start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=673
end-page=680
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Physiological agency of 4-M-1No.4 The subacute toxicity test of 4-M-l in rats
kn-title=4-Methylimidazolの生理作用について （第4報） 4-Methylimidazolの亜急性毒性試験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Physiological and biochemical data in rat injected subacute toxicity dose of 4-M-1were investigated. Obtained results were as follows. Some rats had hypertrophic liver after intraperitoneal injection, but had no biochemical difference from others that hypertrophy was not observed.
en-copyright=
kn-copyright=

en-aut-name=HidakaMasao
en-aut-sei=Hidaka
en-aut-mei=Masao
kn-aut-name=日高政夫
kn-aut-sei=日高
kn-aut-mei=政夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一生理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=605
end-page=620
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of antianginal drugs on the myocardial distribution of coronary flow A experimental study using heated cross-thermocouples
kn-title=虚血性心疾患治療薬の心筋内血流分布におよぼす影響(交叉熱電対法による実験的研究)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Effect of anti-anginal drugs on the distribution of blood flow in the left ventricular free wall has been studied using thirty anesthetized open-chest dogs. The regional myocardial blood flows in the inner-(subendocardial) and outer-(sub-epicardial) layer were continuously monitored by heated cross-thermocouples designed according to Grayson's heat exchange principle. The techniques used were essentially the same as that described by Uchida (1970). The antianginal drug (nitroglycerin, 20 μg/Kg; prenylamine, 1 mg/Kg; dipyridamole, 0.3 mg/Kg; or dilazep, 0.2 mg/Kg) was administered intravenously. The results were as follows: (1) No difference in the regional myocardial blood flow between the inner- and outer-layer was observed. The flow ratio of the inner- to the outer-layer (I/O ratio) was 0.97±0.17. (2) Nitroglycerin produced a slight decrease in the flow through the inner-layer in spite of a remarkable drop in coronary perfusion pressure, while it did a marked decrease through the outer-layer. As the result, I/O ratio was significantly elevated after the injection. (3) Prenylamine produced a moderate increase in the flow through the both layers in spite of a remarkable fall in the coronary perfusion pressure. The ratio was rather elevated after a significant initial decline. (4) Dipyridamole caused a marked increase in the flow through the both layers, whereas I/O ratio was only minimaly lowered. (5) A change similar to that caused by dipyridamole was observed except a slight elevation of the ratio from 20 to 30 minutes when dilazep was injected. As mentioned above, these anti-anginal drugs produced different effects on the flow in the both layers. One of the explanation of these differences observed might be that these drugs have different effects on sites of coronary vessels, large intramural conductive vessels or small resistive vessels. Another explanation could be that these drugs cause different effects on the systemic hemodynamics. For the studies on effect of anti-anginal drugs on the intramyocardial distribution of blood flow, it is necessary that the regional myocardial blood flow must be monitored continuously since the intramyocardial distribution of the blood flow can be changed from time to time after the administration.
en-copyright=
kn-copyright=

en-aut-name=HiranoKazuhiro
en-aut-sei=Hirano
en-aut-mei=Kazuhiro
kn-aut-name=平野和博
kn-aut-sei=平野
kn-aut-mei=和博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=593
end-page=604
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Exercise electrocardiographic studies on left ventricular hypertrophy in essential hypertension
kn-title=本態性高血圧症による左心室肥大心電図と運動負荷心電図
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The exercise electrocardiogram of the patients with left ventricular hypertrophy was studied, especially on its STT change. Seventy six patients with essential hypertension, who were under good control, were included for the study. They were 52 males and 24 females. Their ages ranged from 33 to 70 years (the average was 51.6±7.8 years of age). The patients were divided into four groups according to changes in ST segment and T wave on standard 12 lead ECG (�V, aVR were excluded): Group A consisted of 10 subjects, whose ECG showed so-called "Strain Pattern"; Group B included 22 subjects, showing ischemic depression less than 0.5 mm below the isoelectric line or low T wave (T/R≦1/20 and R≧10mm); Group C included 17 subjects, junctional depression was equal to or exceeded 1.0 mm; Group D included 27 subjects without marked STT change. Twenty healthy men (6 males and 14 females) were studied as control. They ranged in age from 20 to 62 (the average was 36.7 ± 14.1 years of age). As a rule, they were subjected to the Master's test (double two step). In the pre-exercise electrocardiogram of Group A, QRS voltage, LAD and QT ratio were significantly greater than any other groups. In the post-exercise electrocardiogram, Group A showed chiefly T wave changes without ST deviation. I could not find any cases in the group with positive responce. Therefore, the "Strain Pattern" with marked QRS high voltage might be secondary STT changes. On the other hand, patients in Group B and D showed mainly ST changes and most of them were determined to have positive responce of the test. So, the STT changes without marked QRS high voltage might be primary changes.
en-copyright=
kn-copyright=

