start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少 kn-title=Decrease in histamine release from bronchoalveolarcells with aging in patients with atopic asthma sensitive to house dust mite en-subtitle= kn-subtitle= en-abstract=ダニ喘息14例を対象に,ハウスダストエキスによる気道遊走細胞からのヒスタミン遊離と加齢との関連について検討を加えた｡1.気管支肺胞洗浄液(BALF)中の総細胞数は,20-39才の症例群(6.25×10(6)) に比べ,40才以 上の症例群(9.1×10(6)) でやや多い傾向が見られたが,推計学的には有意差は見られなかった｡2.BALF中好酸球数は,20-39才と40才以上の症例群間に差は見られなかった｡3.BALF中好塩基性細胞数は,40才以上の症例群(0.39±0.24×10(2)/m?)に比べ,20-39才の症例群(1.85±1.03×10(2)/m?)において有意に多い傾向が見られた(P<0.001)｡4.ハウスダストエキスによるBALF中細胞からのヒスタミン遊離は,40才以上の症例群(0%) に比べ20-39才の症例群(38.1±24.8%)において有意に高い結果が得られた(P<0.001)。これらの結果より,ダニ喘息(アトピー型喘息)における気道遊走細胞からのヒスタミン遊離は,加齢とともに減少することが示唆された｡ kn-abstract=Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/m?) than in older patients (40+ years) (0.39±0.24×10(2)/m?) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=House dust allergy kn-keyword=House dust allergy en-keyword=Histamine release kn-keyword=Histamine release en-keyword=Bronchoalveolar cells kn-keyword=Bronchoalveolar cells END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=8 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性気管支喘息患者の血清コルチゾールに対する温泉療法の影響 kn-title=Spa therapy and serum cortisol levels in patients with steroid-dependent intractable asthma (SDIA) en-subtitle= kn-subtitle= en-abstract=ステロイド依存性重症難治性気管支喘息患者30名において温泉療法前後の血清コルチゾール値を,臨床病型に基づいて検討した｡1.Ia-1型の症例における血清コルチゾール値は温泉療法前の2.0±0.7μg/d?から9.0±3.lμg/d?に有意に増加していた(p<0.001)｡Ia-2型でも3.3±1.5μg/d?から5.9±3.1g/d?に有意に増加していた(pく0.05)｡ 2.Ib型では温泉療法前後で4.0±1.6μg/d?から7.8±1.4μg/d?に有意に増加した｡一方,U型の症例では,温泉療法前2.7±1.3μg/d?,温泉療法後3.5±3.0μg/d?で有意な変化は認められなかった｡以上のように,温泉療法の血清コルチゾールに対する効果は,Ia-2,Ib型に比較してIa-1型で明らかであった｡一方,U型の気管支喘息症例の血清コルチゾ-ル値は,温泉療法によって有意な変化を認めなかった｡これは長期にわたる副腎皮質ホルモン投与にかかわらず,U型の症例の喘息発作は常に慢性的で重篤であるからと考えられる。 kn-abstract=Serum cortisol levels before and after spa therapy were compared in 30 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. 1. The mean level of serum cortisol in patients with type la-1 asthma was 2.0±0.7mcg/d? before spa therapy, and significantly increased to 9.0±3.1mcg/d?　(p<0.001). The serum cortisol level of patients with type la-2 also significantly increased from 3.3±1.5mcg/d? before spa therapy to 5.9±3.1 mcg/d? after the therapy (p<0.05). 2. The level of serum cortisol in patients with type Ib increased from 4.0±1.6mcg/d? to 7.8±1.4mcg/ d? after spa therapy (p<0.001). In contrast, the serum cortisol levels in patients with type II were not significantly different before (2.7±1.3mcg/d?) and after spa therapy (3.5±3.0mcg/d?). The results showed that an increase in the levels of serum cortisol by spa therapy was more clearly observed in patients with type la-1 asthma compared to that in type la-2 or type Ib, and that, in contrast, the serum cortisol levels in patients with type II asthma did not significantly increase by spa therapy, since their asthma attacks were always severe and chronic in spite of long-term glucocorticoid regimen. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=Serum cortisol level (血清コルチゾール値) kn-keyword=Serum cortisol level (血清コルチゾール値) en-keyword=SDIA (ステロイド依存性重症難治性気管支喘息) kn-keyword=SDIA (ステロイド依存性重症難治性気管支喘息) en-keyword=clinical asthma type (気管支喘息臨床病型) kn-keyword=clinical asthma type (気管支喘息臨床病型) en-keyword=spa therapy (温泉療法) kn-keyword=spa therapy (温泉療法) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=14 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者の気管支肺胞細胞からのヒスタミンとロイコトリエンC4遊離 ―アトピー性喘息におけるヒスタミンの役割について― kn-title=Release of histamine and leukotriene C4 from bronchoalveolar cells in patients with bronchial asthma. A role of histamine in atopic asthma. en-subtitle= kn-subtitle= en-abstract=気管支喘息発作初期に関与する液性因子(ヒスタミン,ロイコトリエン)の役割を明らかにするために,気管支肺胞洗浄(BAL)細胞からのカルシウムイオノフォアA23187によるヒスタミンとロイコトリエンC4 (LTC4)遊離の検討を行った｡