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cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
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start-page=101
end-page=116
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第250回　日本泌尿器科学会岡山地方会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=特別シンポジウム「泌尿器科学：過去・現在・未来」
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=新島端夫
kn-aut-sei=新島
kn-aut-mei=端夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=田中啓幹
kn-aut-sei=田中
kn-aut-mei=啓幹
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=公文裕巳
kn-aut-sei=公文
kn-aut-mei=裕巳
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=東京大学

affil-num=2
en-affil=
kn-affil=川崎医科大学泌尿器科学教室

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 泌尿器病態学
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=83
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dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第147回　岡山外科会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=種本和雄
kn-aut-sei=種本
kn-aut-mei=和雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=67
end-page=69
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=徳永叡教授と脳の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=筒井公子
kn-aut-sei=筒井
kn-aut-mei=公子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=脳神経制御学講座神経機能構造学
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=63
end-page=66
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=脳神経センター大田記念病院
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐藤昇樹
kn-aut-sei=佐藤
kn-aut-mei=昇樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=脳神経センター大田記念病院
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=59
end-page=61
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ES細胞
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=許南浩
kn-aut-sei=許
kn-aut-mei=南浩
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科細胞生物学
en-keyword=ES細胞
kn-keyword=ES細胞
en-keyword=幹細胞
kn-keyword=幹細胞
en-keyword=ノックアウトマウス
kn-keyword=ノックアウトマウス
en-keyword=再生医療
kn-keyword=再生医療
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=53
end-page=57
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=当院における生体部分肺移植の現状
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐野由文
kn-aut-sei=佐野
kn-aut-mei=由文
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=伊達洋至
kn-aut-sei=伊達
kn-aut-mei=洋至
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=永広格
kn-aut-sei=永広
kn-aut-mei=格
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=青江基
kn-aut-sei=青江
kn-aut-mei=基
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡部和倫
kn-aut-sei=岡部
kn-aut-mei=和倫
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=安藤陽夫
kn-aut-sei=安藤
kn-aut-mei=陽夫
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=清水信義
kn-aut-sei=清水
kn-aut-mei=信義
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 腫瘍・胸部外科

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 腫瘍・胸部外科

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 腫瘍・胸部外科

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 腫瘍・胸部外科

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 腫瘍・胸部外科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 腫瘍・胸部外科

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 腫瘍・胸部外科
en-keyword=肺移植
kn-keyword=肺移植
en-keyword=生体部分肺移植
kn-keyword=生体部分肺移植
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=39
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A mechanism of development of arterial thrombosis : β2-glycoprotein I-specific ligand and autoantibody
kn-title=抗リン脂質抗体症候群における動脈血栓の発症機序：β2-グリコプロテインIに特異的なリガンドと自己抗体の関与
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL) appeared in patients with antiphospholipid syndrome (APS). We recently reported that β2-GPI specifically binds to oxidized low-density lipoprotein (oxLDL) and that on of the β2-GPI's major ligands derived from oxLDL, oxLig-1, is 9-(7-ketocholest-5-en-3β-yloxy)-9-oxononanoic acid (J. Lipid Res. 42, 697, 2001). In the present study, it was demonstrated that carboxylated variants of cholesteryl linoleate have a critical role for β2-GPI binding.In vitro experiments indicate that oxLDL was uptaken by macrophages via an interaction among the ligand such as oxLig-1, β2-GPI, and anti-β2-GPI autoantibodies. The uptake was not occurred by cholesterol or its ester without a free carboxyl residue, i.e., cholesteryl lenoleate, by cholesterol, or by 7-ketocholesterol alone, even in the presence of β2-GPI and anti-β2-GPI antibodies. Thus, carboxyl variants of cholesteryl ester specific for β2-GPI may mediate anti-β2-GPI Ab-dependent uptake of oxLDL by macrophages and autoimmune atherogenesis developed in APS.
en-copyright=
kn-copyright=