en-aut-name=MinatoTakeshi
en-aut-sei=Minato
en-aut-mei=Takeshi
kn-aut-name=湊武
kn-aut-sei=湊
kn-aut-mei=武
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=571
end-page=591
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Serum dopamine-β-hydroxylase activity in manic depressive psychosis
kn-title=躁うつ病における血清ドーパミン-β-水酸化酵素活性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The serum DBH (Dopamine-β-Hydroxylase) activity in a total of 177 individuals was determined in this study during the period from June 1974 to June 1975. The subjects were 103 manic-depressive psychosis patients and 43 patients with other diseases who had visited the Neurology Department of the Hiroshima City Hospital and 31 healthy subjects included for comparison. Among the 103 manic-depressive psychosis cases, there were 55 cases, 40 with unipolar depression and 15 with bipolar depression, in whom determination of activity was made during both the depressive and remission phases. Further, in 25 unipolar depression and 6 bipolar depression cases, the diurnal variation of activity was measured and studied in detail. The following results were obtained from the above findings. 1. There was marked individual difference in serum DBH activity. Great individual difference was observed in healthy persons also, but in the same individual the value obtained by repeat test perform 9 months after the initial test showed almost the same result and the rate of variation was less than ± 10% . 2. Comparison of the mean values of serum DBH activity among various diseases showed the values to be high in the order of schizophrenia, neurosis, unipolar depression and bipolar depression, but the differences from healthy persons were not significant. 3. Variation in serum DBH activity in manic-depressive psychosis strongly suggested the heterogeneity of unipolar and bipolar depressions. Further it was also assumed that there were heterogeneous diseases mixed among the unipolar or bipolar depression cases, and thus further subclassification was performed. 4. Cases with unipolar depression were classified into 3 groups according to whether the differece in value of serum DBH activity was significantly higher in the depressive phase than the remission phase (Group �T), unchanged (Group �U) and significantly lowere (Group �V). The respective clinical characteristics were as follows: Group �T consisted of 40% of the unipolar depression cases, was made up predominantly of women and a strong feeling of anxiety prevailed, but the subjects responded well to tricyclic antidepressants. Group �U was composed of 32.5%, the subjects were highly irritant and many did not respond well to tricyclic antidepressants. Group �V consisted of 27.5%, was made up predominantly of males, severe psychomotor retardation was present and the subjects responded well to tricylic antidepressants. 5. All cases with bipolar depression presented the characteristic finding of lower activity values during the depressive phase than the remission phase. Cases with manic phase activity values lower than the remission phase were classified as Group �T and those with higher values Group �U. The respective clinical characteristics were as follows: Group �T was composed of 69.2% of the bipolar depression cases of whom many changed to mania within a short period of time after their depressive phase making it appear as if the depressive and manic phases were one single continuous phase. Group �U was composed of 30.8% and was frequently found in those with a marked manic phase only or in those whom the manic or depressive phase developed independently. 6. The diurnal variation of serum DBH activity in manic-depressive psychosis was not of a fixed pattern such as being low in the morning and high at noon. However, many presented a similar rhythm for both the depressive and remission phases of the disease, but the rate of diurnal variation was greater during the depressive or manic phase than the remission phase. The rate of diurnal variation during the remission phase was about ± 10%.
en-copyright=
kn-copyright=