対象はアトピー性喘息患者7名,非アトピー性喘息患者7名とした｡1.BAL液中の好塩基性細胞の比率は,アトピー性喘息患者において有意に高値を示した｡2.BAL液中ヒスタミン濃度は非アトピー性喘息患者(0mcg/m?)に比して,アトピー性喘息患者(2.3mcg/m?)において有意に高値を示した｡一方,BAL液中LTC4濃度は,アトピー性喘息患者(0.5ng/m?)に比し て非アトピー性喘息患者(2.4ng/m?)において,高値を示したが,有意差は見られなかった｡3.BAL細胞からのヒスタミン遊離は非アトピー性喘息患者(0%)に比して,アトピー性喘息患者(32.6%)において有意に高値を示した｡LTC4遊離はアトピー性瑞息患者(3.5ng/10(6)胞)に比して,非アトピー性喘息患者(ll.3ng/10(6)細胞)において有意に高値を示した｡以上より,喘息発作初期に関与する液性因子としては,アトピー性喘息患者においてはヒスタミンが重要であり,非アトピー性喘息患者においてはLTC4が,重要であることが,明らかになった。 kn-abstract=To clarify the main humoral triggering factor (histamine and/or leukotriene) of the early stage of asthma attacks, the release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells stimulated with Ca ionophore A23187 was examined in 7 patients with atopic asthma, and the results were compared to those in 7 nonatopic asthma patients. 1. The proportion of BAL basophilic cells was significantly higher in atopic patients than in nonatopic patients (p<0.05). 2. The content of histamine in BAL fluid was significantly higher in atopic (2.3mcg/m?) comparted to that in nonatopic patients (0mcg/m?)(p<0.001). The content of LTC4 was high in nonatopic (2.4ng/m?) than in atopic patients (0.5ng/ m?), however, this was not significant. 3. The release of histamine from BAL cells was 32.6% in atopic and 0% in nonatopic patients, and this was significant (p<0.001). The release of LTC4 from BAL cells was significantly higher in nonatopic (11.3ng/10(6)cell) than in atopic (3.5ng/10(6)cell)(p<0.02). The results demonstrate that histamine play more important role in atopic patients as a main triggering factor of attacks than LTC4. In contrast, in nonatopic patients, LTC4 is more predominant than histamine during early stage of asthma attacks. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院臨床検査医学 en-keyword=Histamine kn-keyword=Histamine en-keyword=LTC4 kn-keyword=LTC4 en-keyword=BAL cells kn-keyword=BAL cells en-keyword=atopic asthma kn-keyword=atopic asthma END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=21 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者気管支喘息の各臨床病型における換気機能の特徴 kn-title=Characteristics of ventilatory function in clinical types of bronchial asthma in the elderly en-subtitle= kn-subtitle= en-abstract=気管支喘息55例(老年症例-65才以上-25例,若年症例-59才以下-30例)における換気機能の特徴について,各臨床病型別に検討を加えた｡1.まず対象症例の臨床病型の病態的特徴を,気管支肺胞洗浄(BAL)液中の細胞成分で検討 すると,Uの細気管支閉塞型の症例では,好中球の増加が,またIa-2やIbの過分泌型の症例では好酸球の増加が特徴的であった｡2.% FVC,FEVL(1.0%),% PEFRなどの換気パラメーターは,U型において他の病型に比べ低値を示す傾向は見られたが,各病型間に有意差は見られなかった｡3.% MMF,% V(50),% V(25)などのどちらかと言えば小ないし細気管支領域の換気障害を示す換気パラメーターの値は,老年および若年症例ともU型(細気管支閉塞型)において最も低い値が示された｡そして,若年症例では,U型の症例においてこれからの換気パラメーターの値は,Ia-1型(単純性気管支攣縮型)に比べ有意に低い値を示した｡しかし,老年症例ではU型におけるこれらの換気パラメータ-の値は,他の臨床病型との問に有意の差は見られなかった｡ kn-abstract=Ventilatory function was examined in 55 patients with asthma (25 older patients over the age of 60 and 30 younger patients under the age of 59) in relation to four clinical types classified by clinical symptoms and signs. 1. Regarding cellular composition of bronchoalveolar lavage (BAL) fluid, number of BAL neutrophils was significantly increased in type II, bronchiolar obstruction type, of older and younger patients compared to that in type la-1 and type la-2 of same patients. In contrast, BAL eosinophilia was observed in type la-2 of both older and younger patients and in type Ib of younger patients. 