start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=投稿規定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=130 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Publications and lectures in 1987 kn-title=1987年（1月〜12月）業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=102 end-page=104 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study and trailning in nursing division kn-title=看護部活動報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Nursing section en-aut-sei=Nursing section en-aut-mei= kn-aut-name=三朝分院看護部 kn-aut-sei=三朝分院看護部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=105 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On climatology in Misasa spa (tenth report) kn-title=三朝温泉地の気候について（第10報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1986.4.1-1987.3.31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa spa, Tottori-Ken, Japan, are presented. kn-abstract=われわれは1956年以降三朝温泉地の気候要素について観測を行ってきているが，今回は第10報として，ひきつづき1986年4月1日から1987年3月末日までの1力年の気象観測の資料を報告することとした。なお1985年4月1日以降は自動記録装置が備えられたので，今回の資料はすべてこの自動記録装置によるものである。 en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=97 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Application of personal computer in X-ray room business. kn-title=放射線業務におけるパソコン活用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=1 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=93 end-page=96 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes in X-ray examinations. kn-title=放射線室における患者，検査の推移について ―患者数・件数・撮影枚数― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=83 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=トランスフェリンを介する鉄の細胞内取り込み機序 ―特に肝細胞への取り込みにおける内皮細胞の関与について― kn-title=Transferrin-Mediated Cellular Iron Uptake -Special Implication of Endothelium in Hepatic Iron Uptake- en-subtitle= kn-subtitle= en-abstract=トランスフェリン（Tf）は鉄代謝において重要な役割を担っている。鉄を必要とする細胞の表面には，Tfの特異的受容体が存在し，Ffは受容体との結合に引き続いて，coated　pitsとcoated　vesiclesを介して細胞内に取り込まれる（internalization）。Vesicle内での急速なpHの低下にともない，鉄はTfから分離し，細胞内で分画される。一方，鉄を失ったTf（アポTf）は受容体と結合したまま細胞表面にもどり，中性のpHのもとで受容体から解離する。最近の細胞・分子生物学の進歩，遺伝子クローニング，ならびにモノクローナル抗体の開発により，分子レベルで鉄代謝経路が解明されつつある。今回，これまでの主要な知見をまとめ，特に，最近筆者らの研究により明らかとなった，肝の鉄代謝における内皮細胞の役割について考察した。 kn-abstract=Transferrin (Tf) is thought to play a pivotal role in iron metabolism of various kinds of cells. Tf has specific receptors on the surface of the cells that require iron. Tf-receptor binding is followed by internalization through a system of coated pits and vesicles. The rapid decline of pH of these vesicles leads to the release and sequestration of iron by the cell. Apotransferrin-receptor complex returns to the cell surface, where under neutral pH conditions, apotransferrin is dissociated from the receptor. Recent advances in cellular and molecular biology, gene cloning and monoclonal antibody technique have elucidated many features of these processes at a molecular level. These advances are briefly reviewed, and particularly, our own observations concerning endothelial mediation of uptake of Tf by hepatocytes are discussed. en-copyright= kn-copyright= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=1 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MehdiTavassoli en-aut-sei=Mehdi en-aut-mei=Tavassoli kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=ミシシッピ州立大学医学部 en-keyword=Iron uptake (鉄の細胞内取り込み) kn-keyword=Iron uptake (鉄の細胞内取り込み) en-keyword=Transferrin (トランスフェリン) kn-keyword=Transferrin (トランスフェリン) en-keyword=Receptor-Mediated Endocytosis kn-keyword=Receptor-Mediated Endocytosis en-keyword=Desialation (脱シアル化) kn-keyword=Desialation (脱シアル化) en-keyword=Endothelium (内皮細胞) kn-keyword=Endothelium (内皮細胞) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=68 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Etiology and pathogenesis of chronic pancreatitis kn-title=慢性膵炎の成因，病態と発生機序 en-subtitle= kn-subtitle= en-abstract=Main etiologies of chronic pancreatitis (CP)include "alcoholic" (60%), "idiopathic" (27%)and "biliary" (8%). Clinico-pathological features comprise intractable abdominal pain, maldigestion secodary to exocrine pancreatic insufficiency and diabetes secondary to endocrine pancreatic insufficiency. Death is not infrequent during follow-up. Pathogenesis and evolution of alcoholic CP were discussed in connection with "Big Duct Theory", "Toxic-Metabolic Theory", and "Protein Plug Theory". Diet and congenital predisposition as well as alcoholic comsumption play important roles in various combinations in the pathogenesis and evolution of CP. Important initial lesins of alcoholic CP are probably : (1) pancreatic ductular Obstruction due to proetin plug formation resulting from increased protein and mucoprotein concentration in pancreatic juice ; (2) damage and sloughing of ductular epithelia caused by protein plugs or by a direct toxic effect of ethanol secreted into pancreatic juice, and subsequent ductular stenosis and peri-ductular fibrosis. Parenchymal destruction with interstitial fibrosis is induced upstream to the ductular lesions. These, structural abnormalities and multiple biochemical abnormalities of pancreatic juice further lead to self-perpetuating evolution. Anti-acinar-cell antibody, anti-duet-cell antibody and immune complex in serum are most probably mere epiphenomena and not the causes of CP. kn-abstract=慢性膵炎の成因の主たるものは，アルコール性，特発性，胆石性である。病態面では，社会的・家庭的にもっとも責任が重い壮年期に頑固な疼痛，消化吸収障害，二次性糖尿病のために生活の質が低下することが問題になる。経過中に併発してくる膵およびそのほかの臓器の癌，および糖尿病の合併症による死亡も少なくない。アルコール性慢性膵炎の初期病変の発生機序としては，@膵過分泌の結果として細膵管内に形成される蛋白栓による膵液流出障害と，A蛋白栓あるいはアルコールの直接障害作用による細膵管上皮の損傷，およびその結果生じる膵管狭窄による膵液流出障害が注目されている。膵液流出障害はその上流域に実質細胞の破壊と間質の線維化をおこす。膵液には多くの生化学的異常が認められ，いったん発生した膵管の構造異常とあいまって慢性膵炎進展の原因となる。素因および栄養のアンバランスは発症，進展の促進因子となる。発症を予防し，進展を阻止する手段を開発するためには素因および飲酒・食事を含む環境因子の解析が今後の重要な課題である。 en-copyright= kn-copyright= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=1 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=6 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=成因 (Etiology) kn-keyword=成因 (Etiology) en-keyword=発生機序 (Pathogenesis) kn-keyword=発生機序 (Pathogenesis) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=62 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Allergic reactions for severe intractable asthma and spa therapy kn-title=気管支喘息における重症難治化反応と温泉療法 en-subtitle= kn-subtitle= en-abstract=Reactions for severe intractable asthma and actions of spa therapy on the reactions were discussed. Reactions participatng in onset mechanism of bronchial asthma were divided into three major groups. The first group comprises IgE-mast cell (eliciting phase), histamine (leukotrienes) (reactive phase; humoral phase), and lymphocytes-basophils-eosinophils (reactive phase; cellular phase). The second group comprises IgG-neutrophils, leukotrienes, and neutrophils-lymphocytes-macrophages. The third group is induced by non-IgE reactions, followed by PAF and eosinophils (with blood eosinophilia), and by leukotrienes and lymphocytes (without blood eosinophilia). If these reactions are really present and participate in onset mechanism of bronchial asthma, the first group could be observed in atopic asthma, the second one in late onset asthma, and the third one in so-called intrinsic asthma with blood eosinophilia and in late onset asthma without blood eosinophilia. Spa therapy has clearing actions of airway and improves function of adrenal glands in severe intractable asthma. kn-abstract=予後良好と言われる気管支喘息が，どのような反応系により重症難治化傾向を取るのか，そして温泉療法がどのように作用するのかについて，若干の検討を加えた。