start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Thermal Spring Research, Okayama University en-aut-sei=Institute for Thermal Spring Research, Okayama University en-aut-mei= kn-aut-name=岡山大学温泉研究所 kn-aut-sei=岡山大学温泉研究所 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Thermal Spring Research, Okayama University en-aut-sei=Institute for Thermal Spring Research, Okayama University en-aut-mei= kn-aut-name=岡山大学温泉研究所 kn-aut-sei=岡山大学温泉研究所 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Thermal Spring Research, Okayama University en-aut-sei=Institute for Thermal Spring Research, Okayama University en-aut-mei= kn-aut-name=岡山大学温泉研究所 kn-aut-sei=岡山大学温泉研究所 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=25 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The involvement of ear and throat in rheumatoid arthritis II. On the Rheumatoid Arthritis of Cricoaryenoid Joint kn-title=慢性関節リウマチの耳科･咽喉科領域における障害について 第2報 : 慢性関節リウマチ患者の喉頭所見について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Until 1955 a few reports had been made concerning this problem. On December 1955. Montgomery, Perone and Schall reported four cases of rheumatoid arthritis of cricoarytenoid joint. It seemed to have interested other authors so that Saunders, Pearson, BakerBywaters, Copeman and Polisar reported their clinical findings. In 1957 Pearson presented a histological section of cricoarytenoid joint, showing villous synovial proliferation. In 1959 Montgomery reported another series of additional cases and microscopical findings of the cricoarytenoid joint of two patients with rheumatoid arthritis. This study did not show a complete fibrous ankylosis but severe arthritic changes were seen. In the same year Copeman et al. reported an autopsy case of rheumatoid arthritis with ankylosis of cricoarytenoid joint. In early 1960's Grossman et al. examined 55 patients with rheumatoid arthritis and found 18 patients with some suggestive evidence of cricoarytenoid arthritis. Lofgren and Montgomery examined 100 patients of rheumatoid arthritis, finding 26% of them had involvement of cricoarytenoid joint. They stated that this disease seemed to be more common and more severe in female. Bienenstock stated 17 cases of 64 randomly selected patients with rheumatoid arthritis had one or more symptoms considered to be characteristic of cricoarytenoid arthritis. He claimed that arthritis of cricoarytenoid joint occured much more frequently in patients with rheumatoid arthritis than had been suspected. At postmortem examination Grossman saw histological changes of cricoarytenoid joint characteristics of rheumatoid arthritis in 5 of 11 autopsied patients with rheumatoid arthritis and Bienenstock found the same in 7 of 8 patients. In 1963 for the third time Montgomery discussed of cricoarytenoid arthritis, based on his own experiences and many available literatures. Pathologic changes range between the mere synovial thickning and the complete disruption. Montgomery believed as others did, that in ankylosing chronic stage inspiratory bowing of both vocal cords and absolute fixation of arytenoid cartilage were diagnostic signs of rheumatoid arthritis of cricoarytenoid joint. In 1958 Darke, Wolman and Young reported five cases of laryngeal stridor, where in four cases tracheotomy became necessary. Two of them were brought to autopsy and histological examination. They found evidence of the nerve degeneration and mobile cricoarytenoid joint. The cause of nerve degeneration in the second case was an ischaemic neuropathy from rheumatoid arteritis of vasa nervorum. These findings were different from those of Montgomery and others. In 1965 Wolman, Darke and Young had an opportunity of six more autopsy examples. They confirmed from their own pathologic findings that laryngeal stridor occuring in rheumatoid arthritis was due mainly to arteritis of the vasa nervorum causing ischaemic neuropathy and that polymyositis and joint disease might augment this effect. Woldorf and Webb et aI. introduced both of these opinions. Anyhow, in U. S. A. and in England 25%-28% of rheumatoid arthritis seems to have rheumatoid arthritis of cricoarytenoid joint. On the other hand in our country there has been seen no report on rheumatoid arthritis of cricoarytenoid joint. In order, therefore, to investigate this problem author examined in medical clinic of Misasa branch hospital of Okayama university school of medicine 76 patients of classical and definite rheumatoid arthritis. Their complaints were as follows. 