｡以上より,RA患者は身体に強い痛みを伴っているため精神健康面より身体横能面において制限を有していることが分かった｡
en-copyright=
kn-copyright=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=1
ORCID=

en-aut-name=SendaMasuo
en-aut-sei=Senda
en-aut-mei=Masuo
kn-aut-name=千田益生
kn-aut-sei=千田
kn-aut-mei=益生
aut-affil-num=2
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=3
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=4
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典数
kn-aut-sei=西田
kn-aut-mei=典数
aut-affil-num=6
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=7
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=8
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=9
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=10
ORCID=

en-aut-name=InoueHajime
en-aut-sei=Inoue
en-aut-mei=Hajime
kn-aut-name=井上一
kn-aut-sei=井上
kn-aut-mei=一
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学三朝分院

affil-num=2
en-affil=
kn-affil=岡山大学附属病院リハビリテーション部

affil-num=3
en-affil=
kn-affil=岡山大学三朝分院

affil-num=4
en-affil=
kn-affil=岡山大学三朝分院

affil-num=5
en-affil=
kn-affil=岡山大学三朝分院

affil-num=6
en-affil=
kn-affil=岡山大学三朝分院

affil-num=7
en-affil=
kn-affil=岡山大学三朝分院

affil-num=8
en-affil=
kn-affil=岡山大学三朝分院

affil-num=9
en-affil=
kn-affil=岡山大学三朝分院

affil-num=10
en-affil=
kn-affil=岡山大学三朝分院

affil-num=11
en-affil=
kn-affil=岡山大学附属病院整形外科
en-keyword=SF-36
kn-keyword=SF-36
en-keyword=生活の質 (Quality of Life)
kn-keyword=生活の質 (Quality of Life)
en-keyword=慢性関節リウマチ (Rheumatoid Arthritis)
kn-keyword=慢性関節リウマチ (Rheumatoid Arthritis)
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=113
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=業績集
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=三朝医療センター
kn-aut-sei=三朝医療センター
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=74
end-page=79
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=高齢者気管支喘息の病態におよぼす加齢および喫煙の影響について
en-subtitle=
kn-subtitle=
en-abstract=Influences of aging and cigarette smoking on the pathophysiology in elderly patients wish asthma were examined in 152 patients with asthma and 14 patients with pulmonary emphysema. The low attenuation area (LAA) <-950 HU of the lungs on high-resolution computed tomography (HRCT) was significantly larger in patients over age 70 years than in those under age 49 years. A significant increase in residual
volume (RV) of the lungs and significant decrease in the value of DLco were observed in these patients over age 70 compared to the values in those under age 49. A significant correlation between % LAA and % FEV1.0 was found in patients with asthma (in both smoker and nonsmoker) and with pulmonary emphysema. However, any correlation between % LAA and the
value of DLco was not observed in nonsmoking patients with asthma, suggesting that the influence of smoking on DLco is remarkably larger than the influence of aging.
kn-abstract=高齢者喘息の病態に対する加齢および喫煙の影響について,若干の検討を加えた｡高齢者喘息,特に70才以上の喘息では,HRCT上の1950HU以下の肺のlow attenuation area(LAA)は,苦青年者喘息と比べ有意に増加していた.また,同時にこの年齢層では残気量の有意の増加,拡散能の有意の低下が見られた.% LAAと% 1秒量との間には,喘息の非喫煙例,喫煙例,肺気腫(全例喫煙例),いずれにおいても相関が見られた｡しかし,% LAAと拡散能との間には,喘息の喫煙例および肺気腫では相関が見られたが,非喫煙例では有意の相関は見られなかった｡これは,喫煙の拡散能におよぽす影響が大きいことを示唆しているものと考えられた｡
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=5
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典数
kn-aut-sei=西田
kn-aut-mei=典数
aut-affil-num=6
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=7
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=6
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=7
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=8
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=9
en-affil=
kn-affil=岡山大学三朝分院内科
en-keyword=高齢者喘息 (asthma in the elderly)
kn-keyword=高齢者喘息 (asthma in the elderly)
en-keyword=気腫化傾向 (emphysematous changes)
kn-keyword=気腫化傾向 (emphysematous changes)
en-keyword=HRCT
kn-keyword=HRCT
en-keyword=残気量 (residual volume)
kn-keyword=残気量 (residual volume)
en-keyword=DLco
kn-keyword=DLco
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=80
end-page=83
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=呼吸器疾患に対する温泉療法　−再入院症例を中心に−
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=2000年1月〜12月までの1年間に当院へ入院した呼吸器疾患のうち,気管支喘息99例と肺気腫47例を対象に,年齢･入院期間･入院の理由･再入院率を疾患別･県内外別に比較検討を行った｡年齢では気管支喘息よりも肺気腫の方が,また県内外別では県外よりも県内の方が年齢層が高い傾向であった｡入院期間では気管支喘息･肺気腫とも60日未満の入院期間の症例が多く見られた｡入院の理由では気管支喘息･肺気腫とも県内症例においては急性増悪例が,また県外症例においては症状の改善を目的とした入院が多い傾向であり,再入院率は両
疾患とも県内症例に比べ県外症例の方がより高い傾向であった｡このことから,当院の再入院症例を中心にした呼吸器疾患に対する温泉療法の傾向として,県内症例の再入院の理由の多くは急性増悪であり,遠隔地からの入院症例では症状の改善を目的とした入院が主要な理由であった｡
en-copyright=
kn-copyright=