まず関与する反応系は，その惹起相，反応相（液性因子相，細胞性因子相）の組合せにより，代表的な3つの反応系に分類することができる。1）IgE−肥満細胞（惹起相）；ヒスタミン（ロイコトリエン）（液性因子相）；リンパ球，好塩基球，好酸球（細胞性因子相），2）IgG−好中球；ロイコトリエン；好中球，リンパ球，マクロファージ，3）非IgE系反応；PAF；好酸球，3'）非IgE系反応；ロイコトリエン；リンパ球。このような機序がもし存在するとすれば，1）の反応系の関与する喘息はアトピー型喘息，2）は中高年発症型喘息，3）は所謂内因性喘息，3'）は中高年発症型喘息として把握される可能性が強い。温泉療法は，気道清浄化作用および副腎皮質機能改善作用により，これらの反応系の発現を抑制する。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=難治性喘息 (lntractable asthma)　 kn-keyword=難治性喘息 (lntractable asthma)　 en-keyword=アレルギー反応 (Allergic reaction) kn-keyword=アレルギー反応 (Allergic reaction) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=54 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changing conception of indication for peripheral arterial reconstruction surgery. kn-title=末梢動脈の慢性閉塞性疾患の治療 −変りつつある適応− en-subtitle= kn-subtitle= en-abstract=Peripheral arterial reconstruction surgery for chronic occlusive diseases has not always produced satisfactory results according to long-term (5-10 years) follow-up studies. Furthermore, application of synthetic vascular prostheses of small caliber for peripheral reconstruction is quite restricted to certain circumstances, because of the complications derived from long-term implantation such as thickening and degeneration of the inner capsule and deterioration of the grafts used. On the other hand, experimental studies on ischemic limbs revealed a significant increase of tissue perfusion in 3, 6 and 12 months following ischemia was induced (p<0.001) compared with the acute ischemic stage in freely moving dogs by means of medical mass spectrometry. In addition, subcutaneous tissue perfusion was found increased by about 30 % with CO(2) bathings in combination with Radon inhalation of high concentration (over 5000 Bq/l), which was accompanied by an elevation of subcutaneous pO(2). Therefore, medical treatments such as walking exercise and bathings with CO(2) and Radon based on the natural history of chronic peripheral arterial occlusive diseases, particularly intermittent claudication, appear feasible. kn-abstract=末梢動脈の慢性閉塞性疾患に対する直達血行再建術の長期の予後は必ずしも満足できるものではない。合成代用血管は，長期の植え込みにより内被の肥厚，退行性変性，および材質の変性の様な合併症により，特に小口径の合成代用血管の適応は極めて限られたものになっている。一方，医用質量分析装置を用いた虚血肢の実験的研究によると，自由に運動させた犬の虚血肢では，急性期に比較すると3カ月以後その組織循環は有意に増加することが明らかとなった。また，家兎を用いた実験的研究によると，炭酸泉浴に高濃度のラドン吸入を合併すると皮下組織の組織循環が約30％増加して，同時に皮下の酸素分圧が上昇することを確かめた。従って，切迫壊死の症例をのぞいて，末梢動脈の慢性閉塞性疾患々肢，特に間欠性跛行に対しては，自 然予後を考慮して歩行負荷，および炭酸泉，ラドン泉の温泉療法を用いた保存的療法が長期の予後上効果的である。 en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=NakaoToshihiko en-aut-sei=Nakao en-aut-mei=Toshihiko kn-aut-name=中尾俊彦 kn-aut-sei=中尾 kn-aut-mei=俊彦 aut-affil-num=2 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=3 ORCID= en-aut-name=YagiNobuko en-aut-sei=Yagi en-aut-mei=Nobuko kn-aut-name=矢木信子 kn-aut-sei=矢木 kn-aut-mei=信子 aut-affil-num=4 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=花王株式会社栃木研究所 en-keyword=虚血肢 (lshemic limb) kn-keyword=虚血肢 (lshemic limb) en-keyword=末梢血行再建術 (Peripheral arterial reconstruction) kn-keyword=末梢血行再建術 (Peripheral arterial reconstruction) en-keyword=組織循環 (Tissue perfusion) kn-keyword=組織循環 (Tissue perfusion) en-keyword=歩行運動 (Walking exercise) kn-keyword=歩行運動 (Walking exercise) en-keyword=温泉療法 (Balneotherapy) kn-keyword=温泉療法 (Balneotherapy) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=47 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on steroid-dependent intractable asthma kn-title=ステロイド依存性重症難治性喘息の臨床的検討 −免疫アレルギー学的検討− en-subtitle= kn-subtitle= en-abstract=Clinical studies on steroid-dependent intractable asthma were carried out in 56 patients relating to immuno-allergic aspects. 