2. The values of % FVC, FEV(1.0%) and % PEFR were not significantly different among four clinical types of asthma and between older and younger patients, although the values of these ventilatory parameters in type II asthma showed a tendency to be lower compared to other clinical types. 3. The values of % MMF, % V(50), and % V(25), showing ventilatory dysfunction of small airways, were lowest in type II asthma of both older and younger patients among four clinical types. A significant difference in these ventilatory parameters of type II asthma compared to type la-1 asthma was observed in younger patients, but not in older patients. These results show that ventilatory dysfunction of small airways is related to clinical asthma types in younger patients, and to aging rather than asthma types in older patients. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Ventilatory function (換気機能) kn-keyword=Ventilatory function (換気機能) en-keyword=Clinical asthma type (臨床病型) kn-keyword=Clinical asthma type (臨床病型) en-keyword=BAL cells (BAL細胞) kn-keyword=BAL cells (BAL細胞) en-keyword=aging (加齢) kn-keyword=aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=30 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者の血清コーチゾール値について. 副腎皮質ホルモン投与および年齢との関連 kn-title=Serum cortisol levels in patients with bronchial asthma. Relationship to glucocorticoid therapy and patient age. en-subtitle= kn-subtitle= en-abstract=気管支喘息94例を対象に,副腎皮質ホルモン投与および年齢との関連のもとに,血清コーチゾール値の変動を観察した｡まず副腎皮質ホルモンの投与量および投与期間により以下の3群に分けて検討した｡グループA :副腎皮質ホルモン,プレドニソロンに換算して1日5mg以上を2年間以上にわたり使用している症例,グループB:プレドニソロン1日5mg以下で2年間以内の使用症例, グループC:副腎皮質ホルモンを全く使用していない症例｡その結果,グループAの血清コーチゾ-ル値(2.4±1.2mcg/?)は,グループB (6.8±3.7mcg/?)(p 0.01)やC(12.6±3.9mcg/?)(p 0.001)に比べ有意に低い値であった｡2､グループCでは,70才以上の症例の血清コーチゾ-ル値は,0-39才の症例(p 0.0l),40-49才の症例(p 0.05),そして,50-59才の症例(p 0.02)に比べ有意に低い値であった｡これらの結果は,血清コーチゾール値は,副腎 皮質ホルモンの投与量や投与期間以外にも､加齢による影響を受ける可能性を示唆している｡ kn-abstract=Serum cortisol levels were examined in 94 patients with bronchial asthma in relation to dose of glucocorticoids and age. 1. The level of serum cortisol was significantly lower in group A patients, treated with glucocorticoids (prednisolone of 5mg/day or more) for more than 2 years, (2.4±1.2mcg/?) than in group B, treated with glucocorticoids (prednisolone of 5mg or less) for less than 2 years, (6.8±3.7mcg/?) (p<0.001) and in group C, treated without glucocorticoids, (12.6±3.9mcg/?) (p<0.001). The serum cortisol level was also significantly lower in group B than in group C (p<0.001). 2. The level of serum cortisol was significantly lower in patients over the age of 70 compared to that in those aged between 0 and 39 years (p<0.01) and those between 40 and 49 (p<0.05), and those between 50 and 59 (p<0.02). The level was also lower in patients between 60 and 69 compared to that in those between 0 and 39, however, this was not significant. These results demonstrate that the level of serum cortisol decreases by long-term glucocorticoid regimen and with aging. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=serum cortisol level (血清コーチゾール) kn-keyword=serum cortisol level (血清コーチゾール) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=clinical asthma type (臨床病型) kn-keyword=clinical asthma type (臨床病型) en-keyword=glucocorticoids (副腎皮質ホルモン) kn-keyword=glucocorticoids (副腎皮質ホルモン) en-keyword=aging (加齢) kn-keyword=aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=37 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the relationship between the bone mineral densities measured by QCT and biochemical parameters. kn-title=QCTにより測定した骨塩量と骨代謝マーカーについての検討 en-subtitle= kn-subtitle= en-abstract=Bone mineral densities (BMD) were measured with QCT (quantitative computed tomography) in 24 females aged 57 to 89 years old to evaluate about relationship between BMD and biochemical parameters on bone metabolism (calcium : Ca, ionized calcium : Ca(2+), alkaline phosphatase : ALP, bone type isozyme of alkaline phosphatase : ALP 3 and osteocalcin : OC) in blood. As for exception that Ca was significantly higher in patients aged of 60's in comparison with those of 70's in the examination with regard to age, no significant differences were observed. Significant opposite correlation (r=-0.50, p<0.01) between OC and Ca(2+) and significant positive correlation (r=0.41, p<0.05) between OC and body bass index were observed. No significant correlation was observed between mean BMD and biochemical parameters. A trend of higher ALP 3 and lower OC was observed in adrenocortical steroid (steroid) administration group in comparison with patients with no steroid therapy. Also in steroid administration group, OC value was below 8.4ng/m? in all patients. Thus, it was suspected that the suppression of bone formation was related to the mechanism of osteoporosis induced by steroid. Then, the further studies on the relationship of BMD and these biochemical parameters including those of younger cases were considered necessary to clarify the mechanism of osteoporosis. kn-abstract=当院内科に通院または入院中の女性患者24例(57〜89才,平均71.8才)を対象とし,定量的QCT法による骨塩量測定と同時に血中骨代謝マーカーを測定し検討を行った｡年齢についての検討では,カルシウム(Ca)が70才台で60才台に比べ有意に高値であった以外は年代による有意差は認められなかった｡オステオカルシン(OC)とイオン化Ca(Ca(2+))との間にr=-0.50,p<0.01の有意の逆相関を認め,OCとBody mass indexとの間に有意の正の相関(r=0.41,p<0.05)を認めた｡平均骨塩量と各生化学parameterとの間には有意な相関はみられなかった｡副腎皮質ステロイド剤(ステロイド)投与群では非投与群に比べ,投与群でALP骨型アイソザイム(ALP3)高値,OC低値の傾向がみられた｡またステロイド投与症例はすべてOC値が8.4ng/m?以下であり,ステロイドによる骨粗鬆症誘発の機序として骨形成の抑制が関与している可能性が考えられた｡今後骨塩量と骨代謝マーカーとの関連について,若年者を含めた検討が必要と考えられた｡ en-copyright= kn-copyright= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷ｱ勝朗 kn-aut-sei=谷ｱ kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=NakaiMutsuro en-aut-sei=Nakai en-aut-mei=Mutsuro kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=7 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学附属病院三朝分院放射線室 affil-num=8 en-affil= kn-affil=岡山大学附属病院三朝分院放射線室 en-keyword=骨粗鬆症 (Osteoporosis) kn-keyword=骨粗鬆症 (Osteoporosis) en-keyword=骨塩量 (Bone mineral desity) kn-keyword=骨塩量 (Bone mineral desity) en-keyword=オステオカルシン (Osteocalcin) kn-keyword=オステオカルシン (Osteocalcin) en-keyword=骨型アルカリフォスファターゼ (alkaline phosphatase (bone type isozyme)) kn-keyword=骨型アルカリフォスファターゼ (alkaline phosphatase (bone type isozyme)) en-keyword=イオン化カルシウム (ionized calcium) kn-keyword=イオン化カルシウム (ionized calcium) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=44 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=T cell subpopulation and asthma classification kn-title=気管支喘息臨床病型に対するTリンパ球の関与の検討 en-subtitle= kn-subtitle= en-abstract=To clarify the role of T lymphocyte to patho physio logical changls in He aiways, the relationship between T cell subpopulation in BALF and each clinical asthma type were investigated. The proportion of BALF CD3 +T cells in patients with Ia : simple bronchoconstriction type was 75.6±6.52%, 75.4±16.5% in those with Ib : hypersecretion type and 61.0±12.5% in those with U : bronchiolar obstruction type. No siginificant differences were observed between 3 asthma types. The proportion of BALF CD4 +T cells and CD8 +T cells revealed different tendency in patients with type Ib, compaired to patients with type Ia or type U, but this was not significant. A higher proportion of CD4 + and CD8 +T cells in BALF expressing the T cell activation marker HLA-DR was observed in patients with type Ia. compared to those with other clinial asthma types. However, these were not significant. kn-abstract=気管支喘息症例の臨床病型に対するTリンパ球の役割を明らかにするために,気管支肺胞洗浄液中のCD3,CD4,CD8陽性細胞の比率を検討した｡