en-aut-name=LiuQingping
en-aut-sei=Liu
en-aut-mei=Qingping
kn-aut-name=劉慶平
kn-aut-sei=劉
kn-aut-mei=慶平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学院医歯学総合研究科細胞化学分野
en-keyword=antiphospholipid syndrome  (APS)
kn-keyword=antiphospholipid syndrome  (APS)
en-keyword=atherosclerosis
kn-keyword=atherosclerosis
en-keyword=autoantibody
kn-keyword=autoantibody
en-keyword=β2-glycoprotein I  (β2-GPI)
kn-keyword=β2-glycoprotein I  (β2-GPI)
en-keyword=oxidized LDL  (oxLDL)
kn-keyword=oxidized LDL  (oxLDL)
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=27
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The efficacy and toxicity resulting from recombinant HSV-tk adenoviral vector under the transcriptional control of caveolin-1 promoter for prostate cancer
kn-title=Caveolin-1プロモーターを用いたHerpes Simplex Virus-thymidine kinase遺伝子発現アデノウィルスによる前立腺癌遺伝子治療における有効性と安全性の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The efficacy and toxicity of adenoviral vectors that express Herpes Simplex Virus-thymidine kinase (HSV-tk) gene under the transcriptional control of caveolin-1 promoter  (cav.-1-tk) was compared to Cytomegalovirus (CMV) promoter or Rous sarcoma virus (RSV) promoter HSV-tk for prostate cancer. The cav.-1-tk demonstrated the strong cytotoxicity in vitro for mouse human prostate cancer cell line (178BMA) and human prostate cancer cell line (PC-3), which overxpress caveolin-1 levels. On the other hand, the cytotoxicity was weak for mouse (178PA) and human (LNCaP) prostate cancer cell line, which express low caveolin-1 levels. The antitumor efficacy was observed in each vector in vivo orthotopic model using 178BMA prostate cancer cell line. The immunohistochemical analysis results indicated that not only cancer cells but also tumor vasculature were destroyed by cav.-1-tk. The serum AST levels of cav.-1-tk was minimal change following intravenous injection. Taken together, adenovirus-mediated HSV-tk in situ gene therapy under the transcriptional control of caveolin-1 promoter may be effective and safe for prostate cancer compared to CMV or RSV promoter HSV-tk adenoviral vectors.
en-copyright=
kn-copyright=

en-aut-name=EbaraShin
en-aut-sei=Ebara
en-aut-mei=Shin
kn-aut-name=江原伸
kn-aut-sei=江原
kn-aut-mei=伸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科泌尿器病態学
en-keyword=caveolin-1 promoter
kn-keyword=caveolin-1 promoter
en-keyword=prostate cancer cell line
kn-keyword=prostate cancer cell line
en-keyword=orthotopic model
kn-keyword=orthotopic model
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=19
end-page=26
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=抗リン脂質抗体症候群
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松浦栄次
kn-aut-sei=松浦
kn-aut-mei=栄次
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科病態制御科学専攻病態機構学講座（細胞化学分野）
en-keyword=抗リン脂質抗体
kn-keyword=抗リン脂質抗体
en-keyword=抗リン脂質抗体症候群 (APS)
kn-keyword=抗リン脂質抗体症候群 (APS)
en-keyword=β2-グリコプロテインI (β2-GPI)
kn-keyword=β2-グリコプロテインI (β2-GPI)
en-keyword=動脈血栓
kn-keyword=動脈血栓
en-keyword=酸化LDL
kn-keyword=酸化LDL
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=5
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=腹臥位呼吸管理とARDSの治療戦略上の意義
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=氏家良人
kn-aut-sei=氏家
kn-aut-mei=良人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科生体制御科学専攻・機能制御学講座（救急医学）
en-keyword=ARDS
kn-keyword=ARDS
en-keyword=腹臥位
kn-keyword=腹臥位
en-keyword=EBM
kn-keyword=EBM
en-keyword=有効性
kn-keyword=有効性
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=4
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=私たちの導電染色と導電樹脂―山陽新聞賞を受賞して―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurakamiTakuro
en-aut-sei=Murakami
en-aut-mei=Takuro
kn-aut-name=村上宅郎
kn-aut-sei=村上
kn-aut-mei=宅郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科人体構成学
END