1. In most half of the patients with steroid-dependent intractable asthma, age at onset of the disease was 41 years old or over (so-called "Late Onset Asthma"). 2. The frequency of positive skin reaction for house dust was relatively low. whereas that for Candida was relatively high. 3. The serum IgE concentrations of these patients were in general low. Many patients showed low serum IgE concentrations of less than 300IU/ml. The concentrations of specific IgE antibodies for house dust and Candida albicans were also low. 4. The concentrations of specific IgG antibodies for Candida albicans were high compared to those for house dust. 5. Basophil histamine release induced by house dust and Candida albicans was not so remarkable in majoriy of these patients, while anti-IgE-induced histamine release from basophils ranged widely. 6. In these patients, small airway obstruction was suggested in ventilatory function test. 7. In clinical classificatin of asthma, type Ta; bronchospasm type was a few, while type Tb; hypersecretion and type U; bronchiolor obstruction type were dominant in the cases studied here. kn-abstract=ステロイド依存性重症難治性喘息56例について免疫アレルギー学的検討を行った。その結果41才以降発症のLate　Onset　Asthmaが約半数を占め，血清IgE値が比較的低値であり，ハウスダストに対しての皮内反応，特異的IgE抗体価，ヒスタミン遊離はいずれも全般的に低く，カンジダに対しての皮内反応，特異的IgG抗体価はむしろ比較的高く，肺機能では末梢気道閉塞の傾向が窺われ，臨床分類では，気管支攣縮＋過分泌型，および細気管支閉塞型が多数を占める等の特徴を有することが明らかにされた。 en-copyright= kn-copyright= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= en-aut-name=TsujiMituaki en-aut-sei=Tsuji en-aut-mei=Mituaki kn-aut-name=辻光明 kn-aut-sei=辻 kn-aut-mei=光明 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学第二内科 affil-num=6 en-affil= kn-affil=岡山大学第二内科 affil-num=7 en-affil= kn-affil=岡山大学第二内科 en-keyword=ステロイド依存性喘息 (Steroid-dependent asthma) kn-keyword=ステロイド依存性喘息 (Steroid-dependent asthma) en-keyword=血清IgE (Serum-IgE) kn-keyword=血清IgE (Serum-IgE) en-keyword=特異的IgE (Specific lgE) kn-keyword=特異的IgE (Specific lgE) en-keyword=特異的IgG (Specific IgG) kn-keyword=特異的IgG (Specific IgG) en-keyword=中高年発症型喘息 (Late onset asthma) kn-keyword=中高年発症型喘息 (Late onset asthma) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=42 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Atopic asthma in patients of middle or advanced age kn-title=中高年令者のアトピー型喘息について en-subtitle= kn-subtitle= en-abstract=In order to elucidate the characteristics of atopic asthma in patients of middle or advanced age (over 41 years old), 88 atopic asthmatic patients were divided into 4 groups according to their ages, 0〜20, 21〜40, 41〜60 and over 61 years old, and age, sex, age of onset, past history, family history, number of peripheral eosinophils, serum IgE and skin test were compared among these groups. The results were as follows: Atopic ashmatic patients of middle or advanced age were 1) less frequent in all asthmatic patients of same age group, 2) more frequent in males than in females, 3) higher in averaged age of onset, 4) more frequent in cases without other allergic past histories, 5) less frequently positive to house dust and more frequently positive to Candida and Aspergillus in skin test, 6) not different in family history, number of peripheral eosinophils and serum IgE compared to other groups. kn-abstract=中高年令（41才以上）のアトピー型喘息患者の特徴を明らかにするために，アトピー型喘息患者88例を0〜20才，21〜40才，41〜60才，61才以上の各年令別に分け，年令，性別，発症年令，既往歴，家族歴，末梢血好酸球，血清IgE値，皮内反応の各項目について検討を加えた。