1.Ia気管支攣縮型におけるCD3陽性細胞は75.6±6.52%,Ib:過分泌型では75.4±16.5%,U:細気管支閉塞型では61.0±12.5%であり,いずれの病型においても有意な差は認められなかった｡2.CD4陽性細胞についてはIa型47.4±6.11%,Ib型39.5±8.70%,U型46.3±6.91%,CD8陽性細胞についてはIa型28.3±8.77%,Ib型35.5±12.3%,U型29.4±11.5%と過分泌型 で他の2病型とは違う傾向を示したが,有意ではなかった｡3.活性化を示すHLA-DR陽性細胞はCD4,CD8陽性細胞とも気管支攣縮型で高い傾向が認 められたが有意ではなかった｡以上,今回の検討では各臨床病型間でTリンパ球の関与に明らかな差は見られなかったが,気管支攣縮型に対する活性型Tリンパ球より強い関与の可能性が示唆された｡ en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学附属病院三朝分院内科 en-keyword=気管支喘息臨床病型 (clinical type of beonchial asthma) kn-keyword=気管支喘息臨床病型 (clinical type of beonchial asthma) en-keyword=Tリンパ球 (T-lymphocyte) kn-keyword=Tリンパ球 (T-lymphocyte) en-keyword=CD4陽性リンパ球 (CD4+lymphocyte) kn-keyword=CD4陽性リンパ球 (CD4+lymphocyte) en-keyword=CD8陽性リンパ球 (CD8+lymphocyte) kn-keyword=CD8陽性リンパ球 (CD8+lymphocyte) en-keyword=活性化リンパ球 (activated lymphocyte) kn-keyword=活性化リンパ球 (activated lymphocyte) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=49 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of airway response to salbutamol sulfate and disodium cromoglycate in bronchial asthma by use of body pletysmograph kn-title=気管支喘息における抗喘息薬吸入効果の体プレチスモグラフによる評価 en-subtitle= kn-subtitle= en-abstract=We examined airway response to salbutamol sulfate and disodium cromoglycate (cromolyn) in 11 patients with bronchial asthma (BA), and 9 subjects of controls (no lung diseases), using a constant volume, whole body plethysmograph (Sensor Medics Corporation, Anaheim, California, U.S.A.). The results were expressed by specific airway resistance (sRaw) and specific airway conductance (sGaw), and compared before and 30 minuites after inhalation of agents. The sGaw and sRaw were significantly improved in BA (p<0.01) and in controls (p<0.05) after inhalation of salbutamol sulfate and the improvement rate after inhalation was significantly higher in BA than in controls (p<0.01). In case of cromolyn, there was no significant change of sGaw and sRaw in BA and controls after inhalation, but there was tendency of improvements of sGaw and sRaw in BA, and the improvement rate of these parameters after inhalation was significantly higher in BA than in controls (p<0.01). kn-abstract=サルブタモール,クロモグリク酸ナトリウム(クロモリン)吸入液を,気管支喘息(以下BA)11例,肺病変のない対照群9例に吸入させ,吸入前および吸入後30分に,sRaw(specific airway resistance)とsGaw(specific airway conductance)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, U.S.A.)を用いて測定した。サルブタモールの場合,BAでは吸入後に有意な改善(p<0.01)を認め,対照群でも有意な変化(p<0.05)があったが,改善率(%)はBA が対照群に比べて有意に高かった(p<0.01)｡クロモリンの場合,吸入前後での比較では有意差は認めなかったが,吸入後にBAでは改善,対照群では悪化する傾向があり,改善率(%)はBA が対照群に比べて有意に高値(p<0.01)であった｡ en-copyright= kn-copyright= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=体プレチスモグラフ (body pletysmograph) kn-keyword=体プレチスモグラフ (body pletysmograph) en-keyword=気管支喘息 (bronchial asthma) kn-keyword=気管支喘息 (bronchial asthma) en-keyword=サルブタモール (salbutamol) kn-keyword=サルブタモール (salbutamol) en-keyword=クロモリン (disodium cromoglycate) kn-keyword=クロモリン (disodium cromoglycate) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=57 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for chronic respiratory disease. Recent trends of therapy for patients from distant