Author 岡山大学温泉研究所|
Published Date 1962-04-25
Publication Title 岡山大学温泉研究所報告
Volume volume30
Content Type Others
JaLCDOI 10.18926/40204
Title Alternative Effect of Radioactive Hot Spring Baths on Leukocyte Functions (Wandering Velocity and Carbon-Particle Phagocytic Ability)
FullText URL 030_001_013.pdf
Author Inoue, Masakatsu|
Abstract The author studied the influence of a series of radioactive hot-spring baths, lasting 20 or 30 days, upon leukocyte functions in healthy male rabbits and in patients with rhenmatoid arthritis and other diseases. The radioactive hot springs used were "Hisui-no-Yu" and "Kenkyusho-sen" (the laboratory spring), both in Misasa Spa, the chemical compositions of which are deseribed in Table 1. The following results were obtained: 1) Wandering velocity of pseudo-neutrophilic leukocytes: When a series of plain water baths (41℃., for 5 minutes daily), were administered, velocity increased after the first bathing but later remained fairly constant, compared with initial levels, except for a temporary fall on the 9th day (Fig. 3). During the administration of a series of the weakly radioactive "Kenkyushosen" baths (43℃., for 5 minutes daily), it showed a slight increase during the first week, following a temporary fall after the first bathing, and a decrease during the third week, but it tended to return to the initial level by the forth week (Fig. 1). In the course of a series of the radioactive ·Hisui-no-Yu" baths (40℃., for 10 minutes daily), it increased during the first week and tended to decrease during the second week, but returned to the initial level by the third week (Fig. 2). 2) Phagocytic ability for carbon-particles of pseudo-neutrophic leukocytes in rabbits: When plain water baths were given, phagocytic ability showed a rise on the third day, after which it declined to the initial level and remained fairly constant to the end of the observation period (Fig. 6.). On the other hand, the phagocytic ability of the leukocytes in rabbits of the groups receiving radioactive hot-spring baths increased more and more markedly as serial bathing was continued, although it had slightly decreased immediately after the first bathing. The rise of phagocytic ability in the group bathed in "Kenkyusho-sen" was especially marked on the third and ninth days of serial bathing, and also on the tenth day after serial bathing had been discontinued (Fig. 4). This tendency was also observed in the group bathed in "Hisui-no-Yu", whose phagocytic ability was noticeable especially on the third and 14th days. The degree of the rise in phagocytic ability was demonstrably high in this group than in the former (Fig. 5). Acceleration of the phagocytic function of leukocytes in rabbits was observed up to the 40th day after the series of baths in the radioactive hot spring had been concluded. 3) From these findings. it is obvious that leukocyte function is increased by repeated bathing, but it should be kept in mind that a so-called dissociation phenomenon is present between the wandering velocity and the carbon-phagocytic ability of leukocytes in the groups bathed in hot springs: namely, wandering velocity showed a tendency to decline during the third week, while carbon particle phagocytic ability showed a marked increase during the same week. 4) In order to explore the effects of a series of radioactive hot-spring baths on leukocyte functions in patients with rheumatoid arthritis or other similar diseases (for example, back pain, fibrositis or neuritis), the author examined the wandering velocity and the phagocytic ability of neutrophils, and obtained the following results: The wandering velocity of neutrophils in patients with rheumatoid arthritis or similar diseases generally showed a tendency to increase during the adminlstration of a series of the radioactive "Kenkyusho-sen" baths at a temperature of 42~43℃. (Fig. 7). The carbon-particle phagocytic ability of neutrophils gradually increase from about the seventh day onward and reached a maximum during the second week, in patients with back pain, fibrositis and neuritis (Fig. 8a). In patients with rheumatoid arthritis, however, it declined temporarily on the fifth to seventh days in 3 out of 5 patients but thereafter increased gradually, reaching its maximum on the 20th day (Fig. 8b). Thus, the leukocyte functions in patients with rheumatoid arthritis are accelerated by serial bathing, but the response in some patients may be a decline of carbon-particle phagocytic ability during the first week. This is probably due to the stress bathing imposes on adrenocortical functions. It is believed, on the basis of the facts described above, that follow-up examinations of leucocyte functions can afford a better understanding of the effects of radioactive hot springs on the defence mechanisms operative in living bodies.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 1
