| Author | 岡山大学医学部附属病院三朝分院| |
|---|---|
| Published Date | 1995-09 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume66 |
| Content Type | Others |
| Author | Matsubara, Fumie| Inoue, Taeko| Mifune, Takashi| Tanizaki, Yoshiro| |
|---|---|
| Published Date | 1995-09 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume66 |
| Content Type | Data or Dataset |
| JaLCDOI | 10.18926/15129 |
|---|---|
| FullText URL | 066_085_091.pdf |
| Author | Chowdhury Riaz| Ochi, Koji| Harada, Hideo| Tanaka, Juntaro| Mizushima, Takaaki| Matsumoto, Shuji| Seno, Toshinobu| Ichimura, Mitsuko| Akiyama, Tsuneo| Yokota, Satoshi| |
| Abstract | Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307190 |
| JaLCDOI | 10.18926/15128 |
|---|---|
| Title Alternative | Collagen degradation and in the pathogenesis of dieseases |
| FullText URL | 066_078_084.pdf |
| Author | Ochi, Koji| Harada, Hideo| Chowdhury Riaz| Yamashita, Haruhiro| Ichimura, Mitsuko| Tanaka, Juntaro| Seno, Toshinobu| Matsumoto, Shuji| Mizushima, Takaaki| Yokota, Satoshi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 |
| Keywords | 線維化 (Fibrosis) コラーゲン (Collagen) TIMP (tissue inhibitor of metalloproteinase) MMP (matrix metalloproteinase) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 78 |
| End Page | 84 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307516 |
| JaLCDOI | 10.18926/15127 |
|---|---|
| Title Alternative | Spa therapy and quality of life in patients with bronchial asthma |
| FullText URL | 066_072_077.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | 気管支喘息のなかでも,ステロイド依存性重症難治性喘息では,気管支拡張薬その他の抗喘息薬のみでは発作のコントロ-ルが極めて困難であり,したがって副腎皮質ホルモンの長期投与を余儀なくされる｡そして,投与薬剤,特に気管支拡張薬の心臓刺激作用や副腎皮質ホルモンの副作用,さらには運動誘発喘息がひき起こされやすいなどの理由により,体動制限が加えられることが多い｡このことが,また精神活動の低下へとつながる｡したがって,重症難治性喘息患者のQuality of life (QOL)を高めるためには,薬剤の副作用をできるだけ低くするための投与薬剤の減量をはかるとともに,十分な運動のもとに治療を行い全身状態の改善,それにともなう精神活動の活性化をはかる必要がある｡かかる観点からすれば,温泉療法は最も理想的な治療法であり,その直接作用(気道への作用:気道浄化作用,気道粘膜正常化作用)により,白,他覚症状の改善,換気機能の改善,気道過敏性の低下などが観察される｡また,間接作用(気道以外への作用)により,全身状態の改善,自律神経系の安定化作用,副腎皮質機能の改善作用などが見られる｡すなわち,重症難治性喘息に対する温泉療法では,十分な運動のもとに,精神活動の活性化をともなった喘息症状の改善がはかられるため,患者のQOLをより一層高めることができると判断される｡ |
| Keywords | 温泉療法 (spa therapy) 重症難治性喘息 (lntractable asthma) 運動 (exercise) 精神活動 (phychical activity) QOL |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 72 |
| End Page | 77 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307919 |
| JaLCDOI | 10.18926/15126 |
|---|---|
| Title Alternative | Pelvimetry with smaller radiation field by CC･DR system- An examination on applying to lateral radiography of the pelvis (Guthmann) ― |
| FullText URL | 066_062_071.pdf |
| Author | Nakai, Mutsuo| Akiyama, Tsuneo| Nakagiri, Yoshiyasu| Kobayashi, Yasuaki| |
| Abstract | 100万画素CCDカメラを用いたI.I.-DR装置(CC･DRシステム)をX線骨盤計測に適用するため,被曝線量をはじめとするいくつかの点を検討した｡照射野内の被曝線量は従来の高感度Screen-Film システムであるG12/HRSと同等以下に抑えることが可能であった｡また,CC･DRシステムの9インチ円形照射野は一般的に用いられている大角フィルム面積の1/3であり,胎位の95%を占めるといわれている頭位の撮影においては胎児の生殖腺はもちろん, 赤色骨髄を多く含む脊椎への被曝を大幅に低減できた｡また,新たに開発された距離計測ソフトウェアーの正確度は良好で,通常lmm以下の誤差で測定が可能であることを確認した。その他,装置に標準装備されている自動露出機構の特性についても報告し,最後に撮影時の留意点についても検討した｡ |
| Keywords | 骨盤計測 (Pelvimetry) グースマン法 (Guthmann Position) デジタルラジオグラフィー (digital radiography) 被曝線量 (exposure dose) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 62 |
| End Page | 71 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307350 |
| JaLCDOI | 10.18926/15125 |
|---|---|
| Title Alternative | Spa therapy for chronic respiratory disease. Recent trends of therapy for patients from distant area. |
