start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=1035
end-page=1036
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the influence of mineral ions on bacterial respiration Report II: The mutual action between mineral ions and such substances as inhibitor and antibiotics
kn-title=抄録  抗Histamine剤のリンパ生成に対する作用，ならびにそれが二，三催リンパ物質の作用に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山崎英正
kn-aut-sei=山崎
kn-aut-mei=英正
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=前田寛
kn-aut-sei=前田
kn-aut-mei=寛
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部薬理学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部薬理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=1023
end-page=1034
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the influence of mineral ions on bacterial respiration Report II: The mutual action between mineral ions and such substances as inhibitor and antibiotics
kn-title=金属イオンの細菌の呼吸に及ぼす影響 第2篇 金属イオンと酵素阻害剤及び抗生物質との相互作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As reported before, washing of organisms results in the decrease of their respiration. The addition of mineral ions can restore that decrease, of which, however, the restorationis to a different extent according to the species of organisms and the sorts of substrates. This experiment is performed to study one aspect of the enzyme system of bacterial respiration, by observing the influence of inhibitors and antibiotics on this action of mineral ions. Organisms: Staphylococcus albus, Bacillus dysenteriae (Komagome B III) and Bacillus pyocyaneus. Substrates: Pyruvic acid, α-ketoglutaric acid, glutamic acid and α-glycerophosphoric acid. Mineral ions: Mg(++) and Fe(++) of four different concentrations. Inhibitors: KCN, D. N. P. and monoiodoacetic acid.
Antibiotics: aureomycin, chloramphenicol and penicillin. 1) KCN: The inhibitory action of this substance is antagonized by the mineral ions of high concentration, of which Fe(++) is much more antagonistic than Mg(++). 2) D. N. P.: The inhibitory action of this substance is increased in the case where the bacterial respiration is also increased by the mineral ions. 3) Monoiodoacetic acid: This shows more inhibitory action in the case where the mineral ions are in high concentration. 4) Aureomycin: The inhibitory action of this antibiotic is remarkably antagonized by the mineral ions of high concentration. At the point where Mg(++) is the most effective, however, this shows the most noticeable inhibitory action. 5) Chloramphenicol: This shows little inhibitory action against the respiration of organisms and also has no relation with mineral ions. 6) Penicillin: This is effective to promote the respiration of organisms. It is even more effective in the presence of Mg(++) except in the case of Bacillus dysenteriae. However, its promotive action disappears in the presence of Fe(++).
en-copyright=
kn-copyright=

en-aut-name=AkazawaHiroshi
en-aut-sei=Akazawa
en-aut-mei=Hiroshi
kn-aut-name=赤沢広
kn-aut-sei=赤沢
kn-aut-mei=広
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=1009
end-page=1021
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the influence of mineral ions on bacterial respiration Report I: The decrease of respiration by washing organisms and the influence of mineral ions on it
kn-title=金属イオンの細菌の呼吸に及ぼす影響 第1篇 細菌体洗滌に依る呼吸減少と之に及ぼす金属イオンの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This experiment was performed to study the influence of washing on bacterial respiration and, moreover, to study the effects of various mineral ions on it. Organisms: Bacillus dysenteriae (Komagome B III and Ohno's bacillus) Bacillus coli communis, Bacillus coli communior, Staphylococcus aureus, Staphylococcus albus, Bacillus pneumoniae, Bacillus pyocyaneus, Bacillus proteus (H and Otype) and Bacillus cholerae. Substrates: glucose, α-ketoglutaric acid, pyruvic acid, succinic acid and malic acid. Mineral ions: Fe(++), Fe(+++), Mg(++), Cu(++) and Zn(++) 1) The decrease of respiration by washing varies according to the species of Organisms and the sorts of substrates. 2) The organisms of which respiration is remarkably decreased by washing are Staphylococcus and Bacillus coli. However, the respiration of Bacillus proteus and Bacillus pneumoniae is little decreased by washing. 3) The substrates in which the washing of organisms results in noticeable decrease of bacterial respiration are glucose and pyruvic acid. However, it shows little decrease in malic acid. 4) The addition of mineral ions can restore the respiration decreased by washing, of which the degree of restoration is, however, different according to the species of organisms and the sorts of substrates. 5) The most effective method for adding the mineral ions is to wash organisms with buffer containing the mineral ions and then suspend the washed organisms in the same buffer as that used for washing.
en-copyright=
kn-copyright=