End Page 13
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40213
language Japanese
File Version publisher
NAID 40017532380
JaLCDOI 10.18926/40205
Title Alternative Balneological Studies of Kaike Hot Springs (I) Effect of the Internal Use of Kaike Spring Water on Gastric Acidity
FullText URL pitsr_030_014_019.pdf
Author Kawata, Yoshiro|
Abstract Kaike Hot Spring is situated at the seaside, in the western part of Tottori Prefecture, Japan. In chemical composition it contains 9.3 g. of salts per kilogram of spring water and may be classified as a common salt spring. The author examined the effect of the drinking of Kaike spring water on gastric acidity in 21 patients. a) Two hundred m!. of this spring water were given to 10 patients by stomach tube at 37℃. The gastric acidity of the patients was measured at 30-minute intervals for a period of 105 minutes following the administration of the spring water. In 3 cases of normal acidity and 6 cases of hyperacidiy, the spring water appeared to inhibit the secretion of gastric acid, compared with the effect of the caffein control water. b) Two hundred m!. of the spring water diluted two-fold with tap water were given to 11 patients. In two cases of normal acidity and two cases of hypoacidity, on significant difference was observed between the effects of the spring water and those of the control water. In all 7 cases of hyperacidity, however, the spring water observably depressed the acid secretion of the stomach, as compared with the effect of the control water. On the basis of these results, the author concludes that it is advisable to use the spring water diluted two-fold with tap water for the purpose of treating gastric disorders.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 14
End Page 19
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002401087
JaLCDOI 10.18926/40206
Title Alternative Environmental Health Aspects of Thermal Spring Bathing (I) Electrocardiographic Findings of Residents in the Spa
FullText URL pitsr_030_020_035.pdf
Author Kitayama, Minoru| Kuwada, Akira|
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 20
End Page 35
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40213
language Japanese
File Version publisher
NAID 120002401088
JaLCDOI 10.18926/40207
Title Alternative The Effect of a Single Bath in Radioactive Hot Spring Water on Portal Circulation Time
FullText URL 030_036_039.pdf
Author Nakahara, Yasuhiro|
Abstract Following Ueda-Yasuda's procedure, the author observed changes on the portal blood circulation time, the blood pressure and the pulse rate of five normal men following a bath in radioactive hot spring water. Measurements were taken three times: 30 minutes before the bath, immediately after the bath, and 30 minutes after the bath (the bath waS either 5 or 10 minutes in duration, and ranged in temperature from 41° to 43℃). Portal blood circulation time immediately after a 10 minute bath waS found to be significantly prolonged as compared with that taken 30 minutes before the bath. The changes in blood pressure and pulse rate observed after bathing were similar to those reported by other authors.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 36
End Page 39
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40213
language Japanese
File Version publisher
NAID 40017532382
JaLCDOI 10.18926/40208
Title Alternative A Statistical and Clinical Study of Postoperative Intestinal Adhesions
FullText URL pitsr_030_040_045.pdf
Author Ohtani, Mitsuru|
Abstract The author studied 36 cases of postoperative intestinal adhesions treated in this insitute during the past ten years. The results obtained were as follow. 1) The sex ratio was 21 (male) to 15 (female). 2) Fifty-three percent of the cases ranged from 20 to 40 years in age. 3) The initial operations which supposedly caused the adhesions were appendectomies. 4) Of the primary causative disease of the acute intetinal obstruction group, appendicitis accounted for 62% and gastrointestinal diseases for 15.4%. The primary causative disease of the chronic intestinal obstruction group was found to be appendicitis in about 70% of the cases. 5) The chief complaints made by patients were of vomiting and generalized Severe pain of the abdomen. 6) The most frequent sites of occurrence of the adhesions were the greater omentum, the small intestine and the sutured part of the peritoneum. 7) As regards the final therapeutic approach, in the largest number of cases (36.% of the total) lysis of the adhesion was performed. In most other cases, however, distress was relieved by enterostomy, resection of the bowel, and so on. Finally, the four most recent cases, all of whom suffered from recurrent intestinal obstrution, were relieved of the major portion of their abdominal complaints by a new method, an improvement of the original technique advocated by Noble in 1937. The details of this new technique will be reported in the next issue.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 40