1) dryfeeling of throat 17 (22.4%) 2) slight hoarseness 11 (14.5%) 3) choking by long conversation 1 (1.32%) 4) slight dysphagia 2 (2.6%) The larynx was mirrored indirectly by T?rk's, Killian's and Avellis's position. Any redness, swelling of mucous membrane, abnormality of vocal cords and arytenoid cartilage were not found. en-copyright= kn-copyright= en-aut-name=OdaRei en-aut-sei=Oda en-aut-mei=Rei kn-aut-name=小田ﾔ kn-aut-sei=小田 kn-aut-mei=ﾔ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=5 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The involvement of ear and throat in rheumatoid arthritis I. Hearing in patients with rheumatoid arthritis kn-title=慢性関節リウマチの耳科･咽喉科領域における障害について 第1報 : 慢性関節リウマチ患者における聴力障害について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Since Copeman's report on patients with hearing impairment as "rheumatoid otoarthritis?" has introduced, there have been a few reports on hearing impairment in patients with rheumatoid arthritis such as Goodwill et al. and Djupesland et aI. in European countries. On the contrary in our country there is no reference in association with hearing impairment of rheumatoid arthritis in rheumatic or otological literatures. An audiometric survey was carried out in 76 patients admitted in the Misasa branch hospital of Okayama university school of medicine on the classical or definite rheumatoid arthritis. Patients were excluded from the series if they had scarred or perforated tympanic membrane and history of otorrhea. Thus 67 patients have come to study. As control group, 15 healthy persons in hearing for each ten years, 15-24, 25-34, 35-44, 45-54, 55-64, and over 60 years, were selected and as a physiological hearing limit, rejection limit of hearingloss in dB. was made. Among 67 patients, 111 ears had hearingloss within the above mentioned rejection limit. In 23 ears, hearingloss in dB. were partial or as a whole out of the limit. They have all air-bone-conduction gap. After inflation of Eustachien tube, in most of them air conduction ability showed nearly the same level of bone conduction. In three cases even by inflation, airconduction level did not move. In one case the left side had effusion liquid and its RAreaction was positive. TwO of the former patients and the one whose effusion liquid had positive RA-test followed up for about 3 years. In the former two cases, hearing impairment got worse little by little and recovery by inflation was not seen. On both cases Gelle's test was positive. In the latter hearing impairment slowly got worse. This had lasted for about two months and had recoverd. In the se four cases heairng impairment was probably related to the rheumatoid arthritis and no other causes could be found. en-copyright= kn-copyright= en-aut-name=OdaRei en-aut-sei=Oda en-aut-mei=Rei kn-aut-name=小田ﾔ kn-aut-sei=小田 kn-aut-mei=ﾔ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=69 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The treatment of rheumatoid arthritis with D-penicillamine. Preliminary report kn-title=慢性関節リウマチにおけるD-Penicillamine療法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty patients with classical or definite rheumatoid arthritis were treated with D-Penicillamine. Favorable responses were observed in 75% of the patients. Significant improvement in clinical parameters, such as ESR, CRP, titers of rheumatoid factor and so forth, was noticed in twenty weeks of treatment. Withdrawal from penicillamine treatment was necessitated in four patients because of adverse reactions to the drug. Untoward effects included skin rash (most frequent), pruritis and loss of taste. From this preliminary study we presume that in earlier cases in which rheumatoid lesions may be reversible, more favorable clinical effects would be expected from this agent. en-copyright= kn-copyright= en-aut-name=IshiiHirofumi en-aut-sei=Ishii en-aut-mei=Hirofumi kn-aut-name=石井廣文 kn-aut-sei=石井 kn-aut-mei=廣文 aut-affil-num=1 ORCID= en-aut-name=TakasugiKiyoshi en-aut-sei=Takasugi en-aut-mei=Kiyoshi kn-aut-name=高杉潔 kn-aut-sei=高杉 kn-aut-mei=潔 aut-affil-num=2 ORCID= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=3 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=4 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=41 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Enumeration of T-cells in peripheral blood as well as in joint fluid from patients with rheumatoid arthritis (RA) and the effect of cyclophosphamide kn-title=慢性関節リウマチとT-リンパ球―末梢血,関節液中の分布と免疫抑制剤のおよぼす影響について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gradient centrifugation was quite useful in obtaining "mononuclear" cell fractions from synovial fluids derived from patients with rheumatoid arthritis. The ratio of lymphocytes to monocytoid cells was similar to that seen in peripheral blood. Prior treatment of the fluid with hyaluronidase was found to be necessary to obtain a satisfactory yield of the cells. Sheep erythrocyte rosette-forming lymphocytes (T-cells) were studied in 18 paired samples of synovial fluid and blood in RA and 15 control blood samples from normal persons were also examined. In the paired synovial fluid and blood samples from the RA patients, the mean percentages of the T-cells were 56.6 and 47.1 respectively and the difference was statistically significant (0.01