en-aut-name=AkazawaHiroshi
en-aut-sei=Akazawa
en-aut-mei=Hiroshi
kn-aut-name=赤沢広
kn-aut-sei=赤沢
kn-aut-mei=広
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=995
end-page=1008
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Synthetic Anthelmintics Part 4. Toxicologic Studies on Alkylresorcinols and Alkylchlororesorcinols
kn-title=合成駆虫薬の研究 第4編 Alkylresorcinols及びAlkylchlororesorcinolsの毒性に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Comparative studies of the pharmacological action, especially the toxicity and local irritant properties, was carried out on six compounds which showed marked anthelmintic effect in the foregoing experiments, i.e., 4-n-amylresorcinol (AR), 4-isoamylresorcinol (iso AR), 4-n-hexylresorcinol (HR), 4-n-hexyl-6-chlororesorcinol (HCR), 4-n-octyl-6-chlororesorcinol (OCR), and 4-cyclohexyl-6-chlororesorcinol (CHCR). 2. Oral toxicity in mice, administered as an aqueous suspension, of these compounds were found to be in the order of AR>isoAR>HR>CHCR>HCR>OCR, which agrees with the order of their solubility in water. Principal acute symptom is motor paralysis, and impairment of respiration was the direct cause of death. At times, however, delayed death occurred several days after administration. Oral toxicity was found to be weakened by the addition of olive oil to the chemical. Lethal dose by subcutaneous injection was found to be greater than that of oral administration but the order of LD50 was unchanged. Toxicity on injection into the lymph sac of a frog was in the same order. 3. Slow intravenous injection of CHCR in a rabbit of 2-3 kgm. weight showed that in a dose below 20 mgm./kgm, there were no change in blood pressure or respiration but in 40-50 mgm./kgm. dose, respiration ceased followed by the stoppage of heart beat about 5 minutes later. Artificial respiration administered just before heart failure was successful in reviving the animal. 4. Local irritant action of the six compounds was tested with human tongue, rabbit conjunctiva, shaved skin of a rabbit, and the mucous membrane of the excised dog intestine, and the order of the strength of local irritation agreed well with the foregoing order of toxicity. 5. Administration of 0.2gm./kgm. of the three alylresorcinols in rabbit for five consecutive days failed to give any marked injuries to the gastric membrane but administration of 0.5gm/kgm. of any of these compounds for three days caused erosion, ulceration, and necrosis. 6. Administration of HR as an olive oil solution into the cat stomach with a tube caused death in all three cats tested at 0.3-0.4gm./kgm. dose. The toxicity of other five compounds were greater or lesser than HR, in the same order as in the case of the mouse. The toxic symptom was an ascending paralysis beginning with the hind leg, with a marked restlessness and excitement in the initial period. Acute death was caused by respiration failure and delayed death was more often observed than in the case of the mouse. In acute death, methemoglobin absorption line was seen in the blood of some animals. Toxicity of the aqueous suspension was greater than that of the oil solution. Injuries to the mucous membrane of a cat stomach were reddening, petechial hemorrhage, erosion, and ulceration, in varied degree. The most strongest injury appeared in largest frequencies in alkylresorcinols, and OCR, which had the weakest irritating properties, caused no such injuries even in the same dose as those of the other compounds. 7. Administration of 0.2gm./kgm. in a dog, three times a week for 4-5 weeks, or 0.1gm./kgm. of crystals for 60 consecutive days caused transitory vomiting, loss of appetite, albuminuria, or slight anemia in some animals during the period of administration but no abnormalities were encountered in the others. These symptoms were also more frequent in the two amylresorcinols (AR and isoAR) and were more rarer in the chlorinated derivatives than in HR. Superficial lesion of gastric membrane was observed by 1-3 administrations of 0.05-0.1gm./kgm., but the degree of such injury was much lighter than in the case of a cat. Gastric injuries caused by a long period administration were not necessarily stronger than that caused by a short use. Intestinal injuries chiefly appeared in the duodenum and the large intestines, but in lesser degree than those in the stomach.
en-copyright=
kn-copyright=