| FullText URL | 066_057_061.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | 1995年1月から6月までの半年間に当院へ入院し,温泉療法を受けた慢性呼吸器疾患患者77例について,その地域分布を中心に最近の動向を検討した1.77例中鳥取県内から来院した患者は28例(36.4%)であった｡一方,遠隔地(鳥取県外)からの患者は49例(63.6%)であり,遠隔地から入院してくる患者が増加する傾向か見られた｡2.遠隔地からの入院患者では,兵庫県からの12例(15.6%)が最も多く,次で岡山県8例(10.4%),大阪府7例(9.1%),山口 県5例(6.5%)の順であった｡3.入院患者の年齢分布では,鳥取県内の患者では70才以上の症例が最も多く,次で60-69才の年齢層の順であったが,遠隔地からの患者では,60-69才が最も多く,次で50-59才,40-49才の順であり,鳥取県内に比べ年齢層がやや低い傾向か見られた｡4.慢性呼吸器疾患のうちわけは,気管支喘息が62例と最も多く,全体の80.5%を占め,次で慢性閉塞性細気管支炎6例,肺気腫4例,慢性気管支炎3例の順であった｡ |
| Keywords | 慢性呼吸器疾患 (chronic respiratory disease) 温泉療法 (spa therapy) 遠隔地医療 (therapy for patients from distant area) 年齢 (patient age) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 57 |
| End Page | 61 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307808 |
| JaLCDOI | 10.18926/15124 |
|---|---|
| Title Alternative | Evaluation of airway response to salbutamol sulfate and disodium cromoglycate in bronchial asthma by use of body pletysmograph |
| FullText URL | 066_049_056.pdf |
| Author | Yokota, Satoshi| Mifune, Takashi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | サルブタモール,クロモグリク酸ナトリウム(クロモリン)吸入液を,気管支喘息(以下BA)11例,肺病変のない対照群9例に吸入させ,吸入前および吸入後30分に,sRaw(specific airway resistance)とsGaw(specific airway conductance)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, U.S.A.)を用いて測定した。サルブタモールの場合,BAでは吸入後に有意な改善(p<0.01)を認め,対照群でも有意な変化(p<0.05)があったが,改善率(%)はBA が対照群に比べて有意に高かった(p<0.01)｡クロモリンの場合,吸入前後での比較では有意差は認めなかったが,吸入後にBAでは改善,対照群では悪化する傾向があり,改善率(%)はBA が対照群に比べて有意に高値(p<0.01)であった｡ |
| Keywords | 体プレチスモグラフ (body pletysmograph) 気管支喘息 (bronchial asthma) サルブタモール (salbutamol) クロモリン (disodium cromoglycate) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 49 |
| End Page | 56 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307959 |
| JaLCDOI | 10.18926/15123 |
|---|---|
| Title Alternative | T cell subpopulation and asthma classification |
| FullText URL | 066_044_048.pdf |
| Author | Mifune, Takashi| Yokota, Satoshi| Hosaki, Yasuhiro| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 気管支喘息症例の臨床病型に対するTリンパ球の役割を明らかにするために,気管支肺胞洗浄液中のCD3,CD4,CD8陽性細胞の比率を検討した｡1.Ia気管支攣縮型におけるCD3陽性細胞は75.6±6.52%,Ib:過分泌型では75.4±16.5%,Ⅱ:細気管支閉塞型では61.0±12.5%であり,いずれの病型においても有意な差は認められなかった｡2.CD4陽性細胞についてはIa型47.4±6.11%,Ib型39.5±8.70%,Ⅱ型46.3±6.91%,CD8陽性細胞についてはIa型28.3±8.77%,Ib型35.5±12.3%,Ⅱ型29.4±11.5%と過分泌型 で他の2病型とは違う傾向を示したが,有意ではなかった｡3.活性化を示すHLA-DR陽性細胞はCD4,CD8陽性細胞とも気管支攣縮型で高い傾向が認 められたが有意ではなかった｡以上,今回の検討では各臨床病型間でTリンパ球の関与に明らかな差は見られなかったが,気管支攣縮型に対する活性型Tリンパ球より強い関与の可能性が示唆された｡ |
| Keywords | 気管支喘息臨床病型 (clinical type of beonchial asthma) Tリンパ球 (T-lymphocyte) CD4陽性リンパ球 (CD4+lymphocyte) CD8陽性リンパ球 (CD8+lymphocyte) 活性化リンパ球 (activated lymphocyte) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 44 |
| End Page | 48 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307211 |
| JaLCDOI | 10.18926/15122 |
|---|---|
| Title Alternative | Study on the relationship between the bone mineral densities measured by QCT and biochemical parameters. |
| FullText URL | 066_037_043.pdf |
| Author | Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Yokota, Satoshi| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Nakai, Mutsuro| Akiyama, Tsuneo| |
| Abstract | 当院内科に通院または入院中の女性患者24例(57～89才,平均71.8才)を対象とし,定量的QCT法による骨塩量測定と同時に血中骨代謝マーカーを測定し検討を行った｡年齢についての検討では,カルシウム(Ca)が70才台で60才台に比べ有意に高値であった以外は年代による有意差は認められなかった｡オステオカルシン(OC)とイオン化Ca(Ca(2+))との間にr=-0.50,p<0.01の有意の逆相関を認め,OCとBody mass indexとの間に有意の正の相関(r=0.41,p<0.05)を認めた｡平均骨塩量と各生化学parameterとの間には有意な相関はみられなかった｡副腎皮質ステロイド剤(ステロイド)投与群では非投与群に比べ,投与群でALP骨型アイソザイム(ALP3)高値,OC低値の傾向がみられた｡またステロイド投与症例はすべてOC値が8.4ng/mℓ以下であり,ステロイドによる骨粗鬆症誘発の機序として骨形成の抑制が関与している可能性が考えられた｡今後骨塩量と骨代謝マーカーとの関連について,若年者を含めた検討が必要と考えられた｡ |