結果は，中高年のアトピー型喘息患者は1）その年代の全喘息患者に占める割合は低く，2）男性が多く，3）平均発症年令は高く，4）その他のアレルギー性疾患の既往歴を持たない症例が比較的多く，5）皮内反応では，ハウスダスト陽性率が比較的低く，カンジダ，アスペルギルスの陽性率は比較的高い傾向にあった。6）家族歴，末梢血好酸球，血清IgE値では，明らかな傾向は認められなかった。 en-copyright= kn-copyright= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=アトピー (Atopy) kn-keyword=アトピー (Atopy) en-keyword=中高年令者 (patients of middle or advanced age) kn-keyword=中高年令者 (patients of middle or advanced age) en-keyword=喘息 (asthma) kn-keyword=喘息 (asthma) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=37 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Separation of paripheral leukocytes by counterflow centrifugation elutriation kn-title=JE−6B　rotor（Beckman）による末梢血白血球分離の検討 en-subtitle= kn-subtitle= en-abstract=Separation of peripheral leukocytes was carried out in 5 healthy subjects by counterflow centrifugation elutriation with JE-6B rotor. 1. Number of lymphocytes was predominant at low flow rate (4.5ml/min) of counterflow centrifugation elutriation. 2. As flow rate was increased (9-10ml/min), the purity and number of basophils, and histamine content in the fraction were gradually increased. 3. The purity and number of neutrophils were gradually increased, and the purity was reached the peak at 13ml/min. 4. The purity and number of eosinophils were gradually increased at the late stage of the centrifugation elutriation. The results obtained here might suggest that cell separation by counterflow centrifugation elutriation is more useful for experiments, especially allergy testing, in vitro. kn-abstract=JE−6B　rotor（Beckman）を用いてcounterflow　centrifugation　elutriationによる末梢血白血球の分離を試み，若干の検討を加えた。1．flow　rateが低い場合はリンパ球が大部分を占めたが，flow　rateの増加とともに頻度は減少した。2．　flow　rateの増加とともに，好塩基球の頻度が増加し，9−10ml／minでは頻度のみでなく細胞数の増加も認められた。各fractionにおけるヒスタミン含有量も同様の傾向が認められた。3．好中球のpeakはflow　rate　13ml／minであり以後減少を示した。4．最終段階で好酸球が増加傾向を示しChamber内で最も高値を示した。以上の結果よりcounterflow　centrifugation　elutriationによる末梢血白血球細胞分離は，in　vitroにおける実験に有用な手段である可能性が示唆された。 en-copyright= kn-copyright= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=1 ORCID= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=2 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=3 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=逆流負荷遠心法 (Counterflow centrifugation elutriation) kn-keyword=逆流負荷遠心法 (Counterflow centrifugation elutriation) en-keyword=JE−6Bローター (JE-6B rotor) kn-keyword=JE−6Bローター (JE-6B rotor) en-keyword=細胞分離 (Cell separation) kn-keyword=細胞分離 (Cell separation) en-keyword=好塩基球 (Basophils) kn-keyword=好塩基球 (Basophils) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=31 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息および慢性気管支炎患者における抗ヒトIgEによる好塩基球からのヒスタミン遊離 kn-title=Basophil histamine release by anti-IgE in Subjects of chronic bronchitis and bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息50例，慢性気管支炎8例を対象に，抗ヒトIgE添加時の好塩基球からのヒスタミン遊離を全血法により行ない，その臨床的評価について検討を加えた。抗ヒトIgE海底時のMax　％　histamine releaseの平均は，健康人24.7±14.2％，慢性気管支炎27.7±22.1％，気管支喘息28.4±17.0％であり，3者間に有意の差はみられなかった。すなわち，抗ヒトIgE添加により健康人や慢性気管支炎患者の好塩基球からも有意のヒスタミン遊離が見られた。気管支喘息のなかでは，内因性喘息症例においてヒスタミン遊離（14.1±7.2％）の低い傾向が見られた。Dose-response curveの検討では，健康人，慢性気管支炎症例では全例E（2）からE（1）へかけてのnegative slopeを示した。気管支喘息症例では，血清IgE値500IU/ml以下の症例ではnegative slopeを示す症例が多く，一方501IU/ml以上の症例ではpositive slopeを示す症例がより多く見られた。 kn-abstract=Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7± 14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%). Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1). en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= en-aut-name=TsujiMitsuaki en-aut-sei=Tsuji en-aut-mei=Mitsuaki kn-aut-name=辻光朗 kn-aut-sei=辻 kn-aut-mei=光朗 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Basophil response (好塩基球の反応性) kn-keyword=Basophil response (好塩基球の反応性) en-keyword=Anti-lgE (抗ヒトIgE) kn-keyword=Anti-lgE (抗ヒトIgE) en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=chronic bronchitis (慢性気管支炎) kn-keyword=chronic bronchitis (慢性気管支炎) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=24 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Early diagnosis of pancreatic cancertrial of a mass screening test for detecting early pancreatic cancer kn-title=膵癌の早期診断法の検討 ―膵集検の試み― en-subtitle= kn-subtitle= en-abstract=There is no other way of curing pancreatic cancer than early diagnosis and resection. However, an effective protocol has not been established for detecting early pancreatic cancer among asymptomatic populations by means　of a mass screening test. Therefore, a prospective study was attempted on 776 patients who came to Medical Clinic of Misasa Branch Hospital, Okayama University Medical School mostly for a routine annual check-up. The following tentative protocol was proposed, based on the retrospective analyses of our 13 patients with early pancreatic cancer: (1) a first step test includes serum amylase, elastase T, alkaline phosphatase, r-GTP, carcinoembryonic antigen, fasting blood sugar and routine abdominal ultrasonography (US); (2) a second step test includes thorough abdominal US with various kinds of probes and patients' positioning which was performed on individuals with abnormal findings on the first step test, (3) a third step test includes ERCP which was performed on individuals with abnormal or questionable findings on the second step test. Further detail examinations were performed when ERCP was abnormal or questionable. Consequently 357 patients (46% of the total 776 patients) underwent thorough US and 45 patients (5.8%) underwent ERCP. ERCP findings included pancreatic cancer in two patients, suspect of pancreatic cancer in three, advanced chronic pancreatitis in two, equivocal as for chronic pancreatitis (according to the Cambridge classification) in nine, and normal in 29. Final diagnosis was early pancreatic cancer in one patient, advanced pancreatic cancer in two, and calcified chronic pancreatitis in two; detection rate of pancreatic cancer (0.39%) in this series was slightly higher than that usually reported with a mass screening test for stomach cancer. From a cost-benefit point of view, however, examinations for the pancreas cost 2.6 times as much as those for the stomach. Further studies are needed (1) to refine the protocol, (2) to improve cost-benefit efficiency, (3) and also to confirm by follow-up that no cases of pancreatic cancer have passed through the test undetected. kn-abstract=膵癌を治癒に導くためには早期診断，早期切除以外に方法はない。そこで，無症状者のなかから早期膵癌を発見するためのスクリーニング法を検討するためProspective studyを実施した。人間ドック目的の来院患者を主とする三朝分院外来患者776名を対象とし，一次スクリーニング検査として，血清アミラーゼ，エラスターゼT，CA19−9，アルカリフォスファターゼ，γ-GTP，血糖値の測定および腹部超音波検査を施行し，異常者に対して二次スクリーニングとして腹部超音波検査の再精査およびERCPを施行した。その結果，早期膵癌1例および進行膵癌2例を検出し，膵癌発見率は0.39％　と満足のいく結果が得られた。しかし一次スクリーニング検査の要精検率は46％　と高値を示したこと，一次スクリーニング検査の費用は胃集検の約3.3倍，二次スクリーニング検査の費用は胃精査の約2.6倍かかることからcost-benifitの面で問題となった。また見逃し症例の有無をモニターするためfollow upも今後の問題として残った。