en-aut-name=AshikagaMitsuaki
en-aut-sei=Ashikaga
en-aut-mei=Mitsuaki
kn-aut-name=足利三明
kn-aut-sei=足利
kn-aut-mei=三明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部薬理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=985
end-page=993
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Synthetic Anthelmintics Part 3. Anthelmintic Studies on Alkylresorcinols and Alkylchlororesorcinols
kn-title=合成駆虫薬の研究 第3篇 Alkylresorcinols及びAlkylchlororesorcinoisの駆虫学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Anthelmintic effect in vitro against human and hog ascaris was examined with a total of 27 kinds of 4-alkyl-, 4-alkyl-6-chloro-, 4-alkyl-6-bromo-, and 4-alkyl-2, 6-dichloro-resorcinols in 1:1,000 to 1 2,000 dilutions. Based on the results thereby obtained, 14 kinds of compounds of alkylresorcinol and alkylmonochlororesorcinol series were submitted to anthelmintic treatment in man and their effect was examined by the egg-counting and worm-counting methods. 2. The in vitro effect of alkylresorcinols and their monochloro derivatives was found to be the strongest in hexylresorcinol and became weaker with a larger or smaller number of carbon atoms in the alkyl group. Comparison of the corresponding compounds showed that the alkylresorcinols generally possessed a stronger action than their monochloro derivatives. 3. Anthelmintic effect of alkylrescrcinols in man was also the strongest in the hexyl compound, followed by amyl- and heptyl-resorcinols. In the monochloro derivatives, their anthelmintic effect did not follow the order of their in vitro effect, effect, stronger than hexylresorcinol (m. p. 68-69°) being shown by amyl-(m. p. 43-44°), hexyl-(m. p. 46-48°), heptyl-(m. p. 45-47°), and octyl-chlororesorcinols (m. p. 49-51.5°), as well as by cyclo-hexylchororesorcinol (m. p. 86-88°), whose non-chlorinated compound was totally ineffective. 4. Ascaridical effect of alkylresorcinols decreased by the introduction of one bromine or two chlorine atoms.
en-copyright=
kn-copyright=

en-aut-name=AshikagaMitsuaki
en-aut-sei=Ashikaga
en-aut-mei=Mitsuaki
kn-aut-name=足利三明
kn-aut-sei=足利
kn-aut-mei=三明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部薬理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=977
end-page=984
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Synthetic Anthelmintics Part 2. Anthelmintic Studies on Phenothiazine and Phenothiazone
kn-title=合成駆虫薬の研究 第2篇 Phenothiazine及びPhenothiazoneの駆虫学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Phenothiazine does not possess ascaricidal effect in vitro but was found to effect paralysis of ascaris in a motionless state, in a comparatively dilute solution. These observations have prompted further detailed anthelmintic studies. 2. A total of up to 12 gm. of phenothiazine was administered to 625 ascariasis patients for 1-5 days in various doses and their anthelmintic effect was examined in detail by the egg-counting and also worm-counting methods. It was thereby found that the chemical possessed anthelmintic effect against ascaris and pin-worm but in the dose used, the effect was not superior to that of 0.1 gm. (0.05gm.×2)of santonine against the former. 3. ·Oral administration of 0.2 gm./kgm. of phenothiazine to rabbits and dogs for over 5 consecutive days caused temporary decrease of erythrocytes and hemoglobin content, and transitory increase of leucocytes and reticulocytes. 4. Effect of phenothiazone in causing motionless state of ascaris in vitro and anthelmintic effect in man were far weaker than those of phenothiazine.
en-copyright=
kn-copyright=