| Keywords | 骨粗鬆症 (Osteoporosis) 骨塩量 (Bone mineral desity) オステオカルシン (Osteocalcin) 骨型アルカリフォスファターゼ (alkaline phosphatase (bone type isozyme)) イオン化カルシウム (ionized calcium) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 37 |
| End Page | 43 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307374 |
| JaLCDOI | 10.18926/15121 |
|---|---|
| Title Alternative | 気管支喘息患者の血清コーチゾール値について. 副腎皮質ホルモン投与および年齢との関連 |
| FullText URL | 066_030_036.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Serum cortisol levels were examined in 94 patients with bronchial asthma in relation to dose of glucocorticoids and age. 1. The level of serum cortisol was significantly lower in group A patients, treated with glucocorticoids (prednisolone of 5mg/day or more) for more than 2 years, (2.4±1.2mcg/㎗) than in group B, treated with glucocorticoids (prednisolone of 5mg or less) for less than 2 years, (6.8±3.7mcg/㎗) (p<0.001) and in group C, treated without glucocorticoids, (12.6±3.9mcg/㎗) (p<0.001). The serum cortisol level was also significantly lower in group B than in group C (p<0.001). 2. The level of serum cortisol was significantly lower in patients over the age of 70 compared to that in those aged between 0 and 39 years (p<0.01) and those between 40 and 49 (p<0.05), and those between 50 and 59 (p<0.02). The level was also lower in patients between 60 and 69 compared to that in those between 0 and 39, however, this was not significant. These results demonstrate that the level of serum cortisol decreases by long-term glucocorticoid regimen and with aging. |
| Keywords | serum cortisol level (血清コーチゾール) bronchial asthma (気管支喘息) clinical asthma type (臨床病型) glucocorticoids (副腎皮質ホルモン) aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 30 |
| End Page | 36 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307345 |
| JaLCDOI | 10.18926/15120 |
|---|---|
| Title Alternative | 老年者気管支喘息の各臨床病型における換気機能の特徴 |
| FullText URL | 066_021_029.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Ventilatory function was examined in 55 patients with asthma (25 older patients over the age of 60 and 30 younger patients under the age of 59) in relation to four clinical types classified by clinical symptoms and signs. 1. Regarding cellular composition of bronchoalveolar lavage (BAL) fluid, number of BAL neutrophils was significantly increased in type II, bronchiolar obstruction type, of older and younger patients compared to that in type la-1 and type la-2 of same patients. In contrast, BAL eosinophilia was observed in type la-2 of both older and younger patients and in type Ib of younger patients. 2. The values of % FVC, FEV(1.0%) and % PEFR were not significantly different among four clinical types of asthma and between older and younger patients, although the values of these ventilatory parameters in type II asthma showed a tendency to be lower compared to other clinical types. 3. The values of % MMF, % V(50), and % V(25), showing ventilatory dysfunction of small airways, were lowest in type II asthma of both older and younger patients among four clinical types. A significant difference in these ventilatory parameters of type II asthma compared to type la-1 asthma was observed in younger patients, but not in older patients. These results show that ventilatory dysfunction of small airways is related to clinical asthma types in younger patients, and to aging rather than asthma types in older patients. |
| Keywords | Ventilatory function (換気機能) Clinical asthma type (臨床病型) BAL cells (BAL細胞) aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 21 |
| End Page | 29 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308008 |
| JaLCDOI | 10.18926/15119 |
|---|---|