area. kn-title=慢性呼吸器疾患の温泉療法 ―遠隔地医療の最近の動向― en-subtitle= kn-subtitle= en-abstract=Areas (prefecture) where patients came and patient age were analyzed in 77 patients with respiratory disease who had been admitted at our hospital to have spa therapy during 6 months from January to June in 1995. Of 77 patients, 28 subjects (36.4%) were patients who lived inside Tottori prefecture, and 49 (63.6%) were outside Tottori prefecture (distant area). This suggest that the number of patients from distant area has been increasing. The numbers of patients from Hyogo prefecture (12 subjects ; 15.6%), Okayama (8 ; 10.4%), Osaka (7 ; 9.1%) and Yamaguchi (5 ; 6.5%) were larger than those from other prefectures. Regarding patient age, the numbers of patients over the age of 70 and those aged between 50 and 69 were larger in patients inside Tottori prefecture compared to other age group. In contrast, the numbers of patients aged between 60 and 69, between 50-59, and between 40 and 49 were larger in patients from distant areas than the numbers of other age groups, suggesting mean age of patients from distant areas was lower than that of patients inside Tottori prefecture. The number of patients with bronchial asthma was largest (62 subjects ; 80.5%) among different respiratory diseases. kn-abstract=1995年1月から6月までの半年間に当院へ入院し,温泉療法を受けた慢性呼吸器疾患患者77例について,その地域分布を中心に最近の動向を検討した1.77例中鳥取県内から来院した患者は28例(36.4%)であった｡一方,遠隔地(鳥取県外)からの患者は49例(63.6%)であり,遠隔地から入院してくる患者が増加する傾向か見られた｡2.遠隔地からの入院患者では,兵庫県からの12例(15.6%)が最も多く,次で岡山県8例(10.4%),大阪府7例(9.1%),山口 県5例(6.5%)の順であった｡3.入院患者の年齢分布では,鳥取県内の患者では70才以上の症例が最も多く,次で60-69才の年齢層の順であったが,遠隔地からの患者では,60-69才が最も多く,次で50-59才,40-49才の順であり,鳥取県内に比べ年齢層がやや低い傾向か見られた｡4.慢性呼吸器疾患のうちわけは,気管支喘息が62例と最も多く,全体の80.5%を占め,次で慢性閉塞性細気管支炎6例,肺気腫4例,慢性気管支炎3例の順であった｡ en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=慢性呼吸器疾患 (chronic respiratory disease) kn-keyword=慢性呼吸器疾患 (chronic respiratory disease) en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=遠隔地医療 (therapy for patients from distant area) kn-keyword=遠隔地医療 (therapy for patients from distant area) en-keyword=年齢 (patient age) kn-keyword=年齢 (patient age) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=62 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pelvimetry with smaller radiation field by CC･DR system- An examination on applying to lateral radiography of the pelvis (Guthmann) ― kn-title=100万画素CCDカメラを搭載したT.T.-DRシステムによる小照射野]線骨盤計測法 ―Guthmann法への適用に関する検討― en-subtitle= kn-subtitle= en-abstract=To apply CC･DR system (image intensifier digital radiography system including one million pixel CCD camera)to X-ray pelvimetry, We examined exposure dose of X-ray, radiation field, and accuracy of X-ray pelvimetry by the system. The hazards of radiation by CC･DR system were less than those of radiation by G12/HRS which is high sensitive screen-film system. 9 inch round radiation field by CC・DR system was one third of the area of 14×14 inch film. In cephalic presentation which occurs in about 95% of pregnancies, the damages of radiation by CC･DR system to fetal gonads and spinal bones including bone marrow much were less than those by usual X-ray examination. The accuracy of a distance measuring software devised newly for pelvimetry was reliable, and we could measure diameters with less than 1 mm deviations. Also we report the characteristics of automatic exposure controller annexed to this TV system and enumerate points to which we pay attention on taking a radiograph. Furthermore, It is expected that CC･DR system was useful to apply to superio-interior pelviography (Martius). kn-abstract=100万画素CCDカメラを用いたI.I.