en-aut-name=AshikagaMitsuaki
en-aut-sei=Ashikaga
en-aut-mei=Mitsuaki
kn-aut-name=足利三明
kn-aut-sei=足利
kn-aut-mei=三明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部薬理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=965
end-page=975
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Synthetic Anthelmintics Part 1. Anthelmintic Studies on Diphenyl Ethers and Allied Compounds
kn-title=合成駆虫薬の研究 第1篇 Diphenyl Ether誘導体及び類似化合物の駆虫学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Anthelmintie studies were systematically carried out on 77 kinds of diphenyl ethers and allied compounds. Of these, the compounds which were able to kill the human ascaris-removed by santonin-within one hour by continued immersion in 1 1, 000 dilution of the chemical were 3-hydroxydiphenyl ether (I), 4-hydroxydiphenyl ether (II), 3-hydroxydiphenyl ether carbamide (III), 4, 4'-dimercaptodiphenyl ether (IV), 4-hydroxydiphenylmethane (V), 2-hydroxydipllenylmethane carbamide (VI), 4-hydroxydiphenylmethane carbamide (VII), 2-phenylphenol (VIII), and 2-chloro-4-phenylphenol (IX). The toxicity of I, which was albe to kill ascaris in the shortest period, in mice was slightly weaker than that of hexylresorcinol (HR) but it was more irritant than HR, and its effect on ascaris treatment in man was unreliable. The irritant properties of VIII and IX were about the same as that of HR, and that of II, III, IV, and V was weaker, and VI and VII were non-irritating. Clinical anthelmintie effect of II, III, and VIII was very weak.
en-copyright=
kn-copyright=

en-aut-name=AshikagaMitsuaki
en-aut-sei=Ashikaga
en-aut-mei=Mitsuaki
kn-aut-name=足利三明
kn-aut-sei=足利
kn-aut-mei=三明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部薬理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=959
end-page=963
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Studied of Opticomyelitis
kn-title=視神経脊髓炎の一例について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I expirienced a patient of Devic's disease in a young woman. The onset of this case is sudden and complain headache, vomiting, Cramp and grip, and then followed visual disturbance and difficulty in walking and ataxia. Visual disturbance is no other than retrobulbar neuritis. Walking is ataxic and spastic just like a drunkard and appear paraplegia of legs. Ataxia is lokomotive and static ataxia of body and extremity and complains vertigo and nystagmus, adiadochokinesis, Romberg's sign, asinergia, pastpointing. Those sign considered as cerebellum disturbance, and prove extension of pathologic process in optic nerves, spinal cord and cerebellum. Those symptoma gradually recovered but sometimes appear aggravation and is just like multiple sklerose and differential diagnose is difficult without necessary observation.
en-copyright=
kn-copyright=

en-aut-name=MitsuiHaruya
en-aut-sei=Mitsui
en-aut-mei=Haruya
kn-aut-name=三井春也
kn-aut-sei=三井
kn-aut-mei=春也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山医科大学病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=951
end-page=957
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Frequency of Mental Diseases in Japan
kn-title=本邦精神疾患頻度に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=From the data gathered by myself and other investigators up to 1954 in every district of Japan, I have chosen those of the mother population according to the law of X(2)-distribution and from their average value have concluded that the corrected frequency of principal psychoses in rural districts of Japan is as follows:-
en-copyright=
kn-copyright=

en-aut-name=OchoYakichi
en-aut-sei=Ocho
en-aut-mei=Yakichi
kn-aut-name=大重彌吉
kn-aut-sei=大重
kn-aut-mei=彌吉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部精神病学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=933
end-page=949
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Frequency of Mental Diseases in Mountain Villages in Kume-Gun, Okayama Ken
kn-title=岡山県久米郡山村に於ける精神神経疾患頗度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I have made a report about two villages which may be regarded as random samples of farm villages in mountainious districts, to offer such materials as will help to make accurate statistics in future. Schizophrenia shows a percentage of 0.49 to the population, the corrected frequency being 1.01% (dangerous age 16-40; referred number 2168.0), the percentage of manicdepressive psychosis in 0.04, the corrected frequency 0.12% (dangerous age 21-50; referred number 1710.0) and the percentage of essential epilepsy is 0.11. the corrected frequency 0.17% (dangerous age 21-30; referred number 2922.0).
en-copyright=
kn-copyright=