en-aut-name=MoritaHironori
en-aut-sei=Morita
en-aut-mei=Hironori
kn-aut-name=森田博方
kn-aut-sei=森田
kn-aut-mei=博方
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=社会保険・広島市民病院・神経科
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=553
end-page=570
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the antigenicity of lymphocyte membrane Part�U Immunizing experiment on mice
kn-title=リンパ球膜の抗原性に関する研究 第2編 マウス感作実験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Further investigation concerned on the antigenicity of the lymphocyte membrane was performed in this paper using C57B1 mice and purified lymphocyte membranes which were preparated from either calf thymic lymphocyte (TM) or bovine intestinal lymphnode lymphocyte (LM). The detail of the methods for the purification of lymphocyte membrane were described in the part �T of this article. Intraperitoneal injection of 5, 10 or 100γ of lymphocyte membrane was performed once a week untill 5 weeks. The peripheral blood pictures, diameter of lymphocyte, histological studies on the thymus, lymphnode and spleen, serum protein electrophoresis, immunoelectrosyneresis, RFC and PHA reactivity were examined in these immunized mice. The lymphocytes both in the peripheral blood and lymphatic organs were diminished profoundly in the mice immunized with TM. Especially the lymphocytes in the T dependent area of spleen and lymphnode as well as in the cortical area of the thymus decreased intensively in contrasting with a decrease of B cell area of spleen and lymphnode in the mice immunized with LM. The lymphocyte depletion in the lymphoid organs of the mice immunized with 100γ LM had a similar pattern to those of mice immunized with TM indicating the contamination of TM into the LM preparation up to approximately 6-8%. Temporary increase of α1-globulin, α2-globulin and α3-globulin in this order was noted in serum of the mice immunized with TM, being followed by hypergammaglobulinemia. On the other hand an increase of α3-globulin and then of γ-globulin appeared rapidly in the mice immunized with LM. The discrepancies on the tissue reaction and protein fraction of these two groups suggested the difference of antigenicity between TM and LM on the activation of antibody-forming system.
en-copyright=
kn-copyright=

en-aut-name=KobashiHidehiro
en-aut-sei=Kobashi
en-aut-mei=Hidehiro
kn-aut-name=小橋秀広
kn-aut-sei=小橋
kn-aut-mei=秀広
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=545
end-page=551
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunological studies on chronic myelogenous leukemia Part �U. Humoral immunity in chronic myelogenous leukemia
kn-title=慢性骨髄性白血病の免疫学的研究 第二編 体液性免疫の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To study the humoral reactivity in chronic myelogenous leukemia (CML), the author examined immunoglobuline levels, immune adherence hemagglutination test (IAHA) and lymphocytotoxicity test on the 24 patients admitted to our clinic. The following data were obtained: 1) The 19 patients, whose serum immunoglobuline levels were examined, were all within normal range with mean values of IgA 203±74mg/dl, IgG 1463±275mg/dl and IgM 182±67mg/dl. 2) IAHA was positive in 4 of 24 patients (16.7%) and the reactivity was correlated with the number of peripheral leukemic cells used as antigen; it was positive in 3 of 9 patients (33.3%) with leukemic cells over 4×10(4)/μ 1, but in only one of 15 patients (6.7%) with leukemic cells below 4×10(4)/μ 1. The IAHA test was also correlated with the disease state; none of 4 patients (0%) during blastic crisis of CML showed a positive reaction to their own leukemic cells. 3) Sera from 12 of 17 patients (70.6%) showed a positive lymphocytotoxicity to normal lymphocytes. In its correlation with the disease state, it was positive in 8 of 13 patients (61.5%) during remission and in all the patients (100%) during relapse. From these results it could be concluded that humoral immunity in CML is not so impaired through the clinical course except for blastic crisis.
en-copyright=
kn-copyright=