en-aut-name=
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kn-aut-name=西村伸子
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en-aut-name=
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kn-aut-name=中村寿美江
kn-aut-sei=中村
kn-aut-mei=寿美江
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affil-num=1
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院看護部

affil-num=2
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院看護部

affil-num=3
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院看護部

affil-num=4
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院看護部

affil-num=5
en-affil=
kn-affil=岡山大学医学部付属病院三朝分院看護部
en-keyword=気管支喘息 (asthma)
kn-keyword=気管支喘息 (asthma)
en-keyword=肺気腫 (emphysema)
kn-keyword=肺気腫 (emphysema)
en-keyword=再入院 (readmission)
kn-keyword=再入院 (readmission)
en-keyword=急性増悪 (acute exacerbation)
kn-keyword=急性増悪 (acute exacerbation)
en-keyword=症状の改善 (improvement of symptoms)
kn-keyword=症状の改善 (improvement of symptoms)
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=84
end-page=85
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020201
dt-online=
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en-subject=
kn-subject=
en-title=
kn-title=運動器疾患入院状況
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kn-subtitle=
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kn-copyright=

en-aut-name=
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affil-num=1
en-affil=
kn-affil=看護部
en-keyword=看護部
kn-keyword=看護部
en-keyword=入院状況
kn-keyword=入院状況
en-keyword=運動器疾患
kn-keyword=運動器疾患
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
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article-no=
start-page=86
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dt-accepted=
dt-pub-year=2002
dt-pub=20020201
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en-subject=
kn-subject=
en-title=
kn-title=平成12年度看護部教育･研修･活動状況
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kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

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affil-num=1
en-affil=
kn-affil=看護部
en-keyword=看護部
kn-keyword=看護部
en-keyword=研修会
kn-keyword=研修会
en-keyword=活動
kn-keyword=活動
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=91
end-page=112
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20021201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On climatology in Misasa spa (twenty-third report)
kn-title=三朝温泉地の気候について(第23報)
en-subtitle=
kn-subtitle=
en-abstract=Climatological data ofthe last 12 months (2000. 1. 1.- 2000. 12. 31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa Spa, Tottori-ken, Japan are presented.
kn-abstract=我々は1956年以降､三朝温泉地の気候について観察を行っている｡今回は2000年1月1日から2000年12月末日までの1年間の気象観察資料を報
告する｡機器の故障により､欠落部分が多々あることをお断りしておく。
en-copyright=
kn-copyright=

en-aut-name=MatsubaraFumie
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kn-aut-mei=扶美恵
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en-aut-name=
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kn-aut-name=光延彰子
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ORCID=

en-aut-name=MifuneTakashi
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en-aut-mei=Takashi
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kn-aut-sei=御舩
kn-aut-mei=尚史
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ORCID=

en-aut-name=TanizakiYoshiro
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affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=101
end-page=122
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20011201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On climatology in Misasa spa (twenty-third report)
kn-title=三朝温泉地の気候について(第22報)
en-subtitle=
kn-subtitle=
en-abstract=Climatological data ofthe last 12 months (1999. 1. 1.- 1999. 12. 31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa Spa, Tottori-ken, Japan are presented.
kn-abstract=我々は1956年以降､三朝温泉地の気候について観察を行っている｡今回は1999年1月1日から1999年12月末日までの1年間の気象観察資料を報
告する｡機器の故障により､欠落部分が多々あることをお断りしておく。
en-copyright=
kn-copyright=

en-aut-name=MatsubaraFumie
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en-aut-name=InoueTaeko
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en-aut-name=MifuneTakashi
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ORCID=

en-aut-name=TanizakiYoshiro
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affil-num=1
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kn-affil=

affil-num=4
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kn-affil=

affil-num=5
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kn-affil=
END