en-aut-name=OchoYakichi
en-aut-sei=Ocho
en-aut-mei=Yakichi
kn-aut-name=大重彌吉
kn-aut-sei=大重
kn-aut-mei=彌吉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部精神病学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=919
end-page=932
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The experimental study of Colibacteriophage Report II On the phage growth by nucleus & nuclear substance of blood corpuscle
kn-title=大腸菌ファージの実験的研究 第二編 血球核及び核様物に依る大腸菌ファージの増殖について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In my method for the separation and purification of the colibacteriophage, I employed the chromatograph; but I examined the bacteriosolving phenomenon of the phage by using host bacteriofiltrate and rabitt antiserum for host bacterium, as well as, nucleus and nuclear substance of the blood corpuscle of cock and tortoise. In the former I did not get a good result, but I found that the phage growth was accelerated in a high degree in the latter, and consequently this report was written. First, I defibrinierted the 2cc. blood of cook and tortoise, and made the bloodsuspension by ordinary method and then centrifuged it; added distilled water to the blood-corpuscle after the centrifugation, oscillated, mixed well, and demolished the protoplasm by distilled water. As soon as the white nucleus is suspended uniformly, physiological salt, water is added to it in a large quantity; dissolving the pure dregs which were obtained after severaltimes of centrifugation in 5cc. salt water, I presented the same substance that was completely solved for experiment. Then I dyed and microscoped it, and noticed thickly dyeing nucleus as well as a large number of fine granular substance dottes arround it. The strength of colibacteriophage as contrast was 10(-3), but it rose to 10(-27) when the nucleus and nuclear substance of cock was added to it so that it might he diluted same as the first. Moreover, the strength of phage rose to 10(-20) in the filtrate of this nucleus and nuclear substance. In regard to nucleus and nuclear substance of tortoise, the strength of phage was not so strong as cock, but it rose to 10(-14)
When I heated the nucleus and nuclear substance of cock bloodcorpuscle in the water bath, the degree of growth facility decreased together with the heat, and it seemed that the effect of growth facility is lostt almost at 100-120°C. "The Feulgen Reaktion" of nucleus and nuclear substance of the blood was all positive, and it increased the degree of transparence together with the heat. It was discovered that. DNA is contained in the nucleus of blood together with a little of RNA, and it is difficult to separate the pure nucleus from the blood, so it is considered apparently that the protoplasm has lost its way within it. In a word, both the nucleus and the nuclear substance of the blood are considered that they play an important part in the growth of coli bacteriophage.
en-copyright=
kn-copyright=

en-aut-name=SasakiK.
en-aut-sei=Sasaki
en-aut-mei=K.
kn-aut-name=佐々木峻
kn-aut-sei=佐々木
kn-aut-mei=峻
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=909
end-page=918
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The experimental study of Colibacteriophage Report I Chromatograph of Colibacteriophage
kn-title=大腸菌ファージの実験的研究 第一編 大腸菌ファージのクロマトグラフ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since 1940 the study of phage opened not only the beginning of co-operate study for physicists and chemists, but also the phage came to be clearified its character as the Bacterio Virus gradually. Then the study of phage made not a few contributions to the development of the study of Virus as model material of its kind. Now, these results are due to the endeavors of such scholars as Delbrück, Anderson, Cohen, Putznam, Doermann, Wyckoff and their co-operators mainly. Then, Charles. C. Shepard found out the characteristics of a distinctive nature in paperstrips in the course of investigations for the adsorptive behavior of Viruses. I tried some experiments in the paperchromatograph and capillarglass-chromatograph about the conditions that the phagef of coli-strains being adsorbed and recovered by paper and capillarglass. 1. The solvent employed here was 0.1% bovine serum albumin in 0.1 M sodium chloride. 2. The solution employed was colibacteriophage diluted appropriately in the same solvent. 3. The adsorbent employed was Toyo-filterpaper and capillarglass which were treated previously by 0.01 M hydrochloric acid and then washed by glasswather. 4. The experiments were carried out in an ice-box. At the beginning of an experiment a paperstrip was placed in the test tube so that it might not touch the sides, but touch the 20 ml. of solvent placed beforehand in the bottom of the tube. When the water front passed the second 1.25 cm section, 0.002 ml. of phage diluted in the same solvent appropriately as was placed in the bottom of the tube was quickly placed in the center of the second section and. the paper returned to the position in the tube.
When the water front passed the last marked section, the paper was removed from the tube and ten marked sections were quickly cut off into their respective ten test tubes each containing of a culture of E. coli-strains. For a period of not more than 10 minutes, the ten sections of paper were stirred occasionally and pressed against the sides of the tubes. At the end of it, 0.5 ml. were taken out and added it to 3.0 ml. of 0.7% agar; the resultant 3.5 ml. were mixed up and poured on a 1%, agarplate. There was recovered viable phage in a considerable degree. 5. It seems to me that this recoveries of phage has been carried out due to the presence of bovine serum albumin. The chromatograph conducted here would seem to involbe the mixture of elution and displacement in the Terminology of Tiselius.
en-copyright=
kn-copyright=