en-aut-name=ChenPo-min
en-aut-sei=Chen
en-aut-mei=Po-min
kn-aut-name=陳博明
kn-aut-sei=陳
kn-aut-mei=博明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=535
end-page=543
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunological studies on chronic myelogenous leukemia Part �T. Cell-mediated immunity in chronic myelogenous leukemia
kn-title=慢性骨髄性白血病の免疫学的研究 第一編 細胞性免疫の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cell-mediated immunity in chronic myelogenous leukemia (CML) was investigated by means of three kinds of skin tests, including purified protein derivated of tuberculin (PPD), candida and dinitrochrolobenzene (DNCB), and macrophage migration inhibitory test (MIT). Immunological examinations were made on 21 patients with CML, who have been admitted to our hospital or controled in our outpatient department since October 1974, at the same, 20 healthy adults were used as control study. The following results were obtained: �T. Skin tests: 1) Thirteen (61.9%) of 21 patients showed positive reactions to the PPD at least once throughout clinical course of each patient, while positive in 18 (90.0%) of 20 controls. 2) Candida test was attempted on a total of 13 patients. One (7.7%) of these 13 patients showed positive reaction to the candida, while positive in 9 (45.0%) of 20 healthy subjects. 3) Seven (41.2%) of 17 patients showed positive reactions to the DNCB sensitization, while all of 20 controls proved to be positive. 4) The results of PPD skin test were analyzed according to the stages in clinical course of each individual. Positive reactions were obtained from 50% of the patients at pretreatment stage, 66.6% at remission stage, 20% at relapse stage and 16.6% at blastic crisis. 5) The PPD skin test changed from negative, or false positive, to positive in 5 of 21 cases who had achieved remission during the observation period, while it changed from positive to negative in one case who had relapsed during the same period. It kept positive in 4 of 8 cases who had maintained remission, and kept negative in one relapsing case having failed to achieve remission. In 2 of 6 cases who had a blastic crisis during the observation period, it was positive before the crisis and became false positive after the crisis. According to these results a significant correlation was found between PPD and clinical stage of CML. �U. Macrophage migration inhibitory test (MIT): 1) In the preliminary studies, the optimal ratio was determined that 10(6) lymphocytes react properly to 0.1ml antigen fluid, which is equivalent to 0.11-0.03μ g of protein level and is extracted from the leukemic cells by means of sonication. 2) Eight (53.3%) of 17 patients were regarded as positive in allo-antigen system of MIT and 5 (55.5%) of 9 patients in auto-antigen system. Because of the difficulty of collecting lymphocytes, all MIT were conducted only in the remission stage of each patient. From these results, the following conclusion can be made. Cellular immunity in CML is somewhat impaired at pretreatment or relapsing stage. It is, however, repaired mostly at remission stage and it has a close correlation to clinical stage of CML.
en-copyright=
kn-copyright=

en-aut-name=ChenPo-min
en-aut-sei=Chen
en-aut-mei=Po-min
kn-aut-name=陳博明
kn-aut-sei=陳
kn-aut-mei=博明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=527
end-page=534
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A report of field survey on acatalasemia and hypocatalasemia in 1972 and 1973
kn-title=昭和47年度および48年度 Acatalasemia, Hypocatalasemia 調査集計
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The authors reported the results of field survey on acatalasemia and hypocatalasemia during the year of 1972 and 1973. Seventeen hypocatalasemias were seen in the test of 7,475 individuals at Oahu Is. of Hawaii, U.S.A. Among them two Englishmen, one Portugese and three Filipinos were included. One new acatalasemia case was reported in 1972. Consequently, the total of reported acatalasemias were 97 cases of 47 families by the end of 1973.
en-copyright=
kn-copyright=

en-aut-name=TanakaTohru
en-aut-sei=Tanaka
en-aut-mei=Tohru
kn-aut-name=田中徹
kn-aut-sei=田中
kn-aut-mei=徹
aut-affil-num=1
ORCID=

en-aut-name=TakaharaShigeo
en-aut-sei=Takahara
en-aut-mei=Shigeo
kn-aut-name=高原滋夫
kn-aut-sei=高原
kn-aut-mei=滋夫
aut-affil-num=2
ORCID=

en-aut-name=OguraYoshio
en-aut-sei=Ogura
en-aut-mei=Yoshio
kn-aut-name=小倉義郎
kn-aut-sei=小倉
kn-aut-mei=義郎
aut-affil-num=3
ORCID=