-DR装置(CC･DRシステム)をX線骨盤計測に適用するため,被曝線量をはじめとするいくつかの点を検討した｡照射野内の被曝線量は従来の高感度Screen-Film システムであるG12/HRSと同等以下に抑えることが可能であった｡また,CC･DRシステムの9インチ円形照射野は一般的に用いられている大角フィルム面積の1/3であり,胎位の95%を占めるといわれている頭位の撮影においては胎児の生殖腺はもちろん, 赤色骨髄を多く含む脊椎への被曝を大幅に低減できた｡また,新たに開発された距離計測ソフトウェアーの正確度は良好で,通常lmm以下の誤差で測定が可能であることを確認した。その他,装置に標準装備されている自動露出機構の特性についても報告し,最後に撮影時の留意点についても検討した｡ en-copyright= kn-copyright= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=1 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=2 ORCID= en-aut-name=NakagiriYoshiyasu en-aut-sei=Nakagiri en-aut-mei=Yoshiyasu kn-aut-name=中桐善康 kn-aut-sei=中桐 kn-aut-mei=善康 aut-affil-num=3 ORCID= en-aut-name=KobayashiYasuaki en-aut-sei=Kobayashi en-aut-mei=Yasuaki kn-aut-name=小林靖明 kn-aut-sei=小林 kn-aut-mei=靖明 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 en-keyword=骨盤計測 (Pelvimetry) kn-keyword=骨盤計測 (Pelvimetry) en-keyword=グースマン法 (Guthmann Position) kn-keyword=グースマン法 (Guthmann Position) en-keyword=デジタルラジオグラフィー (digital radiography) kn-keyword=デジタルラジオグラフィー (digital radiography) en-keyword=被曝線量 (exposure dose) kn-keyword=被曝線量 (exposure dose) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=72 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy and quality of life in patients with bronchial asthma kn-title=温泉療法と気管支喘息患者のQOL en-subtitle= kn-subtitle= en-abstract=Bronchial asthma is in qeneral a disease with good prognosis and can be controlled with usual antiasthmatic drugs. However, there are some patients whose asthma attacks can be controlled only with use of qlucocorticoids. In these patients, adverse side effects of many kinds of drugs containing bronchodilators and qlucocorticoids, and exercise-induced asthma attacks are often observed. Thus, the patients have to keep limitation of exercise during treatment of their asthma attacks, leading to decrease psychical activity. Complex spa therapy for bronchial asthma consists of swimming training in a hot spring pool (exercise), inhalation of iodine salt solution and fango therapy. Spa therapy has two kinds of actions : direct action to airways and indirect action to other organs except airways. The direct action of spa therapy improves subjective and objective symptoms, and ventilatory function, and suppress bronchial hyperresponsiveness. In contrast, improvemment of suppressed function of adrenocortical glands, of mental activity, and of autonomic nerve system is observed as indirect action of spa therapy. These actions play an important role for improvement of QOL of patients with bronchial asthma. kn-abstract=気管支喘息のなかでも,ステロイド依存性重症難治性喘息では,気管支拡張薬その他の抗喘息薬のみでは発作のコントロ-ルが極めて困難であり,したがって副腎皮質ホルモンの長期投与を余儀なくされる｡そして,投与薬剤,特に気管支拡張薬の心臓刺激作用や副腎皮質ホルモンの副作用,さらには運動誘発喘息がひき起こされやすいなどの理由により,体動制限が加えられることが多い｡このことが,また精神活動の低下へとつながる｡したがって,重症難治性喘息患者のQuality of life (QOL)を高めるためには,薬剤の副作用をできるだけ低くするための投与薬剤の減量をはかるとともに,十分な運動のもとに治療を行い全身状態の改善,それにともなう精神活動の活性化をはかる必要がある｡かかる観点からすれば,温泉療法は最も理想的な治療法であり,その直接作用(気道への作用:気道浄化作用,気道粘膜正常化作用)により,白,他覚症状の改善,換気機能の改善,気道過敏性の低下などが観察される｡また,間接作用(気道以外への作用)により,全身状態の改善,自律神経系の安定化作用,副腎皮質機能の改善作用などが見られる｡すなわち,重症難治性喘息に対する温泉療法では,十分な運動のもとに,精神活動の活性化をともなった喘息症状の改善がはかられるため,患者のQOLをより一層高めることができると判断される｡ en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=重症難治性喘息 (lntractable asthma) kn-keyword=重症難治性喘息 (lntractable asthma) en-keyword=運動 (exercise) kn-keyword=運動 (exercise) en-keyword=精神活動 (phychical activity) kn-keyword=精神活動 (phychical activity) en-keyword=QOL kn-keyword=QOL END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=78 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Collagen degradation and in the pathogenesis of dieseases kn-title=コラーゲン分解系と疾患 en-subtitle= kn-subtitle= en-abstract=Fibrosis is the result of net accumulation of collagen in the organ. This may occur as a consequence of alterations in the synthesis of collagen, their degradation, or both. Recent investigations revealed that a decrease in collagen degradation plays a crucial role in fibrogenesis. Two pathways exist in collagen degradation : extracellular and intracellular. Each pathway has an important enzyme; that is, matrix metalloproteinases (MMP) and collagenolytic cathepsin, respectively. Collagenolytic activity is regulated at several levels. Expression of MMP and tissue inhibitors of metalloproteinase (TIMP), which act as inhibitors of MMP, is regulated independently by a number of cytokines and growth factors. MMP, which is synthesized in the cell, is secreted in a latent form. Activation of the latent MMP is controlled by TIMP and plasminogen activator inhibitor. TIMP also inhibits activated MMP which can degrade connective tissue matrices including collagens. In the condition where TIMP is predominant over MMP, activity of collagen breakdown is reduced, and consequently collagen deposition occurrs. kn-abstract=組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=3 ORCID= en-aut-name=YamashitaHaruhiro en-aut-sei=Yamashita en-aut-mei=Haruhiro kn-aut-name=山下晴弘 kn-aut-sei=山下 kn-aut-mei=晴弘 aut-affil-num=4 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=8 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学第2内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 en-keyword=線維化 (Fibrosis) kn-keyword=線維化 (Fibrosis) en-keyword=コラーゲン (Collagen) kn-keyword=コラーゲン (Collagen) en-keyword=TIMP (tissue inhibitor of metalloproteinase) kn-keyword=TIMP (tissue inhibitor of metalloproteinase) en-keyword=MMP (matrix metalloproteinase) kn-keyword=MMP (matrix metalloproteinase) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=85 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Experimental model of chronic pancreatitis, a review - Does it really exist? en-subtitle= kn-subtitle= en-abstract=疾患の実験モデルの作成は,その疾患の病因,病態の解明,さらに治療法の開発のために重要である｡筆者らの一人は厚生省難治性膵疾患調査研究班の班員として,慢性膵炎の病態の解明や治療法の開発に関する研究を行っており,その研究の一環として,慢性膵炎の実験モデルの作成を現在行っている｡そこで,これまで報告されている慢性膵炎の実験モデルについて概要を報告した｡種々の動物や方法でヒト慢性膵炎に病因,病態,組織像が類似するモデルの作成が試みられてきたが,そのすべてが合致するような慢性膵炎モデルは確 立されてはいない｡近年の分子生物学的研究の進歩は著しく,実験モデルへの応用が種々なされている現在,より簡便で再現性のある慢性膵炎モデルの作成が望まれるところである｡ kn-abstract=Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=5 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=8 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学第2内科 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=93 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=0n climatology in Misasa spa (seventeenth report) kn-title=三朝温泉地の気候について(第17報) en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 24months (1993.1.1-1994.12.31) obtained by the climate autorecording system at the Misasa Branch in Misasa spa, Tottori-ken, Japan are presented. Because of system disfunction, some data defects are observed in this report. kn-abstract=我々は1956年以降,三朝温泉地の気候要素について観察を行ってきている｡今回は1993年1月1日から1994年12月末日までの2カ年間の気象観測資料を報告する｡1985年4月以降は,自動観察記録装置による資料であるが,今回の報告では装置の故障のため,資料の欠落部分が認められることをお詫びしておきたい｡ en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=InoueTaeko en-aut-sei=Inoue en-aut-mei=Taeko kn-aut-name=井上妙子 kn-aut-sei=井上 kn-aut-mei=妙子 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=134 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END