en-aut-name=SasakiK.
en-aut-sei=Sasaki
en-aut-mei=K.
kn-aut-name=佐々木峻
kn-aut-sei=佐々木
kn-aut-mei=峻
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=899
end-page=908
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the sensitizations period of passive anaphylaxis
kn-title=被働性過敏症に於ける感作持続期間に就て（過敏症研究第2報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The duration of sensitization in guinea pig injected with antiegg white rabbit serum was measured by the passive anaphylaxic method. The results were as follows, 1. The precipitin of the passive sensitized guinea pig remained in its blood vessel in proportion to sensitized precipitin titer. 2. The duration of sensitization measured by foetal anaphylaxis took a longer time in proportion to sensitized antibody titer. 3. It was found that the complement titer after anaphylaxis proved decrease in proportion to the sensitized precipitin titer.
en-copyright=
kn-copyright=

en-aut-name=YamasitaKeizo
en-aut-sei=Yamasita
en-aut-mei=Keizo
kn-aut-name=山下敬三
kn-aut-sei=山下
kn-aut-mei=敬三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=887
end-page=898
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the incubation period active guineapig anaphylaxis egg white as antigen
kn-title=卵白を抗原とする海猽能働性過敏症の潜伏期について（過敏症研究第1報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The incubation period of active-guinea pig anaphylaxis was studied by antigen-antibody dilution method of Ogata. The results were as follows. 1. The small amount of precipitin was produced in guinea pig injected by small amount of antigen, and the typical faetal anaphylaxis proved least within 10 days after injection. 2. Though the typical foetal anaphylaxis was induced 0.5 or 1ml., the severer schock was elicited in guinea pig sensitized 1.0 ml. compared with 0.5 ml. 3. No great difference of antibody production and the incubations period between the method of 2 times succesive injection in guinea pig subctan and the 1 time injection with same quantity could not be found. 4. The production of precipitin was proved an increase propotion to the sensitized antigen quantity and the strength of anaphylaxtic schock was propotional to the antibody titer. 5. It was found out that the sensitized effect of guinea pig injected small amount of antigen to show weaker in the order of intravenous, intraperitoneal and subctaneous method, in derees of reactivity according as the increasing amount of sensitized antigen upper relation seems to become less distinct. 6. Decreasing grad of the temperature was propotional to the strength of anaphylaxis. 7. There could be found no great, pifference in the anaphylaxtie schock due to the body weight.
en-copyright=
kn-copyright=

en-aut-name=YamasitaKeizo
en-aut-sei=Yamasita
en-aut-mei=Keizo
kn-aut-name=山下敬三
kn-aut-sei=山下
kn-aut-mei=敬三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=883
end-page=885
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the effects of X-irradiation upon enzyme activity On accumulative action of X-rays
kn-title=レ線の酵素作用に及ぼす影響 レ線の蓄積作用に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Previously the author carried out experiments on the effects of X-irradiation upon enzyme activity and found that X-irradiation with small doses increases catalytic activity of enzyme, that middle doses inhibits, and what is influenced by X-rays is enzyme itself and not the substrate. Therefore, in order to clarify whether catalytic activity might be increased additionally, or be accumulated gradually until it might have inhibited the enzyme action as well as one middle dose, in case it has reached one middle dose by repeating several small doses with certain interval, so that it should reach irradiation due to one middle dose or not, using papayotin as an enzyme, gelatin as a substrate and the amount of non-protein nitrogen which increased by the gelatin decomposition, was measured. Then the author assured that when irradiation with small doses reached to middle dose by fractional irradiation same as one time of irradiation with middle doses enzyme action was inhibited and X-irradiation accumulated gradually within enzyme.
en-copyright=
kn-copyright=