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=膵集検 (Mass screening) kn-keyword=膵集検 (Mass screening) en-keyword=早期膵癌 (Early pancreatic cancer) kn-keyword=早期膵癌 (Early pancreatic cancer) en-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=17 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of endoscopic ultrasonography (EUS) in the diagnosis of gastric disease. kn-title=胃疾患診断における超音波内視鏡の有用性の検討 en-subtitle= kn-subtitle= en-abstract=We performed EUS in seven cases with gastric cancer, one with gastric malignant lymphoma, two with submucosal tumor of the stomach (SMT), two with tumourous compression by extra-gastric organs and three with others. Except one case with early gastric cancer, the depth of cancerous lnvasion was correct1y diagnosed by EUS. It was posible to detect which layer had SMT in the 5 layer strcture of the gastric wall by EUS and it was helpful in determination of histological origin of SMT. Furthermore EUS was able to make the differential diagnosis between SMT and tumourous compression by extra gastric organ. Our result showed that EUS was a useful procedure in the diagnosis of gastric diseases. kn-abstract=ラジアルセクタ式超音波内視鏡（EUS）を，15例の胃疾患患者に用い，その有用性を検討した。胃癌の深達度診断は併存潰瘍を有するm癌の1例をsm癌とした以外は，いずれも正診であり，胃癌の深達度診断にEUSが有用であることが示唆された。その他，胃粘膜下腫瘍の占拠部位や発育様式の診断や壁外性圧排との鑑別など胃疾患の診断にEUSの有用性が示唆され，文献的考察を加えて報告した。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=5 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=超音波内視鏡 (Endoscopic ultrasonography) kn-keyword=超音波内視鏡 (Endoscopic ultrasonography) en-keyword=胃癌 (Gastric cancer) kn-keyword=胃癌 (Gastric cancer) en-keyword=胃粘膜下腫瘍 (Submucosal tumor of the stomach) kn-keyword=胃粘膜下腫瘍 (Submucosal tumor of the stomach) en-keyword=癌深達度診断 (Diagnosis of the depth of cancerous invasion) kn-keyword=癌深達度診断 (Diagnosis of the depth of cancerous invasion) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=12 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characteristic pancreatographic findings in chronic pancreatitis and their diagnostic value. …Studies on post mortem pancreas… kn-title=慢性膵炎における膵管X線像の診断学的価値 ―屍体膵を用いての検討― en-subtitle= kn-subtitle= en-abstract=Postmortem pancreas tissue was prepared within 6 hours of death for the comparative study of pancreatographic findings and histological findings to define characteristic pancreatographic findings of chronic pancreatitis and determine their diagnostic value. Pancreas tissue was obtained from 25 patients with chronic pancreatitis and 125 with a normal pancreas. Among various pancreatographic findings, irregular dilatation and irregular arrangement of the branches of the pancreatic duct, and also irregular dilatation, rigidity with irregular margin and stenosis with irregular margin of the main pancreatic duct showed the highest sensitivity. specificity, positive predictive value and negative predictive value and conseqently had the highest diagnostic valus. However, the sensitivity was not high enough, indicating that the above pancreatographic findings could be absent at the site of positive histological findings in mild chronic pancreatitis. kn-abstract=慢性膵炎25例および対照として正常例125例計150例の新鮮剖検膵を用いて膵管造影を行い，X線所見と同部位の組織所見とを厳密に対比させ，慢性膵炎における各X線所見の診断学的価値を検討した。その結果，主膵管像では不整拡張像，硬化＋辺縁不整像，狭窄＋辺縁不整像が，分枝像では不整拡張像および不整配列像が，positive predictive value（PPV），specificity（Sf），negative predictive value（NVP）ともに77.1〜100％　の高率を示した。しかしsensitivity（St）は，2.1〜18.1％　と低率であった。したがって，これらの所見は慢性膵炎を診断する上で組織予見性および特異性に優れた診断的価値のあるX線所見と言える。しかし一方では軽症の慢性膵炎の検出能はあまりよくないという限界が膵管造影法にはある。