en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=増田游
kn-aut-sei=増田
kn-aut-mei=游
aut-affil-num=4
ORCID=

en-aut-name=ArakawaKiyoshi
en-aut-sei=Arakawa
en-aut-mei=Kiyoshi
kn-aut-name=荒川清
kn-aut-sei=荒川
kn-aut-mei=清
aut-affil-num=5
ORCID=

en-aut-name=KasaiHideo
en-aut-sei=Kasai
en-aut-mei=Hideo
kn-aut-name=笠井英夫
kn-aut-sei=笠井
kn-aut-mei=英夫
aut-affil-num=6
ORCID=

en-aut-name=TaniWataru
en-aut-sei=Tani
en-aut-mei=Wataru
kn-aut-name=谷互
kn-aut-sei=谷
kn-aut-mei=互
aut-affil-num=7
ORCID=

en-aut-name=ShibaKanji
en-aut-sei=Shiba
en-aut-mei=Kanji
kn-aut-name=芝侃司
kn-aut-sei=芝
kn-aut-mei=侃司
aut-affil-num=8
ORCID=

en-aut-name=KurodaYasuo
en-aut-sei=Kuroda
en-aut-mei=Yasuo
kn-aut-name=黒田泰生
kn-aut-sei=黒田
kn-aut-mei=泰生
aut-affil-num=9
ORCID=

en-aut-name=OkamotoKaneko
en-aut-sei=Okamoto
en-aut-mei=Kaneko
kn-aut-name=岡本かね子
kn-aut-sei=岡本
kn-aut-mei=かね子
aut-affil-num=10
ORCID=

en-aut-name=OhkuraKoji
en-aut-sei=Ohkura
en-aut-mei=Koji
kn-aut-name=大倉興司
kn-aut-sei=大倉
kn-aut-mei=興司
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=11
en-affil=
kn-affil=東京医科歯科大学人類遺伝研空室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=515
end-page=526
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Light and electron microscope study on the nature of the inclusion body in spheroid alveolar epithelial cells
kn-title=円形肺胞壁細胞の封入体の本態についての光顕的―と電顕的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Light and electron microscope studies on the spheroid alveolar epithelial cells of the lung in mice were conducted. By the light microscopy it was found that in the case of the intraperitoneal injection of H(3)-thymidine, S(35)-DL-cysteine and S(35)-H(2)SO(4) into mice, most of siliver particles deposit in the cytoplasm and nucleus of spheroid alveolar cells. In observing this phenomenon by the electron tracers, the above tracers enter not only into the nucleus but also into mitochondria, degenerated mitochondria, and into inclusion bodies of myelin-type or lamellar microbodies in the cytoplasm of the spheroid alveolar cells. From these results it is understood that the inclusion body not clarified at present is formed by the degeneration of mitochondria. This inclusion body seems to be a kind of cytolysomes and by various enzymes contained in it, nucleic acids, proteins, mucopolysaccharides, phosphoric acid ester, and glucuronide are dissolved and finally they are reduced into the myeline figure substance as the endproduct. The endproduct is to be secreted into the alveolar lumen from the spheroid alveolar cell.
en-copyright=
kn-copyright=