End Page 45
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002401089
JaLCDOI 10.18926/40209
Title Alternative Some Clinical Observations on the Menopausal Syndrome and its Therapeutic Approach
FullText URL pitsr_030_046_054.pdf
Author Kumamoto, Hirotada|
Abstract In order to observe the effectiveness of the androgen+estrogen therapy used singly or in combination with the meprobamate therapy, the author has determined the menopausal index, the total serum cholesterol and the systolic blood pressure before and after the administration of these treatments. The following results have been obtained. 1) The menopausal index (Kupperman, 1953) declines more markedly fol1owing the application of the combined therapies than after the use of either, administered singly. 2) Total serum cholesterol decreases most pronouncedly following the use of the combined therapies, to a lesser degree following the administration of A+E, still less following a single administration of meprobamate. It has been found, moreover, that although A+E therapy appreciably decreases total serum cholesterol, the effectiveness of meprobamate is slight in this respect. 3) Either therapy tends to stabilize blood pressure, but the combined treatment is more effective in this regard. It may safely be concluded that the use of these therapies singly or combined, will provide one of the most effective therapeutic approaches to the menopausal syndrome, the more especially so because of the absence of side effects, an important consideration when long term treatment, required in most such cases, is contemplated.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 46
End Page 54
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002401090
JaLCDOI 10.18926/40210
Title Alternative Clinical Studies on Gout 1st Report: Five Cases of Gouty Arthritis
Author Kitayama, Minoru| Kuwada, Akira| Kawata, Yoshiro|
Abstract Five cases of gouty arthritis encountered in the clinic of Branch Hospital of Okayama University at Misasa Spa are described. Case 1: Y.I., a man aged 58, was first seen on April 24, 1961. His first symptoms had occurred 10 years previously, when he was awakened by severe pain in the left instep. The attack resolved within a few days, but since that time he had 2 or 3 attacks of acute arthritis each year, at first restricted to the dorsum of his left foot, near the base of the big toe, but later involving the ankles and the knees. These attacks usually lasted about a week, but recently such attacks had become more frequent and tended to last longer. In early January, 1961, he noticed pain and swelling of the fingers and consulted this clinic for the purpose of obtaining balneotherapy. A tophaceous mass the size of walnut was presnt on the left olecranon. Nine determinations of the blood uric-acid level were made, ranging from 8.1 to 10.1 mg. per 100 ml. The serum cholesterol level was 279 mg. per 100 ml. Treatment combining the use of phenylbutazone and balneothenapy was effective. Case 2: J.K., a man aged 80, was first seen on July 25, 1961. For 4 years he had been subject to attacks of acute arthritis affecting the fingers and toes. On July 16, he had sudden severe pain in the instep of the left foot. His son had probable gout. The metatarso-phalangeal joint of the left big toe was swollen and painful. The blood uric-acid level was 10.1 mg. per 100 ml. Treatment combined the use of phenylbutazone, dietary regulation, and the drinking of radioactive spring water. In Oct. 1961, he wrote saying that he had remained free from symptoms of gout and had no further treatment. Case 3: I.M., a man aged 52, was first seen on January 24, 1962. His symptoms began in 1935 (at the age of 25), when he had sudden severe pain in his right big toe, which rapidly became swollen and red. The pain lasted about a month. After this, he had at least one similar attack of joint pain in each of the next 10 years. In 1945, he noticed a pain in the dorsum of his right foot. The attacks have tended to last longer and to involve multiple joints, most recently the knees and hands being also affected. He was treated for rheumatoid arthritis and hypercholesterolemia. About the middle of January, 1962, the swelling which had first appeared on his right foot in 1935 became very painful and was accompanied by fever (38.