en-aut-name=ImamuraShizuo
en-aut-sei=Imamura
en-aut-mei=Shizuo
kn-aut-name=今村静生
kn-aut-sei=今村
kn-aut-mei=静生
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=879
end-page=881
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Fatigue of Trainmen and Locomotive-Operators
kn-title=尿微量蛋白測定法による列車乗務員の疲労について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The measurements of the fatigue on conductors, porters, locomotive-drivers and locomotive-firemen, were studied by Donaggio-Sato-reaction and serological test. The results were as follows: 1) Trainmen worked for a long time on the train had an accumulation of fatigue on the next day. 2) The porter's fatigue proved greater than conductor's by upper methods. 3) The quantity of urine-protein in trainmen and locomotive-operators was greater than that of workers of lighter kind. 4) The quantity of urine-protein differed individually. 5) The serological test of urine protein, Donaggio reaction and congored-test seemed to have some interrelation among them.
en-copyright=
kn-copyright=

en-aut-name=InoueKuniya
en-aut-sei=Inoue
en-aut-mei=Kuniya
kn-aut-name=井上邦彌
kn-aut-sei=井上
kn-aut-mei=邦彌
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=867
end-page=878
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Method for Preservation of Reaction's Ring in Precipitin Ring Test
kn-title=Gelatin加重層法に依る沈降反応輪保存の研究（抗原抗体稀釈法の研究 第3報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The auther carried out precipitin ring test by adding 2% gelatin to its medium. The results were as follows: 1) The ring test reacted in 2% gelatin solution at 37°C. was able to be stopped and kept as it is by cooling (0°C.) 2) The reaction ring was able to be preserved by upper method for a month at 0°C, except extremely dense part. 3) The velocity of reaction in this method shows slower than that of general method at 37°C, but reaction titer is equal to that of usual method.
en-copyright=
kn-copyright=

en-aut-name=InoueKuniya
en-aut-sei=Inoue
en-aut-mei=Kuniya
kn-aut-name=井上邦彌
kn-aut-sei=井上
kn-aut-mei=邦彌
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=861
end-page=866
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects caused by Time and Temperature at Primany, Incubation of Complement-fixation Test
kn-title=補体結合反応に於ける補体結合の感作条件に関する研究（抗原抗体稀釈法の研究 第2報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) The antibody titer of complement-fixation test increased in proportion to the length of incubated time. 2) The antibody titer of complement-fixation test incubated at 0°C. for 6 hours was nearly equal to that of precipitin ring test. 3) The antibody titer of complement-fixation test incubated at 37°C. is higher than that at 0°C. in cardiolipin antigen system, but in yeastmannan system at 0°C. it proves higher than that at 37°C.
en-copyright=
kn-copyright=

en-aut-name=InoueKuniya
en-aut-sei=Inoue
en-aut-mei=Kuniya
kn-aut-name=井上邦彌
kn-aut-sei=井上
kn-aut-mei=邦彌
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=851
end-page=859
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Comparative Studies on Various Kinds of Antigen Antibody Reactions
kn-title=各種沈降反応系の比較研究（重層法，混合法，新混合法及補体結合法）（抗原抗体稀釈法の研究， 第1報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author studied relations among the antibody titer as well as reaction area in precipitin ring test, precipitin mixture test, new precititin mixture test and complement-fixation test with various antigen antibody systems. The results were as follws. 1) The antigen titer and antibody titer by new method of precipitin mixture test are heigher than that by usual method and equal to that of ring test. 2) The antibody titer of complement-fixation test incubated in refrigerater at 4°C. for 6 hours is nearly equal to that of ring test. 3) The "Bindungs Jone" never fails to appear in evry antigen antibody reactions. (e.g. protein, lipoid polysaccharide systems, simple and compound antigen systems.) 4) In polysaccharide system the antibody titer of precipitin mixture test proves heig her than that of precipittn ring test in most cases.
en-copyright=
kn-copyright=

en-aut-name=InoueKuniya
en-aut-sei=Inoue
en-aut-mei=Kuniya
kn-aut-name=井上邦彌
kn-aut-sei=井上
kn-aut-mei=邦彌
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END