| Title Alternative | 気管支喘息患者の気管支肺胞細胞からのヒスタミンとロイコトリエンC4遊離 ―アトピー性喘息におけるヒスタミンの役割について― |
| FullText URL | 066_014_020.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | To clarify the main humoral triggering factor (histamine and/or leukotriene) of the early stage of asthma attacks, the release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells stimulated with Ca ionophore A23187 was examined in 7 patients with atopic asthma, and the results were compared to those in 7 nonatopic asthma patients. 1. The proportion of BAL basophilic cells was significantly higher in atopic patients than in nonatopic patients (p<0.05). 2. The content of histamine in BAL fluid was significantly higher in atopic (2.3mcg/mℓ) comparted to that in nonatopic patients (0mcg/mℓ)(p<0.001). The content of LTC4 was high in nonatopic (2.4ng/mℓ) than in atopic patients (0.5ng/ mℓ), however, this was not significant. 3. The release of histamine from BAL cells was 32.6% in atopic and 0% in nonatopic patients, and this was significant (p<0.001). The release of LTC4 from BAL cells was significantly higher in nonatopic (11.3ng/10(6)cell) than in atopic (3.5ng/10(6)cell)(p<0.02). The results demonstrate that histamine play more important role in atopic patients as a main triggering factor of attacks than LTC4. In contrast, in nonatopic patients, LTC4 is more predominant than histamine during early stage of asthma attacks. |
| Keywords | Histamine LTC4 BAL cells atopic asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 14 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307251 |
| JaLCDOI | 10.18926/15118 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性気管支喘息患者の血清コルチゾールに対する温泉療法の影響 |
| FullText URL | 066_008_013.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | Serum cortisol levels before and after spa therapy were compared in 30 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. 1. The mean level of serum cortisol in patients with type la-1 asthma was 2.0±0.7mcg/dℓ before spa therapy, and significantly increased to 9.0±3.1mcg/dℓ (p<0.001). The serum cortisol level of patients with type la-2 also significantly increased from 3.3±1.5mcg/dℓ before spa therapy to 5.9±3.1 mcg/dℓ after the therapy (p<0.05). 2. The level of serum cortisol in patients with type Ib increased from 4.0±1.6mcg/dℓ to 7.8±1.4mcg/ dℓ after spa therapy (p<0.001). In contrast, the serum cortisol levels in patients with type II were not significantly different before (2.7±1.3mcg/dℓ) and after spa therapy (3.5±3.0mcg/dℓ). The results showed that an increase in the levels of serum cortisol by spa therapy was more clearly observed in patients with type la-1 asthma compared to that in type la-2 or type Ib, and that, in contrast, the serum cortisol levels in patients with type II asthma did not significantly increase by spa therapy, since their asthma attacks were always severe and chronic in spite of long-term glucocorticoid regimen. |
| Keywords | Serum cortisol level (血清コルチゾール値) SDIA (ステロイド依存性重症難治性気管支喘息) clinical asthma type (気管支喘息臨床病型) spa therapy (温泉療法) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 8 |
| End Page | 13 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307485 |
| JaLCDOI | 10.18926/15117 |
|---|---|
| Title Alternative | ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少 |
| FullText URL | 066_001_007.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/mℓ) than in older patients (40+ years) (0.39±0.24×10(2)/mℓ) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging. |
| Keywords | Bronchial asthma House dust allergy Histamine release Bronchoalveolar cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307845 |