°5~39.℃.). There was no family history of gout. The metatarso-phalangeal joint of the right big toe was swollen and painful, and the right knee was swollen. Determinations of the blood uric-acid level ranged from 5.5 to 12.0 mg. per 100 ml. The serum cholesterol level was 196 mg. per 100 ml. Therapy with phenylbutazone was started on January 24, 1962, in a total daily dose of 200 mg. and by the middle of Feburary, symptoms had disappeared. He discontinued use of the medication, whereupon a recurrent attack appeared. For the first few days he was given phenylbutazone, 400 mg. daily. This dosage was later reduced to 300 mg. daily, and benemid was added. Case 4: Y.U., a man aged 57, was first seen on Feburary 12, 1962. For 8 years he had been subject to attacks of acute arthritis affecting both insteps. Swelling and limited movement were present in the big toes. He had aural tophi. The blood uric-acid level was 8.2 mg. per 100 ml. Case 5: B.A., a man aged 67, was first seen on April 10, 1962. His first relevant symptoms had occurred 3 years previously, when he developed sudden pain and swelling in his right big toe. The pain lasted about 5 days. Since then he had had similar attacks at the rate of five a year. In March, 1962, he had an attack of joint pain in the right ankle lasting 5 days. The blood uric-acid levels ranged from 5.0 to 9.3 mg. per 100 ml. Administration of phenylbutazone, 200 mg. daily, and balneotherapy relieved the symptoms of gouty arthritis. The Use of balneotherapy in the treatment of chronic gouty arthritis will be discussed in a second paper by the present authors in the next volume of this series.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 55
End Page 65
ISSN 0369-7142
language Japanese
File Version publisher
NAID 40017532379
Author 岡山大学温泉研究所|
Published Date 1962-04-25
Publication Title 岡山大学温泉研究所報告
Volume volume30
Content Type Others
JaLCDOI 10.18926/40211
FullText URL pitsr_030_066_071.pdf
Author Kitayama, Minoru| Kuwada, Akira| Kawata, Yoshiro|
Abstract The authors gathered 78 cases of gouty arthritis reported in Japan between 1898 and 1960, and analysed them statistically. 1. The incidence of gouty arthritis appears to have increased since about the end of the 2nd World War, especially since 1955. 2. The age of the presumptive onset of the disease is lower in Japanese than in white populations. 3. In many cases, the gouty patients were wrongly diagnosed as rheumatoid arthritis, synovitis or panaritium patients, and only 20 per cent of the cases examined were diagnosed correctly at the first consultation. The author stresses that diagnosis at an early stage is necessary to avoid serious complications such as cardiovascular and renal involvements. If the condition is satisfactorily controlled by diets and drugs, however, the prognosis for gouty patients is excellent.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 66
End Page 71
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002401091
JaLCDOI 10.18926/40212
Title Alternative A Clinical Investigation of the Gastric Acidity of 113 Patients with Cholecystopathy
Author Nakahara, Yasuhiro| Ohtani, Mitsuru|
Abstract In order to investigate the relationship between gastric acidity and various clinical and labolatory test findings in patients with cholecystopathy, the authors studied the case records of 113 such patients treated at this institute. The results obtained were as follows. 1) Concerning gastric acidity, 13,6%, of the 113 patients showed hyperacidity; 11,1%, normal acidity; 33, 0%, hypoacidity; and 42,3%, anacidity. 2) A higher percentage of cases showing low gastric acidity was found among those patients with a longer history of the disease. 3) Cases evencing lower level of gastric acidity tended to be characterized by a higher frequency of abnormal laboratory findings and clinical symptoms.
Publication Title 岡山大学温泉研究所報告
Published Date 1962-04-25
Volume volume30
Start Page 72
End Page 76
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40213
language Japanese
File Version publisher
NAID 40017532377
Author 岡山大学温泉研究所|
Published Date 1962-04-25
Publication Title 岡山大学温泉研究所報告
Volume volume30
Content Type Others
Author 岡山大学温泉研究所|
Published Date 1962-04-25
Publication Title 岡山大学温泉研究所報告
Volume volume30
Content Type Others