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=MatumotoShuuji en-aut-sei=Matumoto en-aut-mei=Shuuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKouji en-aut-sei=Ochi en-aut-mei=Kouji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=膵管造影像 (pancreatogpaphy) kn-keyword=膵管造影像 (pancreatogpaphy) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=8 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maternal swimming at Misasa Hospital Of Okayama University Medical School First report. Recognition of the pregnant women to maternity swimming kn-title=岡山大学医学部附属病院三朝分院における妊婦水泳　第一報　妊婦水泳に関する妊婦の認識について en-subtitle= kn-subtitle= en-abstract=The sports have been contraindication for pregnant women till resent years. Since Dr. Murooka reported the safety and the effectiveness of maternity swimming in 1978. maternity swimming have been taken up and fasionarised by mass media. And then maternity swimming becomes popular in our all over the country. Now we made inquiries about maternity swimming to 25 pregnant women in our outpatients clinic. (Results) 1. Eightyfour percent of them were interested in maternity swimming. 2. Eightyeight percent of them wanted to swim. 3. Most of them had little knowledge about tocological effectiveness of maternity swimming. (Conclusion) It is nessesary that the enlightenment and the active management of maternity swimming by obstetricians. kn-abstract=妊婦のスポーツに対する考え方は近年まで比較的消極的であったが，最近マスコミに取り上げられるようになり，妊婦水泳・エアロビクスダンス等は全国的にもかなり普及していると思われる。今回外来通院患者を対象に妊婦水泳に関するアンケート調査を行った結果，大多数のものが関心を持ち，また実施希望を持っていることが判明したのでその概要を報告する。 en-copyright= kn-copyright= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=SugaKiyohiro en-aut-sei=Suga en-aut-mei=Kiyohiro kn-aut-name=須賀清博 kn-aut-sei=須賀 kn-aut-mei=清博 aut-affil-num=2 ORCID= en-aut-name=SakataJunko en-aut-sei=Sakata en-aut-mei=Junko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=3 ORCID= en-aut-name=YosidaSachie en-aut-sei=Yosida en-aut-mei=Sachie kn-aut-name=吉田佐知江 kn-aut-sei=吉田 kn-aut-mei=佐知江 aut-affil-num=4 ORCID= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御船政明 kn-aut-sei=御船 kn-aut-mei=政明 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=妊婦水泳 (Maternity swimming) kn-keyword=妊婦水泳 (Maternity swimming) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spe therapy for chronic respiratory disease-in subjects admitted in 1987. kn-title=慢性呼吸器疾患の温泉療法 ―1987年度入院症例を対象に― en-subtitle= kn-subtitle= en-abstract=Backgrounds, immunoallergological characteristics and clinical effects of apa therapy were examined in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1987. 1. Fifty five patients with chronic respiratory diseases comprised 37 patients with bronchial asthma, 3 with diffuse panbronchiolitis, 3 with chronic cough, 2 with allergic granulomatous angitis, 2 with chronic bronchitis, 2 with hypersensitivity pneumonitis, each 1 with bronchiectasia, pulmonary emphysema and lung tuberculosis. 2. Thirty six patients (69.2%) out of the 52 cases had spa therapy. 3. Out of 22 patients coming from Tottori prefecture, 11 cases (42.3%) received spa therapy. On the other hand, spa therapy was carried out for 25 cases (96.2%) out of the 26 cases coming from the other prefectures (long distant areas). 4. Spa therapy was effective in 25 cases (83.3%) out of the 30 patients with bronchial asthma. Spa therapy was also effective for patients with diffuse panbronchiolitis, allergic granulomatous angitis and bronchiectasia. kn-abstract=1987年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者52例を対象に，その背景因子，免疫アレルギー学的要素および温泉療法の臨床効果について検討を加えた。1．対象52例のうちわけは，気管支喘息37例，瀰漫性汎細気管支炎3例，慢性咳嗽3例，アレルギー性肉芽腫性血管炎2例，慢性気管支炎2例，過敏性肺臓炎2例，気管支拡張症，肺気腫，広汎性肺結核症各1例であった。2．これら52症例のうち，温泉療法を受けた症例は36例（69.2％）であった。3．対象症例の地域分布と温泉療法を受けた症例との関係では，鳥取県内の入院症例（26例）で温泉療法を受けた症例は11例（42.3％）であり，県外（遠隔地）からの入院症例（26例）で温泉療法を受けた症例は25例（96.2％）であった。4．温泉療法の臨床効果では，気管支喘息では30例中25例（83.3％）で有効であり，その他1瀰漫性汎細気管支炎，アレルギー性肉芽腫性血管炎，気管支拡張症などで有効であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) kn-keyword=瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) en-keyword=気管支炎 kn-keyword=気管支炎 en-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END