en-aut-name=SuwaKiichi
en-aut-sei=Suwa
en-aut-mei=Kiichi
kn-aut-name=諏訪喜一
kn-aut-sei=諏訪
kn-aut-mei=喜一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部解剖学教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=505
end-page=513
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Light and electron microscope observations of the structures of the elastic components in the arterial wall and their functional, structural mechanism
kn-title=動脈壁の弾性成分の構造の光顕的ーと電顕的検査及びその構造の機能的形成機序について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=From both the light and electron microscope observations of histological structure and mechanisms of contruction of arterial wall, the functional, formative mechanisms of elastic membrane of arterial wall may be explained as follows: The fundamental type of artery is the muscular-type artery in which the chain of smooth muscle cells runs criss-cross wise from left to right or vice versa in Archimedes spiral formation as viewed from the upper surface. That further differentiates and the chain disintegrates, resulting in individual smooth muscle cells bridging between the elastic membranes to form an elastic-type artery. In the case of the muscle-type artery of a relatively high differentiation, the smooth muscle cell chain is divided into equal parts each of which forms an individual Archimedes segment composed of original elastic components. In the case of elastic-type artery within such a segment, cells become individual smooth muscle cells. The elastic component ejected from the cytoplasm of each smooth muscle cell forms the elastic fiber sheath by its kinetic movement. This sheath in the muscle-type is divided into two equal numbers in the center of the above segment, and longitudinal sheath-segments of about one fourth of the original size separate to left and right, then at the horizontal level they form Archimedes segments with the original elastic networks by attaching themselves to the anterior-posterior surfaces and the lateral surface. However, only the inner layer of the internal elastic membrane is formed by the elastic prefibers of high ascending angle produced by endothel cells. In the case of elastic-type artery, the elastic sheath containing the individual smooth muscle cell is similarly divided into two equal parts at the center, which are further split up longitudinally that reinforce the original elastic network to form an elastic membrane. In each elastic sheath there are formed a spiral ascending fiber in the direction of the longitudinal axis and a fiber of approximately circular shape, the former of which becomes an ascending fiber and the latter becomes the longitudinal fiber of the elastic membrane. Therefore, the ascending angle of fiber of the elastic membrane is equal at the opposite surface of the stroma. In addition, the reason why the ascending angle of fiber is higher in the outer-layer fiber than in the inner-layer fiber is because the twisting phenomenon by contracting movement of the smooth muscle cells is stronger in those of the outer layer and the ascending angle of the fiber of elastic sheath is lower in the outer side.
en-copyright=
kn-copyright=

en-aut-name=SuwaKiichi
en-aut-sei=Suwa
en-aut-mei=Kiichi
kn-aut-name=諏訪喜一
kn-aut-sei=諏訪
kn-aut-mei=喜一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部解剖学教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=497
end-page=504
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Light and electron microscope observations of the structures of elastic-type artery and muscular-type artery and their functional, formative mechanism
kn-title=弾性型動脈と筋型動脈の光顕的ーと電顕的検査及びそれらの構造の機能的形成機序
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The arterial wall is all consisted of the chain of fibroblasts that run stereoscopically crisscrossing with each other in the Archimedes spiral formation, as viewed from the upper surface, originating from the endothel cells in the initial embryonic stage, and also with the heterogenous fibroblasts that continue in the same spiral direction. The endothel cells form the elastic prefibers of the subendothelial layer, while the fibroblasts of tunica media which form Archimedes spiral, construct elastic and collagenous fibers and transform into smooth muscle cells. On the other hand, heterogenous fibroblasts construct collagenous and elastic fibers of tunica adventitia. This chain of the smooth muscle cells of tunica media that retains Archimedes spiral, as viewed from the upper surface, is the muscular-type artery and the one that has differentiated and each smooth muscle cells have bridged between elastic membranes is the elastic-type artery.
en-copyright=
kn-copyright=

en-aut-name=SuwaKiichi
en-aut-sei=Suwa
en-aut-mei=Kiichi
kn-aut-name=諏訪喜一
kn-aut-sei=諏訪
kn-aut-mei=喜一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部解剖学教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=7-8
article-no=
start-page=493
end-page=496
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Theoretical study on the structural mechanism of the valves of the venous and thoracic duct wall
kn-title=静脈壁と胸管壁の弁膜の形成機構についての理論的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The height, the size and the interval space of the valves of the vena saphena magna and the ductus thoracicus of adult dogs were measured. As a result it was found that except for a slight difference the height of the valves could be represented by 1/4 wave length, and the interval space between the upper margins of the valves by 1/2 wave length. Such a slight difference seems to be due to the difference in the growth of the venous and thoracic duct wall. From the vascular structure the structural mechanisms of the valves have been described hemodynamically.
en-copyright=
kn-copyright=

en-aut-name=SuwaKiichi
en-aut-sei=Suwa
en-aut-mei=Kiichi
kn-aut-name=諏訪喜一
kn-aut-sei=諏訪
kn-aut-mei